(S)-canadine synthase

In enzymology, a -canadine synthase is an enzyme that catalyzes the chemical reaction
The 4 substrates of this enzyme are (S)-tetrahydrocolumbamine, NADPH, H, and O, whereas its 3 products are Canadine, NADP, and HO.
This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O with NADH or NADPH as one donor, and the other dehydrogenated. The systematic name of this enzyme class is -tetrahydrocolumbamine,NADPH:oxygen oxidoreductase . Other names in common use include -tetrahydroberberine synthase, and -tetrahydrocolumbamine oxidase . This enzyme participates in alkaloid biosynthesis i. It employs one cofactor, heme-thiolate(P-450).