Glycolaldehyde dehydrogenase


In enzymology, glycolaldehyde dehydrogenase is an enzyme that catalyzes the chemical reaction
The three substrates of this enzyme are glycolaldehyde, oxidised nicotinamide adenine dinucleotide, and water. Its products are glycolic acid, reduced NADH, and a proton.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is glycolaldehyde:NAD+ oxidoreductase. This enzyme is also called glycol aldehyde dehydrogenase. This enzyme participates in glyoxylate and dicarboxylate metabolism.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes,, and.