Butyrate—CoA ligase
Butyrate—CoA ligase, also known as xenobiotic/medium-chain fatty acid-ligase, is an enzyme that catalyzes the chemical reaction:
The 3 substrates of this enzyme are ATP, carboxylic acid, and CoA, whereas its 3 products are AMP, diphosphate, and acyl-CoA.
This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. This enzyme participates in the glycine conjugation of xenobiotics and butanoate metabolism.
Nomenclature
The systematic name of this enzyme class is butanoate:CoA ligase. Other names in common use include:- butyryl-CoA synthetase, fatty acid thiokinase,
- acyl-activating enzyme, fatty acid elongate,
- fatty acid activating enzyme,
- fatty acyl coenzyme A synthetase,
- medium chain acyl-CoA synthetase,
- butyryl-coenzyme A synthetase,
- L--3-hydroxybutyryl CoA ligase,
- xenobiotic/medium-chain fatty acid ligase, and
- short-chain acyl-CoA synthetase.
Human proteins containing this domain
- ACSM1
- ACSM2A
- ACSM2B
- ACSM3
- ACSM4
- ACSM5
- ACSM6