2,5-Dimethoxy-4-cyanoamphetamine
2,5-Dimethoxy-4-cyanoamphetamine is a serotonergic drug of the phenethylamine, amphetamine, and DOx families. It is a DOx derivative with a cyano group at the 4position of the molecule.
The effects of DOCN in humans and whether it is a psychedelic are unknown.
Pharmacology
DON shows much lower affinities for the serotonin 5-HT2 receptors than other DOx drugs. However, DOCN also showed by far the greatest degree of selectivity for the serotonin 5-HT2A receptor over the serotonin 5-HT2C receptor of any other assessed DOx drug. Applying this strategy to the 25-NB series resulted in the discovery of 25CN-NBOH, one of the most selective serotonin 5-HT2A receptor agonists discovered to date.
Chemistry
Analogues
Related drugs include DON, 2C-N, DOA, 2C-CN, 25CN-NBOH, and 25CN-NBOMe.
History
DOCN was first described in the scientific literature by Richard Glennon and colleagues by 1989.
Canada
DOCN is a controlled substance in Canada under phenethylamine blanket-ban language.
DOCN is not a controlled substance in the United States as of 2011.