JJC8-089
JJC8-089 is a dopamine reuptake inhibitor that was derived from modafinil and is related to JJC8-016, JJC8-088, and JJC8-091. Its affinity for the dopamine transporter is 37.8nM, for the norepinephrine transporter is 11,820nM, for the serotonin transporter is 6,800nM, and for the sigma σ1 receptor is 2.24nM. It also has significant affinity for several dopamine receptors. JJC8-089 has substantially higher affinity for the DAT than modafinil. The drug shows pro-motivational effects in animals. It was first described in the scientific literature by 2016.