| Title | Released | Developer | Publisher |
| S.C.A.R.S. | 1998 | Vivid Image | Ubisoft |
| S.T.A.L.K.E.R. 2: Heart of Chornobyl | 2024 | GSC Game World | GSC Game World |
| S.T.A.L.K.E.R.: Call of Pripyat | 2009 | GSC Game World | GSC World Publishing, Deep Silver, BitComposer Games |
| S.T.A.L.K.E.R.: Clear Sky | 2008 | GSC Game World | GSC World Publishing, Deep Silver |
| S.T.A.L.K.E.R.: Shadow of Chernobyl | 2007 | GSC Game World | GSC World Publishing, THQ |
| S.W.I.N.E. | 2001 | StormRegion | Fishtank Interactive |
| S40 Racing | 1997 | Digital Illusions CE | Digital Illusions CE |
| Sabotain: Break the Rules | 2004 | Avalon Style Entertainment | Akella |
| The Saboteur | 2009 | Pandemic Studios | Electronic Arts |
| Sacrifice | 2000 | Shiny Entertainment | Interplay Entertainment |
| Saeko: Giantess Dating Sim | 2024 | Safe Havn | Hyper Real |
| Safecracker: The Ultimate Puzzle Adventure | 2006 | Kheops Studio | The Adventure Company |
| Saints Row 2 | 2008 | Volition | THQ |
| Salammbo: Battle for Carthage | 2003 | Cryo Interactive | Cryo Interactive |
| Salt Lake 2002 | 2002 | Attention to Detail | Eidos Interactive |
| Sam & Max Beyond Time and Space | 2007 | Telltale Games | Telltale Games |
| Sam & Max Hit the Road | 2002 | LucasArts | LucasArts |
| Sam & Max Save the World | 2006 | Telltale Games | The Adventure Company, JoWood Productions |
| Sammy Sosa High Heat Baseball 2001 | 2000 | Team.366 | The 3DO Company |
| Sammy Sosa Softball Slam | 2000 | The 3DO Company | The 3DO Company |
| Samurai Shodown II | 1996 | SNK | SNK |
| Samurai Warriors 2 | 2006 | Koei, Omega Force | Koei |
| San Diego Zoo Presents: The Animals! | 1992 | Arnowitz Studios | The Software Toolworks |
| Sanctum | 2011 | Coffee Stain Studios | Coffee Stain Studios |
| Sanctum 2 | 2013 | Coffee Stain Studios | Coffee Stain Studios |
| Sands of Salzaar | 2021 | Han-Squirrel Studio | XD |
| Sangokushi Kōmeiden | 1996 | Koei | Koei |
| Sanitarium | 1998 | DreamForge Intertainment | ASC Games, XS Games, LLC |
| Sanity: Aiken's Artifact | 2000 | Monolith Productions | Fox Interactive |
| SAS: Secure Tomorrow | 2008 | City Interactive | City Interactive |
| Satisfactory | 2024 | Coffee Stain Studios | Coffee Stain Publishing |
| Saturnalia | 2022 | Santa Ragione | Santa Ragione |
| Savage 2: A Tortured Soul | 2008 | S2 Games | S2 Games |
| Savage Skies | 2002 | iRock Interactive | BAM! Entertainment |
| Savage: The Battle for Newerth | 2003 | S2 Games | iGames, TriSynergy |
| Saw | 2009 | Zombie Studios | Konami |
| Saya no Uta | 2003 | Nitroplus | Nitroplus |
| Scan Command: Jurassic Park | 2001 | Knowledge Adventure | Knowledge Adventure |
| Scarface: The World Is Yours | 2006 | Radical Entertainment | Sierra Entertainment |
| Scarlet Weather Rhapsody | 2008 | Twilight Frontier, Team Shanghai Alice | Twilight Frontier, Team Shanghai Alice |
| Scars Above | 2023 | Mad Head Games | Prime Matter |
| Schizm: Mysterious Journey | 2001 | LK Avalon | LK Avalon, The Adventure Company |
| School Tycoon | 2004 | Cat Daddy Games | Global Star Software |
| Scivelation | 2009 | Black Wing Foundation | |
| Scooby-Doo! Mystery of the Fun Park Phantom | 1999 | Engineering Animation, Inc. | SouthPeak Games |
| Scorched 3D | 2001 | Gavin Camp | |
| Scorcher | 1996 | Zyrinx | Scavenger, Inc. |
| Scrapland | 2004 | Mercury Steam Entertainment | Enlight |
| Scratches | 2006 | Nucleosys | Got Game Entertainment |
| Screamer 4x4 | 2001 | Clever's Development | Virgin Interactive |
| Screamer Rally | 1997 | Milestone srl | Virgin Interactive |
| Screencheat | 2014 | Samurai Punk | Surprise Attack |
| Sea Dogs | 2000 | Akella | Bethesda Softworks |
| Sea Life Safari | 2007 | WildTangent | Sierra On-Line |
| Season of the Sakura | 2002 | JAST | JAST, JAST USA |
| SeaWorld Adventure Parks Tycoon | 2003 | Deep Red Games | Activision |
| Second Face, AA Second Face | 2008 | Jospin Le Woltaire | |
| Second Sight | 2004 | Free Radical Design | Codemasters |
| Secret Agent Barbie | 2001 | Gigawatt Studios | Vivendi Universal Interactive Publishing |
| Secret Files 2: Puritas Cordis | 2009 | Fusionsphere Systems | Deep Silver |
| Secret Files: Tunguska | 2006 | Fusionsphere Systems | Dreamcatcher Interactive, The Adventure Company, Deep Silver |
| Secret Maryo Chronicles | 2003 | SMC Development Team | |
| The Secret of the Nautilus | 2001 | Cryo Interactive | Cryo Interactive |
| Secret of the Solstice | 2007 | DNC Entertainment | DNC Entertainment, Outspark |
| Secret Service (2008 video game) | 2008 | Cauldron HQ | Activision Value |
| Secret Service (2001 video game) | 2001 | Fun Labs | Activision Value |
| Secret Service 2 | 2003 | 4D Rulers | Activision Value |
| Secret Weapons Over Normandy | 2003 | Totally Games | LucasArts |
| The Secrets of Atlantis: The Sacred Legacy | 2006 | The Adventure Company | Dreamcatcher Interactive |
| Section 8 | 2009 | TimeGate Studios | SouthPeak Games |
| Section 8: Prejudice | 2011 | TimeGate Studios | TimeGate Studios, Atari |
| Sega Bass Fishing | 2001 | Sega | Sega |
| Sega Genesis Classics | 2010 | Sega | Sega |
| Sega GT | 2001 | Wow Entertainment | Sega Corporation, Sega PC |
| Sega Marine Fishing | 2001 | Wow Entertainment, Inc. | Sega, Empire Interactive Europe Ltd. |
| Sega Rally 2 | 1998 | AM5 | Sega |
| Sega Rally Championship | 1997 | AM5 | Sega |
| Sega Rally Revo | 2007 | SEGA Racing Studio | Sega |
| Sega Smash Pack | 1999 | Sega | Sega |
| Sega Touring Car Championship | 1996 | Sega-AM3 | Sega |
| Sega Worldwide Soccer 97 | 1996 | Sega | Sega |
| Sekiro: Shadows Die Twice | 2019 | FromSoftware | FromSoftware, Activision |
| Sengoku | 2011 | Paradox Development Studio | Paradox Interactive |
| Sentient | 1997 | Psygnosis | Psygnosis |
| Sentinel Returns | 1998 | Hookstone | Psygnosis |
| Senua's Saga: Hellblade II | 2024 | Ninja Theory | Xbox Game Studios |
| Serious Sam: The First Encounter | 2001 | Croteam | Gathering of Developers |
| Serious Sam: The Second Encounter | 2002 | Croteam | Gathering of Developers |
| Serious Sam: Siberian Mayhem | 2022 | Croteam, Timelock Studio | Devolver Digital |
| Serious Sam 2 | 2005 | Croteam | 2K Games |
| Serious Sam 3: BFE | 2011 | Croteam | Devolver Digital |
| Serious Sam 4 | 2020 | Croteam | Devolver Digital |
| The Serpent Rogue | 2022 | Sengi Games | Team17 |
| Session: Skate Sim | 2019 | crea-ture Studios | crea-ture Studios |
| The Settlers II | 2006 | Blue Byte | Ubisoft |
| The Settlers III | 1998 | Blue Byte | Focus Multimedia Ltd. |
| The Settlers III: Quest of the Amazons | 1999 | Blue Byte | Blue Byte |
| The Settlers IV | 2001 | Blue Byte | Blue Byte |
| The Settlers: Heritage of Kings | 2004 | Blue Byte | Ubisoft |
| The Settlers: Rise of an Empire | 2007 | Blue Byte | Ubisoft |
| Settlers 7: Paths to a Kingdom | 2010 | Blue Byte | Ubisoft |
| Seven Kingdoms II: The Fryhtan Wars | 1999 | Enlight | Ubisoft |
| Severance: Blade of Darkness | 2001 | Rebel Act Studios | Codemasters |
| Shadow Gambit: The Cursed Crew | 2023 | Mimimi Games | Mimimi Games, Hooded Horse |
| Shadow Man | 1999 | Acclaim Studios Teesside | Acclaim Entertainment |
| Shadow Master | 1997 | HammerHead | Psygnosis |
| Shadow of Memories | 2001 | Konami | Konami |
| Shadow of the Tomb Raider | 2018 | Eidos-Montréal | Square Enix Europe |
| Shadow Ops: Red Mercury | 2004 | Zombie Studios | Atari |
| Shadow Tactics: Blades of the Shogun | 2016 | Mimimi Productions | Daedalic Entertainment |
| Shadow Warrior | 2013 | Flying Wild Hog | Devolver Digital |
| Shadow Warrior 2 | 2016 | Flying Wild Hog | Devolver Digital |
| Shadow Warrior 3 | 2022 | Flying Wild Hog | Devolver Digital |
| ShadowFlare | 2001 | Denyusha | Emurasoft |
| Shadowgate | 2014 | Zojoi, LLC | Reverb Triple XP |
| Shadowgrounds | 2005 | Frozenbyte | Plan 1, Meridian4 |
| Shadowgrounds: Survivor | 2007 | Frozenbyte | Frozenbyte |
| Shadowrun | 2007 | FASA Interactive | Microsoft Game Studios |
| Shadowrun Returns | 2013 | Harebrained Schemes | Harebrained Schemes |
| Shadowrun: Dragonfall | 2014 | Harebrained Schemes | Harebrained Schemes |
| Shadowrun: Hong Kong | 2015 | Harebrained Schemes | Harebrained Schemes |
| Shadows of the Damned | 2024 | Grasshopper Manufacture | NetEase Entertainment Interactive |
| Shadows: Awakening | 2018 | Games Farm | Kalypso Media |
| Shadows: Heretic Kingdoms | 2014 | Games Farm | bitComposer Games |
| Shadwen | 2016 | Frozenbyte | Frozenbyte |
| Shakedown: Hawaii | 2019 | Vblank Entertainment | Vblank Entertainment |
| Shanghai II: Dragon's Eye | 1994 | Activision | Activision |
| Shank | 2010 | Klei Entertainment | Electronic Arts |
| Shannara | 1995 | Legend Entertainment | Legend Entertainment |
| Shantae: Risky's Revenge | 2014 | WayForward | WayForward |
| Shantae and the Pirate's Curse | 2015 | WayForward | WayForward |
| Shantae: Half-Genie Hero | 2016 | WayForward | WayForward |
| Shantae and the Seven Sirens | 2019 | WayForward | WayForward |
| Shantae Advance: Risky Revolution | 2025 | WayForward | WayForward |
| Shaq Fu: A Legend Reborn | 2015 | Big Deez Productions | Big Deez Productions |
| Shark Tale | 2004 | Edge of Reality | Activision |
| Shattered – Tale of the Forgotten King | 2021 | Redlock Studio | Redlock Studio |
| Shattered Horizon | 2009 | Futuremark Games Studio | Futuremark Games Studio |
| Shattered Union | 2005 | PopTop Software | 2K Games |
| Shaun White Snowboarding | 2008 | Ubisoft Montreal | Ubisoft |
| Sheep | 2000 | Mind's Eye Productions | Empire Interactive |
| Sheep, Dog 'n' Wolf | 2001 | Infogrames | Infogrames |
| Shellshock 2: Blood Trails | 2009 | Rebellion Developments | Eidos Interactive |
| Shellshock: Nam '67 | 2004 | Guerrilla Games | Eidos Interactive |
| Sherlock Holmes Chapter One | 2021 | Frogwares | Frogwares |
| Sherlock Holmes Versus Arsène Lupin | 2007 | Frogwares | Focus Home Interactive |
| Sherlock Holmes Versus Jack the Ripper | 2009 | Frogwares | Focus Home Interactive |
| Sherlock Holmes: The Awakened | 2006 | Frogwares | Focus Home Interactive |
| Sherlock Holmes: The Awakened | 2023 | Frogwares | Frogwares |
| Sherlock Holmes: The Case of the Silver Earring | 2004 | Frogwares | Ubisoft |
| Sherlock Holmes: Crimes & Punishments | 2014 | Frogwares | Frogwares |
| Sherlock Holmes: The Devil's Daughter | 2016 | Frogwares | Frogwares |
| Sherlock Holmes: The Mystery of the Mummy | 2002 | Frogwares | The Adventure Company |
| The Shield | 2007 | Point of View, Inc. | Aspyr Media |
| Shikkoku no Sharnoth: What a Beautiful Tomorrow | 2008 | Liar-soft | Liar-soft |
| Shining Resonance Refrain | 2018 | O-Two | Sega |
| Ship Simulator | 2006 | VSTEP | Lighthouse Interactive |
| The Ship | 2006 | Outerlight | Valve, Mindscape Group, Merscom |
| Shivers | 1995 | Sierra On-Line | Sierra On-Line |
| Shivers II: Harvest of Souls | 1997 | Sierra On-Line | Sierra On-Line |
| Shockwave Assault | 1995 | Paradox Development | Electronic Arts |
| Shogo: Mobile Armor Division | 1998 | Monolith Productions | Monolith Productions |
| Shogun: Total War | 2000 | The Creative Assembly | Electronic Arts |
| Shoot the Bullet | 2005 | Team Shanghai Alice | Team Shanghai Alice |
| The Shore | 2021 | Ares Dragonis | Ares Dragonis |
| Shotest Shogi | 2008 | AI Factory, Rubicon Development | AI Factory, Rubicon Development |
| Shrek 2: Team Action | 2004 | Luxoflux, Amaze Entertainment | Activision |
| Shrek SuperSlam | 2005 | 7 Studios | Activision, Shaba Games |
| Shrek the Third | 2007 | 7 Studios, Shaba Games | Activision |
| Sid Meier's Alpha Centauri | 1998 | Firaxis Games | Electronic Arts |
| Sid Meier's Antietam! | 1998 | Firaxis Games | Electronic Arts |
| Sid Meier's Colonization | 1995 | Microprose | Microprose |
| Sid Meier's Gettysburg! | 1997 | Firaxis Games | Electronic Arts |
| Sid Meier's Pirates! | 2004 | Firaxis Games | Atari, 2K Games, Valve |
| Sid Meier's Railroads! | 2006 | Firaxis Games | 2K Games |
| Sid Meier's SimGolf | 2002 | Maxis | Electronic Arts |
| Sid Meier's Starships | 2015 | Firaxis Games | 2K |
| Siege of Centauri | 2019 | Stardock Entertainment | Stardock Entertainment |
| Sifu | 2022 | Sloclap | Sloclap, Kepler Interactive |
| The Signal from Tölva | 2017 | Big Robot | Big Robot |
| Silent Hill 2 | 2001 | Konami | Konami |
| Silent Hill 3 | 2003 | Konami | Konami |
| Silent Hill 4: The Room | 2004 | Konami | Konami |
| Silent Hill: Homecoming | 2008 | Konami Digital Entertainment, Double Helix Games | Konami Digital Entertainment |
| Silent Hunter II | 2002 | Ultimation Inc. | Focus Multimedia Ltd. |
| Silent Hunter III | 2005 | Ubisoft Bucharest | Ubisoft |
| Silent Hunter 4: Wolves of the Pacific | 2007 | Ubisoft Bucharest | Ubisoft |
| Silent Hunter 5: Battle of the Atlantic | 2010 | Ubisoft Bucharest | Ubisoft |
| Silent Storm | 2003 | Nival Interactive | JoWood Productions |
| Silt | 2022 | Spiral Circus | Mastertronic Group |
| Silver | 1999 | Infogrames | Infogrames |
| Silver Knights | 2002 | Haruo Teshima | |
| Silverfall | 2007 | Monte Cristo | Monte Cristo |
| SimCity | 1991 | Maxis | Maxis |
| SimCity 2000 | 1995 | Maxis | Maxis, Electronic Arts |
| SimCity 3000 | 1999 | Maxis | EA Games |
| SimCity 4 | 2003 | Maxis | Electronic Arts |
| SimCity Societies | 2007 | Tilted Mill Entertainment | Electronic Arts |
| SimCopter | 1996 | Maxis | Electronic Arts |
| SimEarth | 1990 | Maxis | Maxis |
| SimFarm | 1996 | Maxis | Maxis, Mindscape |
| SimGolf | 1996 | Maxis | Maxis |
| SimIsle: Missions in the Rainforest | 1996 | Intelligent Games | Maxis |
| Simon the Sorcerer | 2002 | Adventure Soft | Adventure Soft |
| Simon the Sorcerer II: The Lion, the Wizard and the Wardrobe | 1995 | Adventure Soft | Adventure Soft |
| Simon the Sorcerer 3D | 2002 | Headfirst Productions | Adventure Soft |
| Simon the Sorcerer 4: Chaos Happens | 2007 | Silver Style Entertainment | RTL Enterprises, Playlogic Entertainment |
| SimPark | 1996 | Maxis | Maxis |
| SimPort | 2007 | Tygron, Port of Rotterdam, TU Delft | |
| The Simpsons Cartoon Studio | 1996 | Big Top Productions | Fox Interactive |
| The Simpsons: Hit & Run | 2003 | Radical Entertainment | Vivendi Universal Games |
| The Simpsons: Virtual Springfield | 1997 | Digital Evolution | Fox Interactive |
| The Sims | 2000 | Maxis | Electronic Arts |
| The Sims 2 | 2004 | Maxis | Electronic Arts |
| The Sims 3 | 2009 | Electronic Arts | Electronic Arts |
| SimSafari | 1998 | Electronic Arts, Maxis | Maxis |
| SimTower | 1995 | OPeNBooK Co., Ltd. | Maxis |
| SimTown | 1995 | Maxis | Maxis |
| SimTunes | 1996 | Maxis | Maxis |
| SiN | 1998 | Ritual Entertainment | Activision |
| SiN Episodes | 2006 | Ritual Entertainment | Valve |
| SiN: Wages of Sin | 1999 | 2015, Inc. | Activision |
| Sinbad: Legend of the Seven Seas | 2003 | Small Rockets | Atari SA |
| Singles: Flirt Up Your Life | 2003 | Rotobee | Deep Silver |
| Singles 2: Triple Trouble | 2005 | Rotobee | Deep Silver |
| Singularity | 2010 | Raven Software | Activision |
| The Sinking City | 2019 | Frogwares | Frogwares |
| The Sinking City 2 | 2025 | Frogwares | Frogwares |
| Sinking Island | 2007 | White Birds Productions | Microids/Encore Games |
| Sinner: Sacrifice for Redemption | 2018 | Dark Star | Another Indie |
| Sins of a Solar Empire | 2008 | Ironclad Games | Stardock |
| Six Days in Fallujah | 2010 | Atomic Games | Atomic Games |
| Skateboard Park Tycoon | 2001 | Cat Daddy Games | Activision |
| Ski Park Manager | 2002 | Lankhor | Microids |
| Ski Resort Extreme | 2004 | Cat Daddy Games | Global Star Software |
| Ski Resort Tycoon | 2001 | Cat Daddy Games | Activision Value |
| Ski Resort Tycoon II | 2001 | Cat Daddy Games | Activision Value |
| SkiFree | 2005 | Chris Pirih | Microsoft |
| Skull and Bones | 2024 | Ubisoft Singapore | Ubisoft |
| Skyborg: Into the Vortex | 1995 | Fringe Multimedia | SkyBox International |
| Slave Zero | 1999 | Accolade | Atari, Infogrames |
| Sleeping Dogs | 2012 | United Front Games | Square Enix |
| Slender: The Arrival | 2013 | Blue Isle Studios, Parsec Productions | Blue Isle Studios |
| Slipstream 5000 | 1995 | The Software Refinery | Gremlin Interactive |
| Slipways | 2021 | Beetlewing | Beetlewing |
| Slitterhead | 2024 | Bokeh Game Studio | Bokeh Game Studio |
| Smokin' Guns | 2009 | Smokin' Guns Productions, Iron Claw Interactive | |
| Snake Pass | 2017 | Sumo Digital | Sumo Digital |
| Sniper Elite | 2005 | Rebellion Developments | Atari |
| Sniper Ghost Warrior 3 | 2017 | CI Games | CI Games |
| Sniper Ghost Warrior Contracts | 2019 | CI Games | CI Games |
| Sniper Ghost Warrior Contracts 2 | 2021 | CI Games | CI Games |
| Sniper: Ghost Warrior | 2010 | City Interactive | City Interactive |
| Sniper: Ghost Warrior 2 | 2013 | City Interactive | City Interactive |
| Snood | 1996 | David M. Dobson | Snood World |
| Snoopy vs. the Red Baron | 2006 | Smart Bomb Interactive | Namco Bandai Games America |
| SnowRunner | 2020 | Saber Interactive | Focus Home Interactive |
| Snufkin: Melody of Moominvalley | 2024 | Hyper Games | Raw Fury |
| So Blonde | 2008 | Wizarbox | Eidos Interactive |
| SODA Off-Road Racing | 1997 | Software Allies | Sierra Entertainment |
| Solar 2 | 2011 | Jay Watts | Murudai |
| Solar Ash | 2021 | Heart Machine | Annapurna Interactive |
| Solar Crusade | 1996 | Infogrames | Infogrames |
| Solarix | 2015 | Pulsetense Games | KISS Ltd |
| Soldat | 2002 | Nick "EnEsCe" Cooper, Michal Marcinkowski | |
| Soldier of Fortune | 2000 | Raven Software | Activision |
| Soldier of Fortune II: Double Helix | 2002 | Raven Software | Activision |
| Soldier of Fortune: Payback | 2007 | Cauldron HQ | Activision Value |
| Soldiers at War | 1998 | Random Games | Strategic Simulations, Inc. |
| Soldiers: Heroes of World War II | 2004 | Best Way | Codemasters |
| Söldner-X: Himmelsstürmer | 2007 | SideQuest Studios | eastasiasoft |
| Söldner: Secret Wars | 2004 | Wings Simulations | JoWood Productions |
| Solium Infernum | 2009 | Cryptic Comet | Cryptic Comet |
| The Solus Project | 2016 | Teotl Studios, Grip Digital | Teotl Studios, Grip Digital |
| Soma | 2015 | Frictional Games | Frictional Games |
| Someday You'll Return | 2020 | CBE Software | Bohemia Interactive |
| Songs of Conquest | 2024 | Lavapotion | Coffee Stain Publishing |
| Sonic 3D Blast | 1997 | Traveller's Tales, Sega | Sega |
| Sonic Adventure 2 | 2012 | Sonic Team | Sega |
| Sonic Dash | 2014 | Hardlight | Sega |
| Sonic Dreams Collection | 2015 | Arcane Kids | Arcane Kids |
| Sonic Forces | 2017 | Sonic Team | Sega |
| Sonic Generations | 2011 | Devil's Detail | Sega |
| Sonic Heroes | 2003 | Sega Studio USA | Sega |
| Sonic Lost World | 2015 | Sonic Team, Sega of Europe | Sega |
| Sonic Mania | 2017 | Headcannon, PagodaWest Games | Sega |
| Sonic Mega Collection | 2002 | Sonic Team, VR-1 Japan, Inc., Comolink Inc. | Sega |
| Sonic R | 1997 | Traveller's Tales | Sega |
| Sonic Riders | 2006 | Sonic Team | Sega |
| Sonic the Hedgehog | 2010 | Sonic Team | Sega |
| Sonic the Hedgehog 2 | 2011 | Sonic Team | Sega |
| Sonic the Hedgehog 4: Episode I | 2010 | Dimps, Sonic Team | Sega |
| Sonic the Hedgehog 4: Episode II | 2012 | Dimps, Sonic Team | Sega |
| Sonic CD | 1996 | Sonic Team, Sega PC | Sega |
| Sons of the Forest | 2024 | Endnight Games | Newnight |
| Sorry! | 1998 | Hasbro Interactive | Third-I Productions |
| Soul Axiom | 2016 | Wales Interactive | Wales Interactive |
| Soul Link | 2004 | Navel | Navel |
| Soul of the Ultimate Nation | 2007 | Webzen | Webzen, The9, NHN, ijji |
| Soul Reaver 2 | 2001 | Crystal Dynamics | Eidos Interactive |
| Soulbringer | 2000 | Infogrames | Interplay Entertainment |
| South Park | 1998 | Iguana Entertainment | Acclaim Entertainment |
| South Park: Chef's Luv Shack | 1999 | Acclaim Entertainment | Acclaim Entertainment |
| South Park Rally | 1999 | Tantalus Interactive | Acclaim Entertainment |
| Sovereign Syndicate | 2024 | Crimson Herring Studios | Crimson Herring Studios |
| Space Ace | 2007 | Digital Leisure Inc. | 1C Company |
| The Space Bar | 1997 | Boffo Games | Rocket Science Games, SegaSoft |
| Space Bunnies Must Die! | 1998 | Jinx | Ripcord Games |
| Space Chimps | 2008 | Wicked Witch Software | Brash Entertainment |
| Space Combat | 2004 | Laminar Research | Laminar Research |
| SpaceChem | 2011 | Zachtronics Industries | Zachtronics Industries |
| Space Empires IV | 2000 | Malfador Machinations | Shrapnel Games, Strategy First |
| Space Empires V | 2006 | Malfador Machinations | Strategy First |
| Space Empires: Starfury | 2003 | Malfador Machinations | Shrapnel Games |
| Space Giraffe | 2007 | Llamasoft | Llamasoft |
| Space Hulk: Ascension | 2014 | Full Control | Full Control |
| Space Hulk: Vengeance of the Blood Angels | 1996 | Krisalis Software | Electronic Arts |
| Space Quest 6 | 1995 | Sierra Entertainment | Sierra Entertainment |
| Space Rangers | 2002 | Elemental Games | 1C Company, Micro Application |
| Space Rangers 2: Dominators | 2004 | Elemental Games | 1C Company |
| Space Shuttle Mission 2007 | 2008 | Exciting Simulations | Simsquared Ltd. |
| Space Siege | 2008 | Gas Powered Games | Sega |
| Space Wreck | 2023 | Pahris Entertainment | Pahris Entertainment |
| Spaceward Ho! | 1992 | Delta Tao Software | Delta Tao Software |
| Spartan | 2004 | Slitherine Strategies | Slitherine Strategies |
| Spec Ops: The Line | 2012 | Yager Development | 2K |
| Special Force 2: Tale of the Truthful Pledge | 2007 | Might 3D | Hezbollah Central Internet Bureau |
| Spectromancer | 2008 | Apus Software, Three Donkeys LLC | Apus Software, Three Donkeys LLC |
| The Spectrum Retreat | 2018 | Dan Smith Studios | Ripstone Games |
| Speed Busters | 1998 | Ubi Soft | Ubi Soft |
| Speed Challenge: Jacques Villeneuve's Racing Vision | 2002 | Ubisoft | Ubisoft |
| Speed Demons | 1999 | EMG | Microids |
| Speedball 2 Tournament | 2007 | Kylotonn | Frogster Interactive Pictures |
| Speedboat Attack | 1997 | Criterion Studios | Telstar Electronic Studios |
| Spellbound! | 1998 | The Learning Company | The Learning Company |
| Spellcross | 1998 | Cauldron Ltd. | JRC Interactive |
| SpellForce: The Order of Dawn | 2003 | Phenomic Game Development | Encore, Inc. |
| SpellForce 2: Shadow Wars | 2006 | Phenomic Game Development | JoWooD Productions |
| Spelunky | 2008 | Derek Yu | Independent |
| Spider-Man (2000 video game) | 2000 | Neversoft | Activision |
| Spider-Man (2002 video game) | 2002 | Treyarch, Digital Eclipse Software | Activision |
| Spider-Man 2 (2004 video game) | 2004 | Treyarch, The Fizz Factor, Vicarious Visions, Digital Eclipse, Backbone Entertainment, Aspyr Media | Activision |
| Spider-Man: Friend or Foe | 2007 | Beenox | Activision |
| Spider-Man: Web of Shadows | 2008 | Amaze Entertainment | Activision |
| Split/Second | 2010 | Black Rock Studio | Disney Interactive Studios |
| SpongeBob SquarePants Movie | 2004 | AWE Games | THQ |
| SpongeBob SquarePants: Battle for Bikini Bottom | 2003 | AWE Games, Heavy Iron Studios, Vicarious Visions | THQ |
| SpongeBob SquarePants: Employee of the Month | 2002 | AWE Games | THQ |
| SpongeBob SquarePants: Lights, Camera, Pants! | 2005 | AWE Games, THQ Studio Australia, WayForward Technologies | THQ |
| SpongeBob SquarePants: Operation Krabby Patty | 2001 | AWE Games | THQ |
| Spore | 2008 | Maxis | Electronic Arts |
| Spore Creature Creator | 2008 | Maxis | Electronic Arts |
| Spore Galactic Adventures | 2009 | Maxis | Electronic Arts |
| Sports Car GT | 1999 | Image Space Incorporated | Electronic Arts |
| Spy Fox in "Dry Cereal" | 1997 | Humongous Entertainment | Atari |
| Spy Fox 2: "Some Assembly Required" | 1999 | Humongous Entertainment | Atari |
| Spy Fox 3: "Operation Ozone" | 2001 | Humongous Entertainment | Atari |
| SpyHunter | 2001 | Paradigm Entertainment, Point of View, Inc., Sidhe Interactive | Midway Games |
| SpyHunter 2 | 2003 | Angel Studios | Midway Games |
| Spycraft: The Great Game | 1996 | Activision | Activision |
| Squirrel with a Gun | 2024 | Dee Dee Creations LLC | Maximum Entertainment |
| Stacked with Daniel Negreanu | 2006 | 5000ft | Myelin Media |
| Stairs | 2015 | GreyLight Entertainment | Digital Tribe Games |
| Stalin vs. Martians | 2009 | Black Wing Foundation | Paradox Interactive |
| Stalingrad | 2005 | DTF Games | BlackBean Games, 1C Games |
| Star Defender Series | 2005 | Awem studio | Awem studio |
| Star General | 1996 | Catware | Strategic Simulations |
| Star Hammer: The Vanguard Prophecy | 2015 | Black Lab Games | Slitherine Software |
| Star Trek DAC | 2009 | Naked Sky Entertainment, Bad Robot Interactive | Paramount Digital Entertainment |
| Star Trek Generations | 1997 | Microprose | Microprose |
| Star Trek Online | 2010 | Cryptic Studios | Atari |
| Star Trek: Armada | 2000 | Activision, Mad Doc Software | Activision |
| Star Trek: Armada II | 2001 | Mad Doc Software | Activision |
| Star Trek: Away Team | 2001 | Reflexive Entertainment | Activision |
| Star Trek: Borg | 1996 | Simon & Schuster | Simon & Schuster |
| Star Trek: Bridge Commander | 2002 | Totally Games | Activision |
| Star Trek: ConQuest Online | 2000 | Genetic Anomalies | Activision Publishing |
| Star Trek: Deep Space Nine: Dominion Wars | 2001 | Gizmo Games | Simon & Schuster |
| Star Trek: Deep Space Nine: The Fallen | 2000 | The Collective | Simon & Schuster |
| Star Trek: Elite Force II | 2003 | Ritual Entertainment | Activision |
| Star Trek: Hidden Evil | 1999 | Presto Studios | Activision |
| Star Trek: Klingon Academy | 2000 | 14 Degrees East | Interplay Entertainment |
| Star Trek: Legacy | 2006 | Mad Doc Software | Bethesda Softworks |
| Star Trek: New Worlds | 2000 | 14 Degrees East | Interplay Entertainment |
| Star Trek: Starfleet Academy | 1997 | StarFleet Academy Software, Interplay, High Voltage Software | Interplay Entertainment |
| Star Trek: Starfleet Command | 1999 | Interplay Entertainment | Interplay Entertainment |
| Star Trek: Starfleet Command II: Empires at War | 2000 | Taldren | Interplay Entertainment |
| Star Trek: Starfleet Command III | 2002 | Taldren | Activision |
| Star Trek: Starship Creator | 1998 | Imergy | Simon & Schuster |
| Star Trek: Starship Creator Warp II | 2000 | Imergy | Simon & Schuster |
| Star Trek: Birth of the Federation | 1999 | Microprose | Hasbro |
| Star Trek: The Game Show | 1998 | Sound Source Interactive | Sound Source Interactive |
| Star Trek: The Next Generation: Klingon Honor Guard | 1998 | MicroProse | MicroProse |
| Star Trek: Voyager – Elite Force | 2000 | Raven Software | Activision |
| Star Warped | 1997 | Parroty Interactive | Palladium Interactive |
| Star Wars Battlefront | 2015 | DICE | Electronic Arts |
| Star Wars Battlefront II | 2017 | DICE | Electronic Arts |
| Star Wars Episode I: Racer | 1999 | LucasArts | LucasArts |
| Star Wars Episode I: The Phantom Menace | 1999 | Big Ape Productions | LucasArts |
| Star Wars Galaxies | 2003 | Sony Online Entertainment | LucasArts |
| Star Wars Galaxies: Jump to Lightspeed | 2004 | Sony Online Entertainment | LucasArts |
| Star Wars Jedi: Fallen Order | 2019 | Respawn Entertainment | Electronic Arts |
| Star Wars Jedi Knight II: Jedi Outcast | 2002 | Raven Software, Vicarious Visions | LucasArts, Activision, Aspyr Media, CyberFront |
| Star Wars Jedi Knight: Dark Forces II | 1997 | LucasArts | LucasArts |
| Star Wars Jedi Knight: Jedi Academy | 2003 | Raven Software | LucasArts, Activision |
| Star Wars Jedi Knight: Mysteries of the Sith | 1998 | LucasArts | LucasArts |
| Star Wars: Battlefront | 2004 | Pandemic Studios | LucasArts |
| Star Wars: Battlefront II | 2005 | Pandemic Studios | LucasArts |
| Star Wars: Droid Works | 1998 | Lucas Learning | Lucas Learning |
| Star Wars: Empire at War | 2006 | Petroglyph Games | LucasArts |
| Star Wars: Empire at War: Forces of Corruption | 2006 | Petroglyph | LucasArts |
| Star Wars Episode I: Battle for Naboo | 2000 | Factor 5, LucasArts | LucasArts |
| Star Wars: Force Commander | 2000 | LucasArts, Ronin Entertainment | LucasArts |
| Star Wars: Galactic Battlegrounds | 2001 | LucasArts, Ensemble Studios | LucasArts |
| Star Wars Knights of the Old Republic II: The Sith Lords | 2004 | Obsidian Entertainment | LucasArts |
| Star Wars: Rebellion | 1998 | Coolhand Interactive | LucasArts |
| Star Wars: Republic Commando | 2005 | LucasArts | LucasArts, Activision |
| Star Wars: Rogue Squadron | 1998 | Factor 5, LucasArts | LucasArts |
| Star Wars: Shadows of the Empire | 1997 | LucasArts | LucasArts |
| Star Wars: Starfighter | 2001 | LucasArts | LucasArts |
| Star Wars: The Clone Wars – Republic Heroes | 2009 | Krome Studios | LucasArts |
| Star Wars: The Force Unleashed | 2008 | LucasArts | LucasArts |
| Star Wars: The Old Republic | 2011 | BioWare | LucasArts |
| Star Wars: TIE Fighter | 2001 | Totally Games | LucasArts |
| Star Wars: X-Wing Alliance | 1999 | Totally Games | LucasArts |
| Star Wars: X-Wing vs. TIE Fighter | 1997 | Totally Games | LucasArts |
| Star Wars: Yoda Stories | 1997 | LucasArts | LucasArts |
| Star Wolves | 2004 | X-bow Software | 1C Company |
| StarCraft | 1998 | Blizzard Entertainment | Blizzard Entertainment, Sierra Entertainment |
| StarCraft: Brood War | 1998 | Saffire, Blizzard Entertainment | Blizzard Entertainment, Sierra Entertainment |
| StarCraft II: Heart of the Swarm | 2013 | Blizzard Entertainment | Blizzard Entertainment |
| StarCraft II: Legacy of the Void | 2015 | Blizzard Entertainment | Blizzard Entertainment |
| StarCraft II: Wings of Liberty | 2010 | Blizzard Entertainment | Blizzard Entertainment |
| Stardew Valley | 2016 | ConcernedApe | ConcernedApe |
| Starfield | 2023 | Bethesda Game Studios | Bethesda Softworks |
| Starfield: Shattered Space | 2024 | Bethesda Game Studios | Bethesda Softworks |
| Starlancer | 2000 | Digital Anvil | Microsoft |
| Starpoint Gemini | 2010 | Little Green Men Games | Iceberg Interactive |
| Starpoint Gemini 2 | 2014 | Little Green Men Games | Iceberg Interactive |
| Starpoint Gemini 3 | 2019 | Little Green Men Games | Little Green Men Games |
| Starpoint Gemini Warlords | 2017 | Little Green Men Games | Iceberg Interactive |
| Stars! | 1995 | Jeff Johnson, Jeff McBride | Empire Interactive |
| Starscape | 2004 | Moonpod | Moonpod |
| Starshatter: The Gathering Storm | 2006 | Destroyer Studios | Matrix Games |
| Starship Titanic | 1998 | The Digital Village | Simon & Schuster Interactive |
| Starship Troopers | 2005 | Strangelite | Empire Interactive |
| Starship Troopers: Terran Ascendancy | 2000 | Blue Tongue Entertainment | Microprose |
| Starsiege | 1999 | Dynamix | Dynamix |
| Starsky & Hutch | 2003 | Mind's Eye Productions | Empire Interactive |
| Startopia | 2001 | Mucky Foot Productions | Eidos Interactive |
| State of Decay | 2013 | Undead Labs | Microsoft Studios |
| State of Decay 2 | 2018 | Undead Labs | Microsoft Studios |
| State of Emergency | 2003 | VIS Entertainment | Global Star Software |
| State of War | 2001 | Cypron Studios | Crystal Interactive |
| The Static Speaks My Name | 2015 | the whale husband | the whale husband |
| Steel Division 2 | 2019 | Eugen Systems | Eugen Systems |
| Steel Division: Normandy 44 | 2017 | Eugen Systems | Paradox Interactive |
| Steelrising | 2022 | Spiders | Nacon |
| Steer Madness | 2004 | Veggie Games Inc | Veggie Games Inc |
| Stellar Blade | 2025 | Shift Up | Sony Interactive Entertainment |
| Stellaris | 2016 | Paradox Development Studio | Paradox Interactive |
| Stephen King's F13 | 2000 | Presto Studios | Blue Byte |
| Steven Spielberg's Director's Chair | 1996 | Knowledge Adventure | Knowledge Adventure |
| Still There | 2019 | GhostShark Games | Iceberg Interactive |
| Still Wakes the Deep | 2024 | The Chinese Room | Sumo Group |
| The Stomping Land | 2014 | SuperCrit | SuperCrit |
| Stories Untold | 2017 | No Code | Devolver Digital |
| Storm: Frontline Nation | 2009 | Colossai Studios | SimBin Studios |
| Stormrise | 2009 | The Creative Assembly | Sega |
| A Story About My Uncle | 2014 | Gone North Games | Coffee Stain Studios |
| Stranded Deep | 2022 | Beam Team Games | Beam Team Games |
| Stranded: Alien Dawn | 2023 | Haemimont Games | Frontier Foundry |
| Strange Horticulture | 2022 | Bad Viking | Iceberg Interactive |
| Stranglehold | 2007 | Midway Chicago | Midway Games |
| Strategic Command: European Theater | 2002 | Fury Software | Battlefront.com |
| Stray | 2022 | BlueTwelve Studio | Annapurna Interactive |
| Stray Blade | 2023 | Point Blank Games | 505 Games |
| Street Fighter 30th Anniversary Collection | 2018 | Capcom | Capcom |
| Street Fighter Alpha | 1997 | Capcom | Capcom |
| Street Fighter Alpha 2 | 1996 | Capcom | Capcom |
| Street Fighter IV | 2008 | Dimps, Capcom | Capcom |
| Street Hacker | 2004 | VirtuWeb Interactive | VirtuWeb Interactive |
| Street Racing Syndicate | 2004 | Eutechnyx, Streamline Studios | Namco |
| Streets of SimCity | 1997 | Maxis | Maxis, Electronic Arts |
| Strike Fighters: Project 1 | 2002 | Third Wire Productions | Strategy First |
| Strike Fighters 2 | 2008 | Third Wire Productions | Third Wire Productions |
| Strike Fighters 2: Vietnam | 2009 | Third Wire Productions | Third Wire Productions |
| Strong Bad's Cool Game for Attractive People | 2008 | Telltale Games | Telltale Games |
| Stronghold | 2001 | Firefly Studios | Take 2 Interactive, Gathering of Developers |
| Stronghold 2 | 2005 | Firefly Studios | 2K Games |
| Stronghold Legends | 2006 | Firefly Studios | 2K Games |
| Stronghold: Crusader | 2002 | Firefly Studios | Take 2 Interactive and God Games |
| Stubbs the Zombie in Rebel Without a Pulse | 2005 | Wideload Games | Aspyr Media |
| Stunt GP | 2001 | Team17 | Eon Digital Entertainment |
| Stupid Invaders | 2000 | Ubi Soft | Xilam |
| Stygian: Reign of the Old Ones | 2019 | Cultic Games | 1C Entertainment |
| Styx: Master of Shadows | 2014 | Cyanide | Focus Home Interactive |
| Styx: Shards of Darkness | 2017 | Cyanide | Focus Home Interactive |
| Su-27 Flanker | 1996 | Eagle Dynamics | Strategic Simulations, Inc. |
| Sub Culture | 1997 | Criterion Studios | Ubi Soft |
| Submarine Titans | 2000 | Ellipse Studios | Strategy First |
| Subnautica | 2018 | Unknown Worlds Entertainment | Unknown Worlds Entertainment |
| Subnautica: Below Zero | 2021 | Unknown Worlds Entertainment | Unknown Worlds Entertainment |
| Subsurface Circular | 2017 | Mike Bithell Games | Mike Bithell Games |
| Subterranean Animism | 2008 | Team Shanghai Alice | Team Shanghai Alice |
| Sudeki | 2005 | Climax Group | Microsoft Game Studios |
| The Suffering | 2004 | Surreal Software | Midway Games |
| The Suffering: Ties That Bind | 2005 | Surreal Software | Midway Games |
| The Suicide of Rachel Foster | 2020 | One-O-One Games | Daedalic Entertainment |
| Sumerian Six | 2024 | Artificer | Devolver Digital |
| Summer Athletics | 2008 | 49Games | Digital Entertainment Pool |
| Summer Session | 2008 | Hanako Games, Tycoon Games | Hanako Games, Tycoon Games |
| Summerhouse | 2024 | Friedemann Allmenröder | Future Friends Games |
| Summoner | 2000 | Volition | THQ |
| SunAge | 2007 | Vertex4 | Lighthouse Interactive |
| Sun Haven | 2023 | Pixel Sprout Studios | Pixel Sprout Studios |
| Sunset | 2015 | Tale of Tales | Tale of Tales |
| Sunset Overdrive | 2014 | Insomniac Games | Microsoft Studios |
| Super Amazing Wagon Adventure | 2013 | sparsevector | sparsevector |
| Super Animal Royale | 2021 | Pixile Studios | Pixile Studios |
| Super-Bikes Riding Challenge | 2006 | Milestone | Black Bean Games |
| Super Bubble Pop | 2002 | Zombie Studios | Jaleco |
| Super Columbine Massacre RPG! | 2005 | Danny Ledonne | |
| Super Lucky's Tale | 2017 | Playful | Microsoft Studios |
| Super Match Soccer | 1998 | Cranberry Source | Acclaim Entertainment |
| Super Meat Boy | 2010 | Team Meat | Team Meat |
| Super Puzzle Bobble | 2000 | Taito | Acclaim Entertainment, Taito |
| Super Puzzle Fighter II Turbo | 2007 | Capcom | Capcom |
| Super Woden GP | 2021 | ViJuDa | ViJuDa |
| Superball Arcade | 2003 | Cheeky Monkey Software | Cheeky Monkey Software |
| Supercar Street Challenge | 2001 | Exakt Entertainment | Activision |
| Superhot | 2016 | Superhot Team | Superhot Team |
| Superhot: Mind Control Delete | 2020 | Superhot Team | Superhot Team |
| Superliminal | 2019 | Pillow Castle Games | Pillow Castle Games |
| SuperPower 2 | 2004 | GolemLabs | DreamCatcher Interactive |
| Superstars V8 Racing | 2009 | Milestone srl | Black Bean Games |
| Supreme Commander | 2007 | Gas Powered Games | THQ |
| Supreme Commander 2 | 2010 | Gas Powered Games | Square Enix |
| Supreme Commander: Forged Alliance | 2007 | Gas Powered Games | THQ |
| Supreme Ruler 2010 | 2005 | BattleGoat Studios | Strategy First |
| Supreme Ruler 2020 | 2008 | BattleGoat Studios | Paradox Interactive |
| Supreme Warrior | 1996 | Digital Pictures | Digital Pictures |
| Surf's Up | 2007 | Ubisoft Quebec | Ubisoft |
| The Surge | 2017 | Deck13 Interactive | Focus Home Interactive |
| The Surge 2 | 2019 | Deck13 Interactive | Focus Home Interactive |
| Survival Crisis Z | 2004 | Ska Studios | Ska Studios |
| Survival Project | 2003 | IO Entertainment | Happy Digi, HanbitSoft, et al. |
| Surviving the Aftermath | 2021 | Iceflake Studios | Paradox Interactive |
| Surviving Mars | 2018 | Haemimont Games, Abstraction Games | Paradox Interactive |
| Suzerain | 2020 | Torpor Games | Fellow Traveller Games |
| Sven Co-op | 1999 | Sven Co-op Team | |
| Swamp Buggy Racing | 2000 | Daylight Productions | WizardWorks |
| Swarm | 1998 | Reflexive Entertainment | Reflexive Entertainment |
| SWAT 3: Close Quarters Battle | 1999 | Sierra Northwest | Sierra Entertainment |
| SWAT 4 | 2005 | Irrational Games | Vivendi Universal Games |
| Swing | 1997 | Software 2000 | Software 2000 |
| Switchball | 2007 | Atomic Elbow | Sierra On-Line |
| Sword of the Stars | 2006 | Kerberos Productions | Paradox Interactive, Lighthouse Interactive |
| Sydney 2000 | 2000 | Attention to Detail | Eidos Interactive |
| Sydney Mystery, The | 2003 | Twilight Software | Twilight Software |
| Sylvio | 2015 | Stroboskop | Stroboskop |
| Symbiocom | 1998 | Istvan Pely Productions | Bethesda Softworks |
| Syndicate | 2012 | Starbreeze Studios | Electronic Arts |
| Syndrome | 2016 | Camel 101, Bigmoon Entertainment | Camel 101 |
| System Shock | 2023 | Nightdive Studios | Prime Matter |
| System Shock 2 | 1999 | Irrational Games, Looking Glass Studios | Electronic Arts |