List of special routes of the United States Numbered Highway System
A special route of the United States Numbered Highway System is a route that branches off a U.S. Highway in order to divert traffic from the main highway. Special routes are distinguished from main routes by, in most cases, the addition of an auxiliary plate that describes what type of route it is, while the main highway carries no such sign. In some locations, a single letter is placed after the route number to denote the special route type in lieu of the auxiliary plate.
There are four main types of special routes — alternate, business, bypass, and temporary; though other route types exist.
- Alternate routes exist where an additional road is needed to meet traffic demands. They are to be of equal character and quality compared to the main road.
- Business routes carry traffic through the central business district of a community while the main highway goes around the community.
- Bypasses serve the opposite purpose of business routes. Truck routes are a subset of bypasses.
- Temporary routes complete a gap between two segments of main highway that exists because the main highway has not been fully constructed.
The following U.S. Highway special routes have existed:
- Routes are sorted by position along the main route, from south to north and west to east.
- Defunct routes are listed in italics.
US 1 – US 101
US 1
Bus. US 1 - Florida City to Homestead, FloridaAlt. US 1 - Daytona Beach to St. Augustine, Florida- Bus. US 1 - St. Augustine, FloridaAlt. US 1 - Jacksonville, Florida
- Alt. US 1 - Jacksonville, Florida
- Bus. US 1 - Waycross, Georgia
- Bus. US 1 - Swainsboro, Georgia
- Bus. US 1 - Wadley, Georgia
- Bus. US 1 - Louisville, Georgia
- Conn. US 1 - Augusta, Georgia to North Augusta, South Carolina
- Truck US 1 - Aiken, South Carolina
- Conn. US 1 - Lexington, South Carolina
- Conn. US 1 - Columbia, South Carolina
- Truck US 1 - Camden, South Carolina
- Truck US 1 - Cheraw, South CarolinaUS 1A - Moore County, North CarolinaUS 1A - Southern Pines, North Carolina
- Bus. US 1 - Southern Pines, North Carolina
- Bus. US 1 - Vass to Cameron, North CarolinaUS 1A - Sanford, North Carolina
- Bus. US 1 - Sanford, North CarolinaByp. US 1 - Sanford, North CarolinaUS 1A - Cary to Raleigh, North CarolinaUS 1A - Raleigh, North CarolinaUS 1A - Raleigh, North CarolinaBus. US 1 - Raleigh, North CarolinaByp. US 1 - Raleigh, North Carolina
- US 1A - Wake Forest to Youngsville, North Carolina
- US 1A - Franklinton, North CarolinaUS 1A - Henderson, North Carolina
- Bus. US 1 - Henderson, North CarolinaByp. US 1 - Henderson, North Carolina
- Bus. US 1 - Fredericksburg, VirginiaTruck US 1 - Alexandria, VirginiaByp. US 1 - Washington, D.C.
- Alt. US 1 - Washington, D.C. to Hyattsville, Maryland
- Alt. US 1 - Arbutus to Baltimore
- Bus. US 1 - Bel Air to Hickory, Maryland
- Alt. Truck US 1 - West Grove, PennsylvaniaByp. US 1 - Swarthmore to Hunting Park, Pennsylvania
- Alt. Truck US 1 - Philadelphia
- Bus. US 1 - Penndel, PennsylvaniaAlt. US 1 - Trenton, New Jersey
- Bus. US 1 - Trenton, New JerseyByp. US 1 - Trenton, New JerseyTemp. US 1 - Newark to Jersey City, New Jersey
- Truck US 1 - Newark to Jersey City, New Jersey, via KearnyBus. US 1 - Jersey City, New Jersey to New York state line at New York City US 1A - Port Chester, New YorkUS 1A - Stamford, ConnecticutUS 1A - Darien, ConnecticutUS 1A - Norwalk, ConnecticutUS 1A - Bridgeport, ConnecticutUS 1A - Milford, ConnecticutUS 1A - East Haven, ConnecticutUS 1A - Branford, ConnecticutUS 1A - Old Saybrook, ConnecticutUS 1A - Waterford, ConnecticutUS 1A - Groton, Connecticut
- US 1A - Stonington, Connecticut
- Bus. US 1 - Warwick, Rhode Island
- US 1A - Norwood, Rhode Island to Massachusetts state line at Attleboro, Massachusetts, via Providence, East Providence, and Pawtucket, Rhode Island
- Byp. US 1 - Portsmouth, New Hampshire to Kittery, Maine
- US 1A - York, Maine
- US 1A - Portland, Maine
- Bus. US 1 - Newcastle to Damariscotta, Maine
- US 1A - Rockland, Maine
- US 1A - Stockton Springs to Ellsworth, Maine, via Bangor
- Bus. US 1A - Bangor to Brewer, MaineByp. US 1 - Rockland, Maine
- US 1A - Milbridge to Harrington, Maine
- US 1A - Whitneyville to Machias, MaineUS 1A - Mars Hill to Presque Isle, Maine
- US 1A - Mars Hill to Van Buren, MaineByp. US 1 - Caribou, Maine
US 2
- Bus. US 2 - Cashmere, WashingtonBus. US 2 - Wenatchee, Washington
- Bus. US 2 - Williston, North Dakota
- Bus. US 2 - Minot, North Dakota
- Byp. US 2 - Minot, North Dakota
- Bus. US 2 - Grand Forks, North Dakota to East Grand Forks, Minnesota
- Truck US 2 - Superior, Wisconsin
- Bus. US 2 - Ironwood, Michigan
- Bus. US 2 - Montpelier, Vermont
- Truck US 2 - St. Johnsbury, Vermont
- Alt. US 2 - Orono to Old Town, Maine
- Alt. US 2 - Macwahoc Plantation to Houlton, Maine
US 3
Alt. US 3 – Tyngsborough, Massachusetts to Concord, New HampshireBus. US 3 – Tyngsborough, Massachusetts to Concord, New HampshireByp. US 3 – Concord, New HampshireByp. US 3 – Nashua, New HampshireUS 4
Alt. US 4 – Fair Haven to West Rutland, Vermont- Bus. US 4 – Rutland, VermontAlt. US 4 – Andover to Boscawen, New HampshireByp. US 4 – Concord, New HampshireAlt. US 4 – East Northwood to Dover, New Hampshire
US 5
Alt. US 5 (1933–1941) – New Haven to North Haven, ConnecticutAlt. US 5 (1941–1966) – New Haven to North Haven, ConnecticutAlt. US 5 – New Haven to Meriden, ConnecticutAlt. US 5 (1937–1941) – Lamentation Mountain State Park to Tracy, ConnecticutAlt. US 5 (1940s–1950s) – Lamentation Mountain State Park to Tracy, ConnecticutAlt. US 5 – Berlin, ConnecticutAlt. US 5 – East Hartford to East Windsorhill, ConnecticutUS 5A – Hartford–Windsor, Connecticut city line to Agawam, MassachusettsByp. US 5 – South Deerfield, Massachusetts- Alt. US 5 – St. Johnsbury to St. Johnsbury Center, Vermont
- Alt. US 5 – Newport, Vermont
- Alt. US 5 – Derby Line, Vermont
US 6
- Bus. US 6 – Ely, NevadaSpur US 6 – Ely, NevadaTemp. US 6 – Colton to Castle Gate, Utah
- Bus. US 6 – Helper, Utah
- Bus. US 6 – Price, Utah
- Bus. US 6 – Cisco, UtahByp. US 6 – Grand Junction, Colorado
- Bus. US 6 - Hastings, NebraskaBus. US 6 – Lincoln, NebraskaCity US 6 – Lincoln, NebraskaCity US 6 – Des Moines, IowaCity US 6 – Des Moines, IowaBus. US 6 – Davenport, IowaCity US 6 – Davenport, IowaTemp. US 6 – Moline to Joliet, IllinoisBus. US 6 – Lansing, Illinois to Lake Station, IndianaBus. US 6 – Bremen, Indiana
- Bus. US 6 – Napoleon, OhioAlt. US 6 – Sandusky to Huron, Ohio
- Alt. US 6 – Rocky River to Cleveland, OhioAlt. US 6 – Cleveland to East Cleveland, OhioAlt. US 6 – Euclid to Chardon, OhioByp. US 6 – Union City, Pennsylvania
- Bus. US 6 – Warren, Pennsylvania
- Bus. US 6 – Tunkhannock Township to Tunkhannock, Pennsylvania
- Bus. US 6 – Scranton to Carbondale Township, Pennsylvania
- Alt. US 6 – Philipstown, New York
- Truck US 6 – Woodbury to Highlands, New YorkUS 6A – Newtown to Southbury, ConnecticutUS 6A – Plymouth to Hartford, ConnecticutUS 6A – Woodbury to Willimantic, ConnecticutUS 6A – Coventry to Windham, ConnecticutUS 6A – Danielson, Connecticut
- Bus. US 6 – Scituate, Rhode Island
- Byp. US 6 – Scituate, Rhode Island
- Alt. US 6 – Johnston to Providence, Rhode IslandByp. US 6 – Johnston, Rhode IslandTemp. US 6 – Marion to Wareham, MassachusettsByp. US 6 – Bourne to Sagamore, MassachusettsTemp. US 6 – South Dennis to East Dennis, MassachusettsTemp. US 6 – Harwich to Brewster, Massachusetts
US 7
US 8
Bus. US 8 – Rhinelander, WisconsinUS 9
- Truck US 9 – Georgetown, Delaware
- Bus. US 9 – Five Points to Lewes, DelawareTemp. US 9 – Upper Township to Somers Point, New JerseyAlt. US 9 – South Toms River to Toms River, New JerseyAlt. US 9 – Jersey City, New Jersey to Inwood Hill Park, New YorkTemp. US 9 – Newark to Jersey City, New Jersey
- Truck US 9 – Newark to Jersey City, New JerseyBus. US 9 – Jersey City, New Jersey to New Jersey/New York state line at New York CityAlt. US 9W – Newburgh, New YorkAlt. US 9 – Rouses Point, New York
US 10
Alt. US 10 – Seattle, WashingtonAlt. US 10 – Seattle, Washington to Missoula, MontanaBus. US 10 – Coeur d'Alene, IdahoAlt. US 10 – Drummond to Opportunity, MontanaByp. US 10 – Butte, MontanaByp. US 10S – Butte, MontanaByp. US 10 – Billings, MontanaBus. US 10 – Valley City, North Dakota- Bus. US 10 – Neillsville, WisconsinBus. US 10 – Manitowoc, Wisconsin
- Bus. US 10 – Reed City, Michigan
- Bus. US 10 – Clare, Michigan
- Bus. US 10 – Midland, MichiganBus. US 10 – Flint, MichiganBus. US 10 – Pontiac, Michigan
US 11
Bus. US 11 – Meridian, MississippiByp. US 11 – Tuscaloosa, Alabama- Truck US 11 – Birmingham, AlabamaAlt. US 11 – Chattanooga, TennesseeBus. US 11 – Chattanooga, TennesseeByp. US 11 – Chattanooga, Tennessee
- Byp. US 11 – Cleveland, Tennessee
- Bus. US 11 – Riceville to Athens, Tennessee
- Bus. US 11E – Greeneville, Tennessee
- Truck US 11 – Bristol, Virginia
- Alt. US 11 – Salem to Roanoke, Virginia
- Bus. US 11 – Lexington, VirginiaByp. US 11 – Lexington, Virginia
- Bus. US 11 – Staunton, Virginia
- Truck US 11 – Staunton, Virginia
- Alt. US 11 – Winchester, VirginiaByp. US 11 – Lemoyne, PennsylvaniaAlt. US 11 – Lemoyne, Pennsylvania
US 12
- Bus. US 12 – Walla Walla, Washington
- Bus. US 12 – Missoula, Montana
- Bus. US 12 – Helena, MontanaByp. US 12 – Helena, MontanaTemp. US 12 – Fallon to Ismay, MontanaBus. US 12 – Eau Claire, WisconsinCity US 12 – Eau Claire, Wisconsin
- Bus. US 12 – Lake Delton to West Baraboo, Wisconsin
- Bus. US 12 – Sauk City to Prairie du Sac, WisconsinCity US 12 – Madison, WisconsinBus. US 12 - Madison, WisconsinByp. US 12 - Madison, Wisconsin
- Bus. US 12 – Fort Atkinson, Wisconsin
- Bus. US 12 – Whitewater, WisconsinTemp. US 12 – Big Foot to Crystal Lake, IllinoisBus. US 12 – Des Plaines to ChicagoCity US 12 – Des Plaines to Chicago, IllinoisToll US 12 – Chicago, Illinois to Hammond, IndianaBus. US 12 – Niles, MichiganAlt. US 12 – Kalamazoo, MichiganBus. US 12 – Kalamazoo, MichiganAlt. US 12 – Battle Creek to Springfield, MichiganBus. US 12 – Battle Creek, MichiganBus. US 12 – Marshall, MichiganBus. US 12 – Albion, MichiganBus. US 12 – Jackson, Michigan
- Bus. US 12 – Ypsilanti, Michigan
US 13
- Alt. US 13 – Bethel to Williamston, North Carolina
- Bus. US 13 – Bethel, North CarolinaUS 13A – Windsor, North Carolina
- Bus. US 13 – Windsor, North Carolina
- Bus. US 13 – Suffolk, VirginiaSpur US 13 – Norfolk, Virginia
- Bus. US 13 – Cape Junction to Cheriton, VirginiaByp. US 13 – Cheriton, Virginia
- Bus. US 13 – Eastville, VirginiaByp. US 13 – Eastville, Virginia
- Bus. US 13 – Exmore, VirginiaByp. US 13 – Exmore, Virginia
- Bus. US 13 – Onley to Accomac, VirginiaByp. US 13 – Tasley, VirginiaByp. US 13 – Accomac, Virginia
- Bus. US 13 – Pocomoke City, Maryland
- Bus. US 13 – Fruitland to Salisbury, MarylandAlt. US 13 – Delmar to Seaford, Delaware
- Bus. US 13 – Bridgeville, DelawareAlt. US 13 – Bridgeville, Delaware
- Alt. US 13 – Woodside to Camden, Delaware
- Alt. US 13 – Rodney Village to Dover, Delaware
- Bus. US 13 – Wilmington, DelawareAlt. US 13 – Wilmington to Claymont, DelawareByp. US 13 – Claymont, Delaware to Chester, Pennsylvania
- Bus. US 13 - Trainer to Chester, PennsylvaniaByp. US 13 – Chester to Collingdale, PennsylvaniaByp. US 13 – Darby to Hunting Park, Pennsylvania
- Alt. Truck US 13 – Bensalem Township, Pennsylvania
US 14
- Alt. US 14 – Cody to Burgess Junction, WyomingBus. US 14 – Sheridan, Wyoming
- US 14A – Spearfish to Sturgis, South DakotaBus. US 14 – Rapid City, South Dakota
- Truck US 14 - Pierre, South Dakota
- Bus. US 14 - Huron, South Dakota
- Byp. US 14 – Brookings, South Dakota
- Bus. US 14 – Dodge Center, MinnesotaBus. US 14 – Madison, WisconsinCity US 14 – Madison, Wisconsin
- Bus. US 14 – Janesville, WisconsinCity US 14 – Janesville, WisconsinBus. US 14 – Woodstock, Illinois
US 15
Alt. US 15/US 15A – Walterboro, South Carolina to Creedmoor, North Carolina- Conn. US 15 – Santee, South Carolina
- Conn. US 15 – Summerton, South Carolina
- Conn. US 15 – Sumter to Sumter, South CarolinaAlt. US 15 – Sumter to Society Hill, South CarolinaAlt. US 15 – Dubose to Manville, South CarolinaAlt. US 15 – Hartsville, South Carolina
- Bus. US 15 – Hartsville, South Carolina
- Truck US 15 – Hartsville, South CarolinaBus. US 15 – Bennettsville, South Carolina
- Bus. US 15 – Laurinburg, North CarolinaUS 15A – Sanford, North CarolinaBus. US 15 – Sanford, North CarolinaByp. US 15 – Sanford, North CarolinaUS 15A – Chapel Hill, North CarolinaBus. US 15 – Chapel Hill, North Carolina
- Bus. US 15 – Durham, North CarolinaByp. US 15 – Durham, North CarolinaTruck US 15 – Oxford, North Carolina
- Bus. US 15 – Clarksville, Virginia
- Bus. US 15 – Keysville, Virginia
- Bus. US 15 – Farmville, Virginia
- Alt. US 15 - Farmville, Virginia
- Bus. US 15 – Culpeper, Virginia
- Bus. US 15 – Remington, Virginia
- Bus. US 15 – Warrenton, VirginiaTemp. US 15 – Warrenton to Aldie, Virginia
- Bus. US 15 – Leesburg, VirginiaByp. US 15 – Leesburg, Virginia
- Bus. US 15 – Emmitsburg, Maryland
- Bus. US 15 – Gettysburg, PennsylvaniaBus. US 15 - Shamokin Dam, Pennsylvania
- Bus. US 15 – Mansfield, Pennsylvania
US 16
- Bus. US 16 - Newcastle, Wyoming
- Truck US 16 - Newcastle, WyomingUS 16A – Custer to Keystone, South Dakota
- US 16A – Custer to Keystone, South Dakota
- Byp. US 16 – Hill City, South Dakota
- Truck US 16 - Hill City, South DakotaBus. US 16 – Rapid City, South Dakota
- Byp. US 16 – Rapid City, South Dakota
- Truck US 16 - Rapid City, South DakotaAlt. US 16 – Wall to Kadoka, South DakotaBus. US 16 – Watertown, WisconsinBus. US 16 – Grand Rapids, MichiganByp. US 16 – Grand Rapids, MichiganUS 16A – Novi to Farmington, MichiganBus. US 16 – Farmington, Michigan
US 17
- Truck US 17 – Kissimmee, Florida
- Truck US 17 – Winter Park to Maitland, Florida
- Alt. US 17 – Jacksonville, FloridaAlt. US 17 – Jacksonville, FloridaAlt. US 17 – Savannah, GeorgiaAlt. US 17 – Savannah, Georgia to near Limehouse, South CarolinaAlt. US 17 – Ridgeland, South Carolina
- Alt. US 17 – near Pocotaligo to Georgetown, South CarolinaAlt. US 17 – Yemassee, South Carolina
- Conn. US 17 – Yemassee, South CarolinaAlt. US 17 – Rantowles to Parkers Ferry, South CarolinaAlt. US 17 – Ridgeville, South Carolina
- Alt. Truck US 17 – Summerville, South CarolinaAlt. US 17 – Charleston, South CarolinaBus. US 17 – Mount Pleasant, South CarolinaAlt. US 17 – Myrtle Beach, South Carolina
- Conn. US 17 – Murrells Inlet to Garden City, South Carolina
- Bus. US 17 – Myrtle Beach, South CarolinaByp. US 17 – Myrtle Beach, South Carolina
- Bus. US 17 – Shallotte, North Carolina
- Bus. US 17 – Bolivia, North CarolinaUS 17-1 – North Carolina to Virginia
- Bus. US 17 – Wilmington, North CarolinaTruck US 17 – Wilmington, North Carolina
- Byp. US 17 - Hampstead, North Carolina
- Bus. US 17 – Jacksonville, North Carolina
- Bus. US 17 – New Bern, North Carolina
- Bus. US 17 – Vanceboro, North Carolina
- Bus. US 17 – Chocowinity to Washington, North Carolina
- Byp. US 17 – Washington, North CarolinaAlt. US 17 – Williamston, North Carolina
- Bus. US 17 – Williamston, North CarolinaAlt. US 17 – Windsor, North Carolina
- Byp. US 17 – Windsor, North Carolina
- Bus. US 17 – Edenton, North Carolina
- Bus. US 17 – Hertford to Winfall, North CarolinaAlt. US 17 – Elizabeth City, North Carolina
- Bus. US 17 – Elizabeth City, North Carolina
- Bus. Truck US 17 - Elizabeth City, North Carolina
- Byp. US 17 – Elizabeth City, North Carolina
- Bus. Truck US 17 – Elizabeth City, North Carolina
- Bus. US 17 – South Mills, North Carolina
- Bus. US 17 – Chesapeake, VirginiaBus. US 17 – Portsmouth, Virginia
- Bus. US 17 – Gloucester Courthouse, Virginia
- Bus. US 17 – Saluda, Virginia
- Bus. US 17 – Fredericksburg, VirginiaByp. US 17 – Fredericksburg, Virginia
- Bus. US 17 – Warrenton, Virginia
- Bus. US 17 – Marshall, Virginia
US 18
- Byp. US 18 – Hot Springs, South Dakota
- Truck US 18 – Hot Springs, South Dakota
- Bus. US 18 – Clear Lake, Iowa to Mason City, Iowa
- Bus. US 18 – Mendon Township to Marquette, Iowa
- Bus. US 18 – Mount Horeb, Wisconsin
- Bus. US 18 – Verona, WisconsinAlt. US 18 – Milwaukee, Wisconsin
US 19
Alt. US 19 – Bayonet Point to Brooksville, Florida- Alt. US 19 – St. Petersburg to Holiday, FloridaBus. US 19 – Thomasville to Meigs, Georgia
- Bus. US 19 – Albany, Georgia
- Byp. US 19 – Leesburg, Georgia
- Bus. US 19 – Griffin, GeorgiaBus. US 19 – Southeast of Hapeville to Atlanta, Georgia
- Bus. US 19 – Dahlonega, Georgia
- Bus. US 19 – Murphy, North Carolina
- Bus. US 19 – Andrews, North Carolina
- Truck US 19 – Bryson City to Lake Junaluska, North Carolina
- Conn. US 19 – Bryson City, North CarolinaUS 19A – Waynesville, North CarolinaUS 19A – Ela to Lake Junaluska, North CarolinaUS 19A – Bryson City to Lake Junaluska, North CarolinaByp. US 19 – Bryson City to Lake Junaluska, North CarolinaUS 19A – Asheville, North Carolina
- Bus. US 19 – Asheville, North Carolina
- Bus. US 19 – Woodfin to Weaverville, North CarolinaUS 19A – Cane River to Elk Park, North Carolina
- Truck US 19 – Bristol, Virginia
- Bus. US 19 – Lebanon, Virginia
- Bus. US 19 – Tazewell, Virginia
- Alt. US 19 - Prosperity, West Virginia
- Spur US 19 - Fairmont, West Virginia
- Bus. US 19 – Beckley, West Virginia
- Truck US 19 – Mt. Lebanon to Wexford, Pennsylvania, via Pittsburgh
- Truck US 19 - Harlansburg, Pennsylvania
US 20
- Bus. US 20 - Toledo, Oregon
- Bus. US 20 - Bend, OregonTemp. US 20 - Mountain Home to Carey, Idaho
- Bus. US 20 - Idaho Falls, Idaho
- Bus. US 20 - Rigby, IdahoAlt. US 20 - Sugar City, Idaho to Jackson, Wyoming
- Bus. US 20 - St. Anthony, Idaho
- Bus. US 20 - Mountain View to Casper, WyomingByp. US 20 - Mountain View to Casper, Wyoming
- Bus. US 20 - Douglas, WyomingByp. US 20 - Manville, Wyoming
- Bus. US 20 - South Sioux City, Nebraska to Sioux City, Iowa
- Bus. US 20 - Fort Dodge, Iowa
- Bus. US 20 - Freeport, Illinois
- Bus. US 20 - Rockford to Belvidere, IllinoisBus. US 20 - Elgin, IllinoisCity US 20 - Elmhurst to ChicagoBus. US 20 - Melrose Park to Chicago, IllinoisToll Bus. US 20 - Chicago, Illinois to Hammond, IndianaAlt. US 20 - Tremont to Michigan City, Indiana
- Bus. US 20 - South Bend to Mishawaka, IndianaByp. US 20 - South Bend to Elkhart, IndianaTruck US 20 - Osceola to Elkhart, Indiana
- US 20A - northwest of Holiday City to Maumee, Ohio Bus. US 20 - Toledo to Gibsonburg Junction, OhioTruck US 20 - Perrysburg, Ohio
- Bus. US 20 - Fremont, OhioUS 20A - Rocky River to Cleveland, OhioUS 20A - Cleveland to East Cleveland, Ohio
- Truck US 20 - Silver Creek, New York
- US 20A - Big Tree to South Bloomfield, New YorkByp. US 20 - Lenox, Massachusetts
US 21
- Bus. US 21 - Beaufort, South CarolinaAlt. US 21 - Yemassee, South CarolinaAlt. US 21 - Rowesville, South CarolinaAlt. US 21 - Orangeburg, South CarolinaBus. US 21 - Orangeburg, South Carolina
- Bus. US 21 - Orangeburg, South CarolinaByp. US 21 - Orangeburg, South Carolina
- Conn. US 21 - Orangeburg, South CarolinaSpur US 21 - Orangeburg, South Carolina
- Conn. US 21 - West Columbia, South Carolina
- Conn. US 21 - Columbia, South CarolinaSpur US 21 - Columbia, South CarolinaAlt. US 21 - Ridgeway, South Carolina
- Conn. US 21 - Ridgeway, South Carolina
- Bus. US 21 - Fort Mill, South CarolinaAlt. US 21 - Rock Hill, South CarolinaBus. US 21 - Rock Hill, South CarolinaBus. US 21 - Rock Hill to Fort Mill, South Carolina
- Bus. US 21 - Jonesville to Elkin, North Carolina
- Truck US 21 - Sparta, North CarolinaByp. US 21 - Bluefield, West VirginiaTemp. US 21 - Cuyahoga Heights to Cleveland, Ohio
US 22
Temp. US 22 - Green Tree to Pittsburgh, PennsylvaniaTruck US 22 - Pittsburgh, Pennsylvania- Bus. US 22 - Churchill to Monroeville, Pennsylvania
- Bus. US 22 - Granville Township to Derry TownshipByp. US 22 - Harrisburg, PennsylvaniaAlt. US 22 - Bethlehem to Easton, PennsylvaniaAlt. US 22 - Phillipsburg, New JerseyByp. US 22 - Easton, Pennsylvania to Phillipsburg, New Jersey
US 23
- Bus. US 23 - Waycross, GeorgiaBus. US 23 - Hazlehurst, Georgia
- Bus. US 23 - Cochran, GeorgiaBus. US 23 - Baldwin to Cornelia, Georgia
- Bus. US 23 - Dillsboro to east of Sylva, North Carolina
- Bus. US 23 - Hazelwood to Waynesville, North CarolinaAlt. US 23 - Waynesville, North CarolinaAlt. US 23 - Clyde to Canton, North CarolinaAlt. US 23 - Asheville, North Carolina
- Bus. US 23 - Asheville, North Carolina
- Bus. US 23 - Weaverville, North Carolina
- US 23A - Wolf Laurel, North Carolina
- Bus. US 23 - Gate City, Virginia
- Bus. US 23 - Big Stone Gap to Norton, Virginia, via Appalachia
- Bus. US 23 - Wise, Virginia
- Bus. US 23 - Pound, VirginiaByp. US 23 - Pound, VirginiaBus. US 23 - Pikeville, KentuckyByp. US 23 - Pikeville, KentuckySpur US 23 - Pikeville, KentuckyBus. US 23 - Paintsville, Kentucky
- Bus. US 23 - Ashland, Kentucky
- Spur US 23 - Ashland, Kentucky
- Truck US 23 - South Portsmouth, Kentucky to Portsmouth, Ohio
- Bus. US 23 - Chillicothe, OhioBus. US 23 - Perrysburg to Toledo, Ohio
- Bus. US 23 - Ann Arbor, MichiganBus. US 23 - Fenton, MichiganBus. US 23 - Bridgeport to Saginaw, MichiganBus. US 23 - Bay City, Michigan
- Bus. US 23 - Rogers City, Michigan
US 24
Bus. US 24 – Manitou Springs to Colorado Springs, Colorado- Bus. US 24 – Goodland, KansasOpt. US 24 – Kansas City to Independence, MissouriBus. US 24 – Napoleon to Lexington, Missouri
- Bus. US 24 – Carrollton, MissouriCity US 24 – Kirksville, Missouri
- Bus. US 24 – Paris, Missouri
- Bus. US 24 – Washington, Illinois
- Bus. US 24 – Logansport to Richvalley, Indiana
- Bus. US 24 – Peru, Indiana
- Bus. US 24 – Wabash, IndianaTruck US 24 – Fort Wayne, IndianaAlt. US 24 – Toledo, Ohio to Erie, Michigan Bus. US 24 – Perrysburg to Toledo, OhioUS 24A - southwest of Luna Pier to Erie, Michigan
- Bus. US 24 – Pontiac, Michigan
US 25
- Byp. US 25 - Statesboro, Georgia
- Byp. US 25 - Waynesboro, GeorgiaBus. US 25 - Augusta, Georgia to North Augusta, South Carolina
- Bus. US 25 - Augusta, Georgia to North Augusta, South Carolina
- Conn. US 25 - North Augusta, South Carolina
- Truck US 25 - North Augusta, South CarolinaAlt. US 25 - Edgefield, South Carolina
- Bus. US 25 - Edgefield, South Carolina
- Truck US 25 - Edgefield, South Carolina
- Bus. US 25 - Greenwood, South CarolinaAlt. US 25 - Hodges, South Carolina
- Bus. US 25 - Ware Shoals, South CarolinaBus. US 25 - Greenville, South CarolinaAlt. US 25 - Greenville to near Travelers Rest, South Carolina
- Conn. US 25 - Travelers Rest, South Carolina
- Bus. US 25 - Flat Rock, North Carolina – Hendersonville, North CarolinaUS 25A - Hendersonville, North Carolina
- US 25A - Arden to Asheville, North Carolina
- Bus. US 25 - Marshall, North CarolinaTruck US 25 - Corbin, Kentucky
- Bus. US 25 - Richmond, KentuckyBus. US 25 - Lexington, KentuckyTruck US 25 - Lexington, Kentucky
- Bus. US 25 - Williamstown to Dry Ridge, KentuckyBus. US 25 - Covington, KentuckyBus. US 25 - Perrysburg to Toledo, OhioAlt. US 25 - Toledo, Ohio to Erie, MichiganBus. US 25 - Toledo, OhioUS 25A - Erie, MichiganUS 25A - Port Huron, MichiganBus. US 25 - Port Huron, Michigan
US 26
- Bus. US 26 – Ririe, Idaho
- Bus. US 26 – Mountain View to Casper, Wyoming
- Byp. US 26 – Mountain View to Casper, Wyoming
- Bus. US 26 – Douglas, WyomingCity US 26 – Scottsbluff, Nebraska
US 27
Alt. US 27 - Sebring to Avon Park, FloridaTemp. US 27 - Sebring to Leesburg, FloridaAlt. US 27 - Lady Lake to Belleview, FloridaAlt. US 27 - Haines City to Sunray Deli Estates, Florida- Alt. US 27 - Williston to Perry, Florida
- Bus. US 27 - Attapulgus, Georgia
- Bus. US 27 - Bainbridge, Georgia
- Bus. US 27 - Blakely, Georgia
- Bus. US 27 - Cuthbert, Georgia
- Alt. US 27 - Columbus to Carrollton, Georgia
- Bus. US 27 - Bremen, Georgia
- Bus. US 27 - Buchanan, Georgia
- Bus. US 27 - Cedartown, Georgia
- Bus. US 27 - LaFayette, Georgia
- Bus. US 27 - Chattanooga, Tennessee
- Bus. US 27 - Dayton, Tennessee
- Bus. US 27 - Nicholasville, Kentucky
- Bus. US 27 - Cynthiana, Kentucky
- Conn. US 27 - Cynthiana, KentuckyCity US 27 - Newport, Kentucky to CincinnatiTemp. US 27 - Newport, Kentucky to Cincinnati, Ohio
- Truck US 27 - Cincinnati, OhioTruck US 27 - Fort Wayne, IndianaBus. US 27 - Marshall, MichiganBus. US 27 - Charlotte, MichiganBus. US 27 - Lansing, MichiganTruck US 27 - Lansing, MichiganBus. US 27 - St. Johns, MichiganBus. US 27 - Ithaca, MichiganUS 27A - Alma, MichiganBus. US 27 - Alma, MichiganBus. US 27 - St. Louis, MichiganBus. US 27 - Mount Pleasant, MichiganBus. US 27 - Clare, MichiganBus. US 27 - Harrison, Michigan
US 29
- Truck US 29 - Union Springs, AlabamaBus. US 29 - LaGrange, Georgia
- Alt. US 29 - Palmetto to Red Oak, GeorgiaBus. US 29 - Decatur, Georgia
- Bus. US 29 - Lawrenceville to Winder, GeorgiaBus. US 29 - Lawrenceville to Athens, GeorgiaTemp. US 29 - Athens, GeorgiaAlt. US 29 - Anderson, South Carolina
- Bus. US 29 - Anderson, South Carolina
- Conn. US 29 - Williamston, South CarolinaAlt. US 29 - Greenville, South CarolinaBus. US 29 - Greenville, South Carolina
- Conn. US 29 - Greenville, South Carolina
- Spur US 29 - Greenville, South CarolinaAlt. US 29 - Greenville to Taylors, South CarolinaAlt. US 29 - Greenville to Taylors, South Carolina
- Conn. US 29 - Greenville to Wade Hampton, South CarolinaAlt. US 29 - Wellford, South CarolinaAlt. US 29 - Lyman to North Carolina state line northeast of Blacksburg, South CarolinaAlt. US 29 - Fairforest, South CarolinaConn. US 29 - Spartanburg, South CarolinaUS 29A - Bessemer City, North CarolinaBus. US 29 - Charlotte, North Carolina
- Alt. US 29 - Concord to China Grove, North CarolinaUS 29A (1938–1940) - Kannapolis, North CarolinaUS 29A (1940–1948) - Kannapolis, North CarolinaUS 29A (1948–1997) - Kannapolis, North CarolinaUS 29A - Salisbury, North CarolinaBus. US 29 - Salisbury, North CarolinaUS 29A - Lexington, North CarolinaBus. US 29 - Lexington, North CarolinaUS 29A - Thomasville, North CarolinaBus. US 29 - Thomasville, North CarolinaUS 29A (1934–1948) - High Point, North CarolinaUS 29A (1948–1991) - High Point to Greensboro, North CarolinaUS 29A - Greensboro, North Carolina
- Bus. US 29 - Monticello to Ruffin, North Carolina, via ReidsvilleUS 29A - Reidsville, North CarolinaBus. US 29 (1960–73) - Reidsville, North CarolinaBus. US 29 - Pelham, North Carolina to Danville, VirginiaAlt. US 29 (1936–1941) - Danville, VirginiaAlt. US 29 (1941–1970) - Danville, VirginiaBus. US 29 (1970–1998) - Danville, Virginia
- Bus. US 29 (1996–) - Danville, Virginia to Blairs, Virginia
- Bus. US 29 - Chatham, Virginia
- Bus. US 29 - Gretna, Virginia
- Bus. US 29 - Hurt, Virginia to Altavista, VirginiaAlt. US 29 - Lynchburg, VirginiaBus. US 29 (1971–2005) - Lynchburg, Virginia
- Bus. US 29 (1969–) - Lynchburg to Amherst, Virginia
- Bus. US 29 - Lovingston, Virginia
- Bus. US 29 - Charlottesville, Virginia
- Bus. US 29 - Madison, Virginia
- Bus. US 29 - Culpeper, Virginia
- Bus. US 29 - Remington, Virginia
- Bus. US 29 - Warrenton, Virginia
US 30
- Bus. US 30 - St. Helens, OregonAlt. US 30 - Portland, OregonBus. US 30 - Portland, Oregon
- Byp. US 30 - Portland, Oregon
- Bus. US 30 - Huntington, Oregon
- Bus. US 30 - Ontario, Oregon
- Bus. US 30 - Pocatello, IdahoBus. US 30N - Pocatello, Idaho
- Bus. US 30 - Lava Hot Springs, Idaho
- Byp. US 30 - Kemmerer to Diamondville, Wyoming
- Bus. US 30 - Green River, Wyoming
- Bus. US 30 - Rock Springs, Wyoming
- Bus. US 30 - Rawlins, Wyoming
- Bus. US 30 - Pine Bluffs, Wyoming to Bushnell, NebraskaUS 30A - Clarks, Nebraska to Missouri Valley, IowaBus. US 30 - Wahoo, NebraskaCity US 30 - Wahoo, NebraskaCity US 30A - Wahoo, Nebraska
- Bus. US 30 - Fremont, NebraskaAlt. US 30 - Clarks, Nebraska to Missouri Valley, IowaAlt. US 30 - Ogden to Marshalltown, Iowa
- Bus. US 30 - Marshalltown, Iowa
- Bus. US 30 - Toledo to Tama, Iowa
- Emergency US 30 - Cedar Rapids, IowaAlt. US 30 - Clinton, Iowa to Fulton, IllinoisAlt. US 30 - Sterling to Chicago, IllinoisToll US 30 - Aurora to Ford Heights, IllinoisBus. US 30 - Aurora, IllinoisCity US 30 - Aurora, IllinoisBus. US 30 - Fort Wayne, Indiana
- Bus. US 30 - Van Wert, Ohio
- Bus. US 30 - Upper Sandusky, Ohio
- Bus. US 30 - Bucyrus, Ohio
- Alt. US 30 - Dalton, Ohio
- Truck US 30 - Clinton to Robinson Township, PennsylvaniaTemp. US 30 - Green Tree to Pittsburgh
- Bus. US 30 - Bedford, Pennsylvania
- Bus. US 30 - Everett, Pennsylvania
- Bus. US 30 - Frazer to Parkesburg, Pennsylvania
- Bus. Alt. Truck US 30 - Downingtown, PennsylvaniaAlt. US 30 - Bryn Mawr to Philadelphia, PennsylvaniaByp. US 30 - Bryn Mawr to Philadelphia, Pennsylvania
US 31
Bus. US 31 - Montgomery, AlabamaCity US 31 - Montgomery, AlabamaTruck US 31 - Montgomery, Alabama- US 31A - Pulaski to Nashville, Tennessee
- Bus. US 31A - Lewisburg, Tennessee
- Truck US 31 - Franklin, Tennessee
- Byp. US 31E - Hendersonville, Tennessee Bus. US 31E - Scottsville, KentuckyByp. US 31W - Bowling Green, Kentucky
- Bus. US 31E - Glasgow, Kentucky
- Byp. US 31W - Elizabethtown, Kentucky
- Truck US 31W - Elizabethtown, Kentucky
- Truck US 31E - Bardstown, Kentucky
- Bus. US 31W - West Point, Kentucky
- US 31EX - Mount Washington, KentuckyAlt. US 31 - Dudleytown to Columbus, IndianaByp. US 31 - Kokomo, Indiana
- Bus. US 31 - Peru, IndianaAlt. US 31 - Plymouth, Indiana
- Bus. US 31 - Plymouth, Indiana
- Bus. US 31 - South Bend, IndianaByp. US 31 - South Bend, Indiana Bus. US 31 - Niles to Niles Charter Township, MichiganBus. US 31 - South Haven Charter Township to Casco Township, MichiganBus. US 31 - Holland to Holland Charter Township, MichiganUS 31A - Muskegon Heights to Muskegon, Michigan
- Bus. US 31 - Norton Shores to Muskegon Township, Michigan
- Bus. US 31 - Whitehall Township to Montague Township, Michigan
- Bus. US 31 - Hart Township to Hart, Michigan
- Bus. US 31 - Weare Township to Pentwater Township, Michigan
- Bus. US 31 - Pere Marquette Charter Township, Michigan
US 33
- Bus. US 33 – Stanardsville, Virginia
- Bus. US 33 – Elkton, Virginia
- Bus. US 33 – Nelsonville, Ohio
- Bus. US 33 – Lancaster, OhioBus. US 33 – Fort Wayne, IndianaTruck US 33 – Fort Wayne, Indiana
US 34
- Bus. US 34 - Estes Park, Colorado
- Bus. US 34 - Greeley, ColoradoBus. US 34 - Brush, Colorado
- Bus. US 34 - Glenwood, Iowa
- Bus. US 34 - Chariton, Iowa
- Bus. US 34 - Ottumwa, Iowa
- Bus. US 34 - Fairfield, Iowa
- Bus. US 34 - Westwood to Mount Pleasant, Iowa
US 35
- Spur US 35 – Scott Depot, West VirginiaTemp. US 35 – Point Pleasant, West Virginia to Kanauga, Ohio
- Bus. US 35 – Jackson, Ohio
- Bus. US 35 – Xenia, OhioByp. US 35 – Xenia, Ohio
US 36
Bus US 36 – St. Joseph, Missouri- Bus. US 36 – Cameron, Missouri
- Bus. US 36 – Hamilton, MissouriBus. US 36 – Mooresville, Missouri
- Bus. US 36 – Chillicothe, Missouri
- Bus. US 36 – Brookfield, Missouri
- Bus. US 36 – Macon, MissouriSpur US 36 - Macon, Missouri
- Bus. US 36 – Clarence, Missouri
- Bus. US 36 – Shelbina, Missouri
- Bus. US 36 – Monroe City, Missouri
- Bus. US 36 – Hannibal, MissouriCity US 36 - Hannibal, MissouriTemp. US 36 – Baker to Greenville, Ohio
US 40
Bus. US 40 - Oakland to Berkeley, CaliforniaTemp. US 40 - American Canyon to Cordelia, California[U.S. Route 40 Business (West Sacramento, California|Sacramento, California)|Bus. US 40] - West Sacramento, CaliforniaBus. US 40 - North Sacramento, CaliforniaAlt. US 40 - Davis, California to Reno, NevadaAlt. US 40 - Salt Lake City, UtahAlt. US 40 - Park City, UtahTemp. US 40 - Steamboat Springs to Kremmling, Colorado- Bus. US 40 - WaKeeney, KansasBus. US 40 - Russell, KansasCity US 40 - Salina, KansasAlt. US 40 - Junction City to Grandview Plaza, Kansas
- Bus. US 40 - Junction City to Grandview Plaza, KansasTemp. US 40 - Junction City to Manhattan, KansasTemp. US 40 - Junction City to Topeka, KansasBus. US 40 - Kansas City, KansasOpt. US 40 - Kansas City, MissouriCity US 40 - Kansas City, MissouriAlt. US 40 - Kansas City to Independence, MissouriOpt. US 40 - Kansas City to Leeds, MissouriOpt. US 40 - Independence to Kansas City, MissouriBus. US 40 - Columbia, MissouriByp. US 40 - Wentzville, Missouri to Troy, IllinoisCity US 40 - Pattonville to St. Louis, MissouriTruck US 40 - Frontenac, Missouri to East St. Louis, IllinoisAlt. US 40 - Bridgeton to St. Louis, MissouriBus. US 40 - St. Louis, MissouriSpur US 40 - St. Louis, MissouriBus. US 40 - East St. Louis to Collinsville, IllinoisCity US 40 - East St. Louis to Collinsville, IllinoisAlt. US 40 - East St. Louis to Collinsville, IllinoisAlt. US 40 - Greenville to Vandalia, IllinoisTemp. US 40 - Columbus to Bexley, Ohio
- Spur US 40 - Wheeling, West VirginiaAlt. US 40 - Washington, PennsylvaniaThru US 40 - Washington, Pennsylvania
- Bus. US 40 - Brownsville, PennsylvaniaAlt. US 40 - Uniontown, Pennsylvania
- Bus. US 40 - Uniontown to Hopwood, Pennsylvania
- Alt. US 40 - Keysers Ridge to Cumberland, Maryland
- Scenic US 40 - Bellegrove to Piney Grove, Maryland
- Alt. US 40 - Hagerstown to Frederick, Maryland
- Truck US 40 - Baltimore, Maryland
US 41
Temp. US 41 - Naples Manor to Naples Park, Florida- Bus. US 41 - Fort Myers to North Fort Myers, Florida
- Bus. US 41 - Venice, Florida
- Bus. US 41 - Bradenton, Florida
- Bus. US 41 - Palm River-Clair Mel to north of Tampa, Florida
- Bus. US 41 - Valdosta, Georgia
- Bus. US 41 - Macon, Georgia
- Bus. US 41 - Griffin, GeorgiaBus. US 41 - Southeast of Hapeville to Atlanta, GeorgiaCity US 41 - Atlanta, GeorgiaAlt. US 41 - Atlanta to Marietta, GeorgiaByp. US 41 - Atlanta to Marietta, GeorgiaTemp. US 41 - Atlanta to Marietta, GeorgiaTemp. US 41 - Atlanta to Smyrna, GeorgiaTemp. US 41 - Atlanta to Smyrna, GeorgiaTemp. US 41 - Atlanta, GeorgiaBus. US 41 - Cartersville, Georgia
- Truck US 41 - Ringgold, Georgia
- Alt. US 41 - Monteagle, Tennessee to Hopkinsville, Kentucky
- Byp. US 41A - Clarksville, Tennessee
- Truck US 41 - Hopkinsville, Kentucky
- Alt. US 41 - Madisonville to Henderson, KentuckyBus. US 41 - Terre Haute, Indiana
- Bus. US 41 - Vincennes, Indiana
- Bus. US 41 - Princeton, Indiana
- Bus. US 41 - Evansville, IndianaTemp. US 41 - Lincolnwood to Skokie, IllinoisTemp. US 41 - Highland Park to Del Mar Woods, IllinoisToll US 41 - Lansing to Antioch, IllinoisTemp. US 41 - Milwaukee, WisconsinCity US 41 - Fond du Lac, WisconsinCity US 41 - Oshkosh, Wisconsin
- Bus. US 41 - Appleton, Wisconsin
- Bus. US 41 - De Pere to Ashwaubenon, Wisconsin
- Bus. US 41 - Oconto, Wisconsin
- Bus. US 41 - Peshtigo, WisconsinBus. US 41 - Marquette, MichiganAlt. US 41 - Ishpeming to Negaunee, MichiganBus. US 41 - Baraga, Michigan
US 42
Alt. US 42 – Cincinnati to Sharonville, OhioBus. US 42 – Covington, KentuckyUS 43
Alt. US 43 – Mobile to Chickasaw, AlabamaBus. US 43 – Tuscumbia, AlabamaUS 44
US 44A – Manchester to West Ashford, ConnecticutUS 45
- Bus. US 45 – Shubuta, MississippiBus. US 45 – Meridian, Mississippi
- Alt. US 45 – Northeast of Brooksville to Shannon, MississippiBus. US 45 – south-southeast of Okolona to Shannon, MississippiBus. US 45 – Tupelo, MississippiAlt. US 45 – Southwest of Medina, Tennessee, to Fulton, Kentucky
- Byp. US 45 – Jackson, Tennessee
- Bus. US 45W- Humboldt, TennesseeBus. US 45W – Trenton, Tennessee
- Bus. US 45E – Martin, TennesseeByp. US 45 – Fulton, Kentucky
- Byp. US 45 – Mayfield, Kentucky
- Bus. US 45 – Paducah, KentuckyByp. US 45 – Paducah, KentuckyByp. US 45 – Norris City, Illinois
- Bus. US 45 – New London, Wisconsin
- Bus. US 45 – Wittenberg, Wisconsin
US 49
Bus. US 49 – Hattiesburg, Mississippi- Bus. US 49 – Bentonia, MississippiBus. US 49E – Greenwood, Mississippi
- US 49B – Helena–West Helena, ArkansasUS 49B – Jonesboro, Arkansas
- US 49B – Brookland, Arkansas
- US 49B – Paragould, Arkansas
- US 49Y – Paragould, Arkansas
US 50
Bus. US 50 - Oakland, CaliforniaBus. US 50 - Sacramento, California- Alt. US 50 - signed, but unofficial, route between Pollock Pines and South Lake Tahoe, California
- Temp. US 50 - Carson City, NevadaBus. US 50 - Carson City, Nevada
- Alt. US 50 - Silver Springs to Fallon, Nevada via FernleyAlt. US 50 - Fallon, NevadaAlt. US 50 - Ely, Nevada to Provo, UtahTemp. US 50 - Colton to Castle Gate, Utah
- Bus. US 50 - Pueblo to Avondale, Colorado
- Bus. US 50 - Olathe, ColoradoAlt. US 50 - Garden City, Kansas
- Bus. US 50 - Garden City, KansasByp. US 50 - Garden City, KansasAlt. US 50 - Dodge City, KansasBus. US 50 - Dodge City, KansasByp. US 50 - Dodge City, KansasBus. US 50 - Ottawa, KansasOpt. US 50 - Olathe, Kansas to Lone Jack, Missouri
- Bus. US 50 - Warrensburg, Missouri
- Bus. US 50 - Knob Noster, Missouri
- Spur US 50 - Smithton, Missouri
- Bus. US 50 - California, Missouri
- Bus. US 50 - St. Martins, MissouriBus. US 50 - Jefferson City, Missouri
- Bus. US 50 - Jefferson City, MissouriU.S. Route 50W - Union, MissouriBus. US 50 - Brentwood to St. Louis, MissouriCity US 50 - Brentwood to St. Louis, MissouriByp. US 50 - Mehlville, Missouri to Fairview Heights, IllinoisTruck US 50 - St. Louis, MissouriAlt. US 50 - Sumner to Lawrenceville, Illinois
- Bus. US 50 - Lawrenceville, IllinoisBus. US 50 - Vincennes, IndianaBus. US 50 - Washington, Indiana
- Bus. US 50 - Bedford, IndianaByp. US 50 - Cleves to Milford, OhioTruck US 50 - Cincinnati, OhioAlt. US 50 - Athens, Ohio to Ellenboro, West VirginiaBus. US 50 - Belpre, OhioBus. US 50 - Parkersburg, West VirginiaAlt. US 50 - Washington, D.C.Byp. US 50 - Washington, D.C.Temp. US 50 - Washington, D.C. to Ardmore, Maryland
- Bus. US 50 - Salisbury, Maryland
US 51
- Bus. US 51 – Ponchatoula to Hammond, LouisianaBus. US 51 – McComb, Mississippi
- Bus. US 51 – Crystal Springs, MississippiTruck US 51 – Memphis, Tennessee
- Bus. US 51 – Dyersburg, Tennessee
- Byp. US 51 – Dyersburg, TennesseeBus. US 51 – Elwin to Decatur, Illinois
- Bus. US 51 – Clinton, Illinois
- Bus. US 51 – Bloomington to Normal, IllinoisBus. US 51 – LaSalle, Illinois
- Spur US 51 – Beloit, Wisconsin
- Bus. US 51 – Plover to Stevens Point, Wisconsin
- Bus. US 51 – Rothschild to Wausau, WisconsinBus. US 51 – Merrill, WisconsinBus. US 51 – Tomahawk, Wisconsin
US 52
- Bus. US 52 - Minot, North Dakota
- Bus. US 52 - Harvey, North Dakota
- Bus. US 52 - Valley City, North Dakota
- Truck US 52 - Jamestown, North DakotaAlt. US 52 - Luxemburg to Dubuque, Iowa
- Bus. US 52 - Fowler, IndianaBus. US 52 - Lafayette, Indiana
- Bus. US 52 - Hanging Rock to Coal Grove, Ohio
- Truck US 52 - Williamson, West Virginia to South Williamson, Kentucky
- Alt. US 52 - Welch, West Virginia
- Truck US 52 - Bluefield, West VirginiaUS 52A - Mount Airy, North Carolina
- Bus. US 52 - Mount Airy, North CarolinaUS 52A - Pilot Mountain, North CarolinaBus. US 52 - Pilot Mountain, North CarolinaByp. US 52 - Pilot Mountain, North Carolina
- Bus. US 52 - Albemarle, North Carolina
- Truck US 52 - Cheraw, South Carolina
- Bus. US 52 - Darlington, South CarolinaAlt. US 52 - Florence, South Carolina
- Conn. US 52 - Florence, South Carolina
- Truck US 52 - Florence, South CarolinaAlt. US 52 - Lake City, South Carolina
- Conn. US 52 - North Charleston, South CarolinaAlt. US 52 - North Charleston to Charleston, South CarolinaAlt. US 52 - Charleston, South Carolina
- Spur US 52 - Charleston, South Carolina
US 53
- Bus. US 53 - Eau Claire, WisconsinByp. US 53 - Eau Claire, Wisconsin
- Alt. US 53 - Lake Hallie to Chippewa Falls, Wisconsin
- Bus. US 53 - Minong, Wisconsin
- Bus. US 53 - Solon Springs, Wisconsin
- Bus. US 53 - Superior, Wisconsin
- Bus. US 53 - Virginia, Minnesota
US 54
- Bus. US 54 – El Paso, Texas to Texas/New Mexico state line
- Bus. US 54 – Alamogordo, New Mexico
- Bus. US 54 – Tucumcari, New Mexico
- Bus. US 54 – Lake Ozark, Missouri
- Bus. US 54 – Eldon, MissouriAlt. US 54 – Jefferson City, Missouri
- Bus. US 54 – Fulton, Missouri
- Bus. US 54 – Mexico, Missouri
- Bus. US 54 - Bowling Green, Missouri
- Bus. US 54 – Louisiana, MissouriCity US 54 - Kankakee, IllinoisBus. US 54 – Kankakee, Illinois
US 56
Temp. US 56 - Boise City, Oklahoma to Elkhart, KansasUS 58
- Bus. US 58 - Ewing to Rose Hill, Virginia
- Alt. US 58 - Jonesville to Abingdon, Virginia
- Bus. US 58 - Dryden, Virginia
- Alt. Bus. US 58 - Dryden, Virginia
- Alt. Bus. US 58 - Norton, Virginia
- Bus. US 58 - Gate City, Virginia
- Bus. US 58 - Hillsville, Virginia
- Bus. US 58 - west of Meadows of Dan, Virginia
- Bus. US 58 - Stuart, Virginia
- Bus. US 58 - Martinsville, Virginia
- Bus. US 58 - Danville, Virginia
- Bus. US 58 - Clarksville, Virginia
- Bus. US 58 - Boydton, Virginia
- Bus. US 58 - South Hill, Virginia
- Bus. US 58 - Lawrenceville, Virginia
- Bus. US 58 - Emporia, Virginia
- Bus. US 58 - Courtland, Virginia
- Bus. US 58 - Franklin to Carrsville, Virginia
- Bus. US 58 - Suffolk, VirginiaAlt. US 58 - Portsmouth, Virginia
- Bus. US 58 - Virginia Beach, Virginia
US 59
- Bus. US 59 - Laredo, Texas
- Bus. US 59 - George West, Texas
- Bus. US 59 - Victoria to Telferner, Texas
- Bus. US 59 - El Campo, Texas
- Bus. US 59 - Wharton to Hungerford, TexasAlt. US 59 - Southside Place to Houston, TexasBus. US 59 - Houston, Texas
- Bus. US 59 - Splendora, Texas
- Bus. US 59 - Livingston, Texas
- Bus. US 59 - Lufkin, Texas
- Bus. US 59 - Nacogdoches to Redfield, Texas
- Bus. US 59 - Carthage, Texas
- Bus. US 59 - Jefferson, TexasTemp. US 59 - Maud, Texas to Page, OklahomaBus. US 59 - Texarkana, Texas to Texarkana, ArkansasByp. US 59 - Texarkana, Texas
- Byp. US 59 - Poteau, OklahomaAlt. US 59 - Fort Smith, Arkansas to West Siloam Springs, OklahomaTemp. US 59 - Fort Smith, Arkansas to West Siloam Springs, Oklahoma
- Bus. US 59 - Ottawa, KansasBus. US 59 - Industrial City to St. Joseph, MissouriCity US 59 - Industrial City to St. Joseph, Missouri
US 60
Bus. US 60 – Riverside, CaliforniaBus. US 60 – Banning, CaliforniaBus. US 60 – Superior, ArizonaTemp. US 60 – Globe to Springerville, ArizonaTruck US 60 – Globe, Arizona- Bus. US 60 – Tonkawa, Oklahoma
- Bus. US 60 – Ponca City, OklahomaCity US 60 – Ponca City, Oklahoma
- Bus. US 60 – West Seneca, Oklahoma to Seneca, Missouri
- Bus. US 60 – Neosho, Missouri
- Bus. US 60 – Monett, Missouri
- Bus. US 60 – Verona to Aurora, MissouriBus. US 60 – Springfield, MissouriCity US 60 – Springfield, Missouri
- Bus. US 60 – Rogersville, Missouri
- Bus. US 60 – Mansfield, Missouri
- Bus. US 60 – Mountain Grove, Missouri
- Bus. US 60 – Cabool, Missouri
- Bus. US 60 – Willow Springs, Missouri
- Bus. US 60 – Van Buren, Missouri
- Bus. US 60 – Poplar Bluff, Missouri
- Bus. US 60 – Dexter, Missouri
- Bus. US 60 – Sikeston to Charleston, Missouri
- Bus. US 60 – Paducah, KentuckyCity US 60 – Paducah, Kentucky
- Byp. US 60 – Morganfield, Kentucky
- Truck US 60 – Morganfield, KentuckyBus. US 60 – Owensboro, KentuckyByp. US 60 – Owensboro, Kentucky
- Bus. US 60 – Cloverport, Kentucky
- Alt. US 60 – Louisville, KentuckyBus. US 60 – Louisville, KentuckyTruck US 60 – Louisville, KentuckyBus. US 60 – Frankfort, Kentucky
- Bus. US 60 – Versailles, KentuckyBus. US 60 – Lexington, KentuckyByp. US 60 - Lexington, KentuckyTruck US 60 – Lexington, KentuckyTruck US 60 – Winchester, KentuckyTruck US 60 – Salt Lake to Midland, KentuckyBus. US 60 – Ashland, KentuckyTruck US 60 – Charleston, West Virginia
- Bus. US 60 – Clifton Forge, Virginia
- Truck US 60 - Richmond, VirginiaBus. US 60 – Williamsburg, VirginiaBus. US 60 – Newport News, Virginia
- Alt. US 60 - Norfolk, Virginia
US 61
- Bus. US 61 - Baton Rouge, LouisianaByp. US 61 - Baton Rouge, LouisianaBus. US 61 - St. Francisville, Louisiana
- Bus. US 61 - Natchez, Mississippi
- Bus. US 61 - Port Gibson, Mississippi
- Bus. US 61 - Vicksburg, Mississippi
- Bus. US 61 - Leland, Mississippi
- Bus. US 61 - Merigold to Shelby, MississippiBus. US 61 - Blytheville, ArkansasBus. US 61 - Holland to Steele, Missouri
- Spur US 61 - New Madrid, Missouri
- Bus. US 61 - Sikeston, MissouriBus. US 61 - Cape Girardeau, MissouriCity US 61 - Cape Girardeau, Missouri
- Bus. US 61 - Bowling Green, Missouri
- Spur US 61 - Bowling Green, Missouri
- Bus. US 61 - New London, Missouri
- Bus. US 61 - Hannibal, MissouriCity US 61 - Hannibal, Missouri
- Bus. US 61 - Palmyra, Missouri
- Bus. US 61 - La Grange, Missouri
- Bus. US 61 - Canton, Missouri
- Bus. US 61 - Keokuk, Iowa
- Bus. US 61 - Jefferson Township to Washington Township, Iowa
- Bus. US 61 - Muscatine, Iowa
- Bus. US 61 - Davenport, Iowa
- Bus. US 61 - Maquoketa, Iowa
US 62
- Bus. US 62 - Snyder, OklahomaTemp. US 62 - Lawton, OklahomaTemp. US 62 - Oklahoma City, Oklahoma
- Bus. US 62 - Henryetta, Oklahoma
- Bus. US 62 - Muskogee, Oklahoma
- Bus. US 62 - Tahlequah, OklahomaUS 62B - Fayetteville, ArkansasUS 62B - Rogers, ArkansasUS 62B - Eureka Springs, ArkansasCity US 62 - Eureka Springs, Arkansas
- US 62S - Berryville, Arkansas
- US 62S - Pyatt, Arkansas
- US 62B - Yellville, Arkansas
- US 62B - Cotter, Arkansas
- US 62B - Mountain Home, Arkansas
- US 62B - Prairie Grove, Arkansas
- US 62B - Salem, ArkansasCity US 62 - Sikeston, MissouriTemp. US 62 - Dawson Springs to Nortonville, Kentucky
- Truck US 62 - Elizabethtown, Kentucky
- Truck US 62 - Lawrenceburg, Kentucky
- Bus. US 62 - Maysville, KentuckyTemp. US 62 - Alliance, Ohio
- Bus. US 62 - Sharon, PennsylvaniaByp. US 62 - Sharon, Pennsylvania
- Bus. US 62 - Niagara Falls, New York
US 63
US 63S - Moro Bay, Arkansas- US 63B - Hermitage, Arkansas
- US 63B - Warren, Arkansas
- US 63B - Pine Bluff, ArkansasUS 63S - Hazen, Arkansas
- US 63B - Marked Tree, ArkansasUS 63C - Trumann, ArkansasUS 63B - Jonesboro, Arkansas
- US 63B - Bono, Arkansas
- US 63B - Hoxie, Arkansas
- US 63B - Hardy, Arkansas
- Bus. US 63 - Thayer, Missouri
- Bus. US 63 - West Plains, Missouri
- Bus. US 63 - Willow Springs, Missouri
- Bus. US 63 - Cabool, MissouriBus. US 63 - Columbia, Missouri
- Conn. US 63 - Columbia, MissouriSpur US 63 - Columbia, Missouri
- Bus. US 63 - Renick to Moberly, Missouri
- Bus. US 63 - Kirksville, MissouriCity US 63 - Kirksville, Missouri
- Bus. US 63 - Ottumwa, Iowa
- Bus. US 63 - New Hampton, Iowa
US 64
- Bus. US 64 - Farmington, New MexicoBus. US 64 - Enid, Oklahoma
- Bus. US 64 - Muskogee, Oklahoma
- US 64B - Alma, ArkansasCity US 64 - Alma, Arkansas
- US 64B - Vilonia, ArkansasUS 64B - Beebe, ArkansasCity US 64 - Beebe, Arkansas
- US 64B - Augusta, Arkansas
- US 64B - Patterson to McCrory, Arkansas
- US 64B - Wynne, ArkansasCity US 64 - Wynne, Arkansas
- US 64S - Wynne, Arkansas
- US 64B - Parkin, Arkansas
- US 64B - Earle, Arkansas
- US 64B - Crawfordsville, Arkansas
- Bus. US 64 - Whiteville, Tennessee
- Bus. US 64 - Selmer, Tennessee
- Truck US 64 - Savannah, Tennessee
- Byp. US 64 - Waynesboro, Tennessee
- Bus. US 64 - Lawrenceburg, Tennessee
- Bus. US 64 - Pulaski, Tennessee
- Bus. US 64 - Fayetteville, Tennessee
- Byp. US 64 - Fayetteville, Tennessee
- Bus. US 64 - Winchester to Monteagle, TennesseeBus. US 64 - Chattanooga, Tennessee
- Byp. US 64 - Cleveland, Tennessee
- Alt. US 64 - southeast of Murphy, North Carolina
- Bus. US 64 - Hayesville, North Carolina
- Truck US 64 - Franklin, North Carolina to Hendersonville, North CarolinaBus. US 64 - Rosman, North CarolinaUS 64A - Brevard, North CarolinaBus. US 64 (1960–1980) - Brevard, North Carolina
- Bus. US 64 (2006–) - Brevard, North CarolinaUS 64A - Bat Cave to Morganton, North Carolina
- Bus. US 64 - Morganton, North Carolina
- Byp. US 64 - Morganton, North Carolina
- Truck US 64 - Morganton, North CarolinaUS 64A - Statesville, North CarolinaBus. US 64 - Statesville, North Carolina
- Bus. US 64 - Asheboro, North CarolinaUS 64A - Franklinville to Ramseur, North CarolinaUS 64A - Siler City, North Carolina
- Bus. US 64 - Pittsboro, North CarolinaBus. US 64 - Raleigh, North Carolina
- Bus. US 64 - Raleigh to Zebulon, North Carolina
- Alt. US 64 - Spring Hope to Nashville, North Carolina
- Bus. US 64 - Nashville, North CarolinaUS 64A - Rocky Mount, North Carolina
- Alt. US 64 - Rocky Mount to Tarboro, North Carolina
- Bus. US 64 - Rocky Mount, North CarolinaBus. US 64 - Tarboro to Princeville, North Carolina
- Alt. US 64 - Princeville to Williamston, North CarolinaUS 64A - Williamston, North CarolinaBus. US 64 - Williamston, North Carolina
- Bus. US 64 - Jamesville, North CarolinaAlt. US 64 - Roper, North CarolinaUS 64A - Columbia, North Carolina
- Bus. US 64 - Columbia, North Carolina
- Byp. US 64 - Manns Harbor to Manteo, North Carolina
US 65
Byp. US 65 – Baton Rouge, Louisiana- US 65B – Pine Bluff, ArkansasCity US 65 – Pine Bluff, ArkansasUS 65S – Pine Bluff, Arkansas
- US 65B – Conway, Arkansas
- US 65B – Clinton, Arkansas
- US 65B – Western Grove, Arkansas
- US 65B – Harrison, Arkansas
- Spur US 65 – Tina, Missouri
- Bus. US 65 – Point Lookout to Branson, Missouri
- Bus. US 65 – Ozark, Missouri
- Bus. US 65 – Springfield, MissouriByp. US 65 – Springfield, Missouri
- Spur US 65 – Warsaw, Missouri
- Bus. US 65 – Marshall, Missouri
- Bus. US 65 – Carrollton, Missouri
- Bus. US 65 – Trenton, MissouriCity US 65 – Trenton, Missouri
''US 66''
Alt. US 66 - Los Angeles to Pasadena, CaliforniaBus. US 66 - San Bernardino, CaliforniaCity US 66 - San Bernardino, CaliforniaBus. US 66 - Flagstaff, ArizonaBus. US 66 - Amarillo, TexasCity US 66 - Amarillo, TexasBus. US 66 - Clinton, OklahomaCity US 66 - Clinton, OklahomaAlt. US 66 - Oklahoma City, OklahomaBus. US 66 - Oklahoma City, OklahomaCity US 66 - Oklahoma City, OklahomaBus. US 66 - Tulsa, OklahomaByp. US 66 - Tulsa, OklahomaAlt. US 66 - Joplin, MissouriBus. US 66 - Joplin, MissouriByp. US 66 - Joplin, MissouriAlt. US 66 - Joplin to Webb City, MissouriBus. US 66 - Webb City to Carterville, MissouriAlt. US 66 - Carthage to Kendricktown, MissouriBus. US 66 - Carthage, MissouriAlt. Bus. US 66 - Springfield, MissouriBus. US 66 - Springfield, MissouriByp. US 66 - Springfield, MissouriCity US 66 - Springfield, MissouriBus. US 66 - Lebanon, MissouriBus. US 66 - Waynesville, MissouriSpur US 66 - Fort Leonard Wood, MissouriBus. US 66 - Rolla, MissouriCity US 66 - Rolla, MissouriBus. US 66 - Pacific, MissouriBus. US 66 - St. Louis to Sunset Hills, MissouriByp. US 66 - St. Louis to Sunset Hills, MissouriOpt. US 66 - St. Louis, Missouri to Venice, IllinoisCity US 66 - St. Louis, Missouri to Mitchell, IllinoisCity US 66 - Kirkwood to Bellefontaine Neighbors, MissouriBus. US 66 - East St. Louis to Mitchell, IllinoisTemp. US 66 - Livingston to Springfield, IllinoisBus. US 66 - Springfield, IllinoisCity US 66 - Springfield, IllinoisBus. US 66 - Lincoln, IllinoisCity US 66 - Lincoln, IllinoisBus. US 66 - Bloomington, IllinoisCity US 66 - Bloomington, IllinoisAlt. US 66 - Gardner to Bolingbrook, IllinoisAlt. US 66 - Joliet, IllinoisUS 67
- Bus. US 67 - Presidio, Texas
- Bus. US 67 - San Angelo, Texas
- Bus. US 67 - San Angelo, Texas
- Bus. US 67 - Dublin, Texas
- Bus. US 67 - Stephenville, Texas
- Bus. US 67 - Cleburne, Texas
- Bus. US 67 - Alvarado, TexasBus. US 67 - Midlothian, TexasBus. US 67 - Dallas, TexasBus. US 67 - Greenville, Texas
- Bus. US 67 - Sulphur Springs, Texas
- US 67B - Beebe, Arkansas
- US 67B - Searcy, ArkansasCity US 67 - Searcy, ArkansasCity US 67 - Judsonia, Arkansas
- US 67B - Hoxie to Walnut Ridge, Arkansas
- US 67C - Walnut Ridge, Arkansas
- US 67B - Pocahontas, Arkansas
- US 67B - Biggers, Arkansas
- US 67S - Biggers, ArkansasUS 67B - Reyno, Arkansas
- US 67B - Datto, Arkansas
- US 67S - Datto, Arkansas
- Bus. US 67 - Poplar Bluff, Missouri
- Bus. US 67 - Greenville, Missouri
- Bus. US 67 - Fredericktown, Missouri
- Bus. US 67 - Leadington to Park Hills, MissouriAlt. US 67 - Mehlville, Missouri to Alton, IllinoisByp. US 67 - Mehlville, Missouri to Alton, IllinoisByp. US 67 - Mehlville to Bellefontaine, MissouriAlt. US 67 - Godfrey to Murrayville, Illinois
- Bus. US 67 - Jacksonville, Illinois
- Bus. US 67 - Roseville, Illinois
- Byp. US 67 - Roseville, Illinois
- Alt. US 67 - Riverdale to Le Claire, Iowa
US 68
- Bus. US 68 – Cadiz, Kentucky
- Byp. US 68 – Hopkinsville, Kentucky
- Truck US 68 - Hopkinsville, Kentucky
- Alt. US 68 – Fairview, Kentucky
- Bus. US 68 – Elkton, Kentucky
- Bus. US 68 – Russellville, Kentucky
- Bus. US 68 – Auburn, Kentucky
- Alt. US 68 – Bowling Green, Kentucky
- Bus. US 68 – Bowling Green, Kentucky
- Bus. US 68 – Glasgow, Kentucky
- Truck US 68 - Glasgow, KentuckyBus. US 68 – Lexington, Kentucky
- Bus. US 68 – Paris, KentuckyByp. US 68 – Paris, Kentucky
- Alt. US 68 – Maysville, Kentucky to Aberdeen, Ohio
- Bus. US 68 – Maysville, Kentucky to Aberdeen, OhioByp. US 68 – Springfield, Ohio
US 69
- Bus. US 69 - Lufkin, Texas
- Bus. US 69 - Greenville, Texas
- Bus. US 69 - Trenton, Texas
- Bus. US 69 - Durant, Oklahoma
- Bus. US 69 - McAlester, Oklahoma
- Bus. US 69 - Eufaula, Oklahoma
- Bus. US 69 - Checotah, Oklahoma
- Bus. US 69 - Vinita, Oklahoma
- Bus. US 69 - Miami, OklahomaCity US 69 - Commerce, Oklahoma
- Alt. US 69 - south of Picher, Oklahoma to north of Crestline, Kansas
- Bus. US 69 - Baxter Springs, Kansas
- Bus. US 69 - Columbus, Kansas
- Bus. US 69 - Pittsburg, Kansas
- Bus. US 69 - Frontenac, Kansas
- Bus. US 69 - Franklin to Arma, KansasBus. US 69 - Fort Scott, Kansas
- Bus. US 69 - Overland Park, KansasBus. US 69 - Excelsior Springs, Missouri
- Spur US 69 - Bethany, Missouri
US 70
Bus. US 70 - Pomona, CaliforniaBus. US 70 - Banning, CaliforniaBus. US 70 - Superior, Arizona- Bus. US 70 - Alamogordo, New MexicoBus. US 70 - Ruidoso, New Mexico
- Truck US 70 - Roswell, New MexicoBus. US 70 - Portales, New MexicoAlt. US 70 - Wilson, OklahomaCity US 70 - Wilson, Oklahoma
- Byp. US 70 - Durant, OklahomaTruck US 70 - Durant, Oklahoma
- Bus. US 70 - Hugo, Oklahoma
- Byp. US 70 - Idabel, Oklahoma
- US 70B - De Queen, ArkansasTemp. US 70 - Lockesburg to Kirby, Arkansas
- US 70B - Glenwood, Arkansas
- US 70B - Hot Springs, ArkansasCity US 70 - Hot Springs, ArkansasCity US 70 - Benton, ArkansasUS 70B - Little Rock to North Little Rock, Arkansas
- US 70A - Brownsville to Huntingdon, Tennessee
- Byp. US 70A - Humboldt, Tennessee
- Bus. US 70 - Huntingdon, Tennessee
- Bus. US 70 - Camden, Tennessee
- Bus. US 70 - Dickson, Tennessee
- Bus. US 70 - Lebanon, Tennessee
- Bus. US 70S - McMinnville, Tennessee
- Bus. US 70 - Marshall, North CarolinaUS 70A - Morganton, North Carolina
- Bus. US 70 - Morganton, North CarolinaUS 70A (1946–1948) - Hildebran to Conover, North CarolinaUS 70A (1948–1957) - Hildebran to ConoverUS 70A - Salisbury, North CarolinaUS 70A - Lexington, North CarolinaBus. US 70 - Lexington, North CarolinaBus. US 70 - Thomasville, North CarolinaUS 70A - High Point to Greensboro, North CarolinaUS 70A (1934–1948) - High Point, North CarolinaUS 70A (1948–1957) - High Point, North CarolinaUS 70A - Greensboro, North CarolinaUS 70A (1942–1948) - Hillsborough, North CarolinaUS 70A (1948–1960) - Hillsborough, North Carolina
- Bus. US 70 - Hillsborough, North CarolinaUS 70A - Durham to Raleigh, North CarolinaUS 70A - Durham, North Carolina
- Bus. US 70 - Durham, North CarolinaBus. US 70 - Garner, North Carolina
- Bus. US 70 - Clayton to Smithfield, North CarolinaUS 70A - Smithfield, North Carolina
- Byp. US 70 - Selma, North Carolina
- US 70A - Selma to near Princeton, North Carolina, via [Pine Level, Johnston, Rhode Island|Johnston County, North Carolina|Pine Level]US 70A - Goldsboro, North Carolina
- Bus. US 70 - Goldsboro, North Carolina
- Byp. US 70 - Goldsboro, North CarolinaUS 70A - Kinston, North Carolina
- Bus. US 70 - Kinston, North Carolina
- Bus. US 70 - New Bern, North CarolinaBus. US 70 - Beaufort, North Carolina
US 71
Bus. US 71 – Alexandria, Louisiana- Byp. US 71 – Alexandria, Louisiana
- US 71B – Waldron, Arkansas
- US 71B – Fort Smith to Alma, Arkansas
- US 71B – Fayetteville to Bentonville, ArkansasUS 71S – Fayetteville, ArkansasUS 71B – Bentonville, ArkansasCity US 71 – Bentonville, ArkansasTemp. US 71 – Bentonville, Arkansas to Lanagan, Missouri
- Byp. US 71 - Douglas County, MO to Bella Vista, AR
- Alt. US 71 – Pineville to Anderson, MissouriBus. US 71 – Neosho, MissouriAlt. US 71 – Neosho to Carthage, MissouriOpt. US 71 – Neosho to Carthage, MissouriBus. US 71 – Saginaw to Webb City, Missouri, via Joplin
- Spur US 71 – Milo, MissouriBus. US 71 – Nevada, MissouriBus. US 71 – Butler to Passaic, MissouriBus. US 71 – Kansas City, MissouriCity US 71 – Kansas City, MissouriByp. US 71 – Harrisonville to Ferrelview, Missouri, via Kansas City, MissouriByp. US 71 – Tracy, MissouriByp. US 71 – Platte City, MissouriCity US 71 – Faucett to St. Joseph, Missouri
- Bus. US 71 – St. Joseph to Savannah, Missouri
- Bus. US 71 – Maryville, Missouri
- Bus. US 71 – Clarinda, Iowa
- Bus. US 71 – Storm Lake, Iowa
- Bus. US 71 – Willmar, Minnesota
- Byp. US 71 – Willmar, Minnesota
US 72
Bus. US 72 – Tuscumbia, Alabama- Alt. US 72 – Muscle Shoals to Huntsville, Alabama
- Bus. US 72 – Athens, Alabama
- Bus. US 72 – Scottsboro, Alabama
US 73
Alt. US 73 – Kansas City, Kansas- Truck US 73 – Leavenworth, Kansas
US 74
- US 74A - Asheville to Forest City, North CarolinaUS 74A - Rutherfordton, North Carolina
- Bus. US 74 - Rutherfordton to Mooresboro, North Carolina, via Forest CityUS 74A - Shelby, North Carolina
- Bus. US 74 - Shelby, North CarolinaByp. US 74 - Shelby, North Carolina
- Bus. US 74 - Kings Mountain, North CarolinaUS 74A - Bessemer City, North Carolina
- Byp. US 74 - Stallings to Wingate, North CarolinaUS 74A (1949–1952) - Monroe, North CarolinaUS 74A (1952–1954) - Monroe, North CarolinaUS 74A - Rockingham, North Carolina
- Bus. US 74 - Rockingham to Hamlet, North Carolina
- Bus. US 74 - Laurinburg to Maxton, North Carolina
- Alt. US 74 - Maxton to Lumberton, North Carolina
- Bus. US 74 - Chadbourn to Whiteville, North CarolinaTemp. US 74 - Chadbourn, North CarolinaUS 74A - Leland, North CarolinaUS 74A - Wrightsville Beach, North Carolina
US 75
Temp. US 75 - Galveston to Houston, TexasBus. US 75 - Houston, TexasBus. US 75 - Sherman to Denison, Texas- Bus. US 75 - Durant, Oklahoma
- Bus. US 75 - Henryetta, Oklahoma
- Alt. US 75 - Beggs to Sapulpa, OklahomaTemp. US 75 - Oakhurst to Owasso, OklahomaTemp. US 75 - Oakhurst to Owasso, OklahomaBus. US 75 - Tulsa, Oklahoma
- Bus. US 75 - Altoona, KansasAlt. US 75 - Wakarusa to North Topeka, Kansas
- Bus. US 75 - Topeka, KansasByp. US 75 - Topeka, KansasAlt. US 75 - North Topeka to Hoyt, Kansas
- Bus. US 75 - Nebraska City, Nebraska
- Bus. US 75 - Sioux City, Iowa
- Bus. US 75 - Le Mars, Iowa
US 76
Bus. US 76 – Dalton, Georgia- Truck US 76 – Ringgold, GeorgiaAlt. US 76 – Long Creek, South CarolinaBus. US 76 – Seneca, South Carolina
- Bus. US 76 – Laurens, South CarolinaBus. US 76 – Newberry, South CarolinaByp. US 76 – Newberry, South CarolinaAlt. US 76 – Columbia, South Carolina
- Conn. US 76 – Columbia, South Carolina
- Bus. US 76 – Sumter, South CarolinaByp. US 76 – Sumter, South CarolinaAlt. US 76 – Mayesville, South CarolinaAlt. US 76 – Florence County, South Carolina
- Conn. US 76 – Florence, South CarolinaAlt. US 76 – Marion, South Carolina
- Bus. US 76 – Chadbourn to Whiteville, North CarolinaTemp. US 76 - Chadbourn, North Carolina
US 77
- Bus. US 77-Z – Brownsville, Texas
- Bus. US 77-X – Harlingen, Texas
- Bus. US 77-W – Sebastian to Raymondville, Texas
- Bus. US 77-V II – Riviera, Texas
- Bus. US 77-V – Kingsville to Bishop, Texas
- Bus. US 77-U – Driscoll, Texas
- Bus. US 77-U II – Robstown, Texas
- Bus. US 77-T – Sinton, Texas
- Alt. US 77 – Refugio to Hallettsville, Texas
- Bus. US 77-S – Victoria, Texas
- Alt. Bus. US 77-Q – Yoakum, Texas
- Bus. US 77-L – Waco to Lacy Lakeview, TexasBus. US 77-H – Dallas, TexasBus. US 77 – Ardmore, OklahomaAlt. US 77 – Oklahoma City, OklahomaBus. US 77 – Perry, OklahomaAlt. US 77 – Ponca City, OklahomaBus. US 77 – Ponca City, OklahomaCity US 77 – Ponca City, OklahomaBus. US 77 – Arkansas City, Kansas
- Byp. US 77 – Arkansas City, Kansas
- Truck US 77 – Arkansas City, KansasBus. US 77 – Herington, KansasBus. US 77 – Junction City, Kansas
US 78
Bus. US 78 – Red Banks, MississippiBus. US 78 – Hickory Flat, MississippiAlt. US 78 – Hamilton to Graysville, AlabamaAlt. US 78 – Carbon Hill to Jasper, AlabamaAlt. US 78 – Birmingham to Irondale, AlabamaTruck US 78 – Birmingham, Alabama- Truck US 78 – Leeds, AlabamaBus. US 78 – Anniston, AlabamaAlt. US 78 – Heflin, Alabama, to Villa Rica, Georgia
- Bus. US 78 – Athens, Georgia
- Bus. US 78 – Washington, GeorgiaAlt. US 78 – Aiken, South Carolina
- Truck US 78 – Aiken, South CarolinaAlt. US 78 – Williston, South Carolina
- Conn. US 78 – Blackville, South Carolina
- Bus. US 78 – Blackville, South Carolina
- Conn. US 78 - Southwest of Branchville, South Carolina
US 79
Bus. US 79-A – Austin, TexasBus. US 79-B – Taylor, Texas- Bus. US 79-F – Henderson, Texas
- Bus. US 79-G – Carthage, Texas
- Truck US 79 – Minden, Louisiana
- Byp. US 79 – Homer, Louisiana
- US 79B – Magnolia, ArkansasUS 79C – McNeil, Arkansas
- US 79B – Camden, Arkansas
- US 79B – Bearden, Arkansas
- Alt. US 79 – Thornton to Fordyce, Arkansas
- US 79B – Thornton, Arkansas
- US 79B – Fordyce, Arkansas
- US 79B – Pine Bluff to Altheimer, Arkansas
- US 79B – Stuttgart, ArkansasUS 79C – Stuttgart, Arkansas
- Bus. US 79 – Clarendon, Arkansas
- Bus. US 79 – Brownsville, Tennessee
- Byp. US 79 – Humboldt, Tennessee
US 80
Bus. US 80 - San Diego, CaliforniaBus. US 80 - Winterhaven, California to Yuma, ArizonaAlt. US 80 - Phoenix, ArizonaAlt. US 80 - Phoenix, ArizonaByp. US 80 - Phoenix, ArizonaBus. US 80 - Tucson, ArizonaTruck US 80 - Tombstone, ArizonaTemp. US 80 - Sierra Vista to Bisbee, ArizonaAlt. US 80 - Las Cruces to Anthony, New MexicoAlt. US 80 - El Paso, TexasBus. US 80 - El Paso, TexasBus. US 80 - Sierra Blanca, TexasBus. US 80 - Van Horn, TexasBus. US 80 - Odessa to Midland, TexasBus. US 80 - Big Spring, TexasBus. US 80 - Colorado City, TexasBus. US 80 - Sweetwater, TexasAlt. US 80 - Abilene to Weatherford, TexasBus. US 80 - Abilene, TexasBus. US 80 - Fort Worth, TexasBus. US 80 - Dallas, Texas- Truck US 80 - Minden, Louisiana
- Truck US 80 - Gibsland, Louisiana
- Truck US 80 - Arcadia, LouisianaBus. US 80 - Meridian, Mississippi
- Bus. US 80 - Selma, Alabama
- Truck US 80 - Selma, AlabamaBus. US 80 - Montgomery, AlabamaTemp. US 80 - Columbus to Crystal Valley, GeorgiaToll US 80 - Savannah to Whitemarsh Island, Georgia
US 81
Bus. US 81 - Lytle, TexasBus. US 81 - San Antonio, Texas Bus. US 81 - Austin, TexasBus. US 81 - Waco, TexasAlt. US 81 - Fort Worth, TexasBus. US 81 - Fort Worth, Texas- Bus. US 81 - Rhome, Texas
- Bus. US 81 - Decatur, Texas
- Bus. US 81 - Alvord, TexasAlt. US 81 - Waurika, OklahomaCity US 81 - Duncan, Oklahoma
- Bus. US 81 - Rush Springs, OklahomaByp. US 81 - Wichita, KansasTruck US 81 - Wichita, Kansas
- Bus. US 81 - McPherson, KansasByp. US 81 - McPherson, Kansas – now K-153, but county-installed street signs still reference Byp. US 81.
- Bus. US 81 - Lindsborg, KansasAlt. US 81 - Salina to Minneapolis, KansasCity US 81 - Salina, Kansas
- Bus. US 81 - Fargo, North Dakota
- Bus. US 81 - Grand Forks, North Dakota
US 82
- Truck US 82 - Artesia, New Mexico
- Truck US 82 - Lovington, New Mexico
- Bus. US 82 - Wolfforth, Texas
- Bus. US 82 - Holliday, TexasBus. US 82 - Wichita Falls, Texas
- Bus. US 82 - Paris, Texas
- Bus. US 82 - Clarksville, Texas
- Bus. US 82 - Avery, TexasUS 82T - Stamps, Arkansas
- US 82B - Magnolia, Arkansas
- US 82B - El Dorado, Arkansas
- US 82S - Felsenthal National Wildlife Refuge in Ashley County, Arkansas
- US 82B - Montrose, Arkansas
- US 82S - Montrose, Arkansas
- Bus. US 82 - Eupora, MississippiByp. US 82 - Tuscaloosa, AlabamaAlt. US 82 - Montgomery to Prattville, AlabamaBus. US 82 - Montgomery, AlabamaByp. US 82 (1961–1965) - Montgomery, AlabamaByp. US 82 (1965–1975) - Montgomery, AlabamaCity US 82 - Montgomery, AlabamaTruck US 82 - Montgomery, Alabama
- Bus. US 82 - Albany, Georgia
US 83
- Bus. US 83 – Harlingen to Peñitas, Texas, via McAllen, Texas
- Bus. US 83 – San Ygnacio, TexasBus. US 83 – Laredo, TexasTemp. US 83 – Uvalde to Junction, TexasTemp. US 83 – Big Paint to Junction, Texas
- Bus. US 83 – Abilene, Texas
- Bus. US 83 – Garden City, KansasSpur US 83 – Garden City, Kansas
- Byp. US 83 – Oakley, Kansas
- Bus. US 83 – Pierre, South Dakota
- Byp. US 83 – Pierre, South Dakota
- Bus. US 83 – Minot, North Dakota
- Byp. US 83 – Minot, North Dakota
US 84
- Bus. US 84 – Slaton, Texas
- Bus. US 84 – Snyder, Texas
- Bus. US 84 – Hermleigh, Texas
- Bus. US 84 – Roscoe, TexasBus. US 84 – Abilene, TexasBus. US 84 – Waco, Texas
- Bus. US 84 – Teague, TexasBus. US 84 – Natchez, Mississippi
- Bus. US 84 – Enterprise, Alabama
- Truck US 84 – Enterprise, Alabama
- Bus. US 84 – Dothan, Alabama
- Bus. US 84 – Bainbridge, Georgia
- Bus. US 84 – Thomasville, Georgia
US 85
Bus. US 85 – El Paso, TexasAlt. US 85 – Anthony to Las Cruces, New MexicoByp. US 85 – Santa Fe, New MexicoAlt. US 85 – Barelas to Alameda, New MexicoByp. US 85 – Fountain to Colorado Springs, Colorado- Bus. US 85 – Brighton, Colorado
- Bus. US 85 – Fort Lupton, Colorado
- Bus. US 85 – Platteville, Colorado
- Bus. US 85 – Greeley, ColoradoAlt. US 85 – Mule Creek Junction, Wyoming to Lead, South Dakota
- Truck US 85 – Lead to Deadwood, South Dakota
- Byp. US 85 – Pierre, South Dakota
- Bus. US 85 - Watford City, North Dakota
- Bus. US 85 - Alexander, North DakotaBus. US 85 – Williston, North Dakota
- US 85B – Williams County, North Dakota
US 87
- Bus. US 87 - Stockdale, TexasBus. US 87 - San Antonio, Texas
- Bus. US 87 - Big Spring, Texas
- Bus. US 87 - Lamesa, TexasBus. US 87 - Woodrow, TexasBus. US 87 - Lubbock, Texas
- Bus. US 87 - New Deal, TexasBus. US 87 - Plainview, Texas
- Bus. US 87 - Dalhart, TexasTemp. US 87 - Denver, Colorado
- Bus. US 87 - Cheyenne, Wyoming
- Bus. US 87 - Wheatland, Wyoming
- Bus. US 87 - Douglas, Wyoming
- Bus. US 87 - Casper, Wyoming
- Bus. US 87 - Buffalo, Wyoming
- Bus. US 87 - Sheridan, Wyoming
- Byp. US 87 - Great Falls, Montana
- Byp. US 87 - Lewistown, Montana
US 89
Bus. US 89 – Florence, ArizonaUS 89A – Prescott, ArizonaUS 89A – Prescott to Flagstaff, ArizonaSpur US 89A – Prescott, ArizonaTemp. US 89 – Prescott, ArizonaTruck US 89 – Prescott, Arizona- Spur US 89 – Flagstaff, ArizonaTemp. US 89 – Cameron to Cedar Ridge, Arizona
- Truck US 89 – Cameron, ArizonaUS 89T – Northwest of Tuba City to Page, ArizonaBus. US 89 – Page, ArizonaSpur US 89 – Page, Arizona
- US 89A – Bitter Springs, Arizona to Kanab, UtahUS 89A – Salt Lake CityUS 89A – North Salt Lake to Farmington, UtahTemp. US 89 – Garden City, Utah to Hoback, WyomingByp. US 89 – Great Falls, Montana
US 90
- Alt. US 90 - Seguin to Houston, Texas
- Bus. US 90 - Houston to Barrett, TexasBus. US 90 - Beaumont, TexasBus. US 90 - Houston, TexasByp. US 90 - Houston, Texas
- Bus. US 90 - Orange to Pinehurst, Texas
- Bus. US 90 - Lake Charles, Louisiana
- Bus. US 90 - Lafayette, Louisiana
- Bus. US 90 - Morgan City to Amelia, Louisiana
- Bus. US 90 - Avondale to New Orleans, Louisiana
- Alt. US 90 - Prichard to Mobile, Alabama
- Truck US 90 - Mobile, Alabama
- Alt. US 90 - northwest of Pensacola to Ferry Pass, FloridaAlt. US 90 - Quincy to Tallahassee, Florida
- Alt. US 90 - Jacksonville, Florida
US 91
Bus. US 91 – Corona to Riverside, CaliforniaBus. US 91 – Colton to San Bernardino, CaliforniaBus. US 91 – Victorville, CaliforniaAlt. US 91 – Jean to Las Vegas, NevadaAlt. US 91 – Salt Lake City, UtahAlt. US 91 – North Salt Lake to Farmington, UtahAlt. US 91 – North Salt Lake to Ogden, Utah- Bus. US 91 – McCammon, Idaho
- Bus. US 91 – Inkom, IdahoBus. US 91 – Pocatello, IdahoBus. US 91 – Blackfoot, IdahoBus. US 91 – Idaho Falls, IdahoByp. US 91 – Butte, MontanaBus. US 91 – Helena, Montana
US 92
Bus. US 92 - Lakeland, FloridaUS 93
- Spur US 93 - Kingman, ArizonaAlt. US 93 - Kingman, ArizonaTruck US 93 - Kingman, Arizona to Boulder City, Nevada
- Bus. US 93 - Boulder City, NevadaTruck US 93 - Boulder City, Nevada
- Alt. US 93 - Lages Station to Wells, Nevada, via West WendoverAlt. US 93 - Shoshone to Challis, Idaho, via Arco
- Alt. US 93 - Kalispell, Montana
US 95
Truck US 95 - San Luis, Arizona- Spur US 95 - Parker, ArizonaAlt. US 95 - Las Vegas, Nevada
- Bus. US 95 - Las Vegas, Nevada
- Truck US 95 - Hawthorne, Nevada
- Spur US 95 - Fernley, Nevada
- Alt. US 95 - Schurz to north of Fallon, Nevada via Yerington, Silver Springs, and Fernley, Nevada
- Spur US 95 - Payette, Idaho
- Spur US 95 – Weiser Junction, Oregon to Weiser, Idaho
- Bus. US 95 - Cottonwood, Idaho
- Bus. US 95 - Craigmont, Idaho
- Bus. US 95 - Winchester, Idaho
- Spur US 95 - Lewiston, IdahoBus. US 95 - Potlatch to St. Maries, IdahoAlt. US 95 - Potlach to Wolf Lodge, Idaho, via St. Maries
- Bus. US 95 - Bonners Ferry, Idaho
US 96
US 97
- Bus. US 97 - Klamath Falls, Oregon
- Bus. US 97 - Bend, Oregon
- Bus. US 97 - Redmond, OregonAlt. US 97 - Toppenish to Union Gap, Washington
- Bus. US 97 - Cashmere, Washington
- Alt. US 97 - Wenatchee to Chelan, Washington
- Spur US 97 - Orondo, Washington
- Bus. US 97 - Okanogan to Omak, Washington
US 98
Bus. US 98 – Natchez, Mississippi- Bus. US 98 – Summit to McComb, Mississippi
- Truck US 98 – Mobile, AlabamaTruck US 98 – Spanish Fort, Alabama
- Alt. US 98 – Fairhope to Barnwell, AlabamaAlt. US 98 – Pensacola, Florida
- Bus. US 98 – Pensacola, FloridaToll US 98 – Pensacola to Navarre, FloridaAlt. US 98 – Panama City Beach, Florida – now only State Road 30Byp. US 98 – Panama City Beach, Florida
- Bus. US 98 – Panama City to Parker, FloridaTemp. US 98 – Wakulla to Perry, Florida
- Truck US 98 – Brooksville, FloridaBus. US 98 – Dade City, FloridaTruck US 98 – Dade City, FloridaBus. US 98 – Lakeland, FloridaBus. US 98 – Bartow, FloridaTemp. US 98 – Okeechobee to West Palm Beach, Florida
''US 99''
Bus. US 99 – Banning, CaliforniaBus. US 99 – Pomona, CaliforniaBus. US 99 – Elysian Park to Sylmar, CaliforniaBus. US 99 – Fresno, CaliforniaBus. US 99 – Merced, CaliforniaBus. US 99 – Atwater, CaliforniaAlt. US 99 – Sacramento to Red Bluff, CaliforniaBus. US 99 – Sacramento, CaliforniaBus. US 99 – Gold Hill, OregonBus. US 99 – Green, OregonBus. US 99 – Roseburg, OregonAlt. US 99 – Junction City to Portland, OregonBus. US 99 – Salem, OregonByp. US 99 – Salem, OregonUS 99T – Tukwila, WashingtonAlt. US 99 – Riverton Heights to Seattle, WashingtonAlt. US 99 – Georgetown to Seattle, WashingtonBus. US 99 – SeattleByp. US 99 – SeattleAlt. US 99 – Fairmont to Everett, WashingtonAlt. US 99 – Burlington to Bellingham, WashingtonAlt. US 99 – Bellingham, Washington to the Canada–US borderUS 101
Bus. US 101 – Chula Vista to National City, CaliforniaBus. US 101 – San DiegoAlt. US 101 – Capistrano Beach to Oxnard, CaliforniaBus. US 101 – Buena Park, CaliforniaBus. US 101 – Anaheim, CaliforniaAlt. US 101 – Long Beach, CaliforniaBus. US 101 – Los AngelesByp. US 101 – Anaheim to Los Angeles, CaliforniaAlt. US 101 – Santa Monica, CaliforniaBus. US 101 – Universal City to Woodland Hills, California- Bus. US 101 – Ventura, California
- Bus. US 101 – Santa Maria, California
- Bus. US 101 – Arroyo Grande, California
- Bus. US 101 – Paso Robles, California
- Bus. US 101 – King City, California
- Bus. US 101 – Greenfield, California
- Bus. US 101 – Soledad, California
- Bus. US 101 – Gonzales, California
- Bus. US 101 – Salinas, California
- Bus. US 101 – Gilroy to San Jose, California
- Byp. US 101 – San Jose to San Francisco, CaliforniaAlt. US 101 – San Francisco, California
- Bus. US 101 – Novato, California
- Bus. US 101 – Petaluma, California
- Bus. US 101 – Santa Rosa, California
- Bus. US 101 – Cloverdale, California
- Bus. US 101 – Ukiah, California
- Bus. US 101 – Rio Dell, California
- Bus. US 101 – Fortuna, California
- Bus. US 101 – McKinleyville, California
- Bus. US 101 – Warrenton to Astoria, Oregon
- Alt. US 101 – Ilwaco, WashingtonAlt. US 101 – Long Beach, Washington
- Truck US 101 – Port Angeles, Washington
US 102 – US 199
''US 104''
Alt. US 104 – Niagara Falls, New York''US 111''
Alt. US 111 – Parkton, Maryland to York, Pennsylvania''US 112''
US 112S – Rolling Prairie, Indiana to Union, MichiganBus. US 112 – Niles, MichiganBus. US 112 – Ypsilanti, MichiganByp. US 112 – Ypsilanti, MichiganUS 113
US 117
- Temp. US 117 - Wilmington to Castle Hayne, North CarolinaAlt. US 17 - Burgaw, North Carolina
- Bus. US 117 - Burgaw, North Carolina
- Conn. US 17 - Calypso, North CarolinaBus. US 117 - Calypso to Mount Olive, North Carolina
- Alt. US 117 - Calypso to Brogden, North Carolina
- Conn. US 117 - Calypso, North Carolina
- Alt. US 117 - Goldsboro, North Carolina
- Bus. US 117 - Goldsboro, North CarolinaAlt. US 117 - Goldsboro to Wilson, North Carolina
US 119
- Spur US 119 – Williamson, West Virginia
- Spur US 119 – Charleston, West VirginiaTruck US 119 – Uniontown, PennsylvaniaAlt. US 119 – Greensburg, Pennsylvania
US 123
Bus. US 123 – Seneca, South CarolinaBus. US 123 – Easley, South CarolinaUS 127
- Bus. US 127 - Albany, Kentucky
- Bus. US 127 - Jamestown, KentuckyBus. US 127 - Hustonville, Kentucky
- Byp. US 127 - Danville, Kentucky
- Byp. US 127 - Harrodsburg, Kentucky
- Byp. US 127 - Lawrenceburg, Kentucky
- Truck US 127 - Cincinnati, OhioAlt. US 127 - Hamilton, OhioBus. US 127 - Greenville, Ohio
- Bus. US 127 - Summit Township to Blackman Charter Township, MichiganBus. US 127 - Mason, Michigan
- Bus. US 127 - Lansing to DeWitt Charter Township, Michigan
- Bus. US 127 - [Olive Township, Clinton, Pennsylvania|Clinton County, Michigan|Olive Township] to Bingham Township, Michigan
- Bus. US 127 - Ithaca, Michigan
- Bus. US 127 - Alma, Michigan
- Bus. US 127 - St. Louis to Pine River Township, Michigan
- Bus. US 127 - Union Charter Township to Mount Pleasant, Michigan
- Bus. US 127 - Vernon Township to Clare, Michigan
- Bus. US 127 - Hayes Township to Harrison, Michigan
US 129
Alt. US 129 - Old Town to Branford, FloridaTemp. US 129 - Branford to Live Oak, Florida- Bus. US 129 - Hawkinsville, Georgia
- Alt. US 129 - Hawkinsville to Macon, Georgia, via Cochran
- Bus. US 129 - Eatonton, Georgia
- Byp. US 129 - Madison, Georgia
- Bus. US 129 - Watkinsville, Georgia
- Bus. US 129 - Arcade to Jefferson, GeorgiaAlt. US 129 - Jefferson, Georgia
- Bus. US 129 - Gainesville, GeorgiaByp. US 129 - Gainesville, Georgia
- Byp. US 129 - Cleveland, GeorgiaTruck US 129 - Blairsville, Georgia
US 130
Alt. US 130 – New Brunswick, New Jersey Alt. US 130 – Bridgeport to Thorofare, New JerseyUS 131
- Bus. US 131 - Constantine Township to Constantine, Michigan
- Bus. US 131 - Three Rivers, Michigan
- Bus. US 131 - Kalamazoo, MichiganBus. US 131 - Grand Rapids, MichiganByp. US 131 - Grand Rapids to Plainfield Township, Michigan
- Bus. US 131 - Big Rapids Township to Big Rapids, Michigan
- Bus. US 131 - Cadillac, Michigan
- Bus. US 131 - Cedar Creek Township to Liberty Township, Michigan
US 136
- Bus. US 136 – Albany, Missouri
- Bus. US 136 – Memphis, Missouri
- Spur US 136 – Arbela, Missouri
- Bus. US 136 – Kahoka, Missouri
- Spur US 136 – Wayland, Missouri
US 141
Bus. US 141 – Sheboygan, WisconsinBus. US 141 – Manitowoc, WisconsinUS 150
Bus. US 150 - Peoria, IllinoisCity US 150 - Peoria, IllinoisBus. US 150 - Champaign, IllinoisTemp. US 150 - Ogden to Paris, Illinois- Truck US 150 - Louisville, Kentucky
- Truck US 150 - Bardstown, Kentucky
- Bus. US 150 - Springfield, Kentucky
- Bus. US 150 - Danville, Kentucky
- Byp. US 150 - Danville, Kentucky
- Bus. US 150 - Stanford, Kentucky
- Byp. US 150 - Stanford, Kentucky
US 151
- Bus. US 151 – Cedar Rapids to Marion, Iowa
- Bus. US 151 – Monticello, Iowa
- Bus. US 151 – Cascade, Iowa
- Bus. US 151 – Platteville, Wisconsin
- Bus. US 151 – Mineral Point, WisconsinBus. US 151 – Dodgeville, Wisconsin
- Bus. US 151 – Mount Horeb, Wisconsin
- Bus. US 151 – Verona, Wisconsin
- Bus. US 151 – Sun Prairie, Wisconsin
- Bus. US 151 – Columbus, Wisconsin
- Bus. US 151 – Beaver Dam, Wisconsin
- Bus. US 151 – Waupun, Wisconsin
''US 154''
Spur US 154 - Dodge City, KansasUS 158
Bus. US 158 – Winston-Salem, North CarolinaUS 158A – Oxford, North Carolina- Bus. US 158 – Oxford, North CarolinaUS 158A – Henderson, North Carolina
- Bus. US 158 – Henderson, North CarolinaUS 158A – Warrenton, North Carolina
- Bus. US 158 – Warrenton, North Carolina
- Bus. US 158 – Murfreesboro, North CarolinaUS 158A – Gatesville, North Carolina
- Bus. US 158 – Gatesville, North CarolinaBus. US 158 – Nags Head to Kill Devil Hills, North Carolina
US 160
- Bus. US 160 – Mancos, Colorado
- Bus. US 160 – Durango, Colorado
- Bus. US 160 – Bayfield, Colorado
- Bus. US 160 – Willard, MissouriCity US 160 – Springfield, Missouri
US 165
- Bus. US 165 – Alexandria to Pineville, LouisianaByp. US 165 – Alexandria, Louisiana
- Bus. US 165 – south of Richwood to Monroe, LouisianaByp. US 165 – Monroe, LouisianaUS 165C – Gillett, Arkansas
- US 165B – Gillett, Arkansas
US 166
- Bus. US 166 – Sedan, KansasBus. US 166 – Joplin, MissouriBus. US 166 – Springfield, MissouriCity US 166 – Springfield, MissouriTruck US 166 – Springfield, Missouri
US 167
- Bus. US 167 – Alexandria, Louisiana
- US 167B – El Dorado, Arkansas
- US 167B – Sheridan, Arkansas
- US 167B – Thornton, Arkansas
US 169
Temp. US 169 – Tulsa, Oklahoma- Alt. US 169 – Nowata, Oklahoma
- Bus. US 169 – Garnett, KansasAlt. US 169 – Kansas City, Kansas to Northmoor, Missouri
- Spur US 169 – Smithville, Missouri
- Bus. US 169 – Fort Dodge, Iowa
- Bus. US 169 – Hibbing, Minnesota
- Bus. US 169 – Chisholm, Minnesota
US 171
US 175
Bus. US 175 – Crandall, Texas- Bus. US 175 – Kemp, Texas
- Bus. US 175 – Mabank, Texas
- Bus. US 175 – Athens, Texas
- Bus. US 175 - Poynor, Texas
US 176
Alt. US 176 – Inman, South CarolinaAlt. US 176 – Spartanburg, South Carolina- Conn. US 176 – Spartanburg, South Carolina
- Conn. US 176 – Spartanburg, South CarolinaBus. US 176 – Union, South Carolina
- Conn. US 176 – Union, South Carolina
- Conn. US 176 – Whitmire, South Carolina
US 178
- Conn. US 178 – Northlake, South Carolina
- Bus. US 178 – Greenwood, South CarolinaByp. US 178 – Greenwood, South Carolina
- Conn. US 178 – Saluda, South CarolinaAlt. US 178 – Stedman, South Carolina
- Bus. US 178 – Orangeburg, South CarolinaByp. US 178 – Orangeburg, South Carolina
- Conn. US 178 – Orangeburg, South Carolina
US 180
Alt. US 180 – Hunt to St. Johns, ArizonaBus. US 180 – Eagar, ArizonaBus. US 180 – El Paso, TexasBus. US 180 – Fort Worth, TexasUS 181
- Bus. US 181 – Beeville, Texas
- Bus. US 181 – Kenedy, Texas
- Bus. US 181 – Kenedy, Texas
- Bus. US 181 – Karnes City, Texas
- Bus. US 181 – Karnes City, Texas
US 183
- Bus. US 183 - Gonzales, TexasBus. US 183 - Austin, Texas
- 183A Toll Road - Austin to Leander, TexasTemp. US 183 - Baird to Albany, Texas
- Truck US 183 - Cisco, Texas
- Bus. US 183 - Seymour, TexasAlt. US 183 - Clinton, OklahomaAlt. US 183 - Hays to Big Creek, Kansas
- Byp. US 183 - Hays, Kansas
US 189
Alt. US 189 – Hailstone to Wanship, UtahUS 190
- Bus. US 190 – Copperas Cove, Texas
- Bus. US 190 – Killeen to Harker Heights, Texas
- Bus. US 190 – Heidenheimer, Texas
- Bus. US 190 – Baton Rouge, LouisianaByp. US 190 – Baton Rouge, Louisiana
- Bus. US 190 – Covington, Louisiana
- Bus. US 190 – Slidell, Louisiana
US 191
- Bus. US 191 – Douglas, Arizona
- Spur US 191 – Willcox, Arizona
- Spur US 191 – Bowie, Arizona
- Spur US 191 – Luzena, Arizona
- Spur US 191 – Safford, ArizonaTemp. US 191 – Clifton to Stargo, Arizona
- Bus. US 191 – Helper, Utah
- Bus. US 191 – Lewistown, Montana
US 195
- Spur US 195 – north of Clarkston, Washington to Idaho state line, north of the Clarkston, Washington–Lewiston, Idaho line
- Bus. US 195 – Rosalia, Washington
US 200 – US 299
US 201
- US 201A – Skowhegan to Solon, Maine
- US 201A – Wheeler Hill to Richmond Corner, Maine
US 202
Truck US 202 – Norristown, Pennsylvania- Alt. Truck US 202 - Whitpain Township to Montgomery Township, Pennsylvania
- Bus. US 202 - Montgomeryville to Doylestown, PennsylvaniaTemp. US 202 - Flemington to Bedminster, New Jersey
- Alt. US 202 - Philipstown, New YorkAlt. US 202 - Danbury to Bethel, ConnecticutByp. US 202 - Athol, MassachusettsAlt. US 202 - East Northwood to Rochester, New Hampshire
US 206
US 209
- Truck US 209 - Pottsville to Tamaqua, Pennsylvania
- Truck US 209 - Kresgeville to Brodheadsville, Pennsylvania
- Bus. US 209 - Sciota to Marshalls Creek, Pennsylvania, via Stroudsburg
- Truck US 209 - East Stroudsburg to Marshalls Creek, Pennsylvania
US 211
- Bus. US 211 – Luray, Virginia
- Bus. US 211 – Washington, VirginiaAlt. US 211 – Warrenton to New Baltimore, Virginia
- Bus. US 211 – Warrenton, Virginia
US 212
Byp. US 212 - Billings, Montana- Bus. US 212 - Belle Fourche, South Dakota
US 218
US 219
- Bus. US 219 – Chestnut Ridge, Maryland
- Bus. US 219 – Meyersdale, Pennsylvania
- Alt. US 219 – Carrolltown to Mahaffey, Pennsylvania
- Truck US 219 – Ridgway, Pennsylvania
- Bus. US 219 – southeast of Carrollton to Salamanca, New York
US 220
Bus. US 220 - Ellerbe, North Carolina- Alt. US 220 - Emery to Seagrove, North Carolina
- Bus. US 220 - South of Ulah to Level Cross, North Carolina, via Asheboro
- Bus. US 220 - Madison to Mayodan, North Carolina
- Bus. US 220 - Ridgeway, Virginia
- Bus. US 220 - Martinsville to Collinsville, VirginiaAlt. US 220 - Rocky Mount, Virginia
- Bus. US 220 - Rocky Mount, Virginia
- Alt. US 220 - Roanoke, Virginia
- Bus. US 220 - Roanoke, Virginia
- Bus. US 220 - Clifton Forge, Virginia
- Truck US 220 - La Vale to Cresaptown, Maryland, southbound only, following MD 658 and MD 53
- Bus. US 220 - Bedford, Pennsylvania
- Bus. US 220 - south of Claysburg to Tyrone, Pennsylvania
- Alt. US 220 - Port Matilda to Milesburg, PennsylvaniaTruck US 220 - Williamsport, Pennsylvania
US 221
- Truck US 221 - Perry, Florida
- Truck US 221 - Hazlehurst, GeorgiaByp. US 221 - Greenwood, South CarolinaBus. US 221 - Greenwood, South Carolina
- Truck US 221 - Laurens, South Carolina
- Alt. US 221 - Chesnee, South Carolina to Rutherfordton, North Carolina
- Conn. US 221 - Chesnee, South CarolinaConn. US 221 - Chesnee, South Carolina
- Bus. US 221 - Marion, North Carolina
- Truck US 221 - Linville to Boone, North Carolina
- Bus. US 221 - West Jefferson to Jefferson, North Carolina
- Bus. US 221 - Bedford, Virginia
US 222
US 223
US 224
- Bus. US 224 – Van Wert, Ohio
- Alt. US 224 – Boardman to Poland, Ohio
''US 230''
Byp. US 230 – Harrisburg to Highspire, PennsylvaniaUS 231
- Bus. US 231 – Dothan, Alabama
- Bus. US 231 – Ozark, AlabamaBus. US 231 – Montgomery, AlabamaAlt. US 231 – Sylacauga to Pell City, AlabamaBus. US 231 – Huntsville, Alabama
- Bus. US 231 - Shelbyville, Tennessee
- Truck US 231 – Shelbyville, TennesseeBus. US 231 (1984) – Bowling Green, Kentucky
- Bus. US 231 (1999–present) – Bowling Green, Kentucky
- Truck US 231 – Morgantown, KentuckyByp. US 231 – Lafayette, Indiana
''US 240''
Alt. US 240 – Washington, D.C.Alt. US 240 – Washington, D.C. to Bethesda, MarylandUS 250
- Bus. US 250 – New Philadelphia, OhioTemp. US 250 – Silver Road Junction to Jefferson, Ohio
- Truck US 250 – Philippi, West Virginia
- Truck US 250 – Staunton, VirginiaAlt. US 250 – Charlottesville, Virginia
- Bus. US 250 – Charlottesville, VirginiaByp. US 250 – Charlottesville, Virginia
US 258
- Bus. US 258 – Kinston, North Carolina
- Truck US 258 – Snow Hill, North Carolina
- Bus. US 258 – Farmville, North Carolina
- Bus. US 258 – Franklin, Virginia
- Alt. US 258 – Smithfield, Virginia
- Bus. US 258 – Smithfield, Virginia
- Truck US 258 – Smithfield, Virginia
US 259
''US 260''
Alt. US 260 – Springerville to Eagar, ArizonaUS 264
- Alt. US 264 - west-northwest of Middlesex to Greenville, North CarolinaBus. US 264 - Middlesex to Sims, North CarolinaUS 264A - Wilson, North CarolinaAlt. US 264 - Wilson to Greenville, North CarolinaBus. US 264 - Wilson, North CarolinaUS 264A - Farmville, North CarolinaAlt. US 264 - Farmville to Greenville, North CarolinaUS 264A - Greenville, North CarolinaBus. US 264 - Greenville, North CarolinaUS 264A - Belhaven, North Carolina
- Bus. US 264 - Belhaven, North CarolinaByp. US 264 - Manns Harbor to Manteo, North Carolina
US 270
- Bus. US 270 – Shawnee, Oklahoma
- Bus. US 270 – Wewoka, Oklahoma
- Bus. US 270 – Holdenville, Oklahoma
- US 270B – Hot Springs, ArkansasUS 270B – Magnet Cove, Arkansas
- US 270B – Malvern, Arkansas
US 271
- Bus. US 271 - Pittsburg, Texas
- Bus. US 271 - Mount Pleasant, Texas
- Bus. US 271 - Bogata, Texas
- Bus. US 271 - Deport, Texas
- Bus. US 271 - Paris, Texas
- Bus. US 271 - Hugo, Oklahoma
- Bus. US 271 - Poteau, Oklahoma
US 275
City US 275 – Omaha, NebraskaAlt. US 275 – Waterloo to Fremont, Nebraska- Bus. US 275 – Fremont, Nebraska
US 276
- Conn. US 276 – Travelers Rest, South CarolinaBus. US 276 – Greenville, South CarolinaBus. US 276 – Greenville, South CarolinaByp. US 276 – Greenville, South Carolina
US 277
- Bus. US 277 – Eagle Pass, Texas
- Spur US 277 – Eagle Pass, Texas
- Spur US 277 – Del Rio, TexasBus. US 277 – Abilene, Texas
- Bus. US 277 – Stamford, Texas
- Bus. US 277 – Haskell, Texas
- Bus. US 277 – Weinert, Texas
- Bus. US 277 – Munday, Texas
- Bus. US 277 – Seymour, Texas
- Bus. US 277 – Holliday, TexasAlt. US 277 – Wichita Falls, Texas
- Bus. US 277 – Wichita Falls, Texas
US 278
- US 278B – Hope, Arkansas
- US 278B – Camden, Arkansas
- US 278B – Warren, ArkansasBus. US 278 – Piedmont, Alabama
- Bus. US 278 – Rockmart, Georgia
- Truck US 278 – Madison, Georgia
- Byp. US 278 – Warrenton, Georgia
- Truck US 278 – Warrenton, Georgia
- Conn. US 278 – Ridgeland, South Carolina
- Bus. US 278 – Hilton Head Island, South Carolina
US 281
Temp. US 281 – Brownsville to Pharr, Texas- Spur US 281 – Hidalgo, Texas
- Bus. US 281 – Edinburg, Texas
- Bus. US 281 – Encino, Texas
- Bus. US 281 – Falfurrias, Texas
- Bus. US 281 – Alice, Texas
- Alt. US 281 – southeast of Whitsett to Campbellton, TexasBus. US 281 – Wichita Falls, Texas
- Bus. US 281 – Lawton, Oklahoma
- Spur US 281 – Geary, OklahomaAlt. US 281 – Great Bend, KansasByp. US 281 – Great Bend, Kansas
- Truck US 281 – Jamestown, North Dakota
US 283
US 285
Alt. US 285 – Artesia to South Springs Acres, New Mexico- Truck US 285 – Roswell, New MexicoAlt. US 285 – Santa Fe, New MexicoByp. US 285 – Santa Fe, New Mexico