Tetrahydroxynaphthalene reductase

In enzymology, tetrahydroxynaphthalene reductase is an enzyme that catalyzes the chemical reaction
The two substrates of this enzyme are scytalone and oxidised nicotinamide adenine dinucleotide phosphate. Its products are naphthalene-1,3,6,8-tetrol, reduced NADPH, and a proton.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is scytalone:NADP⁺ Delta5-oxidoreductase.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes,, and.