Diiodophenylpyruvate reductase

In enzymology, a diiodophenylpyruvate reductase is an enzyme that catalyzes the chemical reaction
Thus, the two substrates of this enzyme are 3-(3,5-diiodo-4-hydroxyphenyl)lactate and NAD⁺, whereas its 3 products are 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate, NADH, and H⁺.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is 3-lactate:NAD⁺ oxidoreductase. Other names in common use include aromatic alpha-keto acid, KAR, and 2-oxo acid reductase.
In 2025, this enzyme was found to be identical to, (S)-malate dehydrogenase.