5-Chloro-αET

5-Chloro-αET, or 5-chloro-AET, also known as 5-chloro-α-ethyltryptamine, is a serotonergic agent of the tryptamine and α-alkyltryptamine families. It is the derivative of α-ethyltryptamine with a 5-chloro substitution.

Pharmacology

The drug is known to act as a potent serotonin releasing agent and relatively weak serotonin 5-HT_2A receptor near-full agonist. It shows negligible induction of norepinephrine and dopamine release but does act as a very weak dopamine reuptake inhibitor. 5-Chloro-αET's and values are 33.2nM for serotonin release, 249nM for serotonin 5-HT_2A receptor agonism, 1,838nM for dopamine reuptake inhibition, and >10,000nM for norepinephrine release. The monoamine release assays were performed in rat brain synaptosomes.
Several close analogues of 5-chloro-αET, including 5-chloro-αMT and 5-fluoro-αMT, are known to be potent monoamine oxidase inhibitors, specifically of monoamine oxidase A.

5-Chloro-AET was first described in the scientific literature by at least 1963.

5-Chloro-AET is not an explicitly nor implicitly controlled substance in Canada as of 2025.

5-Chloro-AET is not an explicitly controlled substance in the United States. However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption.