Widespread Positive Selection in Synonymous Sites of Mammalian Genes
Widespread Positive Selection in Synonymous Sites of Mammalian Genes is a scholarly work by Svetlana A. Shabalina, Leonardo Mariño-Ramírez, Igor B. Rogozin, and Eugene Koonin, published in 2007 in ''Molecular Biology and Evolution''. The main subjects of the publication include gene, RNA sequencing, selection (genetic algorithm), genetics, evolutionary biology, Nonsynonymous substitution, molecular evolution, Directional selection, Synonymous substitution, phylogenetic tree, biology, RNA splicing, purifying selection, coding region, ribosome, and intron. The authors detected purifying selection at synonymous sites in approximately 28% of the 1,562 analyzed orthologous genes from mouse and rat, and positive selection in approximately 12% of the genes.