2-Aminoindane


2-Aminoindane is a stimulant of the 2-aminoindane family which has been sold as a designer drug.

Pharmacology

Pharmacodynamics

2-AI is a monoamine releasing agent acting as a selective substrate for NET and DAT. It partially substitutes for amphetamine in rodent drug discrimination tests.

Chemistry

Analogues

2-AI is a rigid analogue of amphetamine and has similar effects in rodents. Other related homologues and rigid analogues of amphetamine include 2-aminotetralin, 2-amino-1,2-dihydronapthalene, 1-naphthylaminopropane, 2-naphthylaminopropane, 1-phenylpiperazine,, and.

Derivatives

A number of derivatives of 2-aminoindane, also known as substituted 2-aminoindanes, are known, including 5-IAI, aprindine, BFAI, BFMAI, DHAI, DOM-AI ETAI, indantadol, MDAI, MEAI, MDMAI, MMAI, NM-2-AI, PNU-99,194, Pyr-AI, and TAI, among others.

Society and culture

Legal status

China

As of October 2015 2-AI is a controlled substance in China.

Finland

Scheduled in the "Government decree on psychoactive substances banned from the consumer market".

Sweden

Sweden's public health agency suggested classifying 2-AI as a hazardous substance, on June 24, 2019.

United States

2-Aminoindane is not scheduled at the federal level in the United States, but may be considered an analog of amphetamine, in which case purchase, sale, or possession could be prosecuted under the Federal Analog Act.