List of enzymes
s are listed here by their classification in the International Union of Biochemistry and Molecular Biology's Enzyme Commission (EC) numbering system:
[:Category:Oxidoreductases] (EC 1) ([Oxidoreductase])
[:Category:EC 1.1] (act on the CH-OH group of donors)
- :Category:EC 1.1.1
- * Alcohol Dehydrogenase (NAD)
- * Alcohol Dehydrogenase (NADP)
- * Homoserine Dehydrogenase
- * Aminopropanol Oxidoreductase
- * Diacetyl Reductase
- * Glycerol Dehydrogenase
- * Propanediol-Phosphate Dehydrogenase
- * Glycerol-3-Phoshitiendopene Dehydrogenase (NAD+)
- * D-xylulose reductase
- * L-xylulose reductase
- * Lactate dehydrogenase
- * Malate dehydrogenase
- * Isocitrate dehydrogenase
- * HMG-CoA reductase
- :Category:EC 1.1.2
- :Category:EC 1.1.3
- * Glucose oxidase
- * L-Gulonolactone oxidase
- * Thiamine oxidase
- * Xanthine oxidase
- Category:EC 1.1.4
- :Category:EC 1.1.5
- ''':Category:EC 1.1.99'''
[:Category:EC 1.2] (act on the aldehyde or oxo group of donors)
- :Category:EC 1.2.1
- * Acetaldehyde dehydrogenase
- * Glyceraldehyde 3-phosphate dehydrogenase
- * Pyruvate dehydrogenase
- :Category:EC 1.2.4
- * Oxoglutarate dehydrogenase
[:Category:EC 1.3] (act on the CH-CH group of donors)
- :Category:EC 1.3.1
- * Biliverdin reductase
- :Category:EC 1.3.2
- :Category:EC 1.3.3
- * Protoporphyrinogen oxidase
- :Category:EC 1.3.5
- :Category:EC 1.3.7
- ''':Category:EC 1.3.99'''
[:Category:EC 1.4] (act on the CH-NH2 group of donors)
[:Category:EC 1.5] (act on CH-NH group of donors)
- :Category:EC 1.5.1
- * Dihydrofolate reductase
- * Methylenetetrahydrofolate reductase
- :Category:EC 1.5.3
- * Sarcosine oxidase
- * Dihydrobenzophenanthridine oxidase
- :Category:EC 1.5.4
- :Category:EC 1.5.5
- :Category:EC 1.5.7
- :Category:EC 1.5.8
- ''':Category:EC 1.5.99'''
[:Category:EC 1.6] (act on NADH or NADPH)
- :Category:EC 1.6.1
- :Category:EC 1.6.2
- :Category:EC 1.6.3
- Category:EC 1.6.4 now :Category:EC 1.8.1
- :Category:EC 1.6.5
- * NADH dehydrogenase
- Category:EC 1.6.6
- Category:EC 1.6.7 now :Category:EC 1.18.1
- Category:EC 1.6.8 now :Category:EC 1.5.1
- ''':Category:EC 1.6.99'''
[:Category:EC 1.7] (act on other nitrogenous compounds as donors)
- :Category:EC 1.7.1
- :Category:EC 1.7.2
- :Category:EC 1.7.3
- * Urate oxidase
- :Category:EC 1.7.7
- :Category:EC 1.7.99
- * Nitrite reductase
- * Nitrate reductase
[:Category:EC 1.8] (act on a sulfur group of donors)
- :Category:EC 1.8.1
- * Glutathione reductase
- * Thioredoxin reductase
- :Category:EC 1.8.2
- :Category:EC 1.8.3
- * Sulfite oxidase
- :Category:EC 1.8.4
- :Category:EC 1.8.5
- Category:EC 1.8.6 deleted, included in EC 2.5.1.18
- :Category:EC 1.8.7
- :Category:EC 1.8.98
- ''':Category:EC 1.8.99'''
[:Category:EC 1.9] (act on a [heme] group of donors)
- :Category:EC 1.9.3
- * Cytochrome c oxidase
- :Category:EC 1.9.6
- Category:EC 1.9.99 transferred, now EC 1.9.98.1
[:Category:EC 1.10] (act on diphenol">benzenediol">diphenols and related substances as donors)
- :Category:EC 1.10.1
- Category:EC 1.10.2
- * Coenzyme Q - [cytochrome c reductase]
- :Category:EC 1.10.3
- * Catechol oxidase
- * Laccase
- ''':Category:EC 1.10.99'''
[:Category:EC 1.11] (act on [peroxide] as an acceptor -- [peroxidase]s)
- :Category:EC 1.11.1
- * Cytochrome c peroxidase
- * Catalase
- * Myeloperoxidase
- * Thyroid peroxidase
- * Glutathione peroxidase
[:Category:EC 1.12] (act on hydrogen as a donor)
- :Category:EC 1.12.1
- :Category:EC 1.12.2
- :Category:EC 1.12.5
- :Category:EC 1.12.7
- :Category:EC 1.12.98
- ''':Category:EC 1.12.99'''
[:Category:EC 1.13] (act on single donors with incorporation of molecular oxygen)
- :Category:EC 1.13.11
- * 4-hydroxyphenylpyruvate dioxygenase
- :Category:EC 1.13.12
- * Renilla-luciferin 2-monooxygenase
- * Cypridina-luciferin 2-monooxygenase
- * Firefly luciferase
- * Watasenia-luciferin 2-monooxygenase
- * Oplophorus-luciferin 2-monooxygenase
[:Category:EC 1.14] (act on paired donors with incorporation of molecular oxygen)
- Cytochrome P450 oxidase
- :Category:Cytochrome P450
- * Aromatase
- * CYP2D6
- * CYP2E1
- * CYP3A4
- * Cytochrome P450 oxidase
- :Category:EC 1.14.12
- * Nitric oxide dioxygenase
- :Category:EC 1.14.13
- * Nitric oxide synthase
- :Category:EC 1.14.14
- * Aromatase
- * CYP2D6
- * CYP2E1
- * CYP3A4
- :Category:EC 1.14.16
- * Phenylalanine hydroxylase
- :Category:EC 1.14.18
- * Tyrosinase
[:Category:EC 1.15] (act on superoxide radicals as acceptors)
[:Category:EC 1.16] (oxidize metal ions)
[:Category:EC 1.17] (act on CH or CH2 groups)
- :Category:EC 1.17.1
- * Leucoanthocyanidin reductase
- * Xanthine dehydrogenase
- * Nicotinate dehydrogenase
- * 4-hydroxy-tetrahydrodipicolinate reductase
- :Category:EC 1.17.2
- * Nicotinate dehydrogenase (cytochrome)
- :Category:EC 1.17.3
- * Xanthine oxidase
- :Category:EC 1.17.4
- * Ribonucleotide reductase
- * Ribonucleoside-triphosphate reductase
- * Vitamin K epoxide reductase
- * Vitamin-K-epoxide reductase (warfarin-sensitive)
- * Vitamin-K-epoxide reductase (warfarin-insensitive)
- * RRM1
- * RRM2
- * RRM2B
- :Category:EC 1.17.5
- * Caffeine dehydrogenase
- :Category:EC 1.17.7
- ''':Category:EC 1.17.99'''
[:Category:EC 1.18] (act on iron–sulfur proteins as donors)
[:Category:EC 1.19] (act on reduced flavodoxin as donor)
[:Category:EC 1.20] (act on phosphorus or arsenic as donors)
- :Category:EC 1.20.1
- :Category:EC 1.20.2
- :Category:EC 1.20.4
- * Arsenate reductase (glutaredoxin)
- * Glutaredoxin
- :Category:EC 1.20.9
- ''':Category:EC 1.20.99'''
[:Category:EC 1.21] (act on X-H and Y-H to form an X-Y bond)
- :Category:EC 1.21.1
- * Iodotyrosine deiodinase
- :Category:EC 1.21.3
- * Isopenicillin N synthase
- * Tetrahydrocannabinolic acid synthase
- :Category:EC 1.21.4
- :Category:EC 1.21.99
- * Thyroxine 5-deiodinase
- * Iodothyronine deiodinase and
[:Category:EC 1.97] (other oxidoreductases)
[:Category:Transferases] (EC 2) ([Transferase])
[:Category:EC 2.1] (transfer one-carbon groups, [Methylase])
- :Category:EC 2.1.1
- * Catechol-O-methyl transferase
- * DNA methyltransferase,,
- * Histone methyltransferase ,
- :Category:EC 2.1.3
- * Aspartate transcarbamoylase
- * Ornithine transcarbamoylase
[:Category:EC 2.2] (transfer [aldehyde] or [ketone] groups)
- :Category:EC 2.2.1
- * Transketolase
- * Transaldolase
- * Acetolactate synthase
- * 2-Succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase
[:Category:EC 2.3] (acyltransferases)
- :Category:EC 2.3.1
- * Aminolevulinic acid synthase
- * Choline acetyltransferase
- :Category:EC 2.3.2
- * Factor XIII
- * Gamma glutamyl transpeptidase
- * Transglutaminase
[:Category:EC 2.4] (glycosyltransferases)
:Category:EC 2.5[:Category:EC 2.5] (transfer [alkyl] or [aryl] groups, other than [methyl] groups)
[:Category:EC 2.6] (transfer nitrogenous groups)
[:Category:EC 2.7] (transfer phosphorus-containing groups)
[:Category:EC 2.8] (transfer sulfur-containing groups)
- : Thiosulfate sulfurtransferase
- : 3-mercaptopyruvate sulfurtransferase
- : Thiosulfate—thiol sulfurtransferase
- : tRNA uracil 4-sulfurtransferase
- : Thiosulfate—dithiol sulfurtransferase
- : Biotin synthase
- : Cysteine desulfurase
- : Lipoyl synthase
- : Molybdenum cofactor sulfurtransferase
- : Thiazole synthase
- : Molybdopterin synthase sulfurtransferase
- : Molybdopterin synthase
- : tRNA-uridine 2-sulfurtransferase
- : tRNA-5-taurinomethyluridine 2-sulfurtransferase
- : tRNA-5-methyluridine 2-sulfurtransferase
[:Category:EC 2.9] (transfer selenium-containing groups)
- : L-seryl-tRNA selenium transferase
- : O-phospho-L-seryl-tRNA:L-selenocysteinyl-tRNA synthase
[:Category:Hydrolases] (EC 3) ([Hydrolase])
[:Category:EC 3.1] (act on [ester] bonds)
- Nuclease
- Endonuclease
- Exonuclease
- :Category:EC 3.1.1
- * Acid hydrolase
- * Phospholipase A
- * Acetylcholinesterase
- * Cholinesterase
- * Lipoprotein lipase
- :Category:EC 3.1.2
- * Ubiquitin carboxy-terminal hydrolase L1
- :Category:EC 3.1.3
- * Phosphatase
- * Alkaline phosphatase
- * Fructose bisphosphatase
- :Category:EC 3.1.4
- * Phospholipase C
- * CGMP specific phosphodiesterase type 5
- * Phospholipase D
- :Category:EC 3.1.21
- * Restriction enzyme Type 1
- * Restriction enzyme Type 2
- * Restriction enzyme Type 3
- * Restriction enzyme Type 4
- * Deoxyribonuclease I
- :Category:EC 3.1.26
- * RNase H
- :Category:EC 3.1.27
- * Ribonuclease
[:Category:EC 3.2] (act on sugars - [glycosylases])
- :Category:EC 3.2.1
- * Amylase
- * Sucrase
- * Chitinase
- * Lysozyme
- * Maltase
- * Lactase
- * Beta-galactosidase
- * Hyaluronidase
Function and clinical importance of some enzymes in category 3.2.1
Amylase
Function: Amylase is an enzyme that is responsible for the breaking of the bonds in starches, polysaccharides, and complex carbohydrates to be turned into simple sugars that will be easier to absorb.Clinical Significance: Amylase also has medical history in the use of Pancreatic Enzyme Replacement Therapy. One of the components is Sollpura, which help in the breakdown of saccharides into simple sugars.
Lysozyme
Function: An enzyme that is produced by animals that forms part of the innate immune system and is abundant in the secretions of saliva, human milk, tears, and mucus. It functions as an antimicrobial agent by splitting the peptidoglycan component of bacterial cell walls, which then leads to cell death.Clinical Significance: Toxic levels of blood are caused by the excessive production of lysozyme's by cancer cells. Lysozyme's have also been associated with Bronchopulmonary dysplasia in newborns and is a key factor in providing the immunology of infants during breast feeding.
Sucrase
Function: Sucrase is a stomachs related protein that mobilizes hydrolysis to convert sucrose into glucose and fructose.Clinical Significance: Low amounts of Sucrose also known as Sucrose intolerance happens when sucrose isn't being discharged in the small digestive tract. A result of this is extra gas.
Lactase
Function: lactase is located in the small digestives system of people and other creatures such as mammals. Lactase is the bases of the total absorption of milk.Clinical Significance: People who are lactose intolerant have medicine that can help with the digestion. When you are lactose intolerant you might experience gas, bloating, and pain along with other symptoms regarding your digestive system.
[:Category:EC 3.3] (act on [ether] bonds)
- :Category:EC 3.3
- Adenosylmethionine hydrolase
- S-adenosyl-L-homocysteine hydrolase
- Alkenylglycerophosphocholine hydrolase
- Alkenylglycerophosphoethanolamine hydrolase
- Cholesterol-5,6-oxide hydrolase
- Hepoxilin-epoxide hydrolase
- Isochorismatase
- Leukotriene-A4 hydrolase
- Limonene-1,2-epoxide hydrolase
- Microsomal epoxide hydrolase
- Trans-epoxysuccinate hydrolase
[:Category:EC 3.4] (act on [peptide bond]s - [Peptidase])
- :Category:EC 3.4.11
- * Alanine aminopeptidase
- :Category:EC 3.4.15
- * Angiotensin converting enzyme
- :Category:EC 3.4.21
- * Serine protease
- * Chymotrypsin
- * Trypsin
- * Thrombin
- * Factor X
- * Plasmin
- * Acrosin
- * Factor VII
- * Factor IX
- * Prolyl oligopeptidase
- * Factor XI
- * Elastase
- * Factor XII
- * Proteinase K
- * Tissue plasminogen activator
- * Protein C
- :Category:EC 3.4.22
- * Separase
- :Category:EC 3.4.23
- * Pepsin
- * Rennet
- * Renin
- * Trypsinogen and
- * Plasmepsin
- :Category:EC 3.4.24
- * Matrix metalloproteinase
- :Category:EC 3.4.25
- * Metalloendopeptidase
[:Category:EC 3.5] (act on carbon–nitrogen bonds, other than peptide bonds)
- :Category:EC 3.5.1
- * Urease
- :Category:EC 3.5.2
- * Beta-lactamase
- :Category:EC 3.5.3
- * Arginase
- :Category:EC 3.5.4
- * Adenosine deaminase
- * GTP cyclohydrolase I
- :Category:EC 3.5.5
- * Nitrilase
[:Category:EC 3.6] (act on [acid anhydride]s)
- :Category:EC 3.6.1
- * Helicase
- * DnaB helicase
- * RecQ helicase
- :Category:EC 3.6.3
- * ATPase
- * NaKATPase
- * ATP synthase
[:Category:EC 3.7] (act on carbon–carbon bonds)
[:Category:EC 3.8] (act on [halide] bonds)
- EC 3.8.1.3 Haloacetate dehalogenase
[:Category:EC 3.9] (act on phosphorus–nitrogen bonds)
- : Phosphoamidase
- : Protein arginine phosphatase
- : Phosphohistidine phosphatase
[:Category:EC 3.10] (act on sulfur–nitrogen bonds)
[:Category:EC 3.11] (act on carbon–phosphorus bonds)
[:Category:EC 3.12] (act on sulfur–sulfur bonds)
[:Category:EC 3.13] (act on carbon–sulfur bonds)
- : UDP-sulfoquinovose synthase
- : 2'-hydroxybiphenyl-2-sulfinate desulfinase
- : 3-sulfinopropanoyl—CoA desulfinase
- : Carbon [disulfide hydrolase]
- : -S-L-cysteine hydrolase
- : Carbonyl sulfide hydrolase
- : S-adenosyl-L-methionine hydrolase
[:Category:Lyases] (EC 4) ([Lyase])
[:Category:EC 4.1] (carbon–carbon [lyase]s)
- :Category:EC 4.1.1
- * Ornithine decarboxylase
- * Uridine monophosphate synthetase
- * Aromatic-L-amino-acid decarboxylase
- * RubisCO
- :Category:EC 4.1.2
- * Fructose-bisphosphate aldolase
[:Category:EC 4.2] (carbon–oxygen [lyase]s)
[:Category:EC 4.3] (carbon–nitrogen [lyase]s)
[:Category:EC 4.4] (carbon–sulfur [lyase]s)
[:Category:EC 4.5] (carbon–halide [lyase]s)
[:Category:EC 4.6] (phosphorus–oxygen [lyase]s)
[:Category:Isomerases] (EC 5) ([Isomerase])
[:Category:EC 5.1] (racemases and epimerases)
- :Category:EC 5.1.1
- Amino-acid racemase: Phenylalanine racemase (ATP-hydrolysing)
- Serine racemase
- :Category:EC 5.1.2
- Mandelate racemase
- :Category:EC 5.1.3
- UDP-glucose 4-epimerase
- :Category:EC 5.1.99
- Methylmalonyl CoA epimerase
[:Category:EC 5.2] (cis-trans-isomerases)
- :Category:EC 5.2
- FKBP: FKBP1A
- FKBP1B
- FKBP2
- FKBP3
- FKBP4
- FKBP5
- FKBP6
- FKBP8
- FKBP9
- FKBP10
- FKBPL
- Cyclophilin
- Parvulin
- Prolyl isomerase
- 2-chloro-4-carboxymethylenebut-2-en-1,4-olide isomerase
- Beta-carotene isomerase
- Farnesol 2-isomerase
- Furylfuramide isomerase
- Linoleate isomerase
- Maleate isomerase
- Maleylacetoacetate isomerase
- Maleylpyruvate isomerase
- Parvulin
- Photoisomerase
- Prolycopene isomerase
- Prolyl isomerase
- Retinal isomerase
- Retinol isomerase
- Zeta-carotene isomerase
[:Category:EC 5.3] (intramolecular">Intramolecular reaction">intramolecular [oxidoreductase]s)
[:Category:EC 5.4] (intramolecular [transferase]s -- [mutase]s)
[:Category:EC 5.99] (other isomerases)
[:Category:Ligases] (EC 6) ([Ligase])
[:Category:EC 6.1] (form carbon–oxygen bonds)
[:Category:EC 6.2] (form carbon–sulfur bonds)
- : Acetate—CoA ligase
- : Medium-chain acyl—CoA ligase
- : Long-chain-fatty-acid—CoA ligase
- : Succinate—CoA ligase (GDP-forming)
- : Succinate—CoA ligase (ADP-forming)
- : Glutarate—CoA ligase
- : Cholate—CoA ligase
- : Oxalate—CoA ligase
- : Malate—CoA ligase
- : Acid—CoA ligase (GDP-forming)
- : Biotin—CoA ligase
- : 4-Coumarate—CoA ligase
- : Acetate—CoA ligase (ADP-forming)
- : 6-carboxyhexanoate—CoA ligase
- : Arachidonate—CoA ligase
- : Acetoacetate—CoA ligase
- : Propionate—CoA ligase
- : Citrate—CoA ligase
- : Long-chain-fatty-acid-luciferin-component ligase
- : Long-chain-fatty-acid-(acyl-carrier-protein) ligase
- : Transferred entry: 6.2.1.30
- : (citrate (pro-3S)-lyase) ligase
- : Dicarboxylate—CoA ligase
- : Phytanate—CoA ligase
- : Benzoate—CoA ligase
- : o-Succinylbenzoate—CoA ligase
- : 4-hydroxybenzoate—CoA ligase
- : 3-alpha,7-alpha-dihydroxy-5-beta-cholestanate—CoA ligase
- : Transferred entry: 6.2.1.7
- : Phenylacetate—CoA ligase
- : 2-furoate—CoA ligase
- : Anthranilate—CoA ligase
- : 4-chlorobenzoate—CoA ligase
- : trans-Feruloyl—CoA synthase
- : ACP-SH:acetate ligase
- : 3-hydroxypropionyl-CoA synthase
- : 3-hydroxybenzoate—CoA ligase
- : (2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA synthase
- : (butirosin acyl-carrier protein)—L-glutamate ligase
- : 4-Hydroxybutyrate—CoA ligase
- : 3-propanoate—CoA ligase
- : 3-oxocholest-4-en-26-oate—CoA ligase
- : 2-hydroxy-7-methoxy-5-methyl-1-naphthoate—CoA ligase
- : 3-propionyl—CoA ligase
- : E1 ubiquitin-activating enzyme
- : L-allo-Isoleucine—holo-CmaA peptidyl-carrier protein ligase
- : Medium-chain-fatty-acid- ligase
- : Carnitine—CoA ligase
- : Long-chain fatty acid adenylyltransferase FadD28
- : 4-hydroxybenzoate adenylyltransferase FadD22
- : 4-hydroxyphenylalkanoate adenylyltransferase FadD29
- : L-Firefly luciferin—CoA ligase
- : L-Proline—L-prolyl-carrier protein ligase
- : D-Alanine—D-alanyl-carrier protein ligase
- : E1 SAMP-activating enzyme
[:Category:EC 6.3] (form carbon–nitrogen bonds)
[:Category:EC 6.4] (form carbon–carbon bonds)
[:Category:EC 6.5] (form [phosphoric ester] bonds)
Other list of enzymes
EnzymesCategory:Enzymes