Selective Pressures at a Codon-level Predict Deleterious Mutations in Human Disease Genes
Selective Pressures at a Codon-level Predict Deleterious Mutations in Human Disease Genes is a scholarly work by Serena Duchi, David Montaner, and Joaquín Dopazo, published in 2006 in ''Journal of Molecular Biology''. The main subjects of the publication include methylation, genome, genetics, neutral mutation, mutation, Synonymous substitution, ribosome, gene, biological function, silent mutation, computational biology, codon usage bias, RNA sequencing, amino acid, coding region, single-nucleotide polymorphism, purifying selection, and biology. The authors demonstrate that the number of residues under strong purifying selection in p53 is much higher than those that are strictly conserved during the evolution of the species.