List of One Life to Live cast members
This is a list of actors and actresses who have had roles on the soap opera One Life to Live. For a full historical character listing, see List of One Life to Live characters.
Celebrity guests
| Guest | Year |
| Joyce Brothers | 1972 |
| Sammy Davis Jr. | 1979 |
| Peabo Bryson | 1985 |
| Beach Boys | 1988 |
| Bill Anderson | 1980s |
| Hugh Downs | 1980s |
| Ivana Trump | 1991 |
| Kurtis Blow | 1991 |
| Dr. Ruth | 1992 |
| Reba McEntire | 1992 |
| Eileen Heckart | 1992 |
| Robin Leach | 1992 |
| Bill Medley | 1994 |
| Darlene Love | 1994 |
| Marsha Mason | 1994 |
| Roberta Peters | 1982 |
| Gene Rayburn | 1970s |
| Little Richard | 1995 |
| Hazel Scott | 1973 |
| Guest | Year |
| The Chieftains | 1996 |
| Robert Vaughn | 1996 |
| Erykah Badu | 1997 |
| Frank McCourt | 1990s |
| Jeremy Roenick | 2000 |
| Chris Therien | 2000 |
| Sheldon Souray | 2000 |
| Kevin Weekes | 2000 |
| Scott Gomez | 2000 |
| Betty Rollin | 2000 |
| Kortney Kayle | 2001 |
| Charles Busch | 2001 |
| Paul Taylor | 2004 |
| Simply Red | 2004 |
| Jai Rodriguez | 2005 |
| Mary J. Blige | 2006, 2008 |
| Desiree Casado | 2006 |
| Marysol Castro | 2006 |
| Lifehouse | 2006, 2010 |
| Guest | Year |
| Jeannie Ortega | 2006 |
| Nelly Furtado | 2007 |
| Joy Behar | 2007 |
| Elisabeth Hasselbeck | 2007 |
| Timbaland | 2007 |
| Keri Hilson | 2007 |
| OneRepublic | 2007 |
| Michelle Veintimilla | 2007 |
| Snoop Dogg | 2008, 2013 |
| Puddle of Mudd | 2008 |
| Plain White T's | 2009 |
| Rachael Yamagata | 2009 |
| The Pussycat Dolls | 2009 |
| Lionel Richie | 2009 |
| Frankie Negrón | 2009 |
| The All-American Rejects | 2009 |
| Wendy Williams | 2011 |
| Kourtney Kardashian | 2011 |