4-Methyl-DMT
4-Methyl-DMT, or 4-Me-DMT, also known as 4-methyl-N,''N-dimethyltryptamine or as 4,N'',N-trimethyltryptamine, is a serotonin receptor modulator and possible psychedelic drug of the tryptamine family related to dimethyltryptamine and psilocin.
Use and effects
4-Methyl-DMT was not included nor mentioned in Alexander Shulgin's book TiHKAL. Its dose in humans is unknown.The related drug 4-methyl-AMT has shown mixed findings in terms of hallucinogenic effects in humans and is clearly less potent than α-methyltryptamine in such regards.
Interactions
Pharmacology
Pharmacodynamics
4-Methyl-DMT showed affinity for the serotonin receptors in the isolated rat stomach fundus strip. Its affinity for these receptors was 7-fold higher than that of dimethyltryptamine, roughly the same as that of psilocin, and about 60% of that of 5-MeO-DMT. However, this assay was subsequently found to be an unreliable predictor of hallucinogenic activity. The receptor in this tissue may correspond to the serotonin 5-HT2B receptor.In other studies, 4-methyl-DMT was assessed and showed affinity for the serotonin 5-HT1E receptor and for the serotonin 5-HT1F receptor. These affinities were similar to but slightly lower than those of DMT.
Like DMT and 5-MeO-DMT, 4-methyl-DMT fully substituted for the psychedelic drug DOM in rodent drug discrimination tests. It was a little more than twice as potent as DMT in this assay but was about half as potent as 5-MeO-DMT. Similarly to diethyltryptamine and dipropyltryptamine, 4-methyl-DMT produced behavioral disruption at higher doses.