Sequence context-specific profiles for homology searching
Sequence context-specific profiles for homology searching is a scholarly work by Johannes Söding, published in 2009 in ''Proceedings of the National Academy of Sciences of the United States of America''. The main subjects of the publication include biology, similarity, benchmark, sequence analysis, sequence database, sequence motif, glossary of archaeology, Alignment-free sequence analysis, RNA sequencing, structural alignment, multiple sequence alignment, Smith–Waterman algorithm, sequence alignment, Sequence logo, computer science, genetics, protein primary structure, computational biology, ribosome, homology, and biological sequence. Standard sequence comparison methods use substitution matrices to find the alignment with the best sum of similarity scores between aligned residues.