1-Methyl-DMT

1-Methyl-DMT, or 1-Me-DMT, also known as 1-methyl-N,''N-dimethyltryptamine or as 1,N'',N-trimethyltryptamine, is a serotonin receptor modulator of the tryptamine family related to dimethyltryptamine and lespedamine.

Pharmacology

Pharmacodynamics

1-Methyl-DMT appears to have similar affinity for serotonin receptors as DMT, but is more toxic than DMT in rodents. In another study, it showed 3-fold higher affinity for the serotonin 5-HT_2A receptor than DMT. In a further study, it showed abolished affinity for the 5-HT_1E receptor and 30-fold lower affinity for the serotonin 5-HT_1F receptor than DMT. 1-Methyl-DMT shows comparable psychoplastogenic effects in preclinical research to DMT.

Chemistry

Synthesis

The chemical synthesis of 1-methyl-DMT has been described.

Analogues

s of 1-methyl-DMT include dimethyltryptamine, 1-methyltryptamine, lespedamine, 1-methylpsilocin, 2-methyl-DMT, 4-methyl-DMT, 5-methyl-DMT, 6-methyl-DMT, and 7-methyl-DMT, among others.

History

The drug was briefly mentioned by Alexander Shulgin in his 1997 book TiHKAL. 1-Methyl-DMT was first described in the scientific literature by Richard Glennon and colleagues in 1979.