Avoiding Dangerous Missense: Thermophiles Display Especially Low Mutation Rates
Avoiding Dangerous Missense: Thermophiles Display Especially Low Mutation Rates is a scholarly work, published in 2009 in ''PLOS Genetics''. The main subjects of the publication include genome, RNA sequencing, mutation, genetics, gene, thermophile, evolution of ageing, neutral mutation, missense mutation, biology, evolutionary dynamics, mutation rate, and virology. An insight originating in the 1920s and maturing in the 1960s proposed that the genomic mutation rate would reflect a balance between the deleterious effect of the average mutation and the cost of further reducing the mutation rate.