4-hydroxyphenylacetaldehyde dehydrogenase

In enzymology, 4-hydroxyphenylacetaldehyde dehydrogenase is an enzyme that catalyzes the chemical reaction
The three substrates of this enzyme are 4-hydroxyphenylacetaldehyde, oxidised nicotinamide adenine dinucleotide, and water. Its products are 4-hydroxyphenylacetic acid, reduced NADH, and a proton.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase. This enzyme is also called 4-HPAL dehydrogenase. This enzyme participates in tyrosine metabolism.