Selection in the evolution of gene duplications
Selection in the evolution of gene duplications is a scholarly work by Eugene Koonin, Yuri Wolf, Fyodor Kondrashov, and Igor B. Rogozin, published in 2002 in ''Genome Biology''. The main subjects of the publication include biology, Genome evolution, molecular evolution, genome, gene family, gene duplication, evolutionary dynamics, RNA sequencing, human evolutionary genetics, gene, Synonymous substitution, ocular adaptation, selection (genetic algorithm), purifying selection, Functional divergence, evolutionary biology, lineage, genetics, Nonsynonymous substitution, ribosome, and phylogenetics. The authors hypothesize that gene duplications that persist in an evolving lineage are beneficial from the time of their origin, due primarily to a protein dosage effect in response to variable environmental conditions; duplications are likely to give rise to new functions at a later phase of their evolution once a higher level of divergence is reached.