Thiamine-phosphate diphosphorylase
In enzymology, a thiamine-phosphate diphosphorylase is an enzyme that catalyzes the chemical reaction
The two substrates of this enzyme are 4-Amino-5-hydroxymethyl-2-methylpyrimidine diphosphate and 4-methyl-5-(2-phosphono-oxyethyl)thiazole; its two products are diphosphate and thiamine monophosphate.
This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. This enzyme is on the biosynthetic pathway to thiamine.
Nomenclature
The systematic name of this enzyme class is 2-methyl-4-amino-5-hydroxymethylpyrimidine-diphosphate:4-methyl-5-thiazole 2-methyl-4-aminopyrimidine-5-methenyltransferase. Other names in common use include- thiamine phosphate synthase,
- thiamine phosphate pyrophosphorylase,
- thiamine monophosphate pyrophosphorylase, and
- TMP-PPase.