List of Mexican Americans
Mexican Americans are residents of the United States who are of Mexican descent. The list includes Mexican immigrants and those who lived in the southwestern United States when the territory was incorporated in 1848.
Sports
American football
- Louie Aguiar – NFL punter
- Joe Aguirre – NFL tight end
- Roberto Aguayo – NFL and NCAA Division I placekicker at Florida State University
- Leo Araguz – NFL kicker and punter
- Joe Arenas – NFL running back, safety, punt returner and kick returner
- Gene Brito – defensive end, 1955 NFL player of the year
- Anthony Calvillo – CFL quarterback
- Greg Camarillo – NFL wide receiver
- Joe Cardona – NFL long snapper
- Tony Casillas – NFL defensive lineman
- Sergio Castillo – NFL kicker and punter
- Jorge Cordova – NFL linebacker
- Frank Corral – NFL placekicker
- Ronnie Cruz – NFL fullback
- Michael Davis – NFL defensive back
- Brian de la Puente – NFL center
- Donnie Edwards – NFL linebacker
- Tom Fears – NFL wide receiver and head coach, member of Pro Football Hall of Fame
- Manny Fernandez – NFL defensive tackle
- Tom Flores – one of two individuals in NFL history to win a Super Bowl as a player, assistant coach and head coach.
- Arian Foster – NFL running back
- Aaron Garcia – college and Arena Football quarterback
- Jeff Garcia – NFL quarterback
- Max Garcia – NFL guard
- Norberto Garrido – NFL offensive lineman
- Roberto Garza – NFL offensive guard
- Zane Gonzalez – NFL placekicker
- Brock Gutierrez – NFL offensive lineman
- Joe Hernandez – NFL wide receiver
- Will Hernandez – NFL guard
- Efren Herrera – NFL placekicker
- Ziggy Hood – NFL defensive end
- David Diaz-Infante – NFL guard and center
- Matt Kalil – NFL offensive tackle
- Ryan Kalil – NFL center
- Joe Kapp – NFL quarterback
- J. P. Losman – NFL quarterback
- Blake Martinez – NFL inside linebacker
- Mike Mohamed – former NFL linebacker
- Max Montoya – NFL
- Matt Moore – NFL quarterback
- Moses Moreno – NFL quarterback
- Zeke Moreno – NFL linebacker
- Anthony Muñoz – Hall of Fame NFL offensive tackle
- Ricky Ortiz – NFL
- Luis Perez – NCAA quarterback
- Mike Perez – NFL quarterback
- Jim Plunkett – NFL quarterback
- Jose Portilla – NFL offensive tackle
- Manny Ramirez – NFL offensive lineman
- Aldo Richins – NFL wingback
- Ron Rivera – NFL linebacker and coach
- Pete Rodriguez – NFL special teams coach
- Ruben Rodriguez – NFL punter
- Tony Romo – NFL quarterback
- Juan Roque – NFL offensive tackle
- Aldrick Rosas – NFL placekicker
- Eddie Saenz – NFL running back
- Mark Sanchez – NFL quarterback
- Rigoberto Sanchez – NFL punter
- Zack Sanchez – NFL cornerback
- Andrew Sendejo – NFL strong safety
- Rafael Septién – NFL placekicker
- Daniel Sepulveda – NFL punter
- Louis Vasquez – NFL offensive lineman
- Danny Villa – NFL guard
- Danny Villanueva – NFL punter/place kicker
- Fred Warner (American football) – NFL linebacker
- Bryce Young - NFL Quarterback
- Tony Zendejas – NFL placekicker
Baseball
- Mike Adams – MLB pitcher
- Hank Aguirre – MLB all-star pitcher
- Mike Aldrete – MLB First Baseman and Outfielder
- Mel Almada – MLB outfielder
- Armando Almanza – MLB pitcher
- Abe Alvarez – MLB pitcher
- Héctor Ambriz – MLB pitcher
- Rubén Amaro Jr. – MLB outfielder
- Bob Apodaca – MLB pitcher and coach
- Frank Arellanes – MLB pitcher
- Fernando Arroyo – MLB pitcher
- Austin Barnes – MLB catcher
- Rod Barajas – MLB catcher
- Cuno Barragan – MLB catcher
- Freddie Benavides – MLB infielder
- Quintin Berry – MLB outfielder and pinch runner
- Matt Bush – MLB pitcher
- Jorge Cantú – MLB infielder
- Cam Carreon – MLB catcher
- Mark Carreon – MLB first baseman
- Cisco Carlos – MLB pitcher
- Jason Castro – MLB catcher
- Cesar Carrillo – MLB pitcher
- Bobby Castillo – MLB pitcher
- Frank Castillo – MLB starting pitcher
- Marty Castillo – MLB catcher and third baseman
- Jaime Cerda – MLB pitcher
- Eric Chavez – MLB third baseman
- Jesse Chavez – MLB pitcher
- Matt Chico – MLB pitcher
- Chad Cordero – MLB relief pitcher
- Pat Corrales – MLB catcher and coach
- Dan Cortes – MLB pitcher
- Jacob Cruz – MLB outfielder
- Bobby Cuellar – MLB pitcher and coach
- Khris Davis – MLB outfielder
- Chris Dominguez – MLB infielder
- Matt Dominguez – MLB infielder
- Chuck Estrada – MLB pitcher
- Johnny Estrada – MLB catcher
- Marco Estrada – MLB pitcher
- Fernando Cortez – MLB infielder
- Danny Espinosa – MLB infielder
- Andre Ethier – MLB outfielder
- Phillip Evans – MLB Infielder
- Carlos Fisher – MLB pitcher
- Jesse Flores – MLB pitcher
- Randy Flores – MLB pitcher
- Ron Flores – MLB pitcher
- Brian Fuentes – MLB all-star relief pitcher
- Yovani Gallardo – MLB pitcher
- Mike Gallego – MLB outfielder and coach
- Greg Garcia – MLB infielder
- Kiko Garcia – MLB infielder
- Mike Garcia – MLB all-star pitcher
- Nomar Garciaparra – MLB all-star shortstop
- Matt Garza – MLB pitcher
- Eddie Gamboa – MLB pitcher
- Chris Gomez – MLB infielder
- Luis Gómez – MLB infielder
- Adrián González – MLB first baseman
- Edgar Gonzalez – MLB infielder
- Michael Gonzalez – MLB closer/pitcher
- Bob Greenwood – MLB pitcher
- Eddie Guardado – MLB all-star pitcher
- Javy Guerra – MLB closer/pitcher
- Carlos Guevara – MLB pitcher
- Jerry Hairston Jr. – MLB Infielder
- Scott Hairston – MLB outfielder
- Dan Haren – MLB all-star pitcher
- Gil Heredia – MLB spot starting pitcher
- David Hernandez – MLB starting pitcher
- Jeremy Hernandez – MLB pitcher
- Daniel Herrera – MLB relief pitcher
- Rudy Jaramillo – Hitting coach
- Jason Jaramillo – MLB catcher
- Jason Jiménez – MLB
- Eddie Leon – MLB infielder
- Nick Leyva – MLB manager
- Albie Lopez – MLB pitcher
- Rafael Martin – MLB relief pitcher
- Alfonso Márquez – MLB Umpire
- Alex Mejia – MLB infielder
- Sergio Mitre – MLB pitcher
- Sid Monge – MLB all-star relief pitcher
- Carlos Muñiz – MLB relief pitcher
- Sandy Nava – MLB infielder
- Efren Navarro – MLB first baseman
- Vidal Nuño – MLB pitcher
- Ricky Nolasco – MLB pitcher
- Edgar Olmos – MLB pitcher
- Augie Ojeda – MLB infielder
- Steve Ontiveros – MLB infielder
- Jesse Orosco – MLB all-star pitcher
- Jorge Orta – MLB all-star second baseman
- Russ Ortiz – MLB pitcher
- Jordan Pacheco – MLB infielder/catcher
- Manny Parra – MLB pitcher
- James Pazos – MLB pitcher
- Marty Perez - Shortstop and baseman
- Óliver Pérez – MLB pitcher
- Chris Prieto – MLB outfielder
- Carlos Quentin – MLB all-star outfielder
- Omar Quintanilla – MLB shortstop
- Erasmo Ramirez – MLB relief pitcher
- Horacio Ramírez – MLB pitcher
- Noe Ramirez – MLB pitcher
- A.J. Ramos – MLB closer pitcher
- Cesar Ramos – MLB relief pitcher
- Rudy Regalado – MLB infielder
- Rick Renteria – MLB infielder and coach
- Anthony Rendon – MLB infielder
- Anthony Reyes – MLB pitcher
- Jo-Jo Reyes – MLB pitcher
- Fernando Rodriguez – MLB pitcher
- Rich Rodriguez – MLB pitcher
- JoJo Romero – MLB pitcher
- Stefen Romero – MLB Outfielder
- Ricky Romero – MLB starting pitcher
- Sergio Romo – MLB pitcher
- Rio Ruiz – MLB infielder
- Adam Rosales – MLB infielder
- Leo Rosales – MLB relief pitcher
- Mark Salas – MLB catcher
- Jeff Salazar – MLB outfielder
- Alex Sanabia – MLB pitcher
- Aaron Sanchez – MLB pitcher
- Freddy Sanchez – MLB all-star infielder and batting champion
- Sergio Santos – MLB relief pitcher
- Rudy Seánez – MLB pitcher
- José Silva – MLB pitcher
- Tyler Skaggs – MLB pitcher
- Frank Snyder – MLB pitcher
- Carlos Torres – MLB relief pitcher
- Mike Torrez – MLB pitcher
- Jason Vargas – MLB pitcher
- Fernando Valenzuela – MLB pitcher
- Anthony Vasquez – MLB pitcher
- Randy Velarde – MLB infielder
- Gil Velazquez – MLB infielder
- Vince Velasquez – MLB pitcher
- Alex Verdugo – MLB outfielder
- Ryan Verdugo – MLB pitcher
- Pedro Villarreal – MLB pitcher
- Fernando Viña – MLB all-star second baseman
- Taijuan Walker – MLB pitcher
- Ted Williams – MLB left fielder and Hall of Fame legend
- Michael Young – MLB all-star MVP, shortstop and batting champion
- Joel Zumaya – MLB pitcher
Basketball
- Mark Aguirre – USBWA college basketball player of the year, 3-time NBA all-star, and 2-time NBA champion
- Jack Avina – college coach
- Devin Booker – guard
- James Borrego – NBA coach
- Kaleb Canales – NBA coach
- Cedric Ceballos – forward
- Rene Herrerias – college coach
- Lorenzo Mata – center
- Elijah Millsap – forward
- Anthony Pedroza – guard
- Paul Stoll – guard
- Juan Toscano-Anderson – forward
- Orlando Méndez-Valdez – guard
- Earl Watson – guard
- Jaime Jaquez Jr. – small forward/shooting guard
Boxing
- Oscar Albarado – light middleweight champion
- Art Aragon – lightweight boxer
- Baby Arizmendi – title holder, Hall of Famer
- Chris Arreola – heavyweight boxer
- Paulie Ayala – WBA bantamweight champion
- Tony Ayala Jr. – junior middleweight boxer
- Carlos Balderas – professional boxer
- Tony Baltazar – professional boxer
- Arnold Barboza Jr. – professional boxer
- David Benavidez – WBC super middleweight champion
- José Benavidez Jr. – WBA interim light welterweight champion
- Norberto Bravo – professional boxer
- Gaby Canizales – bantamweight world champion boxer
- Orlando Canizales – bantamweight world champion boxer, Hall of Famer
- Michael Carbajal – four-time light flyweight champion boxer, Hall of Famer
- Ruben Castillo – professional boxer
- Bobby Chacon – two-time champion boxer, Hall of Famer
- Jesús Chávez – two division world champion
- Jackie Chavez – female boxer and IFBA World super bantamweight champion
- Rudy Cisneros – boxer, Contender contestant
- Diego Corrales – super featherweight and lightweight champion
- Steve Cruz – featherweight champion
- Alberto Dávila – bantamweight champion
- Oscar De La Hoya – ten-time world champion, Hall of Famer
- David Díaz – WBC lightweight champion
- Joseph Diaz – IBF super featherweight champion
- Juan Díaz – WBA and WBO and IBF World lightweight champion
- Marlen Esparza – 2012 women's boxing bronze medalist
- Louie Espinoza – WBA featherweight champion
- Brandon Figueroa – WBC super bantamweight champion
- Omar Figueroa Jr. – WBC lightweight champion
- Alexander Flores – professional boxer
- B. J. Flores – professional boxer
- Joshua Franco – WBA super flyweight champion
- Arturo Frias – world champion
- Alex García – heavyweight boxer
- Roberto Garcia – IBF super featherweight champion
- Ryan Garcia – professional boxer
- Miguel Ángel García – featherweight, super featherweight and lightweight champion, brother of Roberto Garcia
- Jaime Garza – WBC Super bantamweight
- Loreto Garza – world champion light welterweight
- Frankie Gómez – lightweight prospect
- Jaime Manuel Gómez – Mexican-American professional boxer in the Light Middleweight division
- Delia Gonzalez – flyweight female boxer
- Jesús González – amateur champion and Super middleweight contender
- Paul Gonzales – flyweight Olympic gold medalist
- Rodolfo Gonzales – boxer, poet, and leader of the Chicano civil rights movement
- Robert Guerrero – IBF featherweight and super featherweight champion
- Genaro Hernández – WBA and WBC super featherweight champion, Hall of famer
- Jesse James Leija – world champion boxer
- Don Jordan – world welterweight champion
- Willie Jorrín – WBC super bantamweight champion
- Rocky Juarez – Olympic silver medalist
- Brandun Lee – professional boxer
- Richie Lemos – professional boxer
- Carlos Licona – professional boxer
- Danny Lopez – world featherweight champion, Hall of Famer
- Josesito López – professional boxer
- Tony Lopez – three-time world champion
- Steven Luevano – WBO featherweight champion
- Jesse Magdaleno – WBO super bantamweight champion
- Raúl Márquez – world champion boxer and boxing announcer
- Abner Mares – bantamweight, super bantamweight and featherweight champion
- Antonio Margarito – WBO welterweight champion
- Sergio Mora – WBC super welterweight world champion
- Manuel Ortiz – world bantamweight champion, Hall of Famer
- Victor Ortiz – WBC welterweight champion
- Vergil Ortiz Jr. – professional boxer
- Bobby Pacho – professional boxer
- Zack Padilla – light welterweight champion
- Robert Quiroga – IBF superflyweight champion
- José Ramírez – WBC and WBO light welterweight champion
- Mando Ramos – lightweight champion
- Daniel Roman – WBA super bantamweight champion
- Andy Ruiz Jr. – WBA, IBF, WBO and IBO heavyweight champion
- Danny Romero – world champion boxer
- Brandon Ríos – WBA lightweight champion
- David Rodriguez – undefeated heavyweight boxer
- Raul Rojas – WBA featherweight champion
- Joseph Salas – featherweight Olympic silver medalist
- Martha Salazar – WBC heavyweight boxing champion
- Abel Sanchez – professional boxing trainer
- Richie Sandoval – bantamweight champion
- Alex Saucedo – professional boxer
- Maureen Shea – professional boxer, known as the "Real Million Dollar Baby"
- Solly Smith – first Latino featherweight champion of the world
- Mia St. John – WBC champion, professional female boxer
- Johnny Tapia – five-time flyweight, bantamweight and featherweight champion, Hall of famer
- Jesse Valdez – Olympic bronze medalist
- Fernando Vargas – two-time light middleweight champion
- Jessie Vargas – WBA super lightweight and WBO welterweight champion
- Jose Zepeda – professional boxer
Football (soccer)
- Jackie Acevedo – striker
- Isaac Acuña – midfielder
- Emily Alvarado – goalkeeper
- Mónica Alvarado – defender, international footballer
- Ventura Alvarado – defender
- Alejandro Alvarado Jr. – midfielder
- Efraín Álvarez – midfielder
- Carlos Alvarez – midfielder
- Frankie Amaya – midfielder
- Daniel Antúnez – midfielder
- Fernando Arce Jr. – midfielder
- Julián Araujo – defender
- Esteban Arias – defender
- Eder Arreola – midfielder
- Luis Arriaga – midfielder
- Paul Arriola – midfielder
- Josh Atencio – midfielder
- Eric Avila – midfielder
- Carlos Avilez – goalkeeper
- Fidel Barajas – midfielder
- Ivan Becerra – forward
- Julio Benitez – midfielder
- Carlos Bocanegra – center back and captain of the US National Team
- Carlos Borja – defender
- Jonathan Bornstein – defender and midfielder
- Jose Burciaga Jr. – defender
- Christina Burkenroad – forward
- Ariana Calderón – striker
- Javier Casas – midfielder
- Edgar Castillo – defender
- Bri Campos – defender
- Servando Carrasco – midfielder
- Nico Carrera – defender
- Edwin Cerrillo – midfielder
- Alfonso Ocampo-Chavez – forward
- Julian Chavez – midfielder
- Joe Corona – midfielder
- Antonietta Collins – sports commentator and soccer player, daughter of the well-known television reporter María Antonieta Collins
- Chris Cortez – forward
- Ramiro Corrales – midfielder
- Cade Cowell – forward
- Stephanie Cox – defender, Olympic gold medalist
- Renae Cuéllar – forward
- Daniel Cuevas – winger
- Mauricio Cuevas – defender
- A. J. DeLaGarza – defender
- Marco Delgado – midfielder
- Erik Dueñas – defender
- David Estrada – defender
- Marco Farfan – defender
- Janelly Farias – defender
- Omir Fernandez – attacking midfielder
- Vidal Fernandez – midfielder
- Dennis Flores – midfielder
- Jorge Flores – midfielder
- Monica Flores – leftback
- Jaime Frías – defender
- Joe Gallardo – forward
- Christopher Garcia – forward
- Freddie Garcia – forward
- Irving Garcia – midfielder
- Natalie Garcia – defender
- Nick Garcia – defender
- Poli Garcia – midfielder
- Rafael Garcia – midfielder
- Alina Garciamendez – defender
- Greg Garza – defender
- Monica Gerardo – coach and former player
- Luis Gil – midfielder
- Alejandro Guido – attacking midfielder
- Elizabeth Gómez – defender
- Francisco Gomez – midfielder
- Herculez Gomez – forward
- Johan Gomez – forward
- Jonathan Gómez – defender
- Daniel Gonzalez – midfielder
- Jesse González – goalkeeper
- Jonathan Gonzalez – midfielder
- Miguel Gonzalez – midfielder
- Mónica Gonzalez – forward
- Omar Gonzalez – defender
- Antonio De La Torre – defender
- Luis Gil – midfielder
- Sonny Guadarrama – midfielder
- Anisa Guajardo – striker
- Brian Gutiérrez – midfielder
- Diego Gutiérrez – forward
- Nancy Gutiérrez – defender
- Bianca Henninger – goalkeeper
- Alonso Hernández – attacking midfielder
- Daniel Hernández – defender
- Jorge Hernandez – midfielder
- Laurie Hill – midfielder
- Sofia Huerta – forward
- Miguel Ibarra – midfielder
- Rafael Jauregui – midfielder
- Hector Jiménez – defender
- Benji Joya – midfielder
- Freddy Juarez – defender
- Da'vian Kimbrough – forward
- Kiki Lara – midfielder, coach
- Richard Ledezma – midfielder
- Danny Leyva – midfielder
- Ulysses Llanez – forward
- Aaron Lopez – defender
- Mikey Lopez – midfielder
- Rodrigo López – midfielder
- Christian Lucatero – midfielder
- Diego Luna – midfielder
- Richie Marquez – defender
- Alma Martínez – defender
- Antonio Martínez – midfielder
- Gerardo Mascareño – forward
- John Matkin – midfielder
- Cruz Medina – midfielder
- Annia Mejia – defender
- Alex Mendez – midfielder
- Ruben Mendoza – forward
- Martha Moore – defender
- Susana Mora – defender
- Julio César Morales – forward
- Amando Moreno – forward
- Mike Muñoz – midfielder
- Santiago Muñóz – forward
- Christina Murillo – defender
- Lisa Nanez – forward
- Teresa Noyola – attacking midfielder, international player
- Ernest Nungaray – forward
- Juan Pablo Ocegueda – left back
- Gina Oceguera – defender
- David Ochoa – goalkeeper
- Emmanuel Ochoa – goalkeeper
- Sammy Ochoa – forward
- Nathan Ordaz – forward
- Diana Ordóñez – forward
- Emilio Orozco – defender
- Michael Orozco Fiscal – defender
- Ralph Orquin – left back
- Rey Ortiz – forward
- Jesús Padilla – forward, striker
- Miguel Palafox – defender
- Amanda Perez – midfielder
- Ricardo Pepi – forward
- Jonathan Perez – attacking midfielder
- Orlando Perez – defender
- Veronica Perez – forward
- Bruno Piceno – striker
- Mauricio Pineda – defender
- Miguel Ángel Ponce – defender, Olympic gold medalist
- Linnea Quinones – goalkeeper
- Maricarmen Reyes – midfielder, UANL Tigres Feminil
- Nick Rimando – goalkeeper
- Allan Rodríguez – midfielder
- Mario Rodriguez – forward
- Memo Rodríguez – midfielder
- Arianna Romero – defender
- César Romero – forward
- Rubio Rubin – forward
- Adrián Ruelas – striker
- Jennifer Ruiz – midfielder, defender
- Katie Johnson – forward, international footballer
- Jorge Salcedo – defender
- Hugo Salcedo – forward, coach
- Omar Salgado – forward and midfielder
- Shea Salinas – winger
- Tanya Samarzich – forward
- Ashley Sanchez – forward
- Keri Sanchez – defender, coach
- Maria Sánchez – midfielder
- Richard Sánchez – goalkeeper
- Marlene Sandoval – defender
- Sebastian Saucedo – midfielder
- Bianca Sierra – defender, international footballer
- Luis Silva – midfielder
- Sebastian Soto – forward
- Jonathan Top – forward
- Antonio de la Torre – midfielder
- Arturo Torres – defender
- Christian Torres – forward
- José Francisco Torres – midfielder
- Dioselina Valderrama – midfielder
- Obed Vargas – midfielder
- Jose Vasquez – defender
- Julián Vázquez – forward
- Martin Vasquez – midfielder and head coach
- Brandon Vazquez – forward
- Jesús Antonio Vázquez – left back
- Marco Vidal – midfielder
- Jaime Villarreal – midfielder
- Jorge Villafaña – defender
- Jose Villarreal – forward
- Natalie Vinti – defender
- William Yarbrough – goalkeeper
- Carlos Zavala – midfielder
- Adrian Zendejas – goalkeeper
- Alejandro Zendejas – midfielder
- Veronica Zepeda – forward
Golf
- Abraham Ancer – professional golfer
- Alex Aragon – professional golfer
- Homero Blancas – PGA tour winner
- Sam Chavez – professional golfer
- Abe Espinosa – first Hispanic-American to win a championship
- Al Espinosa – PGA tour winner
- Armando Favela – professional golfer
- Robert Gamez – PGA tour winner
- Ernie Gonzalez – PGA tour winner
- Tony Holguin – PGA tour winner
- Joe Jimenez – PGA Senior's champion
- Pat Perez – PGA tour winner
- Nancy Lopez – Hall of Fame American professional golfer
- Lizette Salas – LPGA tour winner
- J. J. Spaun – PGA tour winner
- Lee Trevino – Hall of Fame American professional golfer
Ice hockey
- Scott Gomez – NHL center
- Max Pacioretty – NHL left wing
- Auston Matthews – NHL center
- Matthew Nieto – NHL left wing
- Rhett Rakhshani – NHL right wing
Mixed martial arts
- Joseph Benavidez – UFC, mixed martial arts
- Eddie Bravo – mixed martial arts, Brazilian jiu-jitsu
- Paul Buentello – UFC, mixed martial arts
- Graciela Casillas – kickboxing and boxing title holder, martial arts practitioner
- Henry Cejudo – UFC champion, mixed martial arts
- Carlos Condit – UFC champion, mixed martial arts
- Dominick Cruz – UFC champion, mixed martial arts
- Nate Diaz – UFC, mixed martial arts TUF Winner
- Nick Diaz – UFC, mixed martial arts
- Efrain Escudero – mixed martial arts TUF Winner
- Carla Esparza – UFC champion, mixed martial arts
- Tony Ferguson – mixed martial arts TUF Winner
- Kelvin Gastelum – mixed martial arts TUF Winner
- Edgar Garcia – UFC, mixed martial arts
- Anthony Hernandez – UFC, mixed martial arts
- Roger Huerta – Bellator, mixed martial arts
- Juanito Ibarra – mixed martial arts and boxing trainer
- Ricardo Lamas – UFC, mixed martial arts
- Jonathan Martinez – UFC, mixed martial artist of Mexican and Salvadorian descent
- Rob McCullough – Muay Thai kickboxing, mixed martial arts
- Gilbert Melendez – Strikeforce champion, UFC mixed martial arts
- Brian Ortega – UFC, mixed martial arts
- Tito Ortiz – UFC champion, mixed martial arts
- Damacio Page – UFC, mixed martial arts
- Julianna Peña – UFC, mixed martial arts
- Alex Perez – UFC, mixed martial arts
- Anthony Pettis – UFC champion, mixed martial arts
- Sergio Pettis – UFC, mixed martial arts
- Dominick Reyes – UFC, mixed martial arts
- Ricco Rodriguez – UFC champion, mixed martial arts
- Mia St. John – tae kwon do champion
- Diego Sanchez – UFC, mixed martial arts TUF 1 Winner
- Emmanuel Sanchez – Bellator, mixed martial arts
- Frank Shamrock – UFC champion, mixed martial arts
- Joe Soto – Bellator champion, UFC mixed martial arts
- Jeremy Stephens – UFC, mixed martial arts
- Joe Stevenson – UFC, mixed martial arts
- Cub Swanson – UFC, mixed martial arts
- Manny Tapia – mixed martial arts
- Josh Thomson – Strikeforce champion, UFC mixed martial arts
- Miguel Torres – WEC champion, UFC mixed martial arts
- Charlie Valencia – mixed martial arts
- Cain Velasquez – UFC heavyweight champion, mixed martial arts
- Joey Villasenor – mixed martial arts
- Adrian Yañez – UFC, mixed martial arts
Wrestling
- Aaron Aguilera – professional wrestler
- The Bella Twins – professional wrestlers
- Bayley – professional wrestler
- Sin Cara – professional wrestler
- Manny Fernandez – professional wrestler
- Pepper Gomez – professional wrestler
- Chavo Guerrero Sr. – professional wrestler
- Chavo Guerrero Jr. – professional wrestler
- Eddie Guerrero – professional wrestler
- Gory Guerrero – professional wrestler
- Hector Guerrero – professional wrestler
- Mando Guerrero – professional wrestler
- Gino Hernandez – professional wrestler
- Shawn Hernandez – professional wrestler
- Incognito – professional wrestler
- Kaitlyn – professional wrestler
- Kalisto – professional wrestler
- Paul London – professional wrestler
- Eva Marie – professional wrestler
- Dominik Mysterio – professional wrestler
- Rey Mysterio Jr – professional wrestler
- Magno – professional wrestler
- Shelly Martinez – professional wrestler
- Misterioso – professional wrestler
- JoJo Offerman – professional wrestler
- Roxanne Perez – professional wrestler
- Melina Perez – professional wrestler
- Essa Ríos - professional wrestler
- Johnny Rodz – professional wrestler
- Ricky Romero – professional wrestler
- Tito Santana – professional wrestler
- José Luis Jair Soria – professional wrestler
- Enrique Torres – professional wrestler
- Lady Victoria – professional wrestler
- Chris Youngblood – professional wrestler
- Jay Youngblood – professional wrestler
Other sports
- David Aldana – professional motorcycle racer
- Tony Alva – professional skateboarder, founding member of the Z-Boys.
- Anita Alvarez – synchronized swimmer, Olympic medalist
- Olga Appell – Olympic Track and Field Athlete, winner of the LA Marathon
- Inaki Basauri – rugby union player, member the U.S. national team
- Crystl Bustos – softball player, two-time Olympic Gold and silver medalist
- Steve Caballero – professional skateboarder, pioneer of vertical skating
- Miguel de Capriles – fencer, two time Olympic medalist, and President of the FIE
- Patricia Cardenas – world champion water polo gold medalist
- Henry Cejudo – freestyle wrestler and Olympic gold medalist
- Michael Chacon – professional fixed gear freestyle bike rider
- Antonio Cruz – cyclist, US National Criterium Champion
- Ronnie Deleon – two-time World kickboxing champion
- Erica Dittmer – swimmer
- Ernesto Escobedo – tennis player
- David R. Flores – jockey
- Gary Gabelich – motorsport driver, set the Land Speed Record
- Rudy Galindo – figure skater, U.S. National champion
- Jackie Galloway – taekwondo competitor, Olympic medalist
- Martin Garcia – jockey
- Angélica Gavaldón – tennis player
- Memo Gidley – race car driver
- Mark Gonzales – skateboarder, named by the Transworld Skateboarding magazine as the "Most Influential Skateboarder of all Time"
- Pancho Gonzales – professional tennis player, regarded as one of the greatest of all-time.
- Carlos Gracida – polo player, hall of fame member
- Guillermo Gracida Jr. – polo player, hall of fame member
- Natalia Grossman – professional competition climber
- Jesus Hernandez – race car driver
- Danny Herrera – weightlifting powerlifter
- Jessa Khan – ju-jitsu practitioner, international gold medalist
- Ricardo Laguna – professional BMX rider and television personality
- Arlene Limas – taekwondo, Olympic gold medalist
- Andy Lopez – college baseball coach
- Rob Machado – surfer
- Leonel Manzano – middle-distance runner, Olympic silver medalist
- Bobby Martinez – professional surfer
- Brenda Martinez – track and field athlete
- Mario Martinez – weightlifting powerlifter Olympic silver medalist
- Rachel McLish – bodybuilder, first Ms. Olympia champion
- Marten Mendez – badminton player, U.S national title winner
- Jessica Mendoza – softball player and Olympic Gold and silver medalist
- Marc Frank Montoya – professional snowboarder
- Juan Moreno – taekwondo, two-time Olympic silver medalist
- Sylvia Mosqueda – long-distance runner
- Justine Wong-Orantes – volleyball player, Olympic gold medalist
- Derek Parra – professional speed skater and Olympic gold medalist
- Kevin Peraza – BMX freestyle rider, two-time X Games gold medalist
- Cruz Pedregon – two-time drag racing champion
- Tony Pedregon – two-time drag racing champion
- Tori Pena – pole vaulter
- Stacy Peralta – professional skateboarder, founding member of the Z-Boys.
- Sarah Robles – weightlifter, Olympic medalist
- Paul Rodriguez Jr. – professional skateboarder
- Rico Roman – ice sledge hockey player, Paralympics gold medalist and Purple Heart recipient
- Gene Romero – professional motorcycle racer, winner of the 1970 A.M.A. Grand National Championship and the 1975 Daytona 200
- Leo Romero – professional skateboarder
- Sierra Romero – softball player, first player to record 300 runs, 300 hits and 300 RBI in NCAA history
- Jesse Ruíz – wrestler
- Oz Sanchez – handcyclist and triathlete, six-time Paralympic Games medalist
- Cristian Soratos – middle-distance runner
- Tracee Talavera – gymnast, Olympic silver medalist
- Jorge Torres – long-distance runner
- Vanessa Torres – professional skateboarder
- Tony Trujillo – professional skateboarder
- Benny Urquidez – World kickboxing champion
- Ismael Valenzuela – Kentucky Derby winner
- Patrick Valenzuela – Kentucky Derby and Preakness Stakes winner
- Brenda Villa – World Class water polo player, Olympic gold, silver and bronze medalist
Arts and entertainment
Actors and media personalities
- Dolores del Río was a Mexican actress. With a career spanning more than 50 years, she is regarded as the first major female or male Latin American crossover star in Hollywood.
- Rodolfo Acosta Mexican character actor of Western films
- Rico Alaniz character actor, active during the 1950s and 1990s.
- Jessica Alba Golden Globe nominated actress
- Marilyn Monroe model and actress
- Edward Albert Golden Globe winning actor
- Kevin Alejandro actor
- Ana Alicia actress
- Francia Almendárez actress
- Don Alvarado actor and director who began his career during the silent film era
- Armida actress, singer and dancer
- Joe Arquette actor
- Karan Ashley actor
- Alexis Ayala actor
- Catherine Bach actress
- Jaylen Barron actress
- Alma Beltran actress, appeared in 82 films between 1945 and 2002.
- Robert Beltran actor
- Demián Bichir actor
- Summer Bishil actress
- Luna Blaise actress
- Alexis Bledel actress
- Daniela Bobadilla actress
- Diego Boneta actor
- Jesse Borrego actor
- Sabrina Bryan dancer, choreographer, actress and singer
- Shelbie Bruce actress
- Artt Butler voice actor
- Richard Cabral Emmy nominated actor
- Christian Camargo actor
- Ralph Camargo actor
- Charlie Cannon singer, theater performer
- Steve Cardenas actor
- Leo Carrillo actor, vaudevillian, political cartoonist and conservationist.
- Enrique Castillo actor
- David Castañeda, actor
- Movita Castaneda actress
- Teresa Castillo actress
- Julio Cedillo actor
- Angélica Celaya actress
- Laura Cerón ALMA Award-winning actress
- Damian Chapa actor, film director and producer
- Ricardo Antonio Chavira actor
- Louis C.K. actor, comedian, Emmy Award-winning screenwriter, producer, and director
- Gary Clarke TV actor active during the 1950s–1960s
- Steve Clemente Mexican-born American actor known for his many villainous roles
- Clifton Collins Jr. Emmy Award nominated actor
- Mark Consuelos actor
- Ana Brenda Contreras Mexican-based television actress
- Margarita Cordova actress, most known for her various TV appearances during the '60s
- Raymond Cruz actor
- Kid Cudi musician and actor
- Ethan Cutkosky actor
- Alana de la Garza actress
- Madison De La Garza American actress of Mexican descent
- Gonzalo de la Torre singer and producer
- Kate del Castillo Mexican-born American actress.
- Tony Dalton actor
- Stacey Dash actress
- Emilio Delgado actor; best known for his role of Luis Rodriguez on Sesame Street
- Grey DeLisle singer-songwriter and voice actress
- Alexa Demie actress
- Rosanna DeSoto film and television actress
- Aarón Díaz actor
- Alyssa Diaz actress
- Mónica Dionne American actress of Mexican descent
- Julia Louis-Dreyfus multiple Emmy award-winning actress
- Alejandro Edda actor
- Ayiiia Elizarraras TV personality and model
- Jade Esteban Estrada actor and comedian
- Richard Esteras Screen Actors Guild Award winning actor of Mexican and Puerto Rican descent
- Felipe Esparza actor and comedian
- Tamara Feldman actress
- Abel Fernandez American actor who played in movies from 1953 to 2002.
- Michelle Forbes Emmy nominated and Saturn Award-winning actress
- Eduardo Franco
- Edward Furlong Saturn Award-winning actor
- Vic Fuentes vocalist, guitarist
- Mike Fuentes drummer
- Edy Ganem actress
- Seychelle Gabriel singer and actress, father of part Mexican descent
- Aimee Garcia Screen Actors Guild nominated actress
- Al Ernest Garcia actor and casting director active between 1911 and 1938, known for his association with Charlie Chaplin
- Jeff Garcia comedian and Annie Award-winning voice actor
- Jesse Garcia ALMA Award-winning actor
- Jessica Marie Garcia American actress known for On My Block (TV series), Mexican father
- Michael Garza American actor of Mexican descent
- John Gavin actor, politician and head of the Screen Actors Guild
- William Gaxton actor of film and theatre
- Hunter Gomez American actor
- Selena Gomez actress, singer, model, spokesperson, Mexican father
- Xochitl Gomez actress
- Eiza González actress, model and singer
- Mandy Gonzalez theater and film actress
- Myrtle Gonzalez silent film actress; regarded as Hollywood's first Latin and Hispanic movie star
- Nicholas Gonzalez actor
- Pedro Gonzalez-Gonzalez character actor
- Michele Greene Emmy nominated actress, best known for the role of Abigail Perkins on the series L.A.
- Lita Grey silent film actress
- Jackie Guerra actress
- Noel Gugliemi actor
- Elizabeth Gutiérrez actress
- Froy Gutierrez actor
- Ryan Guzman actor, father of Mexican descent
- Nikki Hahn actress
- Gabriella Hall actress and model
- Laura Harring actress and Miss USA
- Salma Hayek Oscar, Emmy, and Golden Globe nominated actress, TV-film director and producer
- Callie Hernandez actress, singer
- Jay Hernandez actor
- Kristin Herrera actress
- Gabriel Iglesias actor and comedian
- Osvaldo de León Telenovelas actor
- Ana Brenda Contreras TV actress
- Ryan Guzman TV actor
- Mónica Dionne film and TV actress
- Michael Irby actor
- Rebeca Iturbide actress during the Mexican Age of Golden cinema
- Shar Jackson actress
- Anjelah Johnson actress, comedian, and former NFL cheerleader
- Susan Kohner Golden Globe winning and Oscar nominated actress, mother was Lupita Tovar, Mexican actress
- Apollonia Kotero actress, singer and model
- Samuel Larsen actor and singer
- Logan Lerman actor;
- George J. Lewis Mexican-born American actor
- Sebastián Ligarde telenovela actor
- Iyari Limón actress
- Natalia Livingston Emmy Award-winning actress
- Eva Longoria Golden Globe nominated and Screen Actors Guild winning actress and model
- George Lopez actor and comedian
- Mario López actor and host
- Seidy López actress and director
- Linda Loredo actress
- Gabriel Luna actor, best known for his role as Robbie Reyes / Ghost Rider on the series Marvel's Agents of S.H.I.E.L.D.
- Julio Macias actor from On My Block
- Al Madrigal actor and comedian
- Angélica María actress and life-time Grammy Award-winning singer-songwriter. She was one of the main movie and TV attractions in Mexico during the 60s and 70s and the no. 1 record seller in the country during the same period
- Vanessa Marcil Emmy winning actress
- Xolo Maridueña actor
- Constance Marie actress
- Cheech Marin actor and comedian
- Ada Maris actress
- Chrispin Martin actor
- A Martinez Emmy Award-winning actor
- Joaquín Martínez actor, appeared in many Western films
- Kimberly McCullough actress, best known for her role as Robin Scorpio on the soap opera General Hospital
- Alex Meneses actress and model
- Alex Meraz actor
- Yvette Mimieux actress
- Lin-Manuel Miranda American actor, composer, lyricist, singer, rapper, actor, producer, and playwright, known by his roles in Broadway musicals. He is of mostly Puerto Rican descent, but he also is a quarter Mexican.
- Ricardo Montalbán Emmy and Screen Actors Guild award-winning actor
- Carlos Montalbán actor
- Manny Montana American actor of Mexican descent
- Belita Moreno actress
- Rene L. Moreno American actor
- Lindsey Morgan Emmy nominated actress
- Bethany Mota social media personality
- Marisol Nichols actress
- Eva Noblezada actress and singer, two-time Tony Award nominee and Grammy winner
- Ramón Novarro actor, one of the top box office attractions of the 1920s and early 1930s
- Lupita Nyong'o actress, born in Mexico City to Kenyan parents
- Bodie Olmos actor
- Edward James Olmos Golden Globe and Emmy winning actor and director
- Lupe Ontiveros Emmy nominated actress
- Hayley Orrantia American actress, singer-songwriter. Her grandfather is of Mexican descent and she identifies as Latina.
- Jenna Ortega actress
- Joy Page actress
- Sara Paxton actress and singer, mother is Mexican, of Mexican-Jewish descent
- Michael Peña actor
- Walter Perez actor
- Tony Perry guitarist
- Daniella Pineda actress
- Tyler Posey actor
- Mishel Prada actress
- Jaime Preciado bassist
- Anthony Quinn two-time Oscar winning actor
- Cierra Ramirez actress and model
- Efren Ramirez actor
- Danny Ramirez American actor of Colombian and Mexican descent
- Marisa Ramirez actress
- Sara Ramirez Tony Award-winning actress and singer
- Raylene pornographic actress
- Alex Reymundo comedian and actor
- Nicole Richie actress of partial Mexican descent
- Mona Rico actress
- Lauren Ridloff Tony Award-nominated actress
- Emily Rios actress and model
- Lalo Rios actor, active during the 1950s and 1960s
- James Roday actor, father of Mexican descent
- Lee Rodriguez actress
- Rico Rodriguez actor
- Paul Rodriguez comedian and actor
- Patty Rodriguez radio host, entrepreneur, and children's book author
- Valente Rodriguez actor
- Gilbert Roland two-time Golden Globe nominated actor
- Fernanda Romero actress
- Tina Romero Mexico-based actress
- Luis van Rooten Mexican-born American actor
- Gabrielle Ruiz film and theater actress
- Teresa Ruiz actress, won multiple international awards
- Andy Russell born Andrés Rábago in Boyle Heights, California, to Mexican immigrant parents, he was a big-band crooner who sang "Bésame Mucho," the first Spanish-English bilingual song in U.S. recording history. He performed in movies, television, radio and stage in the U.S., Mexico, and Latin America.
- Claudia Salinas actress and model
- Johnny A. Sanchez actor and comedian
- Lauren Sánchez news anchor, entertainment and media personality
- Ref Sanchez actor and photographer
- Paul Sand Tony Award-winning actor
- Miguel Sandoval film and television actor
- Michael Saucedo actor
- Christian Serratos actress, model and singer, of part Mexican descent
- Vinessa Shaw actress
- Stephanie Sigman actress
- Zuleyka Silver actress, model
- Alicia Sixtos actress
- Karla Souza film and television actress
- David Spielberg film and television actor; mother was Mexican American
- Scout Taylor-Compton actress and singer
- Julia Goldani Telles actress
- Tessa Thompson actress
- Raquel Torres actress, active during the 1920s to 1930s
- Renee Torres Mexican American actress and the sister of Raquel Torres
- Emeraude Toubia actress, model
- Elena Tovar Daytime Emmy Award nominated actress
- Lupita Tovar actress
- Danny Trejo actor
- Michael Trevino actor
- Alanna Ubach actress
- Natividad Vacío actor
- Erik Valdez actor
- Jacob Vargas actor
- James Vasquez American actor and director to a Mexican father
- Ray Vasquez American singer, musician, and actor
- Randy Vasquez American actor and director; brother of James Vasquez
- Lupe Vélez one of the first successful Latin American actresses in the United States, began her career in the silent film era
- Vanessa Villela actress
- Melissa Villaseñor actress
- Nena von Schlebrügge actress
- Pee Wee (entertainer) actor and singer
- Victoria Wyndham two-time Emmy nominated actress
- Eduardo Xol actor
- Carmen Zapata actress, appeared in over 100 films and TV series
- Austin Zajur actor
Directors and filmmakers
- Elisa Marina Alvarado – American director
- Guillermo del Toro – film director
- Félix Enríquez Alcalá – television and film director
- Natalia Almada – documentary filmmaker
- Robert Alvarez – animator, television director, and writer
- John A. Alonzo – influential cinematographer, Academy Award nominee and Emmy Award winner
- Michael Arias – anime filmmaker based in Japan
- Eva Aridjis – film director, screenwriter, TV writer
- Roberto Benabib – television writer, producer, and film director, Emmy Award nominee
- J. Robert Bren – screenwriter and producers, wrote 30 films between the '30s and '50s
- Edward Carrere – art director, Academy Award winner and two-time nominee
- Natalie Chaidez – writer and producer, Emmy Award nominee
- Fernanda Coppel – screenwriter and playwright
- Julio Hernández Cordón – director and screenwriter
- Terri Doty – animation voice actress, voice director, and writer
- Mike Elizalde – special makeup effects artist, Academy Award nominee
- Moctezuma Esparza – producer, Academy Award and Emmy Award nominee
- Carlos López Estrada – music video, commercial, and film director
- Hampton Fancher – producer and screenwriter
- William A. Fraker – cinematographer, director, and producer, six-time Academy Award nominee
- Nick Gomez – American film director
- Alfonso Gomez-Rejon – film and television director, two-time Emmy Award nominee
- Neal Jimenez – screenwriter and film director
- Emile Kuri – set decorator, won two Academy Awards and was nominated for six more in the category Best Art Direction
- William Douglas Lansford – screenwriter, film producer, and author
- Paul Lerpae – special effects artist, Academy Award nominee
- Jenée LaMarque – writer and director
- Bill Melendez – animator, director, and producer, eight-time Emmy Award winner and Academy Award nominee
- Steven C. Melendez – animator, director, and producer, Emmy Award winner
- Linda Mendoza – television and film director
- Lindsay Mendez – Tony Award-winning actress
- Adrian Molina – screenwriter, storyboard artist, and animation director, Emmy Award nominee
- Sylvia Morales – director, writer, and producer, Emmy Award nominee
- Gregory Nava – director, producer and screenwriter, Academy Award and Emmy Award nominee
- Tony Olmos – screenwriter, filmmaker and musician
- Edward James Olmos – director and actor, Emmy and Golden Globe winner
- Roberto Orci – screenwriter and producer
- Manuel Perez (animator) – animator and animation director
- Polish brothers – screenwriters and producers
- Lourdes Portillo – Academy Award-nominated filmmaker
- Georgina Garcia Riedel – filmmaker and scriptwriter
- Jonas Rivera – producer with Pixar films, Academy Award winner
- Robert Rodríguez – director, producer and screenwriter
- Phil Roman – animation director, founder of Film Roman animation studio, six-time Emmy Award winner
- Bernardo Ruiz – documentary filmmaker
- Craig Saavedra – producer and director, two-time Tony Award nominee
- Victor Salva – filmmaker
- Jesús Salvador Treviño – television director, three-time Emmy Award nominee
- Jose Luis Valenzuela – theater and film director
- Jeff Valdez – producer, writer, and studio executive
- Luis Valdez – playwright and director
- Chris Weitz – writer, producer, director; grandmother was Mexican actress Lupita Tovar
- Paul Weitz – writer, producer, director; grandmother was Mexican actress Lupita Tovar
- Rudy Zamora – animator and animation director, Emmy Award nominee
- Alfonso Cuarón – film director, producer, editor, and screenwriter
Models
- Arianny Celeste – MMA Ring Girl, model, TV host
- Nikita Dragun – YouTuber, make-up artist, and model
- Ayiiia Elizarraras – TV personality and model
- Wendolly Esparza – beauty pageant titleholder
- Yoanna House – model, fashion model, TV host and America's Next Top model Winner
- Erika Medina – model
- Christian Monzon – model and actor
- Naima Mora – model, fashion model, America's Next Top model winner
- Carter Oosterhouse – Nautica and HGTV's Carter Can
- Nia Sanchez – model, Miss USA 2014
- Mia St. John – professional boxer, model, businesswoman and tae kwon do champion
- Christian Serratos – actress, model and singer
- Frida Sofía – musician, TV host, model, singer and media personality
- Ylianna Guerra – model, beauty pageant titleholder
Musicians, singers and music groups
- 2Mex – rapper
- 6ix9ine – rapper
- Paula DeAnda – singer
- Pepe Aguilar – singer
- Rikk Agnew – singer, musician
- Santiago Almeida – musician, influential in the development of the musical genres of tejano and conjunto
- Anacani – singer
- B-Real – rapper
- Joan Baez – singer-songwriter, activist*
- Baby Bash – rapper
- Jeff Becerra lead singer of the death metal band Possessed
- Becky G – pop singer and rapper
- Berner – rapper and entrepreneur
- Rebecca Black – singer
- Tony Bellamy – musician and vocalist of the Native American rock band Redbone.
- Betzaida – Latin pop singer
- Cedric Bixler-Zavala – singer, musician
- The Blendells – soul band
- Chingo Bling – rapper
- Beau Bokan – lead vocalist
- Ally Brooke – singer, member of Fifth Harmony
- Juan Brujo – lead singer of Brujeria
- Reginald Arvizu bassist from the band Korn
- Sabrina Bryan – singer, actress
- Camila Cabello – singer
- Chuck Cabot – saxophonist and big band leader
- Carla Dirlikov Canales – mezzo-soprano singer
- Las Cafeteras – folk and traditional Mexican musical group
- Laura Canales – Tejano singer
- Nati Cano – Grammy Award-winning mariachi musician
- Stephen Carpenter – co-founder and lead guitarist of the band Deftones
- Vicki Carr – Grammy Award-winning singer
- Albert Castillo – music producer
- Emilio Castillo – founding member of Tower of Power
- Carlos Cavazo – lead guitarist of the rock band Quiet Riot
- Dino Cazares – guitarist
- Ingrid Chavez – singer-songwriter, poet
- Mark Chavez – musician
- El Chicano – soul and jazz band
- Chicano Batman – four-piece Chicano rock band
- Keyshia Cole – R&B singer
- Lisa Coleman – Grammy and ASCAP Award-winning musician/composer, funk keyboardist, member of Prince and The Revolution and Wendy and Lisa
- Ramiro Cortés – classical composer
- Cuco – singer-songwriter, and producer
- Kid Cudi – rapper, singer, record producer, and actor
- Marcos Curiel – guitarist
- Ray Dalton – singer
- Alfonso D'Artega – songwriter and conductor
- Diana DeGarmo – singer, actress
- Fito de la Parra – drummer of Canned Heat
- Zack De La Rocha – rapper, singer, poet, lead member of Rage Against the Machine
- Gonzalo de la Torre – singer, musician
- Grey DeLisle – singer-songwriter, voice actress
- Andrew Martinez – drummer
- Lhasa De Sela – singer-songwriter
- Deorro – DJ
- Dev (singer) – singer, rapper, model and radio host
- Down AKA Kilo – rapper
- Nadir D'Priest – musician
- Sheila E. – musician
- Roberto Enrique – singer-songwriter, actor
- Joe Escalante – musician
- Alejandro Escovedo – singer-songwriter, musician
- Coke Escovedo – percussionist
- Pete Escovedo – percussionist
- Mimi Fariña – singer-songwriter
- Louis Febre – Mexican-born composer
- Freddy Fender – Tejano and country musician
- Fergie – singer-songwriter, actress, member of The Black Eyed Peas
- Rosita Fernández – Tejano singer
- Aundrea Fimbres – singer, member of Danity Kane
- Dom Flemons – singer, Grammy nominee
- Paty Cantú – singer, musician
- Rosie Flores – rockabilly and country singer
- Mando Fresko – DJ, radio personality, actor
- Frost – rapper
- Kap G – rapper
- Victoria Galvan – singer, musician
- Andrew Garcia – musician, American Idol
- Eva Garza – vocalist, film actress
- G-Eazy – rapper
- Gemini – rapper
- Vivica Genaux – operatic mezzo-soprano
- Girl In a Coma – rock band
- Juan Gotti – rapper
- Selena Gomez – singer, actress
- Lalo Guerrero – singer-songwriter
- María Grever – prolific Emmy Award-winning composer who achieved international recognition
- Ha*Ash – rock pop duo
- Cenobio Hernandez – composer
- Daniel Hernandez – rapper also known as 6ix9ine
- Marcos Hernandez – singer-songwriter
- Miguel – recording artist, songwriter, producer of Mexican and African-American descent
- Raymond Herrera – drummer
- David Hidalgo – singer-songwriter
- Marques Houston – singer
- Intocable – Tejano band
- Frankie J – singer
- Johnny J – multi-platinum music producer, rapper, songwriter
- Prima J – Pop duo
- Flaco Jiménez – accordionist, musician
- Santiago Jiménez Jr. – folk musician, won the National Heritage Fellowship for lifetime achievement in traditional Tex-Mex/folk music
- Little Joe – Tejano performer
- Maya Jupiter – DJ, emcee
- Jeanette Jurado – singer, member of the girl group Exposé which achieved much success between 1984 and 1993, becoming the first group to have four top ten hits on the Billboard Hot 100 chart from its debut album
- DJ Kane – singer
- Joshua Kadison – singer-songwriter
- Kehlani – singer
- Down AKA Kilo – rapper
- Apollonia Kotero – actress, singer and model
- Stefano Langone – singer
- Shelly Lares – singer
- Kiana Lede – singer
- Lucky Luciano – rapper
- A Lighter Shade of Brown – rap group
- The Lennon Sisters – vocal group, popular during the '50s and '60s
- Robert Lopez – musician
- Trini Lopez – singer, guitarist
- Demi Lovato – singer and actress
- Kirstin Maldonado – member of Grammy winning group Pentatonix
- Malo – Latin rock and roll soul band
- Angélica María – Lifetime Grammy Award-winning singer-songwriter and actress
- Marisela – singer
- Cruz Martínez – musician, music producer
- Narciso Martínez – musician, influential in the development of the musical genres of tejano and conjunto
- Vicci Martinez – singer-songwriter
- Xiuhtezcatl Martinez – hip hop artist
- Javier Jose Mendoza – conductor
- Julia Michaels – singer-songwriter
- Lydia Mendoza – Tejano music singer
- Jorge Mester – conductor
- Roy Mitchell-Cardenas – rock bassist
- Laura Molina – singer, musician, artist, painter, muralist
- Chris Montez – singer, musician
- Manuel Mora – musician
- Annette Moreno – Grammy nominated Spanish-language Christian music singer
- Chino Moreno – lead singer of Team Sleep and Deftones
- Ricardo Zohn-Muldoon – composer, a finalist for the 2011 Pulitzer Prize for Music
- Myra – singer-songwriter
- Natalie – singer-songwriter
- Los Nativos – rap group
- Emilio Navaira – Tejano singer, Grammy Award winner
- Dave Navarro – guitarist
- Vince Neil – lead vocalist of the band Mötley Crüe
- Asia Nitollano – member of The Pussycat Dolls
- OhGeesy – rapper and member of Shoreline Mafia
- Pete Orta – Grammy Award-winning guitarist Petra
- José Pasillas – drummer
- Sara Paxton – singer, actress
- Pee Wee – singer-songwriter, actor
- Jennifer Peña – Tejano singer
- Bobby Pulido – singer-songwriter
- Amanda Perez – singer-songwriter
- Chris Pérez – singer, operatic soprano
- Chris Pérez – Grammy Award-winning guitarist
- Jay Perez – Tejano singer
- Yolanda Pérez – musician, singer
- Romina Power – singer-songwriter, actress
- Snow Tha Product – rapper
- A.B. Quintanilla – musician, music producer
- Abraham Quintanilla – singer-songwriter
- Ramirez – rapper and songwriter
- Elida Reyna – Tejano singer
- Johnny Richards – jazz composer active during the 1950s and 1960s
- Jenni Rivera – singer-songwriter
- Lil Rob – rapper
- Roger Rocha – singer-songwriter, guitarist for the group 4 Non Blondes
- Johnny Rodriguez – country music singer
- Robert Xavier Rodriguez – classical composer
- Sixto Rodriguez – folk musician
- Chan Romero – singer, musician
- Linda Ronstadt – Grammy Award-winning musician
- Rick Rosas – singer, musician, bassist for Joe Walsh and Neil Young, Crosby Stills Nash and Young, Buffalo Springfield, Crazy horse
- Andy Russell vocalist, specializing in traditional pop and Latin music. His parents were Mexican immigrants
- Sam the Sham – leader of Sam the Sham and the Pharaohs
- Adán Sánchez – singer, son of legendary Chalino Sanchez
- Antonio Sanchez – jazz drummer, composed film score for the film Birdman, Golden Globe nominated
- Jessica Sanchez – singer. Her father is a Mexican American, originally from Texas, and is a US Navy veteran. Her mother is a Filipina from Samal, Bataan, in the Philippines.
- Hope Sandoval – singer-songwriter
- Esteban Jordan – singer-songwriter
- Sonny Sandoval – singer, member of P.O.D.
- Carlos Santana – Grammy Award-winning guitarist
- Selena Quintanilla-Pérez – Tejano superstar / Grammy award-winning singer
- Jessy Serrata – Tejano musician
- Arban Severin – musician, actress
- Mariee Sioux – folk singer-songwriter
- Denise Stefanie – singer
- Steve Soto – punk rock guitarist
- Comanche Sound – Grammy nominated producer
- Shakey Graves – Americana musician
- Esperanza Spalding – jazz singer, musician
- Taboo – rapper, member of The Black Eyed Peas
- Abel Talamantez – singer; former member of Menudo, MDO, Kumbia Kings, Los Super Reyes and Los EnVivo Kings
- John Tejada – electronic musician, music producer
- Thee Midniters – rock and soul band
- Melody Thornton – singer, model, member of The Pussycat Dolls
- Tierra – R&B, soul band
- Randy Torres – guitarist
- Tina Piña Trachtenburg – rock pop band
- Robert Treviño – music conductor
- Robert Trujillo – bassist
- John Trudell – musician, author, poet, political activist
- Chayito Valdez – singer, actress
- Ritchie Valens – singer, musician
- Patrick and Lolly Vegas – Mexican/Yaqui/Shoshone musicians and vocalists of the Native American rock band Redbone.
- Jaci Velasquez – contemporary Christian Latin pop singer
- Julieta Venegas – singer-songwriter, instrumentalist
- Cassie Ventura – singer-songwriter and dancer
- Angela Via – singer-songwriter
- Jasmine Villegas – R&B, pop singer
- Kyle Vincent – singer-songwriter; producer
- Lil Xan – rapper
- Yeat – rapper, singer, producer. His paternal grandmother is Mexican and is from Tijuana.
- Taco Shop Poets – spoken word and world music band
- The Zeros – punk-rock band
- That Mexican OT – rapper
Authors and poets
- Oscar Zeta Acosta – minor novelist, activist, attorney and politician
- Francisco X. Alarcon – author, poet, activist, and college professor
- Alurista – poet, activist, and college professor
- María Amparo Ruiz De Burton – author
- James Anaya – poet
- Rudolfo Anaya – author
- Gloria E. Anzaldúa – author, poet, scholar and activist
- Chloe Aridjis – novelist
- Alfred Arteaga – poet and writer
- Carmen Beltrán – poet and playwright
- Silvester Brito – poet and academic
- Xochiquetzal Candelaria – poet and professor
- Norma Elia Cantú – writer and professor
- Ana Castillo – author, novelist, poet and essayist
- Lorna Dee Cervantes – poet
- Ingrid Chavez – singer-songwriter and poet
- Sandra Cisneros – author, novelist and poet
- María Antonieta Collins – TV host, journalist and author
- Lucha Corpi – poet and writer
- Carlos Cumpián – author and poet
- María Amparo Escandón – novelist, screenwriter, advertising creative director, and film producer
- Diana Gabaldon – novelist
- Dana Gioia – writer, chairman of the National Endowment of the Arts
- Guillermo Gómez-Peña – artist, author, poet and activist
- Rigoberto González – author and critic
- Rodolfo Gonzales – political activist, poet and featherweight boxing champion
- Reyna Grande – author, memoirist
- Juan Felipe Herrera – poet, author, translator and activist
- Miriam Herrera – author and poet
- Rolando Hinojosa – author, novelist, poet and essayist
- Luis Leal (writer) – writer and literary critic
- Elizabeth Martínez – activist and author
- Paul Martínez Pompa – author and poet
- José Montalvo – author, poet and activist
- José Montoya – artist and poet
- Pat Mora – author and poet
- Cherríe Moraga – author, poet, essayist and activist
- Angela Morales – award-winning essayist
- Julian Nava – author, educator and diplomat
- Daniel Olivas – author and attorney
- Americo Paredes – novelist
- Tomás Rivera – author, poet and educator
- Alberto Rios – American poet and author
- Luis J. Rodriguez – author, poet, novelist, journalist, critic and columnist
- Richard Rodriguez – author
- Pam Muñoz Ryan – award-winning children's author
- Luis Omar Salinas – author and poet
- raúlrsalinas – activist and poet
- Erika Sánchez – author and poet
- Ricardo Sánchez – poet and professor
- Ricardo Sanchez – author and United States Army general
- Jimmy Santiago Baca – author and poet
- John Phillip Santos – author, journalist, and filmmaker
- Leslie Marmon Silko – writer, key figure in the First Wave of the Native American Literary Renaissance
- Octavio Solis – award-winning playwright and director
- Gary Soto – author and poet
- Luis Talamantez – poet and activist
- Sergio Troncoso – author, novelist, short-story writer and essayist
- John Trudell – musician, author, poet and political activist
- Luís Alberto Urrea – author, poet, novelist and essayist
- José Antonio Villarreal – author and novelist
- Victor Villaseñor – author and public speaker
- Maria Helena Viramontes – author and professor
- Karen Zacarias – award-winning playwright
Visual arts
- Manuel Gregorio Acosta – artist, painter and illustrator
- Lalo Alcaraz – artist, editorial/comic strip cartoonist
- Juana Alicia – artist, painter and activist
- Carlos Almaraz – street artist and muralist
- Axel Alonso – American comic book creator.
- Pete Alvarado – animation and comicbook artist
- Cecilia Alvarez – artist, painter and muralist
- Natalia Anciso – artist and educator
- Sergio Aragonés – cartoonist, writer
- Don Gregorio Antón – artist, photographer and educator
- Alfonso Arana – artist and painter
- Fortunato Arriola – artist and painter
- Gus Arriola – artist and comic Strip cartoonist
- Judy Baca – artist, painter, muralist and activist
- Patrociño Barela – artist, wood sculptor
- Santa Barraza – artist, painter and activist
- Galo Canote – graffiti artist, painter, muralist and activist
- Mel Casas – artist, painter and activist
- Ako Castuera – artist who is best known for being a writer and storyboard artist on the animated television series Adventure Time
- Yreina Cervantez – artist, painter, activist and muralist
- Jean Charlot – painter and illustrator
- Miguel Condé – artist, painter and print-maker
- Peter Coffin – artist and painter
- Salvador Corona – folk-art style painter
- Enrique Chagoya – artist, painter and print-maker
- Alfredo de Batuc – artist
- Edgar De Evia – photographer
- Jerry De La Cruz – artist and painter
- Roberto De La Rocha – artist, painter and muralist
- Daniel Martin Diaz – artist and painter
- Richard Dominguez – comic book artist and Illustrator.
- Carlos Dorrien – artist and sculptor
- Rodolfo Escalera – artist, painter
- Elsa Flores – street artist
- Diane Gamboa – artist and painter
- Harry Gamboa Jr. – performance artist, photographer and essayist
- Carmen Lomas Garza – artist, painter and illustrator
- Guillermo Gómez-Peña – performance artist, author, activist and educator
- David Gonzales – cartoonist
- Gronk – performance artist, painter and print-maker
- Pedro E. Guerrero – photographer, one of the most sought-after architectural photographers of the 1950s
- Ester Hernandez – artist and painter
- Gilbert Hernandez – cartoonist
- Jaime Hernandez – cartoonist
- Javier Hernandez – comic book artist and radio host
- Judithe Hernández – painter, activist, educator, and public artist
- Mario Hernandez – cartoonist
- Luis Jimenez – artist and sculptor
- Yolanda Lopez – artist, painter, print-maker, educator and movie producer
- Gilbert Luján – artist, painter, muralist and sculptor
- James Luna – installation artist
- Alex Martinez – graffiti artist, illustrator, muralist
- Xavier Martínez – artist, painter and teacher
- Bill Melendez – animator
- Alberto Mijangos – artist and painter
- Mister Cartoon – tattoo and Graffiti artist
- Laura Molina – artist, painter, muralist, and musician
- Franco Mondini-Ruiz – visual artist
- Rhode Montijo – comic book artist and co-creator of the cartoon Happy Tree Friends.
- Rafael Navarro – comic book artist
- Ray Navarro – artist, filmmaker, and HIV/AIDS activist
- Manuel Neri – artist, painter, print-maker and sculptor
- Victor Ochoa – painter, muralist and activist
- Estevan Oriol – photographer and director
- Martín Ramírez – self-taught artist
- Michael Ramirez – Pulitzer Award-winning cartoonist
- Daniel "Chaka" Ramos – graffiti artist
- Miguel Angel Reyes – artist, painter, print-maker, muralist, Illustrator and Instructor
- Anita Rodriguez – artist and painter
- Isis Rodriguez – contemporary painter
- Carlos Saldaña – comic book artist and comedian
- John August Swanson – visual artist
- Alberto Valdés – painter
- Patssi Valdez – painter, artist and activist
- Mark Vallen – artist, figurative realist painter, activist, curator and blogger
- Kathy Vargas – artist and painter
- Rafael Vargas-Suarez – contemporary artist, painter and photographer
- Emigdio Vasquez – artist and muralist
- Jhonen Vasquez – cartoonist, comic book and author
- Joe Vera – graphic artist
- Esteban Villa – artist and muralist
- Kat Von D – tattoo artist and TV personality
- Jorge A. Zapata - architect
Dance
- Michael Balderrama – choreographer, Broadway dancer, and producer
- Corky Ballas – ballroom dancer, holds several Latin dance championship titles
- Mark Ballas – Emmy nominated choreographer, dancer, and musician
- Evelyn Cisneros – ballerina, instructor
- René Elizondo Jr. – dancer, music video director
- Rosa Ramirez Guerrero – founder of the International Folklorico Dance Group
- Cynthia Harvey – former American Ballet Theatre and Royal Ballet principal dancer, artistic director of Jacqueline Kennedy Onassis School
- Tina Landon – choreographer who has worked with numerous musical performers
- José Limón – influential dancer and choreographer, active between 1929 and 1969
- Nicholas Magallanes – principal dancer for the New York City Ballet
- Viktor Manoel – choreographer, writer, and actor
- Tony Meredith – ballroom dancer, choreographer, and US Latin dance Champion
- Tina Ramirez – dancer and choreographer, founder of Ballet Hispanico, the leading Hispanic dance company in the United States.
- Maclovia Ruiz – dancer with the San Francisco Ballet in the 1930s
- Eva Tessler – director, playwright, and dancer
Drag performers
Journalists
- Gustavo Arellano – editor at the Los Angeles Times and writer/creator of ¡Ask a Mexican!
- Ron Arias – highly regarded Chicano writer and correspondent
- Jim Avila – TV journalist and correspondent
- Ana Cabrera – television news anchor
- Ricardo Celis – Spanish language sportscaster
- María Antonieta Collins – TV host, journalist, and author
- Mandalit del Barco – award-winning art and culture reporter for National Public Radio
- Laura Diaz – Southern California newscaster and co-anchor of CBS 2 News
- Giselle Fernández – TV journalist and reporter
- Anselmo L. Figueroa – journalist and political figure
- Carlos Frey">Carlos Gracida">Carlos Frey – investigative journalist
- Luis De La Garza – TV and radio host
- Christy Haubegger – movie producer and founder of Latina Magazine
- Maria Hinojosa – broadcast journalist and correspondent
- Monica C. Lozano – editor, publisher, and CEO of La Opinión, the largest Spanish language newspaper
- Rubén Martínez (writer) – award-winning journalist and author
- Tony Ortega (journalist) – newspaper editor, blogger
- Raul Peimbert – Spanish language TV journalist and newscaster
- John Quiñones – news correspondent, award-winning journalist
- Jorge Ramos – Spanish-language TV news anchor and journalist
- Naibe Reynoso – TV journalist and reporter
- Rubén Salazar – TV journalist and reporter
- María Elena Salinas – Spanish language TV news anchor and journalist
- Lauren Sánchez – Emmy Award-winning journalist
Political figures
- Anabel Abarca – former member of the Chicago City Council
- Oscar Zeta Acosta – politician, attorney, minor novelist and activist
- Adrian Fontes – Secretary of State of Arizona
- Bob Archuleta – member of the California State Senate
- Katherine Archuleta – political executive
- Alexander Arvizu – United States Ambassador to Albania from 2010 to 2015
- Cisco Aguilar – Secretary of State of Nevada
- Pete Aguilar – U.S. representative, former mayor of Redlands, California
- Amanda Aguirre, former member of the Arizona Senate
- Mike Aguirre – former city attorney of San Diego, California
- Lucille Roybal-Allard – former U.S. Congresswoman from California, former member of the California State Assembly
- Arturo Alonso – member of the Oklahoma House of Representatives
- Juan Bautista Alvarado – twice governor of Alta California from 1836 to 1837 and 1838 to 1842
- Toney Anaya – former Governor of New Mexico and former Attorney General of New Mexico
- Rafael Anchia – member of the Texas House of Representatives
- Jerry Apodaca – former Governor of New Mexico former Chair of the President's Council on Physical Fitness and Sports
- Jesse Arreguin – Mayor of Berkeley, California
- Ruben Ayala – former member of the California Senate, former mayor of Chino, California
- Joe Baca – former U.S. Congressman from California and former member of both the California Senate and the California State Assembly
- Joe Baca Jr. – former California State Assembly member
- José Baca – former Lieutenant Governor of New Mexico
- Polly Baca – served as Chair of the Democratic Caucus of the Colorado House of Representatives, former member of the Colorado Senate
- Hector Balderas – former Attorney General of New Mexico, former New Mexico State Auditor, and former member of the New Mexico House of Representatives
- Romana Acosta Bañuelos – former Treasurer of the United States
- Nanette Barragán – U.S. representative
- Rosemary Barkett – former Chief Justice of the Florida Supreme Court, former Judge on the United States Court of Appeals for the Eleventh Circuit
- Xavier Becerra – Former United States Secretary of Health and Human Services, former Attorney General of California, former U.S. representative, former California State Assembly member
- Gina M. Benavides – Justice at the Texas Thirteenth Court of Appeals
- Joseph Bernal – Texas State Representative
- Jaime Herrera Beutler – former U.S. Representative, former member of the Washington House of Representatives
- Rosilicie Ochoa Bogh – member of the California Senate
- Henry Bonilla – former U.S. Congressman from Texas
- Susan Bonilla – former California State Assembly member, Contra Costa County, California Board of Supervisors member
- Flavio Bravo – member of the Arizona Senate
- Columba Bush – former First Lady of Florida
- George P. Bush – former Land Commissioner of Texas, son of Jeb Bush
- Albert Bustamante – former U.S. Congressman from Texas
- Cruz Bustamante – former Lieutenant Governor of California, former Speaker of the California State Assembly
- Ezequiel Cabeza de Baca – former Governor of New Mexico and former Lieutenant Governor of New Mexico
- Anna Escobedo Cabral – 42nd Treasurer of the United States
- Louis Caldera – former United States Secretary of the Army, former member of the California State Assembly
- Kiki Camarena – undercover agent for the United States Drug Enforcement Administration
- Yadira Caraveo – Former U.S. Congresswoman from Colorado, former member of the Colorado House of Representatives
- Jovita Carranza – former Administrator of the Small Business Administration, former Deputy Administrator of the Small Business Administration, former Treasurer of the United States
- Quico Canseco – former U.S. representative from Texas
- Salud Carbajal – U.S. representative
- George Cardenas – member of the Cook County Board of Review, former member of the Chicago City Council
- Tony Cárdenas – Former U.S. representative, former member of the Los Angeles City Council, former California State Assembly member
- Carlos Antonio Carrillo – Gobernador of Alta California,. His father, José Raimundo Carrillo, came from Loreto, Mexico
- José Antonio Carrillo – Californio ranchero, official and politician; brother of Carlos Antonio Carrillo
- Juan Carrillo - member of the California State Assembly
- Juan José Carrillo – first mayor of Santa Monica, California
- Greg Casar – U.S. representative from Texas, former member of the Austin City Council
- Rubén Castillo – Chief Judge of the United States District Court for the Northern District of Illinois
- Carlos Cascos – former Secretary of State of Texas
- Joaquin Castro – United States Representative from Texas, former member of the Texas House of Representatives
- José Castro – acting governor of Alta California in 1835–1836, and Commandante General of the Mexican army in Alta California at the time of the 1846 Bear Flag Revolt and the Mexican–American War of 1846–1848
- Julian Castro – Former Mayor of San Antonio, former U.S. Secretary of Housing and Urban Development, former member of the San Antonio City Council and 2020 U.S. presidential candidate
- Raul Hector Castro – former Governor of Arizona, former U.S. ambassador to Argentina, Bolivia, and El Salvador
- Lauro Cavazos – United States Secretary of Education
- Gabe Cazares – former mayor of Clearwater, Florida
- Cesar Chavez (politician) – former member of the Arizona House of Representatives
- Dennis Chavez – U.S. Senator and Congressman from New Mexico
- Tibo J. Chávez – former Lieutenant Governor of New Mexico and member of the New Mexico Senate
- Juan Ciscomani – U.S. representative from Arizona
- Gil Cisneros – U.S. Congressman from California, former Under Secretary of Defense for Personnel and Readiness
- Henry Cisneros – former Secretary of Housing and Urban Development and mayor of San Antonio, Texas
- Mark Cisneros – member of the Iowa House of Representatives
- Bob Coffin – former member of both the Nevada Senate and the Nevada Assembly
- Frank Coombs – former U.S. congressman from California, former US ambassador to Japan, former Speaker of the California State Assembly
- Patty Contreras – member of the Arizona House of Representatives
- Antonio F. Coronel – former mayor of Los Angeles, former Los Angeles County Assessor, former California State Treasurer
- Lou Correa – U.S. House of Representatives, former member of both the California Senate and the California State Assembly, and former member of the Orange County Board of Supervisors
- Catherine Cortez Masto – U.S. Senator from Nevada, former Nevada Attorney General
- Joe Coto – member of the California State Assembly
- Jose Cruz (Oklahoma politician) – former member of the Oklahoma House of Representatives
- Monica De La Cruz – U.S. Congresswoman from Texas
- Ruth Cruz – member of the Chicago City Council
- Henry Cuellar – U.S. House of Representatives Texas's 28th congressional district, former Secretary of State of Texas, former member of the Texas House of Representatives
- Mariano-Florentino Cuéllar – former associate justice of the Supreme Court of California
- Mike Curb – former Lieutenant Governor of California
- Gonzalo P. Curiel – judge of the United States District Court for the Southern District of California
- Alessandro Cutrona – member of the Ohio House of Representatives
- Billy Dalto – former ember of the Oregon House of Representatives
- James DeAnda – former judge of the United States District Court for the Southern District of Texas, attorney, noted for his activities in defense of Hispanic civil rights, particularly as a plaintiff's attorney in Hernandez v. Texas.
- Ignacio De La Fuente – former Vice Mayor of Oakland, member of the Oakland City Council
- Pablo de la Guerra – former acting Lieutenant Governor of California member of the California State Senate
- Antonio Delgado – Lieutenant Governor of New York, former U.S. congressman from New York
- Ygnacio del Valle – member of the Los Angeles Common Council, California State Assemblyman, Mayor of Los Angeles
- Lori Chavez-DeRemer – U.S. Secretary of Labor, former U.S. Congresswoman from Oregon, former mayor of Happy Valley, Oregon
- Leonora Dodge – state legislator in Vermont
- Rosalba Dominguez – state legislator in Utah
- Elena J. Duarte – Associate Justice of the California Court of Appeal
- Maria Elena Durazo – member of the California Senate
- Luz Escamilla – member of the Utah Senate
- Veronica Escobar – U.S. Congresswoman from Texas
- Gabe Evans - U.S. Congressman from Colorado; former member of the Colorado House of Representatives
- Antonio M. Fernandez – Former U.S. Congressman from New Mexico
- Ben Fernandez – American politician, financial consultant and special ambassador. He was a member of the Republican Party. He ran for President of the United States in 1980, 1984 and 1988, making him America's first major-party presidential contender of Hispanic origin
- Teresa Leger Fernandez – U.S. Congresswoman from New Mexico
- Marco Antonio Firebaugh – former California State Assembly member
- Edgar Flores (politician) – member of the Nevada Senate, and former member of the Nevada Assembly
- Mayra Flores – former U.S. Congresswoman from Texas
- Soñia Galaviz – member of the Idaho House of Representatives
- Mario Gallegos Jr. – former member of both the Texas Senate and the Texas House of Representatives
- Pete Gallego – former U.S. representative, former member of the Texas House of Representatives
- Ruben Gallego – U.S. representative, former member of the Arizona House of Representatives
- Tony Gallegos – Chairman of the Equal Employment Opportunity Commission
- Cristina Garcia – former California State Assembly member
- Joseph Garcia – former Lieutenant Governor of Colorado
- Jesus "Chuy" Garcia – U.S. Congressman from Illinois, former member of the Cook County Board of Commissioners, former member of Illinois Senate, former member of the Chicago City Council, Mayoral Candidate for the city of Chicago
- Jorge Luis Garcia, former member of the Arizona Senate
- Mike Garcia – Former U.S. Congressman from California
- Sylvia Garcia – U.S. Congresswoman from Texas, former member of the Texas Senate
- Ruben Garcia Jr. – former executive assistant director of FBI
- Eric Garcetti – U.S. Ambassador to India, former Mayor of Los Angeles, former President of the Los Angeles City Council
- Gil Garcetti – former Los Angeles County District Attorney
- Edward D. Garza – former mayor San Antonio, Texas and former member of the San Antonio City Council
- Margarito C. Garza – district judge, comic book creator
- Antonio María de la Guerra – Mayor of Santa Barbara, California, California state senator
- José Antonio de la Garza – Mayor of San Antonio, Texas, the first landowner in San Antonio and the first man to create a coin in this state.
- Kika de la Garza – former U.S. Congressman from Texas, former member of the Texas House of Representatives
- Reynaldo Guerra Garza – first Hispanic judge appointed to the U.S. Court of Appeals, former judge on the United States District Court for the Southern District of Texas
- Tony Garza – former U.S. Ambassador to Mexico, former Secretary of State of Texas, former member of the Texas Railroad Commission
- Victor Gordo – Mayor of Pasadena, California
- Jimmy Gomez – U.S. representative from California, former California State Assembly member
- Alberto Gonzales – former United States Attorney General, former White House Counsel, former justice on the Supreme Court of Texas, former Secretary of State of Texas
- Rafael Gonzales – native of San Antonio, Texas, he was governor of Coahuila and Texas.
- Ron Gonzales – former mayor of San José, California
- Tony Gonzales – U.S. representative from Texas
- Cecelia González – member of the Nevada Assembly
- Charlie Gonzalez – former U.S. representative
- Edgar Gonzalez Jr. – member of the Illinois House of Representatives
- Henry Gonzalez – former U.S. representative
- Irma Elsa Gonzalez – former judge of the United States District Court for the Southern District of California
- Lena Gonzalez – member of the California Senate
- Matt Gonzalez – former President of the San Francisco Board of Supervisors
- Ramon Gonzalez Jr. – former member of the Kansas House of Representatives
- Steven Gonzalez – Chief Justice of the Washington Supreme Court
- Vicente Gonzalez – U.S. House of Representatives
- Adelita Grijalva – U.S. representative elect, Pima County Board of Supervisors
- Raúl Grijalva – Former U.S. representative
- Michelle Lujan Grisham – Governor of New Mexico and former U.S. representative
- Patricia Guerrero – Chief Justice of California, former Associate Justice of the California Supreme Court, former Associate Justice of the California Court of Appeal, former Judge of the San Diego County Superior Court
- Yanira Gurrola, member of the New Mexico House of Representatives
- Jeylú Gutiérrez – member of the Chicago City Council
- Philip S. Gutierrez – judge of the United States District Court for the Central District of California
- Eva Guzman – former member of the Supreme Court of Texas
- Isabel Guzman – Administrator of the Small Business Administration
- Lucía Guzmán – former member of the Colorado Senate
- Ana Hernandez - member of the Texas House of Representatives
- Benigno C. Hernandez – former Congressman from New Mexico
- Eunisses Hernandez – member of the Los Angeles City Council
- Melody Hernandez – member of the Arizona House of Representatives
- Norma Hernandez – member of the Illinois House of Representatives
- Roger Hernández – former mayor of West Covina, California, former California State Assembly member
- Tim Hernández - member of the Colorado House of Representatives
- Ruben Hinojosa – former U.S. representative
- Ben Hueso – former member of both the California Senate and the California State Assembly, former member of the San Diego City Council
- Jose Huizar – former member of the Los Angeles City Council
- Lilian Jiménez – member of the Illinois House of Representatives
- Michael Brooks-Jimenez – member of the Oklahoma Senate
- Debora Juarez – former president of the Seattle City Council
- Ruben Kihuen – former U.S. representative, former member of both the Nevada Senate and the Nevada Assembly
- Ricardo Lara – California Insurance Commissioner, former member of both the California Senate and the California State Assembly
- Octaviano Ambrosio Larrazolo – former Governor of New Mexico and first Latino to serve United States Senate
- Idalia Lechuga-Tena – former member of the New Mexico House of Representatives
- Oscar Leeser – Mayor of El Paso
- Teresa Alonso Leon – former member of the Oregon House of Representatives
- Mike Levin – U.S. Representative for California's 49th congressional district since 2019
- Sam Liccardo – U.S. Congressman from California, former mayor of San Jose, California and former member of the San Jose City Council
- Kevin Lincoln – mayor of Stockton, California
- Carmen Lomellin – former U.S. ambassador to the Organization of American States
- Greg Lopez – former U.S. Congressman from Colorado
- Janie Lopez – member of the Texas House of Representatives
- Marco A. López Jr. – Chief of Staff of U.S. Customs and Border Patrol, Director of the Arizona Department of Commerce, Mayor of Nogales, Arizona
- Patty López – member of the San Fernando, California City Council, former member of the California State Assembly
- Anthony Loubet – member of the Utah House of Representatives
- J. M. Lozano – member of the Texas House of Representatives
- Eric Lucero – member of the Minnesota Senate, former member of the Minnesota House of Representatives
- Ben Ray Lujan – U.S. Senator from New Mexico, former U.S. Congressman
- Manuel Lujan Jr. – U.S. representative from New Mexico
- Anna Paulina Luna – first Mexican-American U.S. Congresswoman from Florida
- Casey Luna – former Lieutenant Governor of New Mexico
- Roberto de la Madrid – governor of Baja California
- Abel Maldonado – 47th Lieutenant Governor of California, former member of both the California Senate and the California State Assembly
- Rosario Marin – 41st Treasurer of the United States, former mayor of Huntington Park, California
- Marina Marmolejo – judge of the United States District Court for the Southern District of Texas
- Catherine Cortez Masto – U.S. Senator from Nevada, former Attorney General of Nevada
- Diane Martinez – former member of the California State Assembly
- Hugo Soto-Martinez – member of the Los Angeles City Council
- Matthew G. Martinez – former U.S. Congressman from California, former member of the California State Assembly
- Nury Martinez – former President of the Los Angeles City Council
- Susana Martinez – former governor of New Mexico
- Brian Mast – U.S. representative from Florida
- Gloria Negrete McLeod – former U.S. Congresswoman from California, former member of both the California Senate and the California State Assembly
- Harold Medina – Senior Judge of United States Court of Appeals for the Second Circuit, former judge of the United States District Court for the Southern District of New York
- Carlos Menchaca – former member of the New York City Council
- Susana Mendoza – Illinois Comptroller, former City Clerk of Chicago, and former member of the Illinois House of Representatives.
- Ken Miyagishima – mayor of Las Cruces, New Mexico
- Gloria Molina – former Chair of Los Angeles County, former member of the California State Assembly, former vice-chair of the Democratic National Committee
- Roberto Mondragón – former Lieutenant Governor of New Mexico
- Cindy Montañez – former member of the California State Assembly
- Joseph Montoya – former U.S. Senator and Congressman from New Mexico, former Lieutenant Governor of New Mexico, former member of both the New Mexico Senate and the New Mexico House of Representatives
- Nestor Montoya – former Congressman from New Mexico
- David Sánchez Morales – CIA operative
- Eddie Morales – member of the Texas House of Representatives
- Howie Morales – Lieutenant Governor of New Mexico, former member of the New Mexico Senate
- Carlos R. Moreno – former justice on the California Supreme Court, former US ambassador to Belize, former judge of the United States District Court for the Central District of California
- Helena Moreno – member of the New Orleans City Council, former president of the New Orleans City Council, former member of the Louisiana House of Representatives
- Ramiro Muñiz, known as Ramsey Muñiz – first Hispanic whose name appeared on a Texas gubernatorial general election ballot, in 1972 and 1974, each time as the nominee of the Raza Unida Party but lost both elections.
- Ricardo Muñoz – former member of the Chicago City Council
- Carlos Murguia – former judge of the United States District Court for the District of Kansas
- Mary H. Murguia – Judge of the United States Court of Appeals for the Ninth Circuit, former judge of the United States District Court for the District of Arizona
- Ramón Músquiz – Governor of Coahuila and Texas from 1830 to 1831 and in 1835
- Grace Napolitano – U.S. representative, former member of the California State Assembly
- Cindy Nava, member of the New Mexico Senate
- Julian Nava – former U.S. Ambassador to Mexico
- Pedro Nava – former member of the California State Assembly
- Fabian Núñez – former Speaker of the California State Assembly
- Estevan Ochoa – historic mayor of Tucson, Arizona, he was the first Mexican-American mayor after the Gadsden Purchase of 1854
- Richard Ojeda – former member of the West Virginia Senate
- Fernando M. Olguin – Judge of the United States District Court for the Central District of California
- Darleen Ortega – Judge on the Oregon Court of Appeals
- Liz Ortega – member of the California State Assembly
- Katherine D. Ortega – 38th Treasurer of the United States
- Aaron Ortiz – member of the Illinois House of Representatives
- Solomon Ortiz – former U.S. representative
- Mariano S. Otero – Delegate from the Territory of New Mexico
- Miguel Antonio Otero – former Governor of New Mexico
- Rolando Pablos – former Secretary of State of Texas
- Nick Pacheco – former member of the Los Angeles City Council
- Romualdo Pacheco – former Governor of California, former Lieutenant Governor of California, former California State Treasurer, former US congressman, former US ambassador to Costa Rica, El Salvador, Guatemala, Honduras, and Nicaragua
- Alex Padilla – U.S. Senator from California, former Secretary of State of California, former President of the Los Angeles City Council
- Imelda Padilla – member of the Los Angeles City Council
- Mike Padilla – mayor of Topeka, Kansas
- Steve Padilla – member of the California Senate, former mayor of Chula Vista, California
- Richard Paez – federal judge on the United States Court of Appeals for the Ninth Circuit, former judge of the United States District Court for the Central District of California
- Veronica Paiz – member of the Michigan House of Representatives
- Ed Pastor – former U.S. Congressman from Arizona
- Federico Peña – former mayor of Denver, Colorado, former United States Secretary of Transportation, former United States Secretary of Energy, former member of the Colorado House of Representatives
- Francisco Perea – Delegate from the Territory of New Mexico
- Marie Gluesenkamp Perez – U.S. Congresswoman from Washington
- Andrés Pico – mixed-race Californio youth; a successful rancher and commander; former member of both the California Senate and the California State Assembly; in 19th century California; brother of Pío Pico
- Pío Pico – last Governor of Alta California under Mexican rule
- Margarita Prentice – former member of the Washington Senate and the Washington House of Representatives
- Miguel A. Pulido – Mayor of Santa Ana, California
- Marcelino Quiñonez – former member of the Arizona House of Representatives
- Ceferino Quintana – former Lieutenant Governor of New Mexico
- Robert Ramirez – former member of the Colorado House of Representatives
- Carlos Ramirez-Rosa – member of the Chicago City Council
- Emily Randall – U.S. Congresswoman from Washington, former member of the Washington Senate
- Irma Lerma Rangel – former member of the Texas House of Representatives
- Jose Maria Redondo – Mayor of Yuma, Arizona
- Anthony Rendon – former Speaker of the California State Assembly
- Ben Reyes – former member of the Texas House of Representatives and the Houston City Council
- Silvestre Reyes – former U.S. Congressman from Texas
- Cruz Reynoso – judge on the Supreme Court of California, Presidential Medal of Freedom
- Bill Richardson – former Governor of New Mexico, former United States Ambassador to the United Nations, former United States Secretary of Energy, former U.S. Congressman from New Mexico
- Rebecca Rios – former member of both the Arizona Senate and the Arizona House of Representatives
- Rosa Rios – 43rd Treasurer of the United States, businesswoman, executive and entrepreneur.
- Luz Rivas – U.S. Congresswoman from California; former member of the California State Assembly
- Albert Robles – former mayor of Carson, California and convicted criminal
- Ciro Rodriguez – former U.S. Congressman from Texas, former member of the Texas House of Representatives
- Regina M. Rodriguez – Judge of the United States District Court for the District of Colorado
- Angela Romero - minority leader and member of the Utah House of Representatives
- Brenda Lopez Romero - former member of the Georgia House of Representatives
- Gloria Romero – former member of both the California Senate and the California State Assembly. He was brother of Pío Pico, college professor
- Regina Romero – Mayor of Tucson, Arizona
- Trinidad Romero – Delegate to United States Congress from the Territory of New Mexico
- Edward Roybal – former U.S. representative from California, former member of the Los Angeles City Council
- Blanca Rubio – member of the California State Assembly
- Carmen Rubio – Portland City Commissioner
- Susan Rubio – member of the California Senate
- Ernesto Ruffo Appel – politician and former governor of Baja California
- Raul Ruiz (politician) – U.S. representative
- Mary Salas – former mayor of Chula Vista, California, former member of the California State Assembly
- John Salazar – U.S. representative, former member of the Colorado House of Representatives
- Ken Salazar – Former U.S. Ambassador to Mexico, former United States Secretary of the Interior, former U.S. Senator, former Colorado Attorney General
- Athena Salman – former member of the Arizona House of Representatives
- John Sanchez – former Lieutenant Governor of New Mexico and member of the New Mexico House of Representatives
- Loretta Sanchez – U.S. representative
- Linda Sánchez – U.S. representative
- Brian Sandoval – former Governor of Nevada, former Attorney General of Nevada, former judge of the United States District Court for the District of Nevada, former chair of the Nevada Gaming Commission, and former member of the Nevada Assembly
- Gerardo Sandoval – judge of the Superior Court of California
- Mariana Sandoval – member of the Arizona House of Representatives
- Andrea Salinas – U.S. Congresswoman from Oregon, former member of the Oregon House of Representatives
- Simon Salinas – former member of the California State Assembly
- Oscar De Los Santos – member of the Arizona House of Representatives
- Xochitl Torres Small – former United States Deputy Secretary of Agriculture, former Under Secretary of Agriculture for Rural Development, former US congresswoman from New Mexico
- Daniel Solis – former member of the Chicago City Council
- Hilda Solis – U.S. Secretary of Labor, former U.S. representative, former Chair of Los Angeles County, former member of both the California Senate and the California State Assembly
- Jose Solorio – former member of the Santa Ana, California City Council, former member of the California State Assembly
- Esmeralda Soria – member of the California State Assembly
- Frank Tejeda – former U.S. Congressman from Texas, former member of both the Texas Senate and the Texas House of Representatives
- Cynthia Telles – U.S. Ambassador to Costa Rica
- Raymond Telles – first mayor of a large American city, former US ambassador to Costa Rica
- Hector De La Torre – former member of the California State Assembly
- Esteban Edward Torres – former U.S. Representative from California, former U.S. ambassador to UNESCO, and labor activist
- Ken Trujillo – former candidate for mayor of Philadelphia. He created largest not for profit serving Hispanic community in Philadelphia, The Congreso, which is now one of the largest anti-poverty advocates in the nation and served Philadelphia as City Solicitor and an Assistant U.S. Attorney.
- Abelardo L. Valdez – diplomat and lawyer, President and Vice Chair of the Council of American Ambassadors
- Lupe Valdez – former Sheriff of Dallas County
- Anna M. Valencia – City Clerk of Chicago
- Avelino Valencia – member of the California State Assembly
- Judith Valles – former mayor of San Bernardino, California
- Juan Vargas – U.S. representative, former member of both the California Senate and the California State Assembly, former member of the San Diego City Council
- Nora Vargas – former Chair of the San Diego County Board of Supervisors
- Gabe Vasquez – U.S. Congressman from New Mexico; former member of the Las Cruces, New Mexico City Council
- Gaddi Vasquez – U.S. Ambassador and 8th United States representative to the United Nations Food and Agriculture Organization, former member of the Orange County Board of Supervisors
- Martha Vázquez – judge of the United States District Court for the District of New Mexico
- Blanca Vela – former mayor of Brownsville, Texas
- Filemon Vela Jr. – former U.S. representative
- Andrew Velasquez – Regional Administrator for the U.S. Department of Homeland Security's Federal Emergency Management Agency
- Antonio Villaraigosa – former Mayor of Los Angeles, former member of the Los Angeles City Council, former Speaker of the California State Assembly
- Barbara Vucanovich – American Republican politician. She was the first Latino American to serve in the House of Representatives, representing Nevada.
- Kim McLane Wardlaw – judge of the United States Court of Appeals for the Ninth Circuit, former United States District Court for the Central District of California
- Joe Wardy – former mayor of El Paso, Texas
- Mary Yu – associate justice of the Washington Supreme Court
- Judith Zaffirini – member of the Texas Senate
- Juan Carlos Zarate – former Assistant Secretary of the Treasury for Terrorist Financing
Military
- Anthony Acevedo – soldier during World War II whose diary was instrumental in documenting Nazi atrocities.
- Bertrand Blanchard Acosta – aviator, fighter pilot
- Lucian Adams – Medal of Honor
- Michael J. Aguilar – Marine Corps brigadier general
- Everett Alvarez Jr. – Navy LCdr/pilot who endured 8.5 years in Vietnamese captivity and one of the longest periods as a U.S. prisoner of war
- Cipriano Andrade – served in the United States Navy for forty years
- Juan G. Ayala – two-star General in the U.S. Marine Corps and former Commander of the Marine Corps Installations Command
- Joe R. Baldonado – Medal of Honor
- David B. Barkley – Medal of Honor
- Roy Benavidez – Medal of Honor
- Pedro Cano – Medal of Honor
- Robert Cardenas – U.S. Air Force brigadier general
- Richard E. Cavazos – first U.S. Army Hispanic 4-star general, Distinguished Service Cross
- Manuel Antonio Chaves – soldier in the Mexican Army and rancher in New Mexico
- Kathlene Contres – U.S. Navy
- Emilio A. De La Garza – Medal of Honor
- Jesus S. Duran – Medal of Honor
- Victor H. Espinoza – Medal of Honor
- Santiago J. Erevia – Medal of Honor
- Daniel Fernandez – Medal of Honor
- José María Flores – General and Governor of Alta California
- Guy Gabaldon – Navy Cross recipient, credited with capturing about 1,500 Japanese soldiers and civilians during the Battle of Saipan
- Joe Gandara – Medal of Honor
- Candelario Garcia – Medal of Honor
- Marcario Garcia – Medal of Honor
- Edward Gomez – Medal of Honor
- Eduardo C. Gomez – Medal of Honor
- Harold Gonsalves – Medal of Honor
- David M. Gonzales – Medal of Honor
- Alfredo Cantu "Freddy" Gonzalez – Medal of Honor, KIA in Huế
- Ambrosio Guillen – Medal of Honor
- Rodolfo P. Hernandez – Medal of Honor
- Silvestre S. Herrera – Medal of Honor
- Edward Hidalgo – former Secretary of the Navy
- Jose F. Jimenez – Medal of Honor
- Miguel Keith – Medal of Honor
- Salvador J. Lara – Medal of Honor
- Felix Z. Longoria Jr. – first Mexican American buried in Arlington National Cemetery
- Jose M. Lopez – Medal of Honor
- Benito Martinez – Medal of Honor
- Joe P. Martinez – Medal of Honor
- Joseph V. Medina – Brigadier General
- Louis Gonzaga Mendez Jr. – highly decorated colonel, commander of the 3rd Battalion, 508th Parachute Infantry Regiment. He was born in Mexico.
- Tony Mendez – ex-CIA agent, portrayed in 2012 American film Argo.
- Ernest Medina – Captain of Company C, 1st Battalion, 20th Infantry of the 11th Brigade, Americal Division
- Manuel V. Mendoza – Medal of Honor
- Eugene A. Obregon – Medal of Honor
- Ralph Ambrose O'Neill – flying ace during WWI
- Mike C. Pena – Medal of Honor
- Rafael Peralta – Navy Cross
- Oscar F. Perdomo – United States Air Force flying ace
- Manuel Perez Jr. – Medal of Honor
- Leroy Petry – Medal of Honor
- Lori Piestewa – first woman in the U.S. armed forces killed in the 2003 Iraq war
- Alfred V. Rascon – Medal of Honor
- Eldon Regua – Major General in the US Army reserve
- Louis R. Rocco – Medal of Honor
- Jose Rodela – Medal of Honor
- Cleto Rodriguez – Medal of Honor
- Joseph C. Rodriguez – Medal of Honor
- Alejandro R. Ruiz – Medal of Honor
- Ricardo Sanchez – United States Army General and author
- Marcelino Serna – Distinguished Service Cross
- France Silva – Medal of Honor
- Alberto Valdés - Good Conduct Medal, American Campaign Medal and European African Middle Eastern Campaign Medal
- Jose F. Valdez – Medal of Honor
- Eugene A. Valencia Jr. – flying ace, Navy Cross
- Alfred Valenzuela – major general, United States Army
- Jay R. Vargas – Medal of Honor
- Ysmael R. Villegas – Medal of Honor
- Maximo Yabes – Medal of Honor
- Sam Ybarra – United States Army soldier who served in the Tiger Force commando unit attached to the 101st Airborne Division during the Vietnam War. He was of Mexican and Apache descent.
Singers
- Ana Victoria - Singer-songwriter, daughter of the Mexicans Diego Verdaguer and Amanda Miguel
- Ángela Aguilar - Singer, daughter of Pepe Aguilar
- Ashley Grace - Singer-songwriter and activist, co-founder of the Mexican-American music duo, Ha*Ash
- Addison Rae, Singer and actress
- Becky G - Singer and actress
- Camila Cabello - Singer-songwriter, former member of Fifth Harmony
- Carlos Santana - Guitarist and founding member of Santana
- David Hidalgo - Guitarist, founding member of the Chicano rock band, Los Lobos
- Gerardo Ortiz - Regional Mexican music singer
- Hanna Nicole - Singer-songwriter and producer, co-founder member of the Mexican-American music duo, Ha*Ash
- Joan Baez - Singer-songwriter and activist
- Omar Apollo - Singer and composer
- Pepe Aguilar - Singer and composer, son of the Mexican singers and actors Antonio Aguilar and Flor Silvestre
- Ritchie Valens - Singer and rock and roll pioneer
- Selena - Tejano singer, called queen of Texan music
- Selena Gomez - Singer-songwriter, her song "Lose You To Love Me" reached the top of the Billboard Hot 100
- Tekashi 69 - Rapper and composer, his song "Trollz" with rapper Nicki Minaj reached the top of the Billboard Hot 100
Scholars and educators
- Rodolfo Acuña – historian and professor
- Ricardo Ainslie – psychology professor
- Norma Alarcón – author, professor, and publisher
- Frederick Luis Aldama – university distinguished scholar, writer
- Lena Lovato Archuleta – educator, librarian, and administrator
- Alfred Arteaga – writer, poet, and scholar
- Deborah Berebichez – physicist, data scientist, and educator
- Martha E. Bernal – clinical psychologist
- Elsa Salazar Cade – entomologist/science educator
- Mariano Velazquez de la Cadena – grammarian, scholar, and author
- Nínive Clements Calegari – educator, founder of national literacy program, 826 National, and The Teacher Salary Project.
- Erika Tatiana Camacho – mathematical biologist
- Jimena Canales – physicist and engineer, and award-winning historian of science
- Richard Carranza – Chancellor, New York City Public Schools, appointed in March 2018
- David Carrasco – historian of religion, anthropologist, and Mesoamericanist scholar
- Oscar Casares – author and professor
- Joseph I. Castro – Chancellor of the California State University.
- Lauro Cavazos – U.S. Secretary of Education
- Gery Chico – Chairman of the Illinois State Board of Education, politician and lawyer
- Francisco G. Cigarroa – chancellor of the University of Texas System and president of the UT Health Science Center in San Antonio, Texas.
- Miguel Angel Corzo – CEO and president of LA Plaza de Cultura y Artes
- Maria Cotera – activist, author, researcher, and professor.
- José Cuéllar – professor of Chicano studies
- Robert R. Davila – president of Gallaudet University
- Jorge Calles-Escandón – physician and researcher
- Roberta Fernández – novelist, scholar, critic, and arts advocate professor
- Rosa-Linda Fregoso – professor of Latin American studies
- Miguel García-Garibay – professor of chemistry and the dean of physical sciences at University of California, Los Angeles.
- Alicia Gaspar de Alba – historian, scholar, author
- Ignacio M. Garcia – professor of Western American history
- Juliet V. García – university president
- Laura E. Gómez – president of the Law and Society Association and a professor of law and American studies at the University of New Mexico
- Guillermo Gómez-Peña – performance artist, author, activist and educator
- Juan Gómez-Quiñones – professor, historian, poet and activist
- Martin Guevara Urbina – writer, researcher, the professor whose work focuses on Latino issues
- José Ángel Gutiérrez – professor and attorney
- Ralph C. Guzmán – political scientist, professor, author, Deputy Assistant U.S. Secretary of State, provost Merrill College UC Santa Cruz
- Esteban Rossi-Hansberg – professor of economics at Princeton University
- Arturo Islas – professor of English and novelist
- Kevin Johnson (academic) – Dean of the UC Davis School of Law
- Alejandro L. Madrid – professor of musicology and ethnomusicology at Cornell University
- Juan L. Maldonado – higher education administrator
- Elizabeth Martinez (librarian) – professor and Executive Director of the American Library Association
- Ramiro Martinez Jr. – professor of criminology
- Miguel Méndez (legal scholar) – law professor and political figure
- Rachel Moran – Dean of UCLA School of Law
- Jonathon J. Andrew Muñoz – philosopher and educator
- William Nericcio – Chicano literary theorist, American Literature scholar, and professor
- J. Michael Ortiz – president emeritus of Cal Poly Pomona
- Juan J. de Pablo – professor in the Institute for Molecular Engineering at the University of Chicago
- Pamela Anne Quiroz – professor of sociology
- Alberto Ríos – Regents' Professor at Arizona State University, educator and author.
- Vicki L. Ruiz – historian, president of the American Historical Association
- Ramón Saldívar – author, professor, and researcher of cultural studies, National Humanities Medal recipient
- Rita Sanchez – academic in the field of Chicano studies
- Hortensia Soto – mathematics professor at Colorado State University
- Richard A. Tapia – mathematician
- Josefina Villamil Tinajero – president of the National Association for Bilingual Education
- John D. Trasviña – dean of the University of San Francisco School of Law, former Assistant Secretary of the Office of Fair Housing and Equal Opportunity
- Arnulfo Trejo – writer, college professor, and literary activist
- María Urquides – K-12 educator, "Mother of Bilingual Education"
- Francisco H. Vázquez – scholar and public intellectual
- María Guillermina Valdes Villalva – scholar and social activist
- Maria Cristina Villalobos – professor of mathematics
- Erv Wilson – music theorist
- Leslie Wong – President of San Francisco State University
Science and technology
- Sylvia Acevedo – engineer and businesswoman, worked at NASA's Jet Propulsion Laboratory
- Albert Baez – physicist and professor, developed the X-ray microscope
- John C. Baez – mathematical physicist
- Elsa Salazar Cade – science educator and entomologist
- Víctor Celorio – inventor of Instabook or book on demand
- France A. Córdova – former NASA chief scientist
- Jesús A. De Loera – mathematician at UC Davis
- Teofilo F. Gonzalez – computer scientist and professor
- Sidney M. Gutierrez – former astronaut
- Guadalupe Hayes-Mota – biotechnologist and business director
- José Hernández – former astronaut
- Miguel de Icaza – software programmer
- Lydia Villa-Komaroff – molecular and cellular biologist
- Ynes Mexia – prominent botanist
- Ricardo Miledi – neuroscientist and professor at University of California, Irvine
- Héctor García-Molina – computer scientist and professor in the departments of Computer Science and Electrical Engineering at Stanford University
- Mario J. Molina – co-discoverer of decomposition of ozone with CFC aerosols, Nobel laureate in Chemistry
- Ellen Ochoa – astronaut, director for flight crew operations for NASA
- John D. Olivas – NASA astronaut
- Jorge López (physicist) – physicist and professor
- Alfredo Quiñones-Hinojosa – associate professor of neurosurgery and oncology; director of the Brain Tumor Stem Cell Laboratory at Johns Hopkins University and brain surgeon at Johns Hopkins Hospital
- Paulo Lozano – aerospace engineer at MIT and pioneer in the field of micro-propulsion
- Eloy Rodriguez – biochemist, professor at Cornell University
- Sarah Stewart – pioneered the field of viral oncology research
- Tedy Taylor – theoretical physicist and nuclear weapon designer
- Ignacio Tinoco Jr. – chemist and professor
- Jorge Gardea-Torresdey – chemist and academic
- Nora Volkow – scientist, physician, psychiatrist, great-granddaughter of Leon Trotsky and director of the National Institute on Drug Abuse, part of the National Institutes of Health
Civil rights leaders and community activists
- Lucy G. Acosta – civil rights activist
- Gaylon Alcaraz – community organizer, human rights activist
- Lupe Anguiano – civil rights activist
- Lorena Borjas – Mexican-born American transgender and immigrant rights activist, known as the mother of the transgender Latinx community in Queens, New York
- Norma V. Cantu – civil rights lawyer and college professor
- Carlos Cadena – attorney in the landmark Hernandez v. Texas supreme court case
- Adelfa Botello Callejo – civil rights lawyer
- José Tomás Canales – civil rights activist and politician active during the early 1900s, played key role in the foundation of the League of United Latin American Citizens.
- Aurora Castillo – environmental activist
- Sal Castro – civil rights activist and educator
- Ernesto Chacon – Latino and low income civil rights activist
- César Chávez – labor leader and activist
- Linda Chavez-Thompson – former executive vice-president of the AFL–CIO
- Miguel Contreras – labor leader
- Jeanne Córdova – lesbian and gay rights activist, writer
- Bert Corona – labor and community organizer
- Ricardo Cruz – attorney, civil rights activist
- Jessie Lopez De La Cruz – labor organizer
- Maria Echaveste – former White House Deputy Chief of Staff and Senior Fellow at the Center for American Progress
- Josefina Fierro de Bright – civil rights activist during The Great Depression
- Ernesto Galarza – labor activist, professor, and writer
- Gustavo C. Garcia – attorney in the landmark Hernandez v. Texas supreme court case
- Hector P. Garcia – physician, veteran, and civil rights advocate
- Eva Carrillo de García – missionary, nurse, and civil-rights activist
- Oscar Gomez (activist) student activist
- Erika Guevara Rosas – human rights lawyer, Americas director at Amnesty International
- Anna Nieto-Gómez – activist and journalist
- Rodolfo Gonzales – leader of the Chicano civil rights movement, boxer, poet
- José Ángel Gutiérrez – political activist, founder of the Raza Unida party, writer, and professor
- John J. Herrera – civil rights leader
- Dolores Huerta – civil rights leader
- Jovita Idar – journalist, political activist and civil rights worker
- Ralph Lazo – advocated on behalf of Japanese American internment victims.
- Nativo Lopez – civil rights activist
- Raul Loya – civil rights activist
- Mimi Lozano – co-founded the Society of Hispanic Historical and Ancestral Research
- Angel G. Luévano – labor leader and activist
- Rueben Martinez – activist and businessman
- Vilma Socorro Martínez – civil rights activist, lawyer and diplomat
- Eliseo Medina – labor activist
- Enrique Morones – immigrant human rights activist
- Janet Murguía – civil rights activist
- Ernesto Nieto – founder of the National Hispanic Institute
- Alex Pacheco – activist
- Emiliano Reyes – business executive and humanitarian activist. He is of Mexican and Swedish descent.
- Julian Samora – community activist, teacher, and scholar
- Leila Steinberg – educator dedicated to helping at-risk youth find their voice using an emotional literacy curriculum, best known as mentor of rapper Tupac Shakur.
- Olga Talamante – political activist
- Emma Tenayuca – labor organizer
- Reies López Tijerina – activist, founder of the Alianza Federal de Mercedes
- John Trudell – musician, author, poet, and political activist
- Cristina Tzintzún – organizer, author, and co-founder of the Workers Defense Project
- Baldemar Velasquez – president of the Farm Labor Organizing Committee
- Gustavo Velasquez – Secretary of the Office of Fair Housing and Equal Opportunity
- Delia Villegas Vorhauer – activist, social worker, and writer
- Vicente T. Ximenes – civil rights activist, commissioner of EEOC, and chairman of first Presidential Cabinet on Mexican American Affairs
- Raul Yzaguirre – civil rights activist
Religious figures
- Eusebio L. Elizondo Almaguer – Bishop of the Roman Catholic Archdiocese of Seattle
- Oscar Cantú – Auxiliary Bishop in San Antonio, Texas.
- Minerva G. Carcaño – Bishop in the United Methodist Church
- Arturo Cepeda – Auxiliary Bishop of the Archdiocese of Detroit
- Gilbert Espinosa Chávez – Roman Catholic bishop
- Virgilio Elizondo – Roman Catholic priest, and theologian
- Cirilo Flores – 5th Bishop of San Diego
- Daniel E. Flores – Bishop of Brownsville
- Patrick Flores – Roman Catholic bishop
- Elias Gabriel Galvan – retired Bishop of the United Methodist Church
- Naason Joaquin Garcia – current international leader of the La Luz Del Mundo church, sentenced to nearly 17 years in prison for committing acts of sexual abuse against girls from his community and former pastor of several La Luz Del Mundo churches in California and Arizona between 1994 and 2014
- Richard John Garcia – bishop of Monterey, California
- Gustavo García-Siller – Archbishop of the Archdiocese of San Antonio
- José Horacio Gómez – Archbishop of Los Angeles
- René Henry Gracida – bishop
- Joel Nestali Martinez – Bishop in the United Methodist Church
- Peter Morales – president of the Unitarian Universalist Association
- Eduardo Nevares – Auxiliary Bishop of the Diocese of Phoenix
- Jorge Rodríguez-Novelo – Auxiliary Bishop for the Archdiocese of Denver
- Armando Xavier Ochoa – Bishop of El Paso, TX
- Ricardo Ramírez – Bishop of Las Cruzes, New Mexico.
- Plácido Rodriguez – Bishop of Lubbock, Texas
- Alberto Rojas – Auxiliary Bishop and Episcopal Vicar for the Archdiocese of Chicago.
- Jaime Soto – Roman Catholic coadjutor bishop of Sacramento
- James Anthony Tamayo – Bishop of Laredo, Texas
- Ricardo Watty Urquidi – Bishop of the Diocese of Tepic in Nayarit, Mexico
- Joe S. Vásquez – Bishop of the Roman Catholic diocese of Austin, Texas.
- Gabino Zavala – Auxiliary Bishop of the Archdiocese of Los Angeles
Businesspeople and entrepreneurs
- Manuel Abud – media, television, and cable executive
- Linda G. Alvarado – president and chief executive officer of a large commercial and industrial general contracting firm, co-owner of the Colorado Rockies baseball team.
- María Elena Avila – entrepreneur, philanthropist, and civic leader in California
- Michael Ball – fashion mogul
- Hector Barreto Jr. – 21st Administrator of the US Small Business Administration
- Emilio Diez Barroso – chairman and CEO of NALA Investments, a private investment holding company
- Xochi Birch – computer programmer and entrepreneur
- Adolfo Camarillo – businessman, wealthy landowner, and philanthropist
- Juan Camarillo Jr. – businessman, wealthy landowner, and philanthropist
- Jovita Carranza – President & CEO of the JCR Group, a consulting firm; former Deputy Administrator for the United States Small Business Administration
- Rudy Chapa – track runner and businessman
- Anna Maria Chávez – CEO of the Girl Scouts of the USA
- Chicano Roy – motorbike builder and inventor
- Maria Contreras-Sweet – 24th Administrator of the Small Business Administration, former executive chairwoman and founder of ProAmérica Bank, and California Secretary of Business, Transportation and Housing Agency
- Mike Curb – record company executive, NASCAR car owner, and former Lieutenant Governor of California.
- William Davila – first Mexican-American president of a large supermarket chain
- Gérard Louis-Dreyfus – chairman of Louis Dreyfus Energy Services
- Juan Enríquez – Managing Director of Excel Venture Management, academic, and speaker
- Tavo Hellmund – former racing driver and promoter
- Enrique Hernandez Jr. – business executive, president, and chief executive officer of Inter-Con Security Systems, Inc., and a director of Wells Fargo and McDonald's
- Traci Des Jardins – restaurateur and award-winning chef
- Ninfa Laurenzo – restaurateur
- Bismarck Lepe – information technology CEO and product manager
- Ignacio E. Lozano Sr. – founder of La Opinión, the largest Spanish language newspaper in the US
- Ignacio E. Lozano Jr. – newspaper publisher, ambassador, and corporate director
- José I. Lozano – executive vice-president of Impremedia LLC
- Daniel Lubetzky – entrepreneur, author, and activist, best known as the Founder and CEO of KIND LLC.
- David Martinez – managing partner
- Mariano Martinez (entrepreneur) – inventor, entrepreneur, and restaurateur
- Emilio Azcárraga Milmo – CEO, media mogul
- Richard Montañez – best known for claiming to have invented Flamin' Hot Cheetos
- Kate and Laura Mulleavy – fashion designers
- Oscar Munoz (executive) – CEO of United Airlines
- Hugo Morales (radio) – radio executive
- Arturo Moreno – businessman and owner of the Los Angeles Angels
- Rick Owens – fashion designer
- George Paz – CEO of Express Scripts, the largest pharmacy benefit management organization in the US.
- Dan Peña – financial analyst on Wall Street
- Lisa Garcia Quiroz – media executive, launched People en Español
- Emiliano Reyes – American business executive, humanitarian activist, and Wikipedia author
- Emilio Romano – managing director of Bank of America Merrill Lynch Mexico
- John Romero – video game developer, co-founder of id Software
- Rosa Rios – 43rd and current treasurer of the United States, businesswoman, executive, and entrepreneur.
- Louis Ruiz – creator of Ruiz Foods, Inc.
- Leslie Sanchez – founder and CEO of Impacto Group LLC, a Washington, D.C.-based market research and consulting firm
- Tony Sanchez – businessman, philanthropist, and Democratic politician
- Felix Tijerina – restaurateur, activist, and philanthropist
- Solomon Trujillo – CEO and businessman
- Louis Verdad – fashion designer
- Sam Zamarripa – entrepreneur, author, and public official
- Sergio Zyman – marketing executive
Historical figures
- Gregorio Cortez – Mexican-American outlaw and folk hero
- Joaquin Murrieta – Mexican bandit or Robin Hood during the California Gold Rush of the 1850s.
Food
- Gustavo Brambila – winemaker in the Napa Valley
- Pati Jinich – Emmy nominated chef, TV personality, cookbook author
- Aarón Sanchez – chef and television personality
- Marcela Valladolid – chef and television host
- Traci Des Jardins – American chef and restaurateur
- Claudette Zepeda – award-winning, San Diego-based chef and culinary entrepreneur won the "Battle Chocolate" in Iron Chef: Quest for an Iron Legend
Other
- Andre “Big A” – mechanic known for changing his last name to a blank character to protest the Vietnam War
- Blaire White – YouTuber, political commentator, Internet personality
- Jimmy Santiago Baca – American poet and writer of Apache and Chicano descent
- Johnny Canales – talk show host
- Gregorio Cortez – Mexican-born and a folk hero to the border communities of the United States and Mexico
- Nick Fuentes – far-right political commentator and live streamer
- Mark Hugo Lopez – Director of Hispanic Research at the Pew Research Center
- Oscar Ozzy Lusth – 1st runner-up on Survivor; Cook Islands
- Jair Marrufo – professional soccer referee
- Edmund McMillen – video game designer and artist
- Raul Melgoza – fashion designer
- Cesar Millan – TV personality, dog trainer, and author
- Carmen Osbahr – puppeteers Rosita in the children's series Sesame Street
- Albert Pissis – architect who introduced the Beaux-Arts architectural style to San Francisco
- Richard Ramirez – serial killer
- Dionicio Rodriguez – architect
- John Romero – American director, designer, programmer, and developer in the video game industry; co-founder of id Software
- Baldomero Toledo – professional soccer referee
- Edgar Valdez Villarreal – drug lord
- Luis Velador – two-time World Series of Poker bracelet winner
- Eric Volz – entrepreneur, author, and managing director of an international crisis resource agency
- Eduardo Xol – mostly known for his work as a designer on Extreme Makeover: Home Edition