Rapid evolution of the human mutation spectrum
Rapid evolution of the human mutation spectrum is a scholarly work by Kelley Harris and Jonathan K. Pritchard, published in 2017 in ''eLife''. The main subjects of the publication include gene, RNA sequencing, mutation, genetics, computational biology, evolutionary biology, evolution of ageing, neutral mutation, human evolution, DNA replication proofreading, biology, evolutionary dynamics, DNA replication, mutation rate, rapid evolution, and oncogenomics. Evolutionary theory suggests that in such a system, selection has limited ability to remove genetic variants that change mutation rates by small amounts or in specific sequence contexts.