Gluconate 5-dehydrogenase
In enzymology, gluconate 5-dehydrogenase is an enzyme that catalyzes the chemical reaction
The two substrates of this enzyme are D-gluconic acid and oxidised nicotinamide adenine dinucleotide. Its products are 5-oxo-D-gluconic acid, reduced NADH, and a proton. The enzyme can use nicotinamide adenine dinucleotide phosphate as an alternative cofactor.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-gluconate:NAD+ 5-oxidoreductase. Other names in common use include 5-keto-D-gluconate 5-reductase, 5-keto-D-gluconate 5-reductase, 5-ketogluconate 5-reductase, 5-ketogluconate reductase, and 5-keto-D-gluconate reductase.