| School | Nickname | Location | Conference | Tournament appearance | Last appearance | Consecutive tournament appearances | Previous best performance |
| Alma College | Scots | Alma, MI | Michigan Intercollegiate Athletic Association | 1st | Debut | 1 | Debut |
| Brandeis University | Judges | Waltham, MA | Independent | 5th | 1979 | 5 | World Series Runner-Up |
| Buena Vista College | Beavers | Storm Lake, IA | Iowa Intercollegiate Athletic Conference | 1st | Debut | 1 | Debut |
| Stanislaus State College | Warriors | Turlock, CA | Independent | 5th | 1979 | 5 | National Champion |
| Eastern Connecticut State College | Warriors | Willimantic, CT | Independent | 5th | 1979 | 5 | Regional Runner-Up |
| Elmhurst College | Blue Jays | Elmhurst, IL | College Conference of Illinois and Wisconsin | 1st | Debut | 1 | Debut |
| Illinois Benedictine College | Eagles | Lisle, IL | Northern Illinois-Iowa Conference | 1st | Debut | 1 | Debut |
| Ithaca College | Bombers | Ithaca, NY | Inedependent College Athletic Conference | 5th | 1979 | 5 | World Series Runner-Up |
| Johns Hopkins University | Blue Jays | Baltimore, MD | Independent | 2nd | 1976 | 1 | Regional Fourth place |
| Juniata College | Eagles | Huntingdon, PA | Middle Atlantic States Collegiate Athletic Conference | 2nd | 1978 | 1 | Regional Fifth place |
| Mansfield State College | Mountaineers | Mansfield, PA | Independent/Pennsylvania State Athletic Conference | 3rd | 1979 | 2 | World Series Third place |
| Marietta College | Pioneers | Marietta, OH | Ohio Athletic Conference | 5th | 1979 | 5 | World Series Runner-Up |
| North Adams State College | Mohawks | North Adams, MA | Massachusetts State Collegiate Athletic Conference | 3rd | 1977 | 1 | Regional Fourth place |
| Ohio Northern University | Polar Bears | Ada, OH | Ohio Athletic Conference | 2nd | 1976 | 1 | Regional Fourth place |
| Ramapo College of New Jersey | Roadrunners | Mahwah, NJ | New Jersey State Athletic Conference | 1st | Debut | 1 | Debut |
| Rhode Island College | Anchormen | Providence, RI | Independent | 3rd | 1979 | 3 | World Series Fourth place |
| University of Rochester | Yellowjackets | Rochester, NY | Independent | 1st | Debut | 1 | Debut |
| Glassboro State College | Profs | Glassboro, NJ | New Jersey State Athletic Conference | 5th | 1979 | 5 | National Champion |
| Salisbury State College | Sea Gulls | Salisbury, MD | Independent | 3rd | 1978 | 1 | Regional Third place |
| St. Olaf College | Oles | Northfield, MN | Minnesota Intercollegiate Athletic Conference | 4th | 1979 | 4 | Regional Third place |
| The College of Wooster | Fighting Scots | Wooster, OH | Ohio Athletic Conference | 4th | 1979 | 4 | Regional Runner-Up |
| Lynchburg College | Hornets | Lynchburg, VA | Old Dominion Athletic Conference | 5th | 1979 | 5 | Regional Runner-Up |
| Upsala College | Vikings | East Orange, NJ | Middle Atlantic States Collegiate Athletic Conference | 4th | 1979 | 3 | Regional Third place |
| University of Wisconsin-Oshkosh | Titans | Oshkosh, WI | Wisconsin State University Conference | 2nd | 1979 | 2 | Regional Fourth place |