4-AcO-EPT
4-AcO-EPT, also known as 4-acetoxy-N-ethyl-N-propyltryptamine, is a psychedelic drug of the tryptamine and 4-hydroxytryptamine families related to 4-AcO-DMT. It is the acetate ester of 4-HO-EPT and is thought to act as a prodrug of 4-HO-EPT. Based on online anecdotal reports, 4-AcO-EPT is said to have a dose of 20 to 30mg orally. It shows reduced affinity and agonistic potency at serotonin receptors, including the serotonin 5-HT2A receptor, compared to 4-HO-EPT. Similarly to 4-HO-EPT, 4-AcO-EPT produces the head-twitch response, a behavioral proxy of psychedelic effects, in rodents, and does so with comparable potency, in line with it being a prodrug. 4-AcO-EPT was encountered as a novel designer drug online in 2018, in Europe in 2020, and in the United States in 2021.