List of ambassadors of the United States to Niger
The day before Niger's independence on August 3, 1960, the first American Chargé d'Affaires ad interim, Donald R. Norland, presented his credentials to take effect the following day. The first United States ambassador to Niger, R. Borden Reams was appointed on October 14, 1960 and presented his credentials on November 23.
Ambassadors
| Name | Title | Appointed | Presented credentials | Terminated mission |
| Donald R. Norland - Career FSO | Chargé d'Affaires ad interim | August 3, 1960 | N/A | October 14, 1960 |
| R. Borden Reams - Career FSO | Ambassador Extraordinary and Plenipotentiary | October 14, 1960 | November 23, 1960 | August 2, 1961 |
| Mercer Cook - Political appointee | Ambassador Extraordinary and Plenipotentiary | June 22, 1961 | August 2, 1961 | May 30, 1964 |
| Robert J. Ryan - Career FSO | Ambassador Extraordinary and Plenipotentiary | July 9, 1964 | August 24, 1964 | August 19, 1968 |
| Samuel C. Adams, Jr. - Political appointee | Ambassador Extraordinary and Plenipotentiary | July 24, 1968 | September 10, 1968 | October 3, 1969 |
| Roswell D. McClelland - Career FSO | Ambassador Extraordinary and Plenipotentiary | July 8, 1970 | July 27, 1970 | July 7, 1973 |
| L. Douglas Heck - Career FSO | Ambassador Extraordinary and Plenipotentiary | March 22, 1974 | May 30, 1974 | July 20, 1976 |
| Charles A. James - Political appointee | Ambassador Extraordinary and Plenipotentiary | September 16, 1976 | December 11, 1976 | July 5, 1979 |
| James Keough Bishop - Career FSO | Ambassador Extraordinary and Plenipotentiary | July 2, 1979 | September 1, 1979 | May 29, 1981 |
| William Robert Casey, Jr. - Political appointee | Ambassador Extraordinary and Plenipotentiary | March 9, 1982 | April 3, 1982 | July 29, 1985 |
| Richard Wayne Bogosian - Career FSO | Ambassador Extraordinary and Plenipotentiary | August 1, 1985 | October 11, 1985 | August 7, 1988 |
| Carl Copeland Cundiff - Career FSO | Ambassador Extraordinary and Plenipotentiary | August 12, 1988 | September 9, 1988 | July 10, 1991 |
| Jennifer C. Ward - Career FSO | Ambassador Extraordinary and Plenipotentiary | March 25, 1991 | August 16, 1991 | May 28, 1993 |
| John S. Davison - Career FSO | Ambassador Extraordinary and Plenipotentiary | August 9, 1993 | October 23, 1993 | July 28, 1996 |
| Charles O. Cecil - Career FSO | Ambassador Extraordinary and Plenipotentiary | June 11, 1996 | September 6, 1996 | August 13, 1999 |
| Barbro Owens-Kirkpatrick - Career FSO | Ambassador Extraordinary and Plenipotentiary | August 9, 1999 | October 11, 1999 | July 12, 2002 |
| Gail Dennise Thomas Mathieu - Career FSO | Ambassador Extraordinary and Plenipotentiary | October 3, 2002 | December 4, 2002 | September 30, 2005 |
| Bernadette M. Allen - Career FSO | Ambassador Extraordinary and Plenipotentiary | February 21, 2006 | April 19, 2006 | January 15, 2010 |
| Bisa Williams - Career FSO | Ambassador Extraordinary and Plenipotentiary | August 9, 2010 | October 29, 2010 | September 13, 2013 |
| Eunice S. Reddick - Career FSO | Ambassador Extraordinary and Plenipotentiary | June 30, 2014 | July 21, 2014 | January 25, 2018 |
| Eric P. Whitaker - Career FSO | Ambassador Extraordinary and Plenipotentiary | November 2, 2017 | January 26, 2018 | December 1, 2021 |
| Susan N’Garnim - Career FSO | Chargé d'Affaires ad interim | December 1, 2021 | N/A | August 19, 2023 |
| Kathleen A. FitzGibbon - Career FSO | Ambassador Extraordinary and Plenipotentiary | August 19, 2023 | N/A | Incumbent |