Hydroxymethylglutaryl-CoA reductase
In enzymology, hydroxymethylglutaryl-CoA reductase is an enzyme that catalyzes the chemical reaction
The substrates of this enzyme are mevalonic acid, coenzyme A, and oxidised nicotinamide adenine dinucleotide. Its products are 3-hydroxy-3-methylglutaryl-CoA, reduced NADH, and two protons.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is -mevalonate:NAD+ oxidoreductase . Other names in common use include beta-hydroxy-beta-methylglutaryl coenzyme A reductase, beta-hydroxy-beta-methylglutaryl CoA-reductase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and hydroxymethylglutaryl coenzyme A reductase.