7,N,N-TMT

7,N,''N''-trimethyltryptamine, also known as 7-methyl-DMT, is a serotonin receptor modulator and psychedelic drug of the tryptamine family related to dimethyltryptamine. It was first described by 1978 and was encountered online as a novel designer drug in 2024.

Use and effects

7-Methyl-DMT was not included nor mentioned in Alexander Shulgin's book TiHKAL.

Interactions

Pharmacology

Pharmacodynamics

7-TMT acts as an agonist of 5-HT₂ receptors. In animal tests, both 7-TMT and its 5-methoxy derivative 5-MeO-7-TMT produced behavioural responses similar to those of psychedelic drugs such as DMT, but the larger 7-ethyl and 7-bromo derivatives of DMT did not produce psychedelic responses despite having higher 5-HT₂ receptor affinity in vitro. 7-TMT also weakly inhibits reuptake of serotonin but with little effect on dopamine or noradrenaline reuptake.

Chemistry

Synthesis

The chemical synthesis of 7,N,''N''-TMT has been described.

Analogues

s of 7-methyl-DMT include dimethyltryptamine, 5-MeO-7-TMT, 7-MeO-DMT, 7-hydroxy-DMT, 7-methyl-AET, 7-MeO-DiPT, 7-MeO-MiPT, 7-chloro-AMT, 1-methyl-DMT, 2-methyl-DMT, 4-methyl-DMT, 5-methyl-DMT, and 6-methyl-DMT, among others.

History

7,N,''N''-TMT was first described in the scientific literature by Richard Glennon and colleagues by 1978. It was encountered online as a novel designer drug in 2024.