Testosterone 17beta-dehydrogenase


In enzymology, a testosterone 17beta-dehydrogenase is an enzyme that catalyzes the interconversion of testosterone and androstenedione.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor.

Names

The systematic name of this enzyme class is 17beta-hydroxysteroid:NAD+ 17-oxidoreductase. Other names in common use include 17-ketoreductase and 17beta-HSD. This enzyme participates in androgen and estrogen metabolism.

Variants

There are two variants of the enzyme, one that uses NADP+ as cofactor, and one that uses NAD+ instead.

NAD+

This variant of testosterone 17beta-dehydrogenase uses the cofactor oxidised nicotinamide adenine dinucleotide.

NADP+

This variant of testosterone 17beta-dehydrogenase uses the cofactor oxidised nicotinamide adenine dinucleotide phosphate.