4-hydroxythreonine-4-phosphate dehydrogenase
In enzymology, 4-hydroxythreonine-4-phosphate dehydrogenase is an enzyme that catalyzes the chemical reaction
The two substrates of this enzyme are 4-phosphonooxy-L-threonine and oxidised nicotinamide adenine dinucleotide. Its products are -2-amino-3-oxo-4-phosphonooxybutanoate, reduced NADH, and a proton.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 4-phosphonooxy-L-threonine:NAD+ oxidoreductase. Other names in common use include NAD+-dependent threonine 4-phosphate dehydrogenase, L-threonine 4-phosphate dehydrogenase, 4--L-threonine dehydrogenase, PdxA, and 4--L-threonine:NAD+ oxidoreductase. This enzyme participates in vitamin B6 metabolism.