Substituted isotryptamine

Substituted isotryptamines, or simply isotryptamines, also known as 2-ethylamines, are a group of indoles closely related to the tryptamines but with the ethylamine side chain located at the 1 position of the indole ring system rather than at the 3 position as in tryptamines. Hence, they are positional isomers of tryptamines.
A variety of isotryptamines have been studied and described, including serotonergic psychedelics and psychoplastogens like 6-MeO-isoDMT; non-hallucinogenic psychoplastogens like isoDMT, 5-MeO-isoDMT, and zalsupindole ; serotonin 5-HT_2C receptor agonists like -5,6-difluoro-isoAMT, Ro60-0175, and PNU-181731; serotonin 5-HT₆ receptor modulators; and dual monoamine releasing agents and serotonin receptor agonists like isoAMT.
JRT is the isotryptamine analogue of LSD and may be considered a cyclized isotryptamine.