5-Bromo-DMT
5-Bromo-DMT, or 5-Br-DMT, also known as 5-bromo-N,''N-dimethyltryptamine or by informal names like sea DMT or SpongeBob DMT, is a psychedelic drug and brominated indole alkaloid of the tryptamine family related to dimethyltryptamine. It is the 5-bromo derivative of DMT. The drug is naturally occurring in the sponges Smenospongia aurea and Smenospongia echina, as well as in Verongula rigida'' alongside 5,6-dibromo-DMT and seven other alkaloids. It has been encountered as a novel designer drug.
Use and effects
5-Bromo-DMT was only briefly mentioned in Alexander Shulgin's book TiHKAL and its properties and effects were not described. Subsequently, the drug has been reported by others to have a dose of 20 to 50mg smoked and a duration of 15minutes to 1.5hours. It is minimally active or inactive orally. It was described as producing mild psychedelic effects, such as visuals, pronounced tactile effects, and euphoria. 5-Bromo-DMT was said to be similar to low-dose DMT, but also distinct from it. A 50mg dose was said to be near the limit of what can be physically inhaled. However, it was thought that greater exposure to the drug nonetheless might be able to produce stronger effects. These findings were reported in a Shulgin- or TiHKAL-like style via credible anonymous personal communication with Hamilton Morris and Jason Wallach.Pharmacology
Pharmacodynamics
5-Bromo-DMT is a partial agonist of the serotonin 5-HT2A receptor, with an affinity of 138nM, an of 77.7 to 3,090nM, and an of 34 to 100%. It also shows affinity for the serotonin 5-HT1A, 5-HT2B, and 5-HT2C receptors and for the serotonin transporter . The drug is a weak serotonin 5-HT1A receptor full agonist and a very weak serotonin reuptake inhibitor.In contrast to 5-fluoro-DMT and 5-chloro-DMT, 5-bromo-DMT failed to significantly produce the head-twitch response, a behavioral proxy of psychedelic effects, in rodents. As such, 5-bromo-DMT would be expected to be non-hallucinogenic in humans. In addition, 5-bromo-DMT antagonized the head-twitch response induced by 5-fluoro-DMT. On the other hand, 5-bromo-DMT produced antidepressant-like effects, hypolocomotion or sedative-like effects, and hypothermia in rodents. Moreover, 5-bromo-DMT has been found to produce psychoplastogenic effects.