(R)-2-hydroxyacid dehydrogenase
In enzymology, a -2-hydroxyacid dehydrogenase is an enzyme that catalyzes the chemical reaction
The 3 substrates of this enzyme are (2R)-3-sulfolactic acid, NAD, and NADP, whereas its 4 products are 3-sulfopyruvic acid, NADH, NADPH, and H. This enzyme is important in the metabolism of archaea, particularly their biosynthesis of coenzymes such as coenzyme M, tetrahydromethanopterin and methanofuran.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is -2-hydroxyacid:NAD oxidoreductase. Other names in common use include -sulfolactate:NAD oxidoreductase, L-sulfolactate dehydrogenase, ComC, and -sulfolactate dehydrogenase.