Fumarate reductase
Fumarate reductase is the enzyme that converts fumarate to succinate, and is important in microbial metabolism as a part of anaerobic respiration. The catalyzed reaction is:
Fumarate reductases can be divided into three classes depending on the electron acceptor:
- Fumarate reductase (NADH)
- Fumarate reductase (CoM/CoB) :
- : This enzyme is present in most methanogenic archea. It is cytoplasmic and uses coenzymes M and B as hydrogen donors.
- Fumarate reductase (quinol)
- : The membrane-bound enzyme covalently linked to flavin cofactors, which is composed of 3 or 4 subunits, transfers electrons from a quinol to fumarate. This class of enzyme is thus involved in the production of ATP by oxidative phosphorylation.