List of EC numbers (EC 1)

This list contains a list of EC numbers for the first group, EC 1, oxidoreductases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology. All official information is tabulated at the website of the committee. The database is developed and maintained by Andrew McDonald.

EC 1.1 Acting on the CH-OH group of donors

EC 1.1.4 With a disulfide as acceptor

EC 1.1.4.1: Now EC 1.17.4.4, vitamin-K-epoxide reductase
EC 1.1.4.2: Now EC 1.17.4.5, vitamin-K-epoxide reductase

EC 1.1.5 With a quinone or similar compound as acceptor

EC 1.1.5.1: deleted, see EC 1.1.99.18 cellobiose dehydrogenase
: quinoprotein glucose dehydrogenase
: glycerol-3-phosphate dehydrogenase (quinone)
: malate dehydrogenase (quinone)
: alcohol dehydrogenase (quinone)
: formate dehydrogenase-N
: cyclic alcohol dehydrogenase (quinone)
: quinate dehydrogenase (quinone)

EC 1.1.9 With a copper protein as acceptor

: alcohol dehydrogenase (azurin)

EC 1.1.98 With other, known, acceptors

EC 1.1.98.1: Now EC 1.1.9.1, alcohol dehydrogenase
: glucose-6-phosphate dehydrogenase (coenzyme-F₄₂₀)
: decaprenylphospho-β-D-ribofuranose 2-oxidase
EC 1.1.98.3: decaprenylphospho-β-D-ribofuranose 2-dehydrogenase
EC 1.1.98.4: F₄₂₀H₂:quinone oxidoreductase
EC 1.1.98.5: secondary-alcohol dehydrogenase (coenzyme-F₄₂₀)
EC 1.1.98.6: ribonucleoside-triphosphate reductase (formate)
EC 1.1.98.7: serine-type anaerobic sulfatase-maturating enzyme

EC 1.1.99 With unknown physiological acceptors

: choline dehydrogenase
: L-2-hydroxyglutarate dehydrogenase
: gluconate 2-dehydrogenase (acceptor)
: dehydrogluconate dehydrogenase
EC 1.1.99.5: now EC 1.1.5.3, glycerol-3-phosphate dehydrogenase
: D-2-hydroxy-acid dehydrogenase
: lactate—malate transhydrogenase
EC 1.1.99.8: Now EC 1.1.2.7, methanol dehydrogenase and EC 1.1.2.8, alcohol dehydrogenase.
: pyridoxine 5-dehydrogenase
EC 1.1.99.10: Now EC 1.1.5.9, glucose 1-dehydrogenase
EC 1.1.99.11: Now classified as EC 1.1.5.14, fructose 5-dehydrogenase
: sorbose dehydrogenase
: glucoside 3-dehydrogenase
: glycolate dehydrogenase
EC 1.1.99.15: Now EC 1.5.1.20, methylenetetrahydrofolate reductase
EC 1.1.99.16: Now EC EC 1.1.5.4, malate dehydrogenase
EC 1.1.99.17: Now EC 1.1.5.2, quinoprotein glucose dehydrogenase
: cellobiose dehydrogenase (acceptor)
EC 1.1.99.19: Now EC 1.17.99.4, uracil/thymine dehydrogenase
: alkan-1-ol dehydrogenase (acceptor)
: D-sorbitol dehydrogenase (acceptor)
: glycerol dehydrogenase (acceptor)
EC 1.1.99.23: Now EC 1.1.2.6, polyvinyl alcohol dehydrogenase
: hydroxyacid-oxoacid transhydrogenase
EC 1.1.99.25: Now EC 1.1.5.8, quinate dehydrogenase,
: 3-hydroxycyclohexanone dehydrogenase
: (R)-pantolactone dehydrogenase (flavin)
: glucose-fructose oxidoreductase
: pyranose dehydrogenase (acceptor)
: 2-oxoacid reductase
: (S)-mandelate dehydrogenase
: L-sorbose 1-dehydrogenase
EC 1.1.99.33: Now EC 1.17.99.7, formate dehydrogenase
EC 1.1.99.34: now EC 1.1.98.2, glucose-6-phosphate dehydrogenase
: soluble quinoprotein glucose dehydrogenase
: alcohol dehydrogenase (nicotinoprotein)
: methanol dehydrogenase (nicotinoprotein)
: 2-deoxy-scyllo-inosamine dehydrogenase (AdoMet-dependent)
: D-2-hydroxyglutarate dehydrogenase
EC 1.1.99.40: (R)-2-hydroxyglutarate—pyruvate transhydrogenase
EC 1.1.99.41: 3-hydroxy-1,2-didehydro-2,3-dihydrotabersonine reductase
EC 1.1.99.42: 4-pyridoxic acid dehydrogenase

EC 1.2 Acting on the aldehyde or oxo group of donors

EC 1.2.1 With NAD⁺ or NADP⁺ as acceptor

EC 1.2.1.1: deleted, replaced by EC 1.1.1.284, S-glutathione dehydrogenase and EC 4.4.1.22, S-glutathione synthase
EC 1.2.1.2: Now EC 1.17.1.9, formate dehydrogenase
: aldehyde dehydrogenase (NAD⁺)
: aldehyde dehydrogenase (NADP⁺)
: aldehyde dehydrogenase (NAD(P)⁺)
EC 1.2.1.6: deleted
: benzaldehyde dehydrogenase (NADP⁺)
: betaine-aldehyde dehydrogenase
: glyceraldehyde-3-phosphate dehydrogenase (NADP⁺)
: acetaldehyde dehydrogenase (acetylating)
: aspartate-semialdehyde dehydrogenase
: glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)
: glyceraldehyde-3-phosphate dehydrogenase (NADP⁺) (phosphorylating)
EC 1.2.1.14: Now EC 1.1.1.205, IMP dehydrogenase
: malonate-semialdehyde dehydrogenase
: Succinate-semialdehyde dehydrogenase | succinate-semialdehyde dehydrogenase
: glyoxylate dehydrogenase (acylating)
: malonate-semialdehyde dehydrogenase (acetylating)
: aminobutyraldehyde dehydrogenase
: glutarate-semialdehyde dehydrogenase
: glycolaldehyde dehydrogenase
: lactaldehyde dehydrogenase
: 2-oxoaldehyde dehydrogenase (NAD⁺)
: succinate-semialdehyde dehydrogenase (NAD⁺)
: branched-chain α-keto acid dehydrogenase system
: 2,5-dioxovalerate dehydrogenase
: methylmalonate-semialdehyde dehydrogenase (CoA-acylating)
: benzaldehyde dehydrogenase (NAD⁺)
: aryl-aldehyde dehydrogenase
: aryl-aldehyde dehydrogenase (NADP⁺)
: L-aminoadipate-semialdehyde dehydrogenase
: aminomuconate-semialdehyde dehydrogenase
: (R)-dehydropantoate dehydrogenase
EC 1.2.1.34: Now EC 1.1.1.131, mannuronate reductase
EC 1.2.1.35: Now EC 1.1.1.203, uronate dehydrogenase
: retinal dehydrogenase
EC 1.2.1.37: Now EC 1.17.1.4, xanthine dehydrogenase
: N-acetyl-γ-glutamyl-phosphate reductase
: phenylacetaldehyde dehydrogenase
EC 1.2.1.40: part of EC 1.14.13.15, cholestanetriol 26-monooxygenase
: glutamate-5-semialdehyde dehydrogenase
: hexadecanal dehydrogenase (acylating)
EC 1.2.1.43: Now EC 1.17.1.10, formate dehydrogenase
: cinnamoyl-CoA reductase
EC 1.2.1.45: Now EC 1.1.1.312, 2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase
: formaldehyde dehydrogenase
: 4-trimethylammoniobutyraldehyde dehydrogenase
: long-chain-aldehyde dehydrogenase
: 2-oxoaldehyde dehydrogenase (NADP⁺)
: long-chain-fatty-acyl-CoA reductase
: pyruvate dehydrogenase (NADP⁺)
: deleted 2025
: 4-hydroxyphenylacetaldehyde dehydrogenase
: γ-guanidinobutyraldehyde dehydrogenase
EC 1.2.1.55: Now EC 1.1.1.279, -3-hydroxyacid-ester dehydrogenase
EC 1.2.1.56: Now EC 1.1.1.280, -3-hydroxyacid-ester dehydrogenase
: butanal dehydrogenase
: phenylglyoxylate dehydrogenase (acylating)
: glyceraldehyde-3-phosphate dehydrogenase (NAD(P)⁺)
: 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase
: 4-hydroxymuconic-semialdehyde dehydrogenase
: 4-formylbenzenesulfonate dehydrogenase
: 6-oxohexanoate dehydrogenase
: 4-hydroxybenzaldehyde dehydrogenase (NAD⁺)
: salicylaldehyde dehydrogenase
EC 1.2.1.66: Now EC 1.1.1.306, S-(hydroxymethyl)mycothiol dehydrogenase
: vanillin dehydrogenase
: coniferyl-aldehyde dehydrogenase
: fluoroacetaldehyde dehydrogenase
: glutamyl-tRNA reductase
: succinylglutamate-semialdehyde dehydrogenase
: erythrose-4-phosphate dehydrogenase
: sulfoacetaldehyde dehydrogenase
: abieta-7,13-dien-18-al dehydrogenase
: malonyl CoA reductase (malonate semialdehyde-forming)
: succinate-semialdehyde dehydrogenase (acylating)
: 3,4-dehydroadipyl-CoA semialdehyde dehydrogenase (NADP⁺)
: 2-formylbenzoate dehydrogenase
: succinate-semialdehyde dehydrogenase (NADP⁺)
: long-chain acyl- reductase|long-chain acyl- reductase
: sulfoacetaldehyde dehydrogenase (acylating)
: β-apo-4′-carotenal oxygenase
: 3-succinoylsemialdehyde-pyridine dehydrogenase
: alcohol-forming fatty acyl-CoA reductase
: 2-hydroxymuconate-6-semialdehyde dehydrogenase
: geranial dehydrogenase
EC 1.2.1.87: propanal dehydrogenase (CoA-propanoylating)
EC 1.2.1.88: L-glutamate γ-semialdehyde dehydrogenase
EC 1.2.1.89: D-glyceraldehyde dehydrogenase (NADP⁺)
EC 1.2.1.90: glyceraldehyde-3-phosphate dehydrogenase |glyceraldehyde-3-phosphate dehydrogenase
EC 1.2.1.91: 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase
EC 1.2.1.92: 3,6-anhydro-α-L-galactose dehydrogenase
EC 1.2.1.93: formate dehydrogenase. Now EC 1.17.1.11, formate dehydrogenase *
EC 1.2.1.94: farnesal dehydrogenase
EC 1.2.1.95: L-2-aminoadipate reductase
EC 1.2.1.96: 4-hydroxybenzaldehyde dehydrogenase (⁺+)
EC 1.2.1.97: 3-sulfolactaldehyde dehydrogenase
EC 1.2.1.98: 2-hydroxy-2-methylpropanal dehydrogenase
EC 1.2.1.99: 4-(γ-glutamylamino)butanal dehydrogenase
EC 1.2.1.100: 5-formyl-3-hydroxy-2-methylpyridine 4-carboxylic acid 5-dehydrogenase
EC 1.2.1.101: L-tyrosine reductase
EC 1.2.1.102: isopyridoxal dehydrogenase (5-pyridoxate-forming)
EC 1.2.1.103: -6-phospho-L-2-aminoadipate reductase|-6-phospho-L-2-aminoadipate reductase
EC 1.2.1.104: pyruvate dehydrogenase system
EC 1.2.1.105: 2-oxoglutarate dehydrogenase system
EC 1.2.1.106: -5-phospho-L-glutamate reductase|-5-phospho-L-glutamate reductase
EC 1.2.1.107: glyceraldehyde-3-phosphate dehydrogenase (arsenate-transferring)

EC 1.2.2 With a cytochrome as acceptor

: formate dehydrogenase (cytochrome)
EC 1.2.2.2: Now covered by EC 1.2.5.1, pyruvate dehydrogenase
EC 1.2.2.3: Now EC 1.17.2.3, formate dehydrogenase
EC 1.2.2.4: Now classified as EC 1.2.5.3, aerobic carbon monoxide dehydrogenase

EC 1.2.3 With oxygen as acceptor

: aldehyde oxidase
EC 1.2.3.2: Now EC 1.17.3.2, xanthine oxidase
: pyruvate oxidase
: oxalate oxidase
: glyoxylate oxidase
: pyruvate oxidase (CoA-acetylating)
: indole-3-acetaldehyde oxidase
: pyridoxal oxidase
: aryl-aldehyde oxidase
EC 1.2.3.10: deleted, activity due to EC 1.2.2.4 carbon-monoxide dehydrogenase
EC 1.2.3.11: Now included with EC 1.2.3.1, aldehyde oxidase
EC 1.2.3.12: Now included with EC 1.2.3.1, aldehyde oxidase
EC 1.2.3.13: Now EC 1.14.13.82, vanillate monooxygenase
: Abscisic-aldehyde oxidase
EC 1.2.3.15: (methyl)glyoxal oxidase

EC 1.2.4 With a disulfide as acceptor

: pyruvate dehydrogenase (acetyl-transferring)
: oxoglutarate dehydrogenase (succinyl-transferring)
EC 1.2.4.3: Now included with EC 1.2.4.4, 3-methyl-2-oxobutanoate dehydrogenase
: 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)

EC 1.2.5 With a quinone or similar compound as acceptor

: pyruvate dehydrogenase (quinone)
EC 1.2.5.2: aldehyde dehydrogenase (quinone)
EC 1.2.5.3: aerobic carbon monoxide dehydrogenase

EC 1.2.7 With an iron–sulfur protein as acceptor

: pyruvate synthase
EC 1.2.7.2: Now included with EC 1.2.7.1, pyruvate synthase.
: 2-oxoglutarate synthase
: anaerobic carbon monoxide dehydrogenase
: aldehyde ferredoxin oxidoreductase
: glyceraldehyde-3-phosphate dehydrogenase (ferredoxin)
: 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)
: indolepyruvate ferredoxin oxidoreductase
EC 1.2.7.9: deleted, identical to EC 1.2.7.3, 2-oxoglutarate synthase
: oxalate oxidoreductase
EC 1.2.7.11: 2-oxoacid oxidoreductase (ferredoxin)
EC 1.2.7.12: formylmethanofuran dehydrogenase

EC 1.2.98: With other, known physiological acceptors

EC 1.2.98.1: formaldehyde dismutase

EC 1.2.99: With unknown physiological acceptors

EC 1.2.99.1: Now EC 1.17.99.4, uracil/thymine dehydrogenase
EC 1.2.99.2: Now EC 1.2.7.4, carbon-monoxide dehydrogenase
EC 1.2.99.3: Now EC 1.2.5.2, aldehyde dehydrogenase
EC 1.2.99.4: Now EC 1.2.98.1, formaldehyde dismutase
EC 1.2.99.5: Now EC 1.2.7.12, formylmethanofuran dehydrogenase
: carboxylate reductase
: aldehyde dehydrogenase (FAD-independent)
EC 1.2.99.8: glyceraldehyde dehydrogenase (FAD-containing)
EC 1.2.99.9: Now EC 1.17.98.3, formate dehydrogenase
EC 1.2.99.10: 4,4′-diapolycopenoate synthase

EC 1.3 Acting on the CH-CH group of donors

EC 1.3.1 With NAD⁺ or NADP⁺ as acceptor

: dihydrouracil dehydrogenase (NAD⁺)
: dihydropyrimidine dehydrogenase (NADP⁺)
: Δ⁴-3-oxosteroid 5β-reductase
EC 1.3.1.4: transferred to EC 1.3.1.22, 3-oxo-5α-steroid 4-dehydrogenase
: cucurbitacin Δ²³-reductase
: fumarate reductase (NADH)
: meso-tartrate dehydrogenase
: acyl-CoA dehydrogenase (NADP⁺)
: enoyl- reductase |enoyl- reductase
: enoyl- reductase |enoyl- reductase
: 2-coumarate reductase
: prephenate dehydrogenase
: prephenate dehydrogenase (NADP⁺)
: dihydroorotate dehydrogenase (NAD⁺)
: dihydroorotate dehydrogenase (NADP⁺)
: β-nitroacrylate reductase
: 3-methyleneoxindole reductase
: kynurenate-7,8-dihydrodiol dehydrogenase
: cis-1,2-dihydrobenzene-1,2-diol dehydrogenase
: trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
: 7-dehydrocholesterol reductase
: 3-oxo-5α-steroid 4-dehydrogenase (NADP⁺)
EC 1.3.1.23: Identical to EC 1.3.1.3, Δ4-3-oxosteroid 5β-reductase
: biliverdin reductase
: 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase
EC 1.3.1.26: Now EC 1.17.1.8, 4-hydroxy-tetrahydrodipicolinate reductase
: 2-hexadecenal reductase
: 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
: cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase
EC 1.3.1.30: transferred to EC 1.3.1.22, 3-oxo-5α-steroid 4-dehydrogenase
: 2-enoate reductase
: maleylacetate reductase
: protochlorophyllide reductase
: 2,4 Dienoyl-CoA reductase (NADPH)
EC 1.3.1.35: Now EC 1.14.19.22, microsomal oleoyl-lipid 12-desaturase
: geissoschizine dehydrogenase
: cis-2-enoyl-CoA reductase (NADPH)
: trans-2-enoyl-CoA reductase (NADPH)
: trans-2-enoyl-CoA reductase (NADPH)
: 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate reductase
: xanthommatin reductase
: 12-oxophytodienoate reductase
: arogenate dehydrogenase
: trans-2-enoyl-CoA reductase (NAD⁺)
: 2′-hydroxyisoflavone reductase
: biochanin-A reductase
: α-santonin 1,2-reductase
: 13,14-dehydro-15-oxoprostaglandin 13-reductase
: cis-3,4-dihydrophenanthrene-3,4-diol dehydrogenase
EC 1.3.1.50: n Now EC 1.1.1.252 tetrahydroxynaphthalene reductase
: 2′-hydroxydaidzein reductase
EC 1.3.1.52: Now EC 1.3.8.5, 2-methyl-branched-chain-enoyl-CoA reductase
: (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate dehydrogenase
: precorrin-6A reductase
EC 1.3.1.55: identical to EC 1.3.1.25, 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase
: cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase
: phloroglucinol reductase
: 2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase
EC 1.3.1.59: There is no evidence that the enzyme exists
: dibenzothiophene dihydrodiol dehydrogenase
EC 1.3.1.61: identical to EC 1.3.1.53, (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate dehydrogenase
: pimeloyl-CoA dehydrogenase
EC 1.3.1.63: Now EC 1.21.1.2, 2,4-dichlorobenzoyl-CoA reductase
: phthalate 4,5-cis-dihydrodiol dehydrogenase
: 5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline dehydrogenase
: cis-dihydroethylcatechol dehydrogenase
: cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate dehydrogenase
: 1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase
: zeatin reductase
: Δ¹⁴-sterol reductase
: Δ^24(24¹)-sterol reductase
: Δ²⁴-sterol reductase
: 1,2-dihydrovomilenine reductase
: 2-alkenal reductase|2-alkenal reductase
: 3,8-divinyl protochlorophyllide a 8-vinyl-reductase (NADPH)
: precorrin-2 dehydrogenase
: anthocyanidin reductase| anthocyanidin reductase
: arogenate dehydrogenase (NADP⁺)
: arogenate dehydrogenase (NAD(P)⁺)
EC 1.3.1.80: Now classified as EC 1.3.7.12, red chlorophyll catabolite reductase
: (+)-pulegone reductase
: (-)-isopiperitenone reductase
: geranylgeranyl diphosphate reductase
: acrylyl-CoA reductase (NADPH)
: crotonyl-CoA carboxylase/reductase
: crotonyl-CoA reductase
: 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate dehydrogenase
: tRNA-dihydrouridine^16/17 synthase (NAD(P)⁺)
: tRNA-dihydrouridine⁴⁷ synthase (NAD(P)⁺)
: tRNA-dihydrouridine^20a/20b synthase (NAD(P)⁺)
: tRNA-dihydrouridine²⁰ synthase (NAD(P)⁺)
: artemisinic aldehyde Δ¹¹⁽¹³⁾-reductase
: very-long-chain enoyl-CoA reductase
: polyprenol reductase
: acrylyl-CoA reductase (NADH)
: Botryococcus squalene synthase
: botryococcene synthase
EC 1.3.1.98: Now known to be catalyzed by two different enzymes, EC 1.3.1.122, -8-oxocitronellyl enol synthase, and EC 5.5.1.34, -cis,trans-nepetalactol synthase
EC 1.3.1.100: chanoclavine-I aldehyde reductase
EC 1.3.1.101: 2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase |2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase
EC 1.3.1.102: 2-alkenal reductase (NADP+)
EC 1.3.1.103: 2-haloacrylate reductase
EC 1.3.1.104: enoyl- reductase |enoyl- reductase
EC 1.3.1.105: 2-methylene-furan-3-one reductase
EC 1.3.1.106: cobalt-precorrin-6A reductase
EC 1.3.1.107: sanguinarine reductase
EC 1.3.1.108: caffeoyl-CoA reductase
EC 1.3.1.109: butanoyl-CoA dehydrogenase complex (NAD⁺, ferredoxin)
EC 1.3.1.110: lactate dehydrogenase (NAD⁺,ferredoxin)
EC 1.3.1.111: geranylgeranyl-bacteriochlorophyllide a reductase
EC 1.3.1.112: anthocyanidin reductase |anthocyanidin reductase
EC 1.3.1.113: (4-alkanoyl-5-oxo-2,5-dihydrofuran-3-yl)methyl phosphate reductase
EC 1.3.1.114: 3-dehydro-bile acid Δ^4,6-reductase
EC 1.3.1.115: 3-oxocholoyl-CoA 4-desaturase
EC 1.3.1.116: 7β-hydroxy-3-oxochol-24-oyl-CoA 4-desaturase
EC 1.3.1.117: hydroxycinnamoyl-CoA reductase
EC 1.3.1.118: meromycolic acid enoyl- reductase|meromycolic acid enoyl- reductase
EC 1.3.1.119: chlorobenzene dihydrodiol dehydrogenase
EC 1.3.1.120: cyclohexane-1-carbonyl-CoA reductase NADP⁺)
EC 1.3.1.121: 4-amino-4-deoxyprephenate dehydrogenase
EC 1.3.1.122: (S)-8-oxocitronellyl enol synthase
EC 1.3.1.123: 8-oxogeranial reductase
EC 1.3.1.124: 2,4-dienoyl-CoA reductase |2,4-dienoyl-CoA reductase

EC 1.3.2 With a cytochrome as acceptor

EC 1.3.3 With oxygen as acceptor

EC 1.3.5 With a quinone or related compound as acceptor

EC 1.3.7 With an iron–sulfur protein as acceptor

EC 1.3.8 With a flavin as acceptor

: short-chain acyl-CoA dehydrogenase
: 4,4′-diapophytoene desaturase (4,4′-diapolycopene-forming)
: (R)-benzylsuccinyl-CoA dehydrogenase
: isovaleryl-CoA dehydrogenase
: 2-methyl-branched-chain-enoyl-CoA reductase
: glutaryl-CoA dehydrogenase (ETF)
: medium-chain acyl-CoA dehydrogenase
: long-chain acyl-CoA dehydrogenase
: very-long-chain acyl-CoA dehydrogenase
EC 1.3.8.10: cyclohex-1-ene-1-carbonyl-CoA dehydrogenase
EC 1.3.8.11: cyclohexane-1-carbonyl-CoA dehydrogenase (electron-transfer flavoprotein)
EC 1.3.8.12: (2S)-methylsuccinyl-CoA dehydrogenase
EC 1.3.8.13: crotonobetainyl-CoA reductase
EC 1.3.8.14: L-prolyl- dehydrogenase|L-prolyl- dehydrogenase
EC 1.3.8.15: 3-(aryl)acrylate reductase
EC 1.3.8.16: 2-amino-4-deoxychorismate dehydrogenase
EC 1.3.8.17: dehydro coenzyme F₄₂₀ reductase

EC 1.3.98 With other,known physiological acceptors

: dihydroorotate dehydrogenase (fumarate)
EC 1.3.98.2: Now EC 1.3.4.1, fumarate reductase
EC 1.3.98.3: coproporphyrinogen dehydrogenase
EC 1.3.98.4: 5a,11a-dehydrotetracycline reductase
EC 1.3.98.5: hydrogen peroxide-dependent heme synthase
EC 1.3.98.6: AdoMet-dependent heme synthase
EC 1.3.98.7: -tyrosine decarboxylase|-tyrosine decarboxylase

EC 1.3.99 With unknown physiological acceptors

EC 1.3.99.1: The activity is included in EC 1.3.5.1, succinate dehydrogenase
EC 1.3.99.2: Now EC 1.3.8.1, butyryl-CoA dehydrogenase.
EC 1.3.99.3: now EC 1.3.8.7, medium-chain acyl-CoA dehydrogenase, EC 1.3.8.8, long-chain acyl-CoA dehydrogenase and EC 1.3.8.9, very-long-chain acyl-CoA dehydrogenase
: 3-oxosteroid 1-dehydrogenase
: 3-oxo-5α-steroid 4-dehydrogenase (acceptor)
: 3-oxo-5β-steroid 4-dehydrogenase
EC 1.3.99.7: Now EC 1.3.8.6, glutaryl-CoA dehydrogenase
: 2-furoyl-CoA dehydrogenase
EC 1.3.99.9: Now EC 1.21.99.1, β-cyclopiazonate dehydrogenase
EC 1.3.99.10: Now EC 1.3.8.4, isovaleryl-CoA dehydrogenase
EC 1.3.99.11: transferred to EC 1.3.5.2, dihydroorotate dehydrogenase
EC 1.3.99.12: Now classified as EC 1.3.8.5, 2-methyl-branched-chain-enoyl-CoA reductase
: Now EC 1.3.8.8, long-chain-acyl-CoA dehydrogenase
: cyclohexanone dehydrogenase
EC 1.3.99.15: Now EC 1.3.7.8
: isoquinoline 1-oxidoreductase
: quinoline 2-oxidoreductase
: quinaldate 4-oxidoreductase
: quinoline-4-carboxylate 2-oxidoreductase
EC 1.3.99.20: Now EC 1.3.7.9, 4-hydroxybenzoyl-CoA reductase
EC 1.3.99.21: Now EC 1.3.8.3, -benzylsuccinyl-CoA dehydrogenase
EC 1.3.99.22: Now EC 1.3.98.3, coproporphyrinogen dehydrogenase
: all-trans-retinol 13,14-reductase
EC 1.3.99.24: Now EC 1.3.8.16, 2-amino-4-deoxychorismate dehydrogenase
: carvone reductase
: all-trans-ζ-carotene desaturase
: 1-hydroxycarotenoid 3,4-desaturase
: phytoene desaturase (neurosporene-forming)
: phytoene desaturase (zeta-carotene-forming)
: phytoene desaturase (3,4-didehydrolycopene-forming)
: phytoene desaturase (lycopene-forming)
: glutaryl-CoA dehydrogenase (non-decarboxylating)
EC 1.3.99.33: urocanate reductase
EC 1.3.99.34: Now classified as EC 1.3.7.11, 2,3-bis-O-geranylgeranyl-sn-glycero-phospholipid reductase
EC 1.3.99.35: Now EC 1.3.7.15, chlorophyllide a reductase *
EC 1.3.99.36: cypemycin cysteine dehydrogenase (decarboxylating)
EC 1.3.99.37: 1-hydroxy-2-isopentenylcarotenoid 3,4-desaturase
EC 1.3.99.38: menaquinone-9 β-reductase
EC 1.3.99.39: carotenoid φ-ring synthase
EC 1.3.99.40: carotenoid χ-ring synthase

EC 1.4 Acting on the CH-NH₂ group of donors

EC 1.4.1 With NAD⁺ or NADP⁺ as acceptor

: alanine dehydrogenase
: glutamate dehydrogenase
: glutamate dehydrogenase (NAD(P)⁺)
: glutamate dehydrogenase (NADP⁺)
: L-amino-acid dehydrogenase
EC 1.4.1.6: deleted, Now included with EC 1.21.4.1, D-proline reductase
: serine 2-dehydrogenase
: valine dehydrogenase (NADP⁺)
: leucine dehydrogenase
: glycine dehydrogenase
: L-erythro-3,5-diaminohexanoate dehydrogenase
: 2,4-diaminopentanoate dehydrogenase
: glutamate synthase (NADPH)
: glutamate synthase (NADH)
: lysine dehydrogenase
: diaminopimelate dehydrogenase
: N-methylalanine dehydrogenase
: lysine 6-dehydrogenase
: tryptophan dehydrogenase
: phenylalanine dehydrogenase
: aspartate dehydrogenase
EC 1.4.1.22: there is no overall consumption of NAD⁺ during the reaction. As a result, transfer of the enzyme from EC 4.3.1.12 was not necessary and EC 1.4.1.22 was withdrawn before being made official
: valine dehydrogenase (NAD⁺)
: 3-dehydroquinate synthase II
EC 1.4.1.25: L-arginine dehydrogenase
EC 1.4.1.26: 2,4-diaminopentanoate dehydrogenase (NAD⁺)
EC 1.4.1.27: glycine cleavage system

EC 1.4.2 With a cytochrome as acceptor

: glycine dehydrogenase (cytochrome)

EC 1.4.3 With oxygen as acceptor

: D-aspartate oxidase
: L-amino-acid oxidase
: D-amino-acid oxidase
: monoamine oxidase
: pyridoxal 5′-phosphate synthase
EC 1.4.3.6: replaced by two enzymes, EC 1.4.3.21 (primary-amine oxidase) and EC 1.4.3.22 (diamine oxidase)
: D-glutamate oxidase
: ethanolamine oxidase
EC 1.4.3.9: Now included with EC 1.4.3.4 amine oxidase
: putrescine oxidase
: L-glutamate oxidase
: cyclohexylamine oxidase
: protein-lysine 6-oxidase
: L-lysine oxidase
: D-glutamate(D-aspartate) oxidase
: L-aspartate oxidase
EC 1.4.3.17: Now EC 1.3.3.10, tryptophan α,β-oxidase
EC 1.4.3.18: Not approved as the enzyme was shown to be a dehydrogenase and not an oxidase (see EC 1.5.99.12, cytokinin dehydrogenase)
: glycine oxidase
: L-lysine 6-oxidase
: primary-amine oxidase
: diamine oxidase
: 7-chloro-L-tryptophan oxidase
: pseudooxynicotine oxidase
EC 1.4.3.25: L-arginine oxidase
EC 1.4.3.26: pre-mycofactocin synthase

EC 1.4.4 With a disulfide as acceptor

EC 1.4.4.1: Now EC 1.21.4.1, D-proline reductase
: glycine dehydrogenase (aminomethyl-transferring)

EC 1.4.5 With a quinone or other compound as acceptor

: D-amino acid dehydrogenase (quinone)

EC 1.4.7 With an iron–sulfur protein as acceptor

: glutamate synthase (ferredoxin)

EC 1.4.9 With a copper protein as acceptor

EC 1.4.98 With other, known physiological acceptors

: NOW 1.4.9.1 methylamine dehydrogenase (amicyanin)

EC 1.4.99 With unknown physiological acceptors

EC 1.4.99.1: Now EC 1.4.99.6, D-arginine dehydrogenase
: taurine dehydrogenase
EC 1.4.99.3: Now EC 1.4.9.1, methylamine dehydrogenase
EC 1.4.99.4: Now EC 1.4.9.2, aralkylamine dehydrogenase
: glycine dehydrogenase (cyanide-forming)
EC 1.4.99.6: D-arginine dehydrogenase

EC 1.5 Acting on the CH-NH group of donors">Electron donor">donors

EC 1.5.1 With NAD⁺ or NADP⁺ as acceptor

: 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NAD(P)H)
: pyrroline-5-carboxylate reductase
: dihydrofolate reductase
EC 1.5.1.4: Now included with EC 1.5.1.3 dihydrofolate reductase
: methylenetetrahydrofolate dehydrogenase (NADP⁺)
: formyltetrahydrofolate dehydrogenase
: saccharopine dehydrogenase (NAD⁺, L-lysine-forming)
: saccharopine dehydrogenase (NADP⁺, L-lysine-forming)
: saccharopine dehydrogenase (NAD⁺, L-glutamate-forming)
: saccharopine dehydrogenase (NADP⁺, L-glutamate-forming)
: D-octopine dehydrogenase
EC 1.5.1.12: Now EC 1.2.1.88, L-glutamate γ-semialdehyde dehydrogenase
EC 1.5.1.13: Now EC 1.17.1.5, nicotinate dehydrogenase
EC 1.5.1.14: Now included with EC 1.5.1.21 Δ¹-piperideine-2-carboxylate reductase
: methylenetetrahydrofolate dehydrogenase (NAD⁺)
: D-lysopine dehydrogenase
: alanopine dehydrogenase
: ephedrine dehydrogenase
: D-nopaline dehydrogenase
: methylenetetrahydrofolate reductase (NAD(P)H)
: 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH)
: strombine dehydrogenase
: tauropine dehydrogenase
: N⁵-(carboxyethyl)ornithine synthase
: thiomorpholine-carboxylate dehydrogenase
: β-alanopine dehydrogenase
: 1,2-dehydroreticulinium reductase (NADPH)
: opine dehydrogenase
EC 1.5.1.29: Now covered by EC 1.5.1.38, EC 1.5.1.39 and EC 1.5.1.41
: flavin reductase (NADPH)
: berberine reductase
: vomilenine reductase
: pteridine reductase
: 6,7-dihydropteridine reductase
EC 1.5.1.35: identical to EC 1.2.1.19, aminobutyraldehyde dehydrogenase, as the substrates 1-pyrroline and 4-aminobutanal are interconvertible
: flavin reductase (NADH)
: FAD reductase (NADH)
: FMN reductase (NADPH)
: FMN reductase (NAD(P)H)
: 8-hydroxy-5-deazaflavin:NADPH oxidoreductase
: riboflavin reductase (NAD(P)H)
: FMN reductase (NADH)
: carboxynorspermidine synthase
: festuclavine dehydrogenase
: FAD reductase (NAD(P)H)
EC 1.5.1.46: agroclavine dehydrogenase
EC 1.5.1.47: dihydromethanopterin reductase |dihydromethanopterin reductase
EC 1.5.1.48: 2-methyl-1-pyrroline reductase
EC 1.5.1.49: 1-pyrroline-2-carboxylate reductase |1-pyrroline-2-carboxylate reductase
EC 1.5.1.50: dihydromonapterin reductase
EC 1.5.1.51: N--L-lutamate dehydrogenase|N--L-lutamate dehydrogenase
EC 1.5.1.52: staphylopine dehydrogenase
EC 1.5.1.53: methylenetetrahydrofolate reductase (NADPH)
EC 1.5.1.54: methylenetetrahydrofolate reductase (NADH)

EC 1.5.3 With oxygen as acceptor

: sarcosine oxidase
: N-methyl-L-amino-acid oxidase
EC 1.5.3.3: deleted
: N⁶-methyl-lysine oxidase
: (S)-6-hydroxynicotine oxidase
: (R)-6-hydroxynicotine oxidase
: L-pipecolate oxidase
EC 1.5.3.8: Now included with EC 1.3.3.8, tetrahydroberberine oxidase
EC 1.5.3.9: Now EC 1.21.3.3, reticuline oxidase
: dimethylglycine oxidase
EC 1.5.3.11: Now included with EC 1.5.3.13, EC 1.5.3.14, EC 1.5.3.15, EC 1.5.3.16 and EC 1.5.3.17
: dihydrobenzophenanthridine oxidase
: N¹-acetylpolyamine oxidase
: polyamine oxidase (propane-1,3-diamine-forming)
: N⁸-acetylspermidine oxidase (propane-1,3-diamine-forming)
: spermine oxidase
: non-specific polyamine oxidase
: L-saccharopine oxidase
: 4-methylaminobutanoate oxidase (formaldehyde-forming)
: N-alkylglycine oxidase
: 4-methylaminobutanoate oxidase (methylamine-forming)
EC 1.5.3.22: coenzyme F₄₂₀H₂ oxidase
EC 1.5.3.23: glyphosate oxidoreductase

EC 1.5.4 With a disulfide as acceptor

: pyrimidodiazepine synthase

EC 1.5.5 With a quinone or similar compound as acceptor

: electron-transferring-flavoprotein dehydrogenase
EC 1.5.5.2: proline dehydrogenase
EC 1.5.5.3: hydroxyproline dehydrogenase

EC 1.5.7 With an iron–sulfur protein as acceptor

: methylenetetrahydrofolate reductase (ferredoxin)
EC 1.5.7.2: coenzyme F₄₂₀ oxidoreductase (ferredoxin)

EC 1.5.8 With a flavin or flavoprotein as acceptor

EC 1.5.98 With other, known, physiological acceptors

EC 1.5.98.1: ethylenetetrahydromethanopterin dehydrogenase
EC 1.5.98.2: 5,10-methylenetetrahydromethanopterin reductase
EC 1.5.98.3: coenzyme F₄₂₀:methanophenazine dehydrogenase

EC 1.5.99 With unknown physiological acceptors

EC 1.5.99.1: Now EC 1.5.8.3, sarcosine dehydrogenase
EC 1.5.99.2: Now EC 1.5.8.4, dimethylglycine dehydrogenase
: L-pipecolate dehydrogenase
: nicotine dehydrogenase
: methylglutamate dehydrogenase
: spermidine dehydrogenase
EC 1.5.99.7: Now EC 1.5.8.2, trimethylamine dehydrogenase
EC 1.5.99.8: Now EC 1.5.5.2, proline dehydrogenase
EC 1.5.99.9: transferred to EC 1.5.98.1, methylenetetrahydromethanopterin dehydrogenase
EC 1.5.99.10: Now EC 1.5.8.1, dimethylamine dehydrogenase
EC 1.5.99.11: transferred to EC 1.5.98.2, 5,10-methylenetetrahydromethanopterin reductase
: cytokinin dehydrogenase
: D-proline dehydrogenase
: 6-hydroxypseudooxynicotine dehydrogenase
EC 1.5.99.15: dihydromethanopterin reductase (acceptor)

EC 1.6 Acting on NADH or NADPH

EC 1.6.1 With NAD or NADP as acceptor

EC 1.6.2 With a heme protein as acceptor

EC 1.6.2.1: now EC 1.6.99.3 NADH dehydrogenase
: cytochrome-b₅ reductase
EC 1.6.2.3: deleted
: NADPH—hemoprotein reductase
: NADPH—cytochrome-c₂ reductase
: leghemoglobin reductase

EC 1.6.3 With oxygen as acceptor

: NAD(P)H oxidase (H₂O₂-forming)
EC 1.6.3.2: NAD(P)H oxidase (H₂O-forming)
EC 1.6.3.3: NADH oxidase (H₂O₂-forming)
EC 1.6.3.4: NADH oxidase (H₂O-forming)
EC 1.6.3.5: renalase

EC 1.6.4 With a disulfide as acceptor (deleted sub-class)

EC 1.6.4.1: now cystine reductase
EC 1.6.4.2: now glutathione-disulfide reductase
EC 1.6.4.3: now dihydrolipoyl dehydrogenase
EC 1.6.4.4: now protein-disulfide reductase
EC 1.6.4.5: now thioredoxin-disulfide reductase
EC 1.6.4.6: now CoA-glutathione reductase
EC 1.6.4.7: now asparagusate reductase
EC 1.6.4.8: now trypanothione-disulfide reductase
EC 1.6.4.9: now bis-γ-glutamylcystine reductase
EC 1.6.4.10: now CoA-disulfide reductase

EC 1.6.5 With a quinone or similar compound as acceptor

EC 1.6.5.1: deleted
: NAD(P)H dehydrogenase (quinone)
EC 1.6.5.3: now NADH:ubiquinone reductase
: monodehydroascorbate reductase (NADH)
: NADPH:quinone reductase
: p-benzoquinone reductase (NADPH)
: 2-hydroxy-1,4-benzoquinone reductase
: Now, NADH:ubiquinone reductase
: NADH:ubiquinone reductase (non-electrogenic)
: NADPH dehydrogenase (quinone)
EC 1.6.5.11: Identical to, NADH:quinone reductase (non-electrogenic)
EC 1.6.5.12: demethylphylloquinone reductase

EC 1.6.6 With a nitrogenous group as acceptor

EC 1.6.6.1: Now, nitrate reductase
EC 1.6.6.2: Now, nitrate reductase
EC 1.6.6.3: Now, nitrate reductase
EC 1.6.6.4: Now, nitrite reductase
EC 1.6.6.5: Now, nitrite reductase
EC 1.6.6.6: Now, hyponitrite reductase
EC 1.6.6.7: Now, azobenzene reductase
EC 1.6.6.8: Now, GMP reductase
EC 1.6.6.9: Now known to be catalysed by, trimethylamine-N-oxide reductase
EC 1.6.6.10: Now, nitroquinoline-N-oxide reductase]
EC 1.6.6.11: Now, hydroxylamine reductase
EC 1.6.6.12: Now, 4-phenylazoxybenzene reductase
EC 1.6.6.13: Now, N-hydroxy-2-acetamidofluorene reductase

EC 1.6.7 With an iron–sulfur protein as acceptor (deleted sub-subclass)

EC 1.6.7.1: now ferredoxin—NADP⁺ reductase
EC 1.6.7.2: now rubredoxin—NAD⁺ reductase
EC 1.6.7.3: now ferredoxin—NAD⁺ reductase

EC 1.6.8 With a flavin as acceptor (deleted sub-subclass)

EC 1.6.8.1: Now FMN reductase
EC 1.6.8.2: Now flavin reductase

EC 1.6.99 With unknown physiological acceptors

: NADPH dehydrogenase
EC 1.6.99.2: Now, NADH dehydrogenase
EC 1.6.99.6: Now, NADPH dehydrogenase
EC 1.6.99.7: Now, 6,7-dihydropteridine reductase
EC 1.6.99.8: Deleted
EC 1.6.99.9: Now, cobalamin reductase
EC 1.6.99.10: included in, 6,7-dihydropteridine reductase
EC 1.6.99.11: Deleted
EC 1.6.99.12: Now, cyanocobalamin reductase
EC 1.6.99.13: Now, ferric-chelate reductase

EC 1.7 Acting on other nitrogenous compounds as donors

EC 1.7.1 With NAD⁺ or NADP⁺ as acceptor

: nitrate reductase (NADH)
: nitrate reductase (NAD(P)H)
: nitrate reductase (NADPH)
: nitrite reductase (NAD(P)H)
: hyponitrite reductase
: azobenzene reductase
: GMP reductase
EC 1.7.1.8: deleted
: nitroquinoline-N-oxide reductase
: hydroxylamine reductase (NADH)
: 4-(dimethylamino)phenylazoxybenzene reductase
: N-hydroxy-2-acetamidofluorene reductase
: preQ₁ synthase
: nitric oxide reductase (NAD(P), nitrous oxide-forming)
: nitrite reductase (NADH)
: nitrobenzene nitroreductase
: FMN-dependent NADH-azoreductase

EC 1.7.2 With a cytochrome as acceptor

: nitrite reductase (NO-forming)
: nitrite reductase (cytochrome; ammonia-forming)
: trimethylamine-N-oxide reductase
: nitrous-oxide reductase
: nitric oxide reductase (cytochrome c)
: hydroxylamine dehydrogenase
: hydrazine synthase
: hydrazine dehydrogenase

EC 1.7.3 With oxygen as acceptor

: nitroalkane oxidase
: acetylindoxyl oxidase
: factor-independent urate hydroxylase
EC 1.7.3.4: Now covered by, hydroxylamine dehydrogenase, and, hydroxylamine oxidase
: 3-aci-nitropropanoate oxidase
: hydroxylamine oxidase (cytochrome)

EC 1.7.5 With a quinone or similar compound as acceptor

EC 1.7.6 With a nitrogenous group as acceptor

: nitrite dismutase

EC 1.7.7 With an iron–sulfur protein as acceptor

EC 1.7.99 With other acceptors

: hydroxylamine reductase
EC 1.7.99.2: deleted: reaction may have been due to the combined action of nitrous-oxide reductase and nitric-oxide reductase
EC 1.7.99.3: Now included with, nitrite reductase
EC 1.7.99.4: Now, nitrate reductase,, nitrate reductase,, nitrate reductase,, nitrate reductase,, nitrate reductase and, nitrate reductase
EC 1.7.99.5: Now included with, methylenetetrahydrofolate reductase
EC 1.7.99.6: Now nitrous-oxide reductase
EC 1.7.99.7: Now nitric oxide reductase
: hydroxylamine oxidoreductase
EC 1.7.99.8: Now classified as, hydrazine dehydrogenase

EC 1.8 Acting on a sulfur group of donors

EC 1.8.1 With NAD⁺ or NADP⁺ as acceptor

EC 1.8.1.1: deleted
: sulfite reductase (NADPH)
: hypotaurine dehydrogenase
: dihydrolipoyl dehydrogenase
: 2-oxopropyl-CoM reductase (carboxylating)
: cystine reductase
: glutathione-disulfide reductase
: protein-disulfide reductase
: thioredoxin-disulfide reductase
: CoA-glutathione reductase
: asparagusate reductase
: trypanothione-disulfide reductase
: bis-γ-glutamylcystine reductase
: CoA-disulfide reductase
: mycothione reductase
: glutathione amide reductase
: dimethylsulfone reductase
: NAD(P)H sulfur oxidoreductase (CoA-dependent)
: sulfide dehydrogenase
: 4,4′-dithiodibutanoate disulfide reductase
: dissimilatory dimethyldisulfide reductase
: dissimilatory sulfite reductase

EC 1.8.2 With a cytochrome as acceptor

: sulfite dehydrogenase (cytochrome)
: thiosulfate dehydrogenase
: sulfide-cytochrome-c reductase (flavocytochrome c)
: dimethyl sulfide:cytochrome c₂ reductase
: thiosulfate reductase (cytochrome)
: S-disulfanyl-L-cysteine oxidoreductase
: thiocyanate desulfurase

EC 1.8.3 With oxygen as acceptor

EC 1.8.4 With a disulfide as acceptor

: glutathione—homocystine transhydrogenase
: protein-disulfide reductase (glutathione)
: glutathione—CoA-glutathione transhydrogenase
: glutathione—cystine transhydrogenase
EC 1.8.4.5: Now, L-methionine -S-oxide reductase and, L-methionine -S-oxide reductase
EC 1.8.4.6: due to, peptide-methionine (S)-S-oxide reductase
: enzyme-thiol transhydrogenase (glutathione-disulfide)
: phosphoadenylyl-sulfate reductase (thioredoxin)
: adenylyl-sulfate reductase (glutathione)
: adenylyl-sulfate reductase (thioredoxin)
: peptide-methionine (S)-S-oxide reductase
: peptide-methionine (R)-S-oxide reductase
: L-methionine (S)-S-oxide reductase
: L-methionine (R)-S-oxide reductase
: protein dithiol oxidoreductase (disulfide-forming)
: thioredoxin:protein disulfide reductase

EC 1.8.5 With a quinone or similar compound as acceptor

: glutathione dehydrogenase (ascorbate)
: thiosulfate dehydrogenase (quinone)
: respiratory dimethylsulfoxide reductase
: bacterial sulfide:quinone reductase
: thiosulfate reductase (quinone)
: sulfite dehydrogenase (quinone)
: glutathionyl-hydroquinone reductase
: eukaryotic sulfide quinone oxidoreductase
: protein dithiol:quinone oxidoreductase DsbB
: DsrC-trisulfide reductase

EC 1.8.6 With a nitrogenous group as acceptor (deleted sub-subclass)

: Now included with glutathione transferase

EC 1.8.7 With an iron–sulfur protein as acceptor

: assimilatory sulfite reductase (ferredoxin)
: ferredoxin:thioredoxin reductase
: ferredoxin:CoB-CoM heterodisulfide reductase

EC 1.8.98 With other, known, acceptors

EC 1.8.99 With other acceptors

EC 1.8.99.1: Now covered by, assimilatory sulfite reductase and, assimilatory sulfite reductase
: adenylyl-sulfate reductase
EC 1.8.99.3: an in vitro artifact of, dissimilatory sulfite reductase
EC 1.8.99.4: Now, phosphoadenylyl-sulfate reductase
EC 1.8.99.5: Now, dissimilatory sulfite reductase

EC 1.9 Acting on a heme group of donors

EC 1.9.3 With oxygen as acceptor

EC 1.9.3.1: Now, cytochrome-c oxidase
EC 1.9.3.2: Now included with, nitrite reductase

EC 1.9.6 With a nitrogenous group as acceptor

: nitrate reductase (cytochrome)

EC 1.9.98 With other, known, physiological acceptors

: iron—cytochrome-c reductase

EC 1.9.99 With other acceptors

EC 1.9.99.1: Now, iron—cytochrome-c reductase

EC 1.10 Acting on diphenols and related substances as donors

EC 1.10.1 With NAD⁺ or NADP⁺ as acceptor

: trans-acenaphthene-1,2-diol dehydrogenase

EC 1.10.2 With a cytochrome as acceptor

EC 1.10.2.1: The activity is covered by, ascorbate ferrireductase (transmembrane)
EC 1.10.2.2: Now, quinol—cytochrome-c reductase

EC 1.10.3 With oxygen as acceptor

: catechol oxidase
: laccase
: L-ascorbate oxidase
: o-aminophenol oxidase
: 3-hydroxyanthranilate oxidase
: rifamycin-B oxidase
EC 1.10.3.7: Now, sulochrin oxidase
EC 1.10.3.8: Now, sulochrin oxidase
: photosystem II
EC 1.10.3.10: Now, ubiquinol oxidase
: ubiquinol oxidase (non-electrogenic)
: Now, menaquinol oxidase
EC 1.10.3.13: Now, caldariellaquinol oxidase
EC 1.10.3.14: Now, ubiquinol oxidase
: grixazone synthase
: dihydrophenazinedicarboxylate synthase
: superoxide oxidase

EC 1.10.5 With a quinone or related compound as acceptor

: ribosyldihydronicotinamide dehydrogenase (quinone)

EC 1.10.9 With a copper protein as acceptor

EC 1.10.9.1: Now, plastoquinol—plastocyanin reductase

EC 1.10.99 With unknown physiological acceptors

EC 1.10.99.1: Now plastoquinol—plastocyanin reductase
EC 1.10.99.2: Now ribosyldihydronicotinamide dehydrogenase
EC 1.10.99.3: Now violaxanthin de-epoxidase

EC 1.11 Acting on a peroxide as acceptor

EC 1.11.1 Peroxidases

: NADH peroxidase
: NADPH peroxidase
: fatty-acid peroxidase
EC 1.11.1.4: Now tryptophan 2,3-dioxygenase
: cytochrome-c peroxidase
: catalase
: peroxidase
: iodide peroxidase
: glutathione peroxidase
: chloride peroxidase
: L-ascorbate peroxidase
: phospholipid-hydroperoxide glutathione peroxidase
: manganese peroxidase
: lignin peroxidase
EC 1.11.1.15: Now described by, thioredoxin-dependent peroxiredoxin;, glutaredoxin-dependent peroxiredoxin;, NADH-dependent peroxiredoxin;, glutathione-dependent peroxiredoxin;, lipoyl-dependent peroxiredoxin; and, mycoredoxin-dependent peroxiredoxin
: versatile peroxidase
: glutathione amide-dependent peroxidase
: bromide peroxidase
: dye decolorizing peroxidase
: prostamide/prostaglandin F_2α synthase
: catalase-peroxidase
: hydroperoxy fatty acid reductase
: (S)-2-hydroxypropylphosphonic acid epoxidase
: thioredoxin-dependent peroxiredoxin
: glutaredoxin-dependent peroxiredoxin
: NADH-dependent peroxiredoxin
: glutathione-dependent peroxiredoxin
: lipoyl-dependent peroxiredoxin
: mycoredoxin-dependent peroxiredoxin

EC 1.11.2 Peroxygenase

: unspecific peroxygenase
: myeloperoxidase
: plant seed peroxygenase
: fatty-acid peroxygenase
: 3-methyl-L-tyrosine peroxygenase
: L-tyrosine peroxygenase

EC 1.12 Acting on hydrogen as donor

EC 1.12.1 With NAD⁺ or NADP⁺ as acceptor

: Now EC 1.12.7.2, ferredoxin hydrogenase
: hydrogen dehydrogenase
: hydrogen dehydrogenase (NADP⁺)
: hydrogenase (NAD⁺, ferredoxin)
: hydrogen dehydrogenase |hydrogen dehydrogenase

EC 1.12.2 With a cytochrome as acceptor

: cytochrome-c₃ hydrogenase

EC 1.12.5 With a quinone or similar compound as acceptor

: hydrogen:quinone oxidoreductase

EC 1.12.7 With an iron–sulfur protein as acceptor

EC 1.12.7.1: Now, ferredoxin hydrogenase
: ferredoxin hydrogenase

EC 1.12.98 With other known acceptors

EC 1.12.99 With unknown physiological acceptors

EC 1.12.99.1: Now, coenzyme F₄₂₀ hydrogenase
EC 1.12.99.2: Now shown to be two enzymes,, Methanosarcina-phenazine hydrogenase and, CoB—CoM heterodisulfide reductase
EC 1.12.99.3: Now, hydrogen:quinone oxidoreductase
EC 1.12.99.4: Now, 5,10-methenyltetrahydromethanopterin hydrogenase
EC 1.12.99.5: Identical to, 3-hydroxy-4-oxoquinoline 2,4-dioxygenase
: hydrogenase (acceptor)

EC 1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

EC 1.13.11 With incorporation of two atoms of oxygen

: catechol 1,2-dioxygenase
: catechol 2,3-dioxygenase
: protocatechuate 3,4-dioxygenase
: gentisate 1,2-dioxygenase
: homogentisate 1,2-dioxygenase
: 3-hydroxyanthranilate 3,4-dioxygenase
EC 1.13.11.7: deleted
: protocatechuate 4,5-dioxygenase
: 2,5-dihydroxypyridine 5,6-dioxygenase
: 7,8-dihydroxykynurenate 8,8a-dioxygenase
: tryptophan 2,3-dioxygenase
: linoleate 13S-lipoxygenas
EC 1.13.11.13: The activity is the sum of several enzymatic and spontaneous reactions
: 2,3-dihydroxybenzoate 3,4-dioxygenase
: 3,4-dihydroxyphenylacetate 2,3-dioxygenase
: 3-carboxyethylcatechol 2,3-dioxygenase
: indole 2,3-dioxygenase
: persulfide dioxygenase
: cysteamine dioxygenase
: cysteine dioxygenase
EC 1.13.11.21: Now, β-carotene 15,15′-monooxygenase
: caffeate 3,4-dioxygenase
: 2,3-dihydroxyindole 2,3-dioxygenase
: quercetin 2,3-dioxygenase
: 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase
: peptide-tryptophan 2,3-dioxygenase
: 4-hydroxyphenylpyruvate dioxygenase
: 2,3-dihydroxybenzoate 2,3-dioxygenase
: stizolobate synthase
: stizolobinate synthase
: arachidonate 12-lipoxygenase
EC 1.13.11.32: Now, nitronate monooxygenase
: arachidonate 15-lipoxygenase
: arachidonate 5-lipoxygenase
: pyrogallol 1,2-oxygenase
: chloridazon-catechol dioxygenase
: hydroxyquinol 1,2-dioxygenase
: 1-hydroxy-2-naphthoate 1,2-dioxygenase
: biphenyl-2,3-diol 1,2-dioxygenase
: arachidonate 8-lipoxygenase
: 2,4′-dihydroxyacetophenone dioxygenase
EC 1.13.11.42: identical to, tryptophan 2,3-dioxygenase
: lignostilbene αβ-dioxygenase
EC 1.13.11.44: Activity is covered by, linoleate 8R-lipoxygenase and, 9,12-octadecadienoate 8-hydroperoxide 8S-isomerase
: linoleate 11-lipoxygenase
: 4-hydroxymandelate synthase
: 3-hydroxy-4-oxoquinoline 2,4-dioxygenase
: 3-hydroxy-2-methyl-quinolin-4-one 2,4-dioxygenase
: chlorite O₂-lyase
: acetylacetone-cleaving enzyme
: 9-cis-epoxycarotenoid dioxygenase
: indoleamine 2,3-dioxygenase
: acireductone dioxygenase (Ni²⁺-requiring)
: acireductone dioxygenase |acireductone dioxygenase
: sulfur oxygenase/reductase
: 1,2-dihydroxynaphthalene dioxygenase
: gallate dioxygenase
: linoleate 9S-lipoxygenase
: torulene dioxygenase
: inoleate 8R-lipoxygenase
: linolenate 9R-lipoxygenase
: linoleate 10R-lipoxygenase
: β-carotene 15,15′-dioxygenase
: 5-nitrosalicylate dioxygenase
: carotenoid isomerooxygenase
: hydroquinone 1,2-dioxygenase
: 8′-apo-β-carotenoid 14′,13′-cleaving dioxygenase
: 9-cis-β-carotene 9′,10′-cleaving dioxygenase
: carlactone synthase
: all-trans-10′-apo-β-carotenal 13,14-cleaving dioxygenase
: carotenoid-9′,10′-cleaving dioxygenase
: 2-hydroxyethylphosphonate dioxygenase
: methylphosphonate synthase
: 2-aminophenol 1,6-dioxygenase
: all-trans-8′-apo-β-carotenal 15,15′-oxygenase
: 2-amino-5-chlorophenol 1,6-dioxygenase
: oleate 10S-lipoxygenase
: 2-amino-1-hydroxyethylphosphonate dioxygenase (glycine-forming)
: aerobic 5,6-dimethylbenzimidazole synthase
: (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase
: 7,8-dihydroneopterin oxygenase
: 8′-apo-carotenoid 13,14-cleaving dioxygenase
: 4-hydroxy-3-prenylphenylpyruvate oxygenase
: crocetin dialdehyde synthase
: exo-cleaving rubber dioxygenase
: 5-aminosalicylate 1,2-dioxygenase
: endo-cleaving rubber dioxygenase
: isoeugenol monooxygenase
: (hydroxymethyl)phosphonate dioxygenase
: phosphonate dioxygenase |phosphonate dioxygenase
: 3-mercaptopropionate dioxygenase
: fatty acid α-dioxygenase

EC 1.13.12 With incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)

: arginine 2-monooxygenase
: lysine 2-monooxygenase
: tryptophan 2-monooxygenase
: lactate 2-monooxygenase
: Renilla-type luciferase
: Cypridina-luciferin 2-monooxygenase
: firefly luciferase
: Watasenia-luciferin 2-monooxygenase
: phenylalanine 2-monooxygenase
EC 1.13.12.10: Reaction covered by, L-lysine 6-monooxygenase (NADPH)
EC n1.13.12.11: The activity is due to, flavin-containing monooxygenase
EC 1.13.12.12: transferred to, 8-apo-β-carotenoid 14′,13′-cleaving dioxygenase
: Oplophorus-luciferin 2-monooxygenase
EC 1.13.12.14: Now, chlorophyllide-a oxygenase
: 3,4-dihydroxyphenylalanine oxidative deaminase
: nitronate monooxygenase
: dichloroarcyriaflavin A synthase
: dinoflagellate luciferase
: 2-oxoglutarate dioxygenase (ethene-forming)
: noranthrone monooxygenase
: tetracenomycin-F1 monooxygenase
: deoxynogalonate monooxygenase
: 4-hydroxy-3-prenylbenzoate synthase
: calcium-regulated photoprotein

EC 1.13.99 Miscellaneous

: inositol oxygenase
EC 1.13.99.2: Now, benzoate 1,2-dioxygenase
: tryptophan 2′-dioxygenase
EC 1.13.99.4: Now, 4-chlorophenylacetate 3,4-dioxygenase
EC 1.13.99.5: now, 3-hydroxy-4-oxoquinoline 2,4-dioxygenase

EC 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

EC 1.14.1 With NADH or NADPH as one donor (deleted sub-subclass)

EC 1.14.1.1: now, unspecific monooxygenase
EC 1.14.1.2: now, kynurenine 3-monooxygenase
EC 1.14.1.3: deleted, covered by, squalene monooxygenase and, lanosterol synthase
EC 1.14.1.4: now, kynurenine 7,8-hydroxylase
EC 1.14.1.5: now ; imidazoleacetate 4-monooxygenase
EC 1.14.1.6: now, steroid 11β-monooxygenase
EC 1.14.1.7: now, steroid 17α-monooxygenase
EC 1.14.1.8: now, steroid 21-monooxygenase
EC 1.14.1.9: deleted
EC 1.14.1.10: now estradiol 6β-monooxygenase
EC 1.14.1.11: deleted

EC 1.14.2 With ascorbate as one donor (deleted sub-subclass)

EC 1.14.2.1: now, dopamine β-monooxygenase
EC 1.14.2.2: now, 4-hydroxyphenylpyruvate dioxygenase

EC 1.14.3 With reduced pteridine as one donor (deleted sub-subclass)

EC 1.14.3.1: now, phenylalanine 4-monooxygenase

EC 1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

: γ-butyrobetaine dioxygenase
: procollagen-proline dioxygenase
: pyrimidine-deoxynucleoside 2′-dioxygenase
: procollagen-lysine 5-dioxygenase
EC 1.14.11.5: Now included with thymine dioxygenase
: thymine dioxygenase
: procollagen-proline 3-dioxygenase
: trimethyllysine dioxygenase
: flavanone 3-dioxygenase
: pyrimidine-deoxynucleoside 1′-dioxygenase
: hyoscyamine (6S)-dioxygenase
: gibberellin-44 dioxygenase
: gibberellin 2β-dioxygenase
EC 1.14.11.14: Now, 6β-hydroxyhyoscyamine epoxidase
: gibberellin 3β-dioxygenase
: peptide-aspartate β-dioxygenase
: taurine dioxygenase
: phytanoyl-CoA dioxygenase
EC 1.14.11.19: Now, anthocyanidin synthase
: deacetoxyvindoline 4-hydroxylase
: clavaminate synthase
EC 1.14.11.22: Now, flavone synthase
EC 1.14.11.23: Now, flavonol synthase
: 2′-deoxymugineic-acid 2′-dioxygenase
: mugineic-acid 3-dioxygenase
: deacetoxycephalosporin-C hydroxylase
: -lysine-36 demethylase|-dimethyl-L-lysine³⁶ demethylase
: proline 3-hydroxylase
: hypoxia-inducible factor-proline dioxygenase
: hypoxia-inducible factor-asparagine dioxygenase
: thebaine 6-O-demethylase
: codeine 3-O-demethylase
: DNA oxidative demethylase
EC 1.14.11.34: Now, 2-oxoglutarate/L-arginine monooxygenase/decarboxylase
: 1-deoxypentalenic acid 11β-hydroxylase
: pentalenolactone F synthase
: pentalenolactone F synthase
: kanamycin B dioxygenase
: verruculogen synthase
: L-asparagine hydroxylase
: enduracididine β-hydroxylase
: L-arginine hydroxylase
: tRNA^Phe (7-(3-amino-3-carboxypropyl)wyosine³⁷-C²)-hydroxylase
: (S)-dichlorprop dioxygenase (2-oxoglutarate)
: (R)-dichlorprop dioxygenase (2-oxoglutarate)
: L-isoleucine 4-hydroxylase
: 2-aminoethylphosphonate dioxygenase
: -arginine 3-hydroxylase|-arginine 3-hydroxylase
: xanthine dioxygenase
: uridine-5′-phosphate dioxygenase
EC|1.14.11.50: Now, -deoxypodophyllotoxin synthase
: DNA N⁶-methyladenine demethylase
: validamycin A dioxygenase
: mRNA N⁶-methyladenine demethylase
: mRNA N¹-methyladenine demethylase
: ectoine hydroxylase
: L-proline cis-4-hydroxylase
: L-proline trans-4-hydroxylase
: ornithine lipid ester-linked acyl 2-hydroxylase
: 2,4-dihydroxy-1,4-benzoxazin-3-one-glucoside dioxygenase
: scopoletin 8-hydroxylase
: feruloyl-CoA 6-hydroxylase
: trans-4-coumaroyl-CoA 2-hydroxylase
: peptidyl-lysine (3S)-dioxygenase
: glutarate dioxygenase
: -dimethyl-L-lysine^9 demethylase|-dimethyl-L-lysine⁹ demethylase
: -trimethylL-lysine^9 demethylase|-trimethylL-lysine⁹ demethylase
: -trimethyl-LL-lysine^4 demethylase|-trimethyl-LL-lysine⁴ demethylase
: -trimethyl-L-lysine^27 demethylase|-trimethyl-L-lysine²⁷ demethylase
: -trimethyl-L-lysine^37 demethylase|-trimethyl-L-lysine³⁷ demethylase
: 7-deoxycylindrospermopsin hydroxylase
: methylphosphonate hydroxylase
: phosphonate dioxygenase|phosphonate dioxygenase
: -arginine 3-hydroxylase|-arginine 3-hydroxylase
: L-isoleucine 3¹-dioxygenase
: 3¹-hydroxy-L-isoleucine 4-dioxygenase
: L-glutamate 3(R)-hydroxylase
: alkyl sulfatase

EC 1.14.12 With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor

: anthranilate 1,2-dioxygenase (deaminating, decarboxylating)
EC 1.14.12.2: Now anthranilate 3-monooxygenase
: benzene 1,2-dioxygenase
EC 1.14.12.4:, 3-hydroxy-2-methylpyridinecarboxylate monooxygenase
EC 1.14.12.5: Now, 5-pyridoxate monooxygenase
EC 1.14.12.6: Now, 2-hydroxycyclohexanone 2-monooxygenase
: phthalate 4,5-dioxygenase
: 4-sulfobenzoate 3,4-dioxygenase
: 4-chlorophenylacetate 3,4-dioxygenase
: benzoate 1,2-dioxygenase
: toluene dioxygenase
: naphthalene 1,2-dioxygenase
: 2-halobenzoate 1,2-dioxygenase
: 2-aminobenzenesulfonate 2,3-dioxygenase
: terephthalate 1,2-dioxygenase
: 2-hydroxyquinoline 5,6-dioxygenase
: nitric oxide dioxygenase
: biphenyl 2,3-dioxygenase
: 3-phenylpropionate dioxygenase
EC 1.14.12.20: Now classified as, pheophorbide a oxygenase.
EC 1.14.12.21: Now, benzoyl-CoA 2,3-epoxidase
: carbazole 1,9a-dioxygenase
: nitroarene dioxygenase
: 2,4-dinitrotoluene dioxygenase
: p-cumate 2,3-dioxygenase
: chlorobenzene dioxygenase

EC 1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

: salicylate 1-monooxygenase
: 4-hydroxybenzoate 3-monooxygenase
EC 1.14.13.3: Now, 4-hydroxyphenylacetate 3-monooxygenase
: melilotate 3-monooxygenase
: imidazoleacetate 4-monooxygenase
: orcinol 2-monooxygenase
: phenol 2-monooxygenase
: flavin-containing monooxygenase
: kynurenine 3-monooxygenase
: 2,6-dihydroxypyridine 3-monooxygenase
EC 1.14.13.11: Now, trans-cinnamate 4-monooxygenase
EC 1.14.13.12: Now, benzoate 4-monooxygenase
EC 1.14.13.13: Now classified as, calcidiol 1-monooxygenase
: trans-cinnamate 2-monooxygenase
EC 1.14.13.15: Now, cholestanetriol 26-monooxygenase
: cyclopentanone monooxygenase
EC 1.14.13.17: Now, cholesterol 7α-monooxygenase
: 4-hydroxyphenylacetate 1-monooxygenase
: taxifolin 8-monooxygenase
: 2,4-dichlorophenol 6-monooxygenase
EC 1.14.13.21: Now, flavonoid 3′-monooxygenase
: cyclohexanone monooxygenase
: 3-hydroxybenzoate 4-monooxygenase
: 3-hydroxybenzoate 6-monooxygenase
: methane monooxygenase (soluble)
EC 1.14.13.26: Now classified as, phosphatidylcholine 12-monooxygenase
: 4-aminobenzoate 1-monooxygenase
EC 1.14.13.28: Now, 3,9-dihydroxypterocarpan 6a-monooxygenase
: 4-nitrophenol 2-monooxygenase
EC 1.14.13.30: Now, leukotriene-B₄ 20-monooxygenase
: 2-nitrophenol 2-monooxygenase
: albendazole monooxygenase
: 4-hydroxybenzoate 3-monooxygenase (NAD(P)H)
: leukotriene-E₄ 20-monooxygenase
: anthranilate 3-monooxygenase (deaminating)
EC 1.14.13.36: Now, 5-O--D-quinate 3′-monooxygenase
EC 1.14.13.37: Now, methyltetrahydroprotoberberine 14-monooxygenase
: anhydrotetracycline monooxygenase
: nitric-oxide synthase
: anthraniloyl-CoA monooxygenase
EC 1.14.13.41: Now, tyrosine N-monooxygenase
EC 1.14.13.42: The activity is covered by, 4-hydroxyphenylacetaldehyde oxime monooxygenase
: questin monooxygenase
: 2-hydroxybiphenyl 3-monooxygenase
EC 1.14.13.45: Now, CMP-N-acetylneuraminate monooxygenase
: (-)-menthol monooxygenase
EC 1.14.13.47: Now, (S)-limonene 3-monooxygenase
EC 1.14.13.48: Now classified as, -limonene 6-monooxygenase
EC 1.14.13.49: Now classified as, -limonene 6-monooxygenase
: magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase
: vanillate monooxygenase
: precorrin-3B synthase
: 4-hydroxyacetophenone monooxygenase
EC 1.14.13.85: Now, glyceollin synthase
EC 1.14.13.86: The activity is covered by, 2-hydroxyisoflavanone synthase
EC 1.14.13.87: Now, licodione synthase]
EC 1.14.13.88: Now, flavanoid 3,5-hydroxylase
EC 1.14.13.89: Now, isoflavone 2-hydroxylase
EC 1.14.13.90: Now, zeaxanthin epoxidase
EC 1.14.13.91: Now, deoxysarpagine hydroxylase
: phenylacetone monooxygenase
EC 1.14.13.93: Now, -abscisic acid 8-hydroxylase
EC 1.14.13.94: Now, lithocholate 6β-hydroxylase
EC 1.14.13.95: Now included with, 5β-cholestane-3α,7α-diol 12α-hydroxylase
EC 1.14.13.96: Now, 5β-cholestane-3α,7α-diol 12α-hydroxylase
EC 1.14.13.97: Now, taurochenodeoxycholate 6α-hydroxylase
EC 1.14.13.98: Now, cholesterol 24-hydroxylase
EC 1.14.13.99: Now, 24-hydroxycholesterol 7α-hydroxylase
EC 1.14.13.100: Now classified as, 25/26-hydroxycholesterol 7α-hydroxylase
: senecionine N-oxygenase
EC 1.14.13.102: Now, psoralen synthase
EC 1.14.13.103: Now, 8-dimethylallylnaringenin 2-hydroxylase
: Now, -menthofuran synthase
: monocyclic monoterpene ketone monooxygenase
EC 1.14.13.106: now classified as, epi-isozizaene 5-monooxygenase.
: limonene 1,2-monooxygenase
EC 1.14.13.108: Now, abieta-7,13-diene hydroxylase
EC 1.14.13.109: Now, abieta-7,13-dien-18-ol hydroxylase
EC 1.14.13.110: Now, geranylgeraniol 18-hydroxylase
: methanesulfonate monooxygenase
EC 1.14.13.112: Now, 3-epi-6-deoxocathasterone 23-monooxygenase
: FAD-dependent urate hydroxylase
: 6-hydroxynicotinate 3-monooxygenase
EC 1.14.13.115: Now, angelicin synthase
: Now, geranylhydroquinone 3-hydroxylase
EC 1.14.13.117: Now, isoleucine N-monooxygenase
EC 1.14.13.118: Now, valine N-monooxygenase
EC 1.14.13.119: Now, 5-epiaristolochene 1,3-dihydroxylase
EC 1.14.13.120: Now, costunolide synthase
EC 1.14.13.121: Now, premnaspirodiene oxygenase
: chlorophyllide-a oxygenase
EC 1.14.13.123: Now, germacrene A hydroxylase
EC 1.14.13.124: now classified as, phenylalanine N-monooxygenase
EC 1.14.13.125: Now, tryptophan N-monooxygenase
EC 1.14.13.126: Now, vitamin D₃ 24-hydroxylase
: 3-(3-hydroxyphenyl)propanoate hydroxylase
: 7-methylxanthine demethylase
EC 1.14.13.129: Now, β-carotene 3-hydroxylase
: pyrrole-2-carboxylate monooxygenase
: dimethyl-sulfide monooxygenase
EC 1.14.13.132: Now, squalene monooxygenase
EC 1.14.13.133: Now, pentalenene oxygenase
EC 1.14.13.134: Now, β-amyrin 11-oxidase
: 1-hydroxy-2-naphthoate hydroxylase
EC 1.14.13.136: Now, 2-hydroxyisoflavanone synthase
EC 1.14.13.137: Now, indole-2-monooxygenase
EC 1.14.13.138: Now, indolin-2-one monooxygenase
EC 1.14.13.139: Now, 3-hydroxyindolin-2-one monooxygenase
EC 1.14.13.140: Now, 2-hydroxy-1,4-benzoxazin-3-one monooxygenase.
EC 1.14.13.141: Now, cholest-4-en-3-one 26-monooxygenase
EC 1.14.13.142: Now, 3-ketosteroid 9α-monooxygenase
EC 1.14.13.143: Now ent-isokaurene C2/C3-hydroxylase
EC 1.14.13.144: Now, 9β-pimara-7,15-diene oxidase
EC 1.14.13.145: Now, ent-cassa-12,15-diene 11-hydroxylase
: taxoid 14β-hydroxylase
: taxoid 7β-hydroxylase
: trimethylamine monooxygenase
: phenylacetyl-CoA 1,2-epoxidase
EC 1.14.13.150: Now, α-humulene 10-hydroxylase
EC 1.14.13.151: Now, linalool 8-monooxygenase
EC 1.14.13.152: Now, geraniol 8-hydroxylase
: (+)-sabinene 3-hydroxylase
: erythromycin 12-hydroxylase
: α-pinene monooxygenase
EC 1.14.13.156: Now, 1,8-cineole 2-endo-monooxygenase
EC 1.14.13.157: Now, 1,8-cineole 2-exo-monooxygenase
EC 1.14.13.158: Now, amorpha-4,11-diene 12-monooxygenase
EC 1.14.13.159: Now, vitamin D 25-hydroxylase
: (2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA 1,5-monooxygenase
: (+)-camphor 6-exo-hydroxylase
EC 1.14.13.162: Now, 2,5-diketocamphane 1,2-monooxygenase
: 6-hydroxy-3-succinoylpyridine 3-monooxygenase
EC 1.14.13.164: withdrawn: see, carotenoid isomerooxygenase
EC 1.14.13.165: Now classified as, nitric-oxide synthase
: 4-nitrocatechol 4-monooxygenase
: 4-nitrophenol 4-monooxygenase
: indole-3-pyruvate monooxygenase
EC 1.14.13.169: Now, sphingolipid C4-monooxygenase
: pentalenolactone D synthase
: neopentalenolactone D synthase
: salicylate 5-hydroxylase
EC 1.14.13.173: Now, 11-oxo-β-amyrin 30-oxidase
EC 1.14.13.174: Now, averantin hydroxylase
EC 1.14.13.175: Now, aflatoxin B synthase
EC 1.14.13.176: Now, tryprostatin B 6-hydroxylase
EC 1.14.13.177: Now, fumitremorgin C monooxygenase
: methylxanthine N¹-demethylase
: methylxanthine N³-demethylase
: aklavinone 12-hydroxylase
: 13-deoxydaunorubicin hydroxylase
: 2-heptyl-3-hydroxy-4(1H)-quinolone synthase
EC 1.14.13.183: Now, dammarenediol 12-hydroxylase
EC 1.14.13.184: Now, protopanaxadiol 6-hydroxylase
EC 1.14.13.185: Now, pikromycin synthase
EC 1.14.13.186: Now, 20-oxo-5-O-mycaminosyltylactone 23-monooxygenase
: L-evernosamine nitrososynthase
EC 1.14.13.188: Now, 6-deoxyerythronolide B hydroxylase
: 5-methyl-1-naphthoate 3-hydroxylase
EC 1.14.13.190: Now, ferruginol synthase
EC 1.14.13.191: Now, ent-sandaracopimaradiene 3-hydroxylase
EC 1.14.13.192: Now, oryzalexin E synthase
EC 1.14.13.193: Now, oryzalexin D synthase
EC 1.14.13.194: Now, phylloquinone ω-hydroxylase
: L-ornithine N⁵-monooxygenase (NADPH)
: L-ornithine N^5-monooxygenase |L-ornithine N⁵-monooxygenase
EC 1.14.13.197: Now, dihydromonacolin L hydroxylase
EC 1.14.13.198: Now, monacolin L hydroxylase
EC 1.14.13.199: Now, docosahexaenoic acid ω-hydroxylase
: tetracenomycin A2 monooxygenase-dioxygenase
EC 1.14.13.201: Now, β-amyrin 28-monooxygenase
EC 1.14.13.202: Now, methyl farnesoate epoxidase
EC 1.14.13.203: Now, farnesoate epoxidase
EC 1.14.13.204: Now, long-chain acyl-CoA ω-monooxygenase
EC 1.14.13.205: Now, long-chain fatty acid ω-monooxygenase
EC 1.14.13.206: Now, laurate 7-monooxygenase
EC 1.14.13.207: Now, ipsdienol synthase
: benzoyl-CoA 2,3-epoxidase
: salicyloyl-CoA 5-hydroxylase
: 4-methyl-5-nitrocatechol 5-monooxygenase
: rifampicin monooxygenase
: 1,3,7-trimethyluric acid 5-monooxygenase
EC 1.14.13.213: Now, bursehernin 5-monooxygenase
EC 1.14.13.214: Now, -4′-demethyl-deoxypodophyllotoxin 4-hydroxylase
: protoasukamycin 4-monooxygenase
: asperlicin C monooxygenase
: protodeoxyviolaceinate monooxygenase
: 5-methylphenazine-1-carboxylate 1-monooxygenase
: resorcinol 4-hydroxylase (NADPH)
: resorcinol 4-hydroxylase (NADH)
EC 1.14.13.221: Now, cholest-4-en-3-one 26-monooxygenase
: aurachin C monooxygenase/isomerase
: 3-hydroxy-4-methylanthranilyl- 5-monooxygenase|3-hydroxy-4-methylanthranilyl- 5-monooxygenase
: violacein synthase
: F-actin monooxygenase
: acetone monooxygenase (methyl acetate-forming)
: propane 2-monooxygenase
: jasmonic acid 12-hydroxylase
: tert-butyl alcohol monooxygenase
: butane monooxygenase (soluble)
: tetracycline 11a-monooxygenase
: 6-methylpretetramide 4-monooxygenase
: 4-hydroxy-6-methylpretetramide 12a-monooxygenase
: 5a,11a-dehydrotetracycline 5-monooxygenase
: indole-3-acetate monooxygenase
: toluene 4-monooxygenase
: aliphatic glucosinolate S-oxygenase
: dimethylamine monooxygenase
: carnitine monooxygenase
: 2-polyprenylphenol 6-hydroxylase
: 5-pyridoxate monooxygenase
: 3-hydroxy-2-methylpyridine-5-carboxylate monooxygenase
: toluene 2-monooxygenase
: phenol 2-monooxygenase (NADH)
: assimilatory dimethylsulfide S-monooxygenase
: 4β-methylsterol monooxygenase
: stachydrine N-demethylase

EC 1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

: unspecific monooxygenase
EC 1.14.14.2: Now included with unspecific monooxygenase
: alkanal monooxygenase (FMN-linked)
EC 1.14.14.4: identical to, choline monooxygenase.
: alkanesulfonate monooxygenase
EC 1.14.14.6: Now, methanesulfonate monooxygenase
EC 1.14.14.7: transferred to, tryptophan 7-halogenase
: anthranilate 3-monooxygenase (FAD)
: 4-hydroxyphenylacetate 3-monooxygenase
: nitrilotriacetate monooxygenase
: styrene monooxygenase
: 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase
: 4-butanoyl- monooxygenase| 4-butanoyl- monooxygenase
: aromatase
: -3-amino-3-propanoyl- monooxygenase|-3-amino-3-propanoyl- monooxygenase
: steroid 21-monooxygenase
: squalene monooxygenase
: heme oxygenase (biliverdin-producing)
: steroid 17α-monooxygenase
: phenol 2-monooxygenase (FADH₂)
: dibenzothiophene monooxygenase
: dibenzothiophene sulfone monooxygenase
: cholesterol 7α-monooxygenase
: vitamin D 25-hydroxylase
: cholesterol 24-hydroxylase
: 24-hydroxycholesterol 7α-hydroxylase
: resorcinol 4-hydroxylase (FADH₂)
: long-chain alkane monooxygenase
: 25/26-hydroxycholesterol 7α-hydroxylase
: isobutylamine N-monooxygenase
: ipsdienol synthase
: 17α-hydroxyprogesterone deacetylase
: ethylenediaminetetraacetate monooxygenase
: methanesulfonate monooxygenase (FMNH₂)
: dimethylsulfone monooxygenase
: tyrosine N-monooxygenase
: 4-hydroxyphenylacetaldehyde oxime monooxygenase
: valine N-monooxygenase
: isoleucine N-monooxygenase
: phenylalanine N-monooxygenase
: (E)-2-methylbutanal oxime monooxygenase
: homomethionine N-monooxygenase
: (methylsulfanyl)alkanaldoxime N-monooxygenase
: phenylacetaldehyde oxime monooxygenase
: aromatic aldoxime N-monooxygenase
: pimeloyl- synthase|pimeloyl- synthase
: nitric-oxide synthase (flavodoxin)
: jasmonoyl-L-amino acid 12-hydroxylase
: 12-hydroxyjasmonoyl-L-amino acid 12-hydroxylase
: tabersonine 3-oxygenase
: (S)-limonene 6-monooxygenase
: (S)-limonene 7-monooxygenase
: (R)-limonene 6-monooxygenase
: phenylacetate 2-hydroxylase
: quinine 3-monooxygenase
: 1,8-cineole 2-exo-monooxygenase
: taurochenodeoxycholate 6α-hydroxylase
: trimethyltridecatetraene synthase
: dimethylnonatriene synthase
: ferruginol monooxygenase
: carnosic acid synthase
: salviol synthase
: β-amyrin 16β-monooxygenase
: β-amyrin 6β-monooxygenase
: sugiol synthase
: marmesin synthase
: 11-hydroxysugiol 20-monooxygenase
: syn-pimaradiene 3-monooxygenase
: ent-cassadiene hydroxylase
: ent-sandaracopimaradiene 3-hydroxylase
: cucurbitadienol 11-hydroxylase
: drimenol monooxygenase
: albendazole monooxygenase (sulfoxide-forming)
: albendazole monooxygenase (hydroxylating)
: fenbendazole monooxygenase (4′-hydroxylating)
: ent-isokaurene C2/C3-hydroxylase
: phenylacetonitrile α-monooxygenase
: phylloquinone ω-hydroxylase
: docosahexaenoic acid ω-hydroxylase
: long-chain fatty acid ω-monooxygenase
: flavanoid 3′,5′-hydroxylase
: flavonoid 3′-monooxygenase
: geraniol 8-hydroxylase
: linalool 8-monooxygenase
: 7-deoxyloganate 7-hydroxylase
: ent-kaurene monooxygenase
: 2-hydroxyisoflavanone synthase
: isoflavone 3′-hydroxylase
: 4′-methoxyisoflavone 2′-hydroxylase
: isoflavone 2′-hydroxylase
: trans-cinnamate 4-monooxygenase
: benzoate 4-monooxygenase
: 3,9-dihydroxypterocarpan 6a-monooxygenase
: leukotriene-B4 20-monooxygenase
: germacrene A hydroxylase
: 5-O-(4-coumaroyl)-D-quinate 3′-monooxygenase
: methyltetrahydroprotoberberine 14-monooxygenase
: protopine 6-monooxygenase
: (S)-limonene 3-monooxygenase
: dihydrosanguinarine 10-monooxygenase
: dihydrochelirubine 12-monooxygenase
: N-methylcoclaurine 3′-monooxygenase
: tabersonine 16-hydroxylase
: vinorine hydroxylase
: taxane 10β-hydroxylase
: taxane 13α-hydroxylase
: ent-kaurenoic acid monooxygenase
: 2,5-diketocamphane 1,2-monooxygenase
: 3-hydroxyindolin-2-one monooxygenase
: 2-hydroxy-1,4-benzoxazin-3-one monooxygenase
: 9β-pimara-7,15-diene oxidase
: ent-cassa-12,15-diene 11-hydroxylase
: α-humulene 10-hydroxylase
: amorpha-4,11-diene 12-monooxygenase
: 11-oxo-β-amyrin 30-oxidase
: averantin hydroxylase
: aflatoxin B synthase
: tryprostatin B 6-hydroxylase
: fumitremorgin C monooxygenase
: dammarenediol 12-hydroxylase
: protopanaxadiol 6-hydroxylase
: oryzalexin E synthase
: oryzalexin D synthase
: dihydromonacolin L hydroxylase
: monacolin L hydroxylase
: β-amyrin 28-monooxygenase
: methyl farnesoate epoxidase
: farnesoate epoxidase
: long-chain acyl-CoA ω-monooxygenase
: laurate 7-monooxygenase
: bursehernin 5′-monooxygenase
: (–)-4′-demethyl-deoxypodophyllotoxin 4-hydroxylase
: 1,8-cineole 2-endo-monooxygenase
: β-amyrin 24-hydroxylase
: glyceollin synthase
: deoxysarpagine hydroxylase
: (+)-abscisic acid 8′-hydroxylase
: lithocholate 6β-hydroxylase
: 5β-cholestane-3α,7α-diol 12α-hydroxylase
EC 1.14.14.140: Now included with, flavanone 2-hydroxylase
: psoralen synthase
: 8-dimethylallylnaringenin 2′-hydroxylase
: (+)-menthofuran synthase
: abieta-7,13-diene hydroxylase
: abieta-7,13-dien-18-ol hydroxylase
: geranylgeraniol 18-hydroxylase
: 3-epi-6-deoxocathasterone 23-monooxygenase
: angelicin synthase
: 5-epiaristolochene 1,3-dihydroxylase
: costunolide synthase
: premnaspirodiene oxygenase
: β-amyrin 11-oxidase
: indole-2-monooxygenase
: sterol 14α-demethylase
: 3,6-diketocamphane 1,2-monooxygenase
: tryptophan N-monooxygenase
: indolin-2-one monooxygenase
: carotenoid ε hydroxylase
: dolabradiene monooxygenase
: zealexin A1 synthase
: nepetalactol monooxygenase
: flavanone 2-hydroxylase
: (S)-1-hydroxy-N-methylcanadine 13-hydroxylase
: fraxetin 5-hydroxylase
: indole-3-carbonyl nitrile 4-hydroxylase
: (S)-N-methylcanadine 1-hydroxylase
: (13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine 8-hydroxylase
: germacrene A acid 8β-hydroxylase
: eupatolide synthase
: 8-epi-inunolide synthase
: β-amyrin 16α-hydroxylase
: 3,5,6-trichloropyridin-2-ol monooxygenase
: 2,4,6-trichlorophenol monooxygenase
: geranylhydroquinone 3′′-hydroxylase
: ferruginol synthase
: taxadiene 5α-hydroxylase
: ultra-long-chain fatty acid ω-hydroxylase

EC 1.14.15 With reduced iron–sulfur protein as one donor, and incorporation of one atom of oxygen

: camphor 5-monooxygenase
EC 1.14.15.2: Now, 2,5-diketocamphane 1,2-monooxygenase.
: alkane 1-monooxygenase
: steroid 11β-monooxygenase
: corticosterone 18-monooxygenase
: cholesterol monooxygenase (side-chain-cleaving)
: choline monooxygenase
: steroid 15β-monooxygenase
: spheroidene monooxygenase
: (+)-camphor 6-endo-hydroxylase
: pentalenic acid synthase
EC 1.14.15.12 : pimeloyl- synthase. Now, pimeloyl- synthase
: pulcherriminic acid synthase
: methyl-branched lipid ω-hydroxylase
: cholestanetriol 26-monooxygenase
: vitamin D₃ 24-hydroxylase
: pheophorbide a oxygenase
: calcidiol 1-monooxygenase
: C-19 steroid 1α-hydroxylase
: heme oxygenase (biliverdin-producing, ferredoxin)
: zeaxanthin epoxidase
: vitamin D 1,25-hydroxylase
: chloroacetanilide N-alkylformylase
: β-carotene 3-hydroxylase
: p-cymene methyl-monooxygenase
: toluene methyl-monooxygenase
: β-dihydromenaquinone-9 ω-hydroxylase
: cholest-4-en-3-one 26-monooxygenase |cholest-4-en-3-one 26-monooxygenase
: cholest-4-en-3-one 26-monooxygenase |cholest-4-en-3-one 26-monooxygenase
: 3-ketosteroid 9α-monooxygenase
: 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase
: pentalenene oxygenase
: pikromycin synthase
: 20-oxo-5-O-mycaminosyltylactone 23-monooxygenase
: 6-deoxyerythronolide B hydroxylase
: sterol 14α-demethylase (ferredoxin)
: luteothin monooxygenase
: N,N-dimethyl phenylurea N-demethylase
: epi-isozizaene 5-monooxygenase

EC 1.14.16 With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor

: phenylalanine 4-monooxygenase
: tyrosine 3-monooxygenase
EC 1.14.16.3: withdrawn owing to insufficient evidence (anthranilate 3-monooxygenase)
: tryptophan 5-monooxygenase
: alkylglycerol monooxygenase
: mandelate 4-monooxygenase
: phenylalanine 3-monooxygenase

EC 1.14.17 With reduced ascorbate as one donor, and incorporation of one atom of oxygen into the other donor

: dopamine β-monooxygenase
EC |1.14.17.2: deleted, now included with monophenol monooxygenase
: peptidylglycine monooxygenase
: aminocyclopropanecarboxylate oxidase

EC 1.14.18 With another compound as one donor, and incorporation of one atom of oxygen into the other donor

: tyrosinase
: CMP-N-acetylneuraminate monooxygenase
: methane monooxygenase (particulate)
: phosphatidylcholine 12-monooxygenase
: sphingolipid C4-monooxygenase
: 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase
: dihydroceramide fatty acyl 2-hydroxylase
EC 1.14.18.8: Now included with, 5β-cholestane-3α,7α-diol 12α-hydroxylase
: 4α-methylsterol monooxygenase
: plant 4,4-dimethylsterol C-4α-methyl-monooxygenase
: plant 4α-monomethylsterol monooxygenase
: 2-hydroxy fatty acid dioxygenase

EC 1.14.19 With oxidation of a pair of donors resulting in the reduction of O₂ to two molecules of water

: stearoyl-CoA 9-desaturase
: acyl- desaturase| stearoyl- 9-desaturase
: linoleoyl-CoA desaturase
: acyl-lipid (11-3)-desaturase
: acyl-CoA 11-(Z)-desaturase
: acyl-CoA (9+3)-desaturase
EC 1.14.19.7: Now, -2-hydroxypropylphosphonic acid epoxidase
: pentalenolactone synthase
: tryptophan 7-halogenase
: icosanoyl-CoA 5-desaturase
: acyl- 4-desaturase|acyl- 4-desaturase
: acyl-lipid ω-(9-4) desaturase
: acyl-CoA 15-desaturase
: linoleoyl-lipid Δ⁹ conjugase
: (11Z)-hexadec-11-enoyl-CoA conjugase
: linoleoyl-lipid Δ¹² conjugase (11E,13Z-forming)
: sphingolipid 4-desaturase
: sphingolipid 8-(E)-desaturase
: sphingolipid 10-desaturase
: Δ⁷-sterol 5(6)-desaturase
: cholesterol 7-desaturase
: acyl-lipid ω-6 desaturase (cytochrome b₅)
: acyl-lipid (n+3)-(Z)-desaturase (ferredoxin)
: acyl-CoA 11-(E)-desaturase
: acyl-lipid ω-3 desaturase (cytochrome b₅)
: acyl- 6-desaturase|acyl- 6-desaturase
: sn-2 palmitoyl-lipid 9-desaturase
: sn-1 stearoyl-lipid 9-desaturase
: sphingolipid 8-(E/Z)-desaturase
: acyl-lipid (8-3)-desaturase
: acyl-lipid (7-3)-desaturase
: palmitoyl-CoA 14-(E/Z)-desaturase
: Δ¹² acyl-lipid conjugase (11E,13E-forming)
: acyl-lipid (9+3)-(E)-desaturase
: sn-2 acyl-lipid ω-3 desaturase (ferredoxin)
: sn-1 acyl-lipid ω-3 desaturase (ferredoxin)
: acyl-CoA 5-desaturase
: acyl-lipid Δ⁶-acetylenase
: acyl-lipid Δ¹²-acetylenase
: hex-5-enoyl- acetylenase|hex-5-enoyl- acetylenase
: sterol 22-desaturase
: palmitoyl- 7-desaturase|palmitoyl- 7-desaturase
: palmitoyl- 3--desaturase|palmitoyl- 3--desaturase
: acyl-CoA (8-3)-desaturase
: sn-1 oleoyl-lipid 12-desaturase
: sn-1 linoleoyl-lipid 6-desaturase
: acyl-lipid (9-3)-desaturase
: tert-amyl alcohol desaturase
: tetracycline 7-halogenase
: noroxomaritidine synthase
: (S)-corytuberine synthase
: camalexin synthase
: all-trans-retinol 3,4-desaturase
: 1,2-dehydroreticuline synthase
: 4-hydroxybenzoate brominase (decarboxylating)
: 1H-pyrrole-2-carbonyl- chlorinase|1H-pyrrole-2-carbonyl- chlorinase
: 1H-pyrrole-2-carbonyl- brominase|1H-pyrrole-2-carbonyl- brominase
: tryptophan 5-halogenase
: tryptophan 6-halogenase
: 7-chloro-L-tryptophan 6-halogenase
: dihydrorhizobitoxine desaturase
: secologanin synthase
: pseudobaptigenin synthase
: (S)-stylopine synthase
: (S)-cheilanthifoline synthase
: berbamunine synthase
: salutaridine synthase
: (S)-canadine synthase
: biflaviolin synthase
: mycocyclosin synthase
: fumitremorgin C synthase
: (–)-pluviatolide synthase
: (S)-nandinine synthase
: (+)-piperitol/(+)-sesamin synthase
: very-long-chain acyl-lipid ω-9 desaturase
: flavone synthase II
: plasmanylethanolamine desaturase
: decanoyl- acetylenase|decanoyl- acetylenase

EC 1.14.20 With 2-oxoglutarate as one donor, and the other dehydrogenated

: deacetoxycephalosporin-C synthase
EC 1.14.20.2: Now, 2,4-dihydroxy-1,4-benzoxazin-3-one-glucoside dioxygenase
: (5R)-carbapenem-3-carboxylate synthase
: anthocyanidin synthase
: flavone synthase I
: flavonol synthase
: 2-oxoglutarate/L-arginine monooxygenase/decarboxylase (succinate-forming)
: (–)-deoxypodophyllotoxin synthase
: L-tyrosine isonitrile desaturase
: L-tyrosine isonitrile desaturase/decarboxylase
: 3--1H-indole synthase|3--1H-indole synthase
: 3--1H-indole synthase|3--1H-indole synthase
: 6β-hydroxyhyoscyamine epoxidase
: hapalindole-type alkaloid chlorinase
: L-threonyl- 4-chlorinase|L-threonyl- 4-chlorinase

EC 1.14.21 With NADH or NADPH as one donor, and the other dehydrogenated

EC 1.14.21.1: Now, -stylopine synthase
EC 1.14.21.2: Now, -cheilanthifoline synthase
EC 1.14.21.3: Now, berbamunine synthase
EC 1.14.21.4: Now, salutaridine synthase
EC 1.14.21.5: Now, -canadine synthase
EC 1.14.21.6: Now, Δ⁷-sterol 5(6)-desaturase
EC 1.14.21.7: Now, biflaviolin synthase
EC 1.14.21.8: Now, pseudobaptigenin synthase
EC 1.14.21.9: Now, mycocyclosin synthase *
EC 1.14.21.10: Now, fumitremorgin C synthase *
EC 1.14.21.11: Now, -pluviatolide synthase *
EC 1.14.21.12: Now, -nandinine synthase *

EC 1.14.99 Miscellaneous

: prostaglandin-endoperoxide synthase
: kynurenine 7,8-hydroxylase
EC 1.14.99.3: Now, heme oxygenase
: progesterone monooxygenase
EC 1.14.99.5: Now, stearoyl-CoA 9-desaturase
EC 1.14.99.6: Now, acyl- desaturase
EC 1.14.99.7: Transferred to, squalene monooxygenase
EC 1.14.99.8: Now included with unspecific monooxygenase
EC 1.14.99.9: Now classified as, steroid 17α-monooxygenase
EC 1.14.99.10: Now, steroid 21-monooxygenase
: estradiol 6β-monooxygenase
: 4-androstene-3,17-dione monooxygenase
EC 1.14.99.13: Now, 3-hydroxybenzoate 4-monooxygenase
: progesterone 11α-monooxygenase
: 4-methoxybenzoate monooxygenase (O-demethylating)
EC 1.14.99.16: Now, methylsterol monooxygenase
EC 1.14.99.17: Now, glyceryl-ether monooxygenase
EC 1.14.99.18: deleted
EC 1.14.99.19: Now classified as, plasmanylethanolamine desaturase
: phylloquinone monooxygenase (2,3-epoxidizing)
: Latia-luciferin monooxygenase (demethylating)
: ecdysone 20-monooxygenase
: 3-hydroxybenzoate 2-monooxygenase
: steroid 9α-monooxygenase
: Now, linoleoyl-CoA desaturase
: 2-hydroxypyridine 5-monooxygenase
EC 1.14.99.27: Now classified as, juglone 3-monooxygenase
EC 1.14.99.28: Now, linalool 8-monooxygenase
: deoxyhypusine monooxygenase
EC 1.14.99.30: Now, 9,9′-dicis-ζ-carotene desaturase.
EC 1.14.99.31: Now classified as, myristoyl-CoA 11- desaturase
EC 1.14.99.32: Now classified as, acyl-CoA 11--desaturase
EC 1.14.99.33: Now, acyl-lipid Δ¹²-acetylenase
: monoprenyl isoflavone epoxidase
: thiophene-2-carbonyl-CoA monooxygenase
EC 1.14.99.36: Now classified as, β-carotene 15,15′-dioxygenase
EC 1.14.99.37: Now, taxadiene 5α-hydroxylase
: cholesterol 25-hydroxylase
: ammonia monooxygenase
EC 1.14.99.40: Now, 5,6-dimethylbenzimidazole synthase
EC 1.14.99.41: Now, all-trans-8′-apo-β-carotenal 15,15′-oxygenase
EC 1.14.99.42: Now, crocetin dialdehyde synthase
EC 1.14.99.43: Now, β-amyrin 24-hydroxylase
: diapolycopene oxygenase
EC 1.14.99.45: Now, carotene ε-monooxygenase
: pyrimidine oxygenase
: (+)-larreatricin hydroxylase
: heme oxygenase (staphylobilin-producing)
EC 1.14.99.49: Now, 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase
: γ-glutamyl hercynylcysteine S-oxide synthase
: hercynylcysteine S-oxide synthase
: L-cysteinyl-L-histidinylsulfoxide synthase
: lytic chitin monooxygenase
: lytic cellulose monooxygenase (C1-hydroxylating)
: lytic starch monooxygenase
: lytic cellulose monooxygenase (C4-dehydrogenating)
: heme oxygenase (mycobilin-producing)
: heme oxygenase (biliverdin-IX-β and δ-forming)
: tryptamine 4-monooxygenase
: 3-demethoxyubiquinol 3-hydroxylase
: cyclooctat-9-en-7-ol 5-monooxygenase
: cyclooctatin synthase
: β-carotene 4-ketolase
: zeaxanthin 4-ketolase
: 4-amino-L-phenylalanyl- 3-hydroxylase|4-amino-L-phenylalanyl- 3-hydroxylase
: -N^6,N^6-dimethyl-L-lysine^4 FAD-dependent demethylase|-N⁶,N⁶-dimethyl-L-lysine⁴ FAD-dependent demethylase
: α-N-dichloroacetyl-p-aminophenylserinol N-oxygenase
: 4-aminobenzoate N-oxygenase
: tRNA 2-(methylsulfanyl)-N⁶-isopentenyladenosine³⁷ hydroxylase

EC 1.15 Acting on superoxide as acceptor

EC 1.15.1

EC 1.16 Oxidizing metal ions

EC 1.16.1 With NAD⁺ or NADP⁺ as acceptor

: mercury(II) reductase
: diferric-transferrin reductase
EC 1.16.1.3: deleted since no specific enzyme catalysing this activity has been identified
: cob(II)alamin reductase
EC 1.16.1.5: deleted since the enzyme the entry was based on was later shown to be, pyruvate dehydrogenase.
: cyanocobalamin reductase (cyanide-eliminating)
: ferric-chelate reductase
: reductase| reductase
: ferric-chelate reductase (NADPH)
: ferric-chelate reductase |ferric-chelate reductase

EC 1.16.3 With oxygen as acceptor

: ferroxidase
: bacterial non-heme ferritin
: manganese oxidase

EC 1.16.5 With a quinone or similar compound as acceptor

EC 1.16.5.1: Now, ascorbate ferrireductase

EC 1.16.8 With a flavin as acceptor

EC 1.16.8.1: activity now known to be catalyzed by, corrinoid adenosyltransferase

EC 1.16.9 With a copper protein as acceptor

: iron:rusticyanin reductase

EC 1.16.98 With other, known, physiological acceptors

EC 1.16.98.1: Now iron:rusticyanin reductase

EC 1.16.99 With unknown physiological acceptors

: reductase| reductase

EC 1.17 Acting on CH or CH₂ groups

EC 1.17.1 With NAD or NADP as acceptor

: CDP-4-dehydro-6-deoxyglucose reductase
EC 1.17.1.2: now classified as, 4-hydroxy-3-methylbut-2-enyl diphosphate reductase
: leucoanthocyanidin reductase
: xanthine dehydrogenase
: nicotinate dehydrogenase
EC 1.17.1.6: Now, bile-acid 7α-dehydroxylase. It is now known that FAD is the acceptor and not NAD⁺ as was thought previously
EC 1.17.1.7: Now, 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase
: 4-hydroxy-tetrahydrodipicolinate reductase
: formate dehydrogenase
: formate dehydrogenase (NADP⁺)
: formate dehydrogenase (NAD⁺, ferredoxin)

EC 1.17.2 With a cytochrome as acceptor

EC 1.17.3 With oxygen as acceptor

EC 1.17.4 With a disulfide as acceptor

: ribonucleoside-diphosphate reductase
: ribonucleoside-triphosphate reductase (thioredoxin)
EC 1.17.4.3: transferred to, -4-hydroxy-3-methylbut-2-enyl-diphosphate synthase.
: vitamin-K-epoxide reductase (warfarin-sensitive)
: vitamin-K-epoxide reductase (warfarin-insensitive)

EC 1.17.5 With a quinone or similar compound as acceptor

EC 1.17.7 With an iron–sulfur protein as acceptor

: (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (ferredoxin)
: 7-hydroxymethyl chlorophyll a reductase
: (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin)
: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase

EC 1.17.98 With other, known, physiological acceptors

EC 1.17.98.1: bile-acid 7α-dehydroxylase. Now known to be catalyzed by multiple enzymes.
: bacteriochlorophyllide c C-7¹-hydroxylase
: formate dehydrogenase (coenzyme F₄₂₀)
: formate dehydrogenase (hydrogenase)

EC 1.17.99 With unknown physiological acceptors

EC 1.17.99.1: Now EC 1.17.9.1, 4-methylphenol dehydrogenase
: ethylbenzene hydroxylase
: 3α,7α,12α-trihydroxy-5β-cholestanoyl-CoA 24-hydroxylase
: uracil/thymine dehydrogenase
EC 1.17.99.5: Now classified as EC 1.17.98.1, bile-acid 7α-dehydroxylase
: epoxyqueuosine reductase
EC 1.17.99.7: Now classified as EC 1.17.98.4, formate dehydrogenase
: limonene dehydrogenase
: heme a synthase
: steroid C-25 hydroxylase
: 3-oxo-Δ¹-steroid hydratase/dehydrogenase

EC 1.18 Acting on iron–sulfur proteins as donors

EC 1.18.1 With NAD⁺ or NADP⁺ as acceptor

: rubredoxin—NAD⁺ reductase
: ferredoxin—NADP⁺ reductase
: ferredoxin—NAD⁺ reductase
: rubredoxin—NAD(P)⁺ reductase
: Putidaredoxin—NAD⁺ reductase
: adrenodoxin-NADP⁺ reductase
: ferredoxin—NAD(P)⁺ reductase (naphthalene dioxygenase ferredoxin-specific)
EC 1.18.1.8: Now, ferredoxin—NAD⁺ oxidoreductase

EC 1.18.2 With dinitrogen as acceptor (deleted sub-subclass)

EC 1.18.2.1: now, nitrogenase

EC 1.18.3 With H⁺ as acceptor (deleted sub-subclass)

EC 1.18.3.1: Now, ferredoxin hydrogenase

EC 1.18.6 With dinitrogen as acceptor

: nitrogenase
: vanadium-dependent nitrogenase

EC 1.18.96 With other, known, acceptors (deleted sub-subclass)

EC 1.18.96.1: Now, superoxide reductase

EC 1.18.99 With H⁺ as acceptor (deleted sub-subclass)

EC 1.18.99.1: Now, ferredoxin hydrogenase

EC 1.19 Acting on reduced flavodoxin as donor

EC 1.19.1 With NAD⁺ or NADP⁺ as acceptor

: flavodoxin—NADP⁺ reductase

EC 1.19.6 With dinitrogen as acceptor

: nitrogenase (flavodoxin)

EC 1.20 Acting on phosphorus or arsenic in donors

EC 1.20.1 Acting on phosphorus or arsenic in donors, with NAD⁺ as acceptor

: phosphonate dehydrogenase

EC 1.20.2 Acting on phosphorus or arsenic in donors, with NAD(P)⁺ as acceptor

: arsenate reductase (cytochrome c)

EC 1.20.4 Acting on phosphorus or arsenic in donors, with disulfide as acceptor

EC 1.20.9 With a copper protein as acceptor

: arsenate reductase (azurin)

EC 1.20.98 With other, known acceptors

EC 1.20.98.1: Now, arsenate reductase

EC 1.20.99 With unknown physiological acceptors

: arsenate reductase (donor)

EC 1.21 Catalysing the reaction X-H + Y-H = X-Y

EC 1.21.3 With oxygen as acceptor

: isopenicillin-N synthase
: columbamine oxidase
: reticuline oxidase
: sulochrin oxidase ((+)-bisdechlorogeodin-forming)
: sulochrin oxidase ((-)-bisdechlorogeodin-forming)
: aureusidin synthase
: tetrahydrocannabinolic acid synthase
: cannabidiolic acid synthase
EC 1.21.3.9: now classified as, dichlorochromopyrrolate synthase

EC 1.21.4 With a disulfide as acceptor

: D-proline reductase (dithiol)
: glycine reductase
: sarcosine reductase
: betaine reductase
: tetrachlorohydroquinone reductive dehalogenase

EC 1.21.98 With other, known, physiological acceptors

: cyclic dehypoxanthinyl futalosine synthase
: dichlorochromopyrrolate synthase
: anaerobic magnesium-protoporphyrin IX monomethyl ester cyclase
: PqqA peptide cyclase

EC 1.21.99 With unknown physiological acceptors

: β-cyclopiazonate dehydrogenase
EC 1.21.99.2: Now classified as, cyclic dehypoxanthinyl futalosine synthase.
: thyroxine 5-deiodinase
: thyroxine 5′-deiodinase
: tetrachloroethene reductive dehalogenase

EC 1.22 Acting on halogen in donors

EC 1.22.1 With NAD⁺ or NADP⁺ as acceptor

EC 1.22.1.1: Now, iodotyrosine deiodinase

EC 1.23 Reducing C-O-C group as acceptor

EC 1.23.1 With NADH or NADPH as donor

: (+)-pinoresinol reductase
: (+)-lariciresinol reductase
: (–)-pinoresinol reductase
: (–)-lariciresinol reductase

EC 1.97 Other oxidoreductases

EC 1.97.1 Sole sub-subclass for oxidoreductases that do not belong in the other subclasses

: chlorate reductase
: pyrogallol hydroxytransferase
EC 1.97.1.3: Now, sulfhydrogenase, since hydrogen is known to be the electron donor
: -activating enzyme|-activating enzyme
EC 1.97.1.5: Now, arsenate reductase
EC 1.97.1.7: Now, methylarsonate reductase
EC 1.97.1.8: Now, tetrachloroethene reductive dehalogenase
: selenate reductase
EC 1.97.1.10: Now thyroxine 5′-deiodinase
EC 1.97.1.11: Now thyroxine 5-deiodinase.
: photosystem I

EC 1.98 Enzymes using H₂ as reductant (deleted subclass)

EC 1.98.1.1: Now, ferredoxin hydrogenase

EC 1.99 Other enzymes using O₂ as oxidant

EC 1.99.1 Hydroxylases (now covered by EC 1.14)

EC 1.99.1.1: deleted, Now, ferredoxin hydrogenase
EC 1.99.1.2: deleted, Now, phenylalanine 4-monooxygenase
EC 1.99.1.3: deleted, nicotinate 6-hydroxylase
EC 1.99.1.4: deleted, tryptophan 5-hydroxylase
EC 1.99.1.5: deleted, Now, kynurenine 3-monooxygenase
EC 1.99.1.6: deleted, steroid 11α-hydroxylase
EC 1.99.1.7: deleted, Now, steroid 11β-monooxygenase
EC 1.99.1.8: deleted, steroid 6β-hydroxylase
EC 1.99.1.9: deleted, Now, steroid 17α-monooxygenase
EC 1.99.1.10: deleted, steroid 19-hydroxylase
EC 1.99.1.11: deleted, Now, steroid 21-monooxygenase
EC 1.99.1.12: deleted, alkoxyaryl hydroxylase
EC 1.99.1.13: deleted, covered by and by
EC 1.99.1.14: deleted, Now, 4-hydroxyphenylpyruvate dioxygenase

EC 1.99.2 Oxygenases (now covered by EC 1.13)

EC 1.99.2.1: deleted, now, lipoxygenase
EC 1.99.2.2: deleted, now, catechol 1,2-dioxygenase
EC 1.99.2.3: deleted, now, protocatechuate 3,4-dioxygenase
EC 1.99.2.4: deleted, now, gentisate 1,2-dioxygenase
EC 1.99.2.5: deleted, now, homogentisate 1,2-dioxygenase
EC 1.99.2.6: deleted, now, inositol oxygenase