2,5-dioxovalerate dehydrogenase

In enzymology, a 2,5-dioxovalerate dehydrogenase is an enzyme that catalyzes the chemical reaction
The three substrates of this enzyme are 2,5-dioxovalerate, oxidised nicotinamide adenine dinucleotide phosphate, and water. Its products are α-ketoglutaric acid, reduced NADPH, and a proton.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2,5-dioxopentanoate:NADP+ 5-oxidoreductase. Other names in common use include 2-oxoglutarate semialdehyde dehydrogenase, and alpha-ketoglutaric semialdehyde dehydrogenase. This enzyme participates in ascorbate and aldarate metabolism.