Nucleotide sequence divergence and functional constraint in mRNA evolution
Nucleotide sequence divergence and functional constraint in mRNA evolution is a scholarly work, published in 1980 in ''Proceedings of the National Academy of Sciences of the United States of America''. The main subjects of the publication include biology, nucleic acid sequence, molecular clock, conserved sequence, RNA splicing, Functional divergence, genetics, methylation, codon usage bias, protein primary structure, molecular evolution, ribosome, amino acid, biological sequence, gene, nucleotide, and Synonymous substitution. Comparison of about 50 pairs of homologous nucleotide sequences for different genes revealed that the substitutions between synonymous codons occurred at much higher rates than did amino acid substitutions.