List of largest selling pharmaceutical products
Best selling pharmaceuticals of U.S. market
The top 5 best selling pharmaceuticals 2015–2019. Sales in billion USD.| Rank | Drug | Main indication | Trade name | 2015 | 2016 | 2017 | 2018 | 2019 |
| 1 | adalimumab | rheumatoid arthritis | Humira | 10.1 | 13.5 | 16.3 | 18.4 | 21.4 |
| 2 | apixaban | anticoagulant | Eliquis | 1.6 | 3.0 | 4.6 | 7.1 | 9.9 |
| 3 | etanercept | rheumatoid arthritis | Enbrel | 7.2 | 7.6 | 7.9 | 8.0 | 8.1 |
| 4 | ustekinumab | psoriasis | Stelara | 2.0 | 2.6 | 3.7 | 5.0 | 6.6 |
| 5 | pembrolizumab | oncology | Keytruda | 0.4 | 0.7 | 2.2 | 4.3 | 6.5 |
Best selling pharmaceuticals of 2017/18
The top 16 best selling pharmaceuticals of 2017/18.| Rank | Drug | Main indication | Trade name | 2018 sales | 2017 sales |
| 1 | adalimumab | rheumatoid arthritis | Humira | 19 936 | 18427 |
| 3 | apixaban | anticoagulant | Eliquis | 9872 | 7395 |
| 4 | lenalidomide | multiple myeloma | Revlimid | 9685 | 8187 |
| 5 | nivolumab | oncology | Opdivo | 7570 | 5763 |
| 6 | pembrolizumab | oncology | Keytruda | 7171 | 3809 |
| 7 | etanercept | rheumatoid arthritis | Enbrel | 7126 | 7885 |
| 8 | trastuzumab | breast cancer | Herceptin | 6981 | 7013 |
| 9 | bevacizumab | colon cancer | Avastin | 6847 | 6686 |
| 10 | rituximab | non-Hodgkin's lymphoma | Rituxan, MabThera | 6750 | 7298 |
| 11 | rivaroxaban | anticoagulant | Xarelto | 6589 | 6234 |
| 12 | aflibercept | Eylea | 6551 | 5830 | |
| 13 | infliximab | Remicade | 5908 | 7152 | |
| 14 | Pneumococcal conjugate vaccine | Prevnar 13 Prevenar 13 | 5802 | 5601 | |
| 15 | ustekinumab | Stelara | 5156 | 4011 | |
| 16 | pregabalin | epilepsy | Lyrica | 4970 | 5065 |