List of modafinil analogues and derivatives


This page lists chemical compounds similar to modafinil, known as modafinil analogues and derivatives. These are structural analogues and derivatives of modafinil, a drug that affects dopamine levels in the brain in an unusual way. Modafinil is a drug that helps keep people awake and alert.
Most of the listed modafinil analogues are drugs that specifically target dopamine reuptake with stronger effects compared to modafinil. The modafinil analogues are of interest in the potential treatment of a condition involving the misuse of stimulant drugs, as drugs that help increase motivation to treat motivational disorders, and for treatment of neurodegenerative diseases such as Alzheimer's disease.
Modafinil analogues acting as DRIs include both drugs similar to modafinil that affect dopamine without causing stimulant effects such as flmodafinil and JJC8-016 and drugs that affect dopamine in a way similar to cocaine such as JJC8-088. Besides their potential medical use, modafinil analogues, including adrafinil, flmodafinil, fladrafinil, and modafiendz, are also sold online as substances that are believed to improve cognitive functions such as memory and focus.
A limitation of some modafinil analogues such as JJC8-016 is blocking a specific protein that can lead to heart problems.

List of modafinil analogues and derivatives

In addition to the above, further modafinil analogues have also been described.