5-Fluoro-DMT
5-Fluoro-DMT, or 5-F-DMT, also known as 5-fluoro-N,''N''-dimethyltryptamine, is a psychedelic drug of the tryptamine family related to dimethyltryptamine and to other psychedelic tryptamines like 5-chloro-DMT and 5-bromo-DMT.
Use and effects
5-Fluoro-DMT was not included nor mentioned in Alexander Shulgin's book TiHKAL.Pharmacology
Pharmacodynamics
5-Fluoro-DMT is known to have affinity for and to act as an agonist of the serotonin 5-HT1A and 5-HT2A receptors. Fluorination of psychedelic tryptamines either reduces or has little effect on serotonin 5-HT2A and 5-HT2C receptor affinity or intrinsic activity, although 6-fluoro-DET is inactive as a psychedelic despite acting as a 5-HT2A agonist, while 4-fluoro-5-methoxy-DMT is a much stronger agonist at the serotonin 5-HT1A receptor than at the serotonin 5-HT2A receptor.5-Fluoro-DMT produces a robust head-twitch response in mice, and hence is a putative serotonergic psychedelic. In another study however, it failed to substitute for LSD in rodent drug discrimination tests, at least at the assessed doses. The drug also produces hypolocomotion and hypothermia in rodents.