Premios 40 Principales for Best Latin Song
The Premios 40 Principales for Best Latin Song is an honor presented annually at the Los 40 Principaless, a ceremony that recognizes excellence, creates a greater awareness of cultural diversity and contributions of Latino artists in the international scene.
Juanes is the most awarded songwriter in the category with two. Shakira and Cali & El Dandee are the only lyricists to be nominated twice in the same year: Shakira in 2011, and Cali & El Dandee one year later. After an eight-year absence, the award was revived for the 2020 edition as Los 40 expanded the Latin category.
Category facts
;Most Wins in Category| Rank | 1st | 2nd |
| Artist | Juanes | Shakira Camila Don Omar Lucenzo Cali & El Dandee Maluma |
| Total Wins | 2 wins | 1 wins |
;Most Nominations
| Rank | 1st | 2nd | 3rd |
| Artist | Shakira | Juanes Maná | Cali & El Dandee Julieta Venegas Paulina Rubio Camilo |
| Total Nominations | 5 Nominations | 3 Nominations | 2 nominations |