Samuel Spencer

• Samuel Spencer , North Carolina judge, lawyer, and Revolutionary War colonel
• Samuel M. Spencer, politician on Hawaii island
• Samuel R. Spencer, American politician, lieutenant governor of Connecticut
• Samuel Spencer , first president of the Southern Railway
• S. B. Spencer, mayor of Atlanta, Georgia
• Sam Spencer, English footballer
• Samuel Reid Spencer Jr., president of Davidson College
• Samuel A. Spencer, American politician in the Virginia House of Delegates
• Samuel Spencer , president of the District of Columbia Board of Commissioners