6-Methyl-DMT


6-Methyl-DMT, or 6-Me-DMT, also known as 6-methyl-N,''N-dimethyltryptamine or as 6,N'',N-trimethyltryptamine, is a serotonin receptor modulator of the tryptamine family related to dimethyltryptamine. It is the 6-methyl derivative of DMT.

Use and effects

6-Methyl-DMT was not included nor mentioned in Alexander Shulgin's book TiHKAL.

Pharmacology

Pharmacodynamics

6-Methyl-DMT showed about half the affinity of DMT for the ketanserin-labeled serotonin 5-HT2 receptor. The drug did not substitute for 5-MeO-DMT in rodent drug discrimination tests. According to David E. Nichols, 6-substituted tryptamines in general may be inactive as serotonergic psychedelics. However, 6-fluoro-AMT is known to be robustly active as a psychedelic.

Chemistry

Synthesis

The chemical synthesis of 6-methyl-DMT has been described.

Analogues

s of 6-methyl-DMT include dimethyltryptamine, 6-MeO-DMT, 6-MeO-DiPT, 6-MeO-MiPT, 6-hydroxy-DMT, 6-hydroxy-DET, 6-fluoro-DMT, 6-fluoro-DET, 6-fluoro-AMT, O-4310, 1-methyl-DMT, 2-methyl-DMT, 4-methyl-DMT, 5-methyl-DMT, and 7-methyl-DMT, among others.

History

6-Methyl-DMT was first described in the scientific literature by Richard Glennon and colleagues by 1980.