Southern Railway
- Alabama Great Southern Railroad
- Alton and Southern Railway
- Arkansas Southern Railroad
- Austrian Southern Railway
- Austrian Southern Railway Company
- Buenos Aires Great Southern Railway
- California Southern Railroad
- Canada Southern Railway
- Dakota Southern Railway
- Georgia Southern Railroad
- Great Southern Railway (disambiguation)
- Illinois Southern Railway
- Indiana Southern Railroad
- Iowa Southern Railroad
- Kansas Southern Railway
- Louisiana Southern Railway
- Main Southern railway line, New South Wales
- Minnesota Southern Railway
- Montana Southern Railway
- New Brunswick Southern Railway
- New Jersey Southern Railroad
- Norfolk Southern Railway
- Ohio Southern Railroad (disambiguation)
- Quebec Southern Railway
- South Line (disambiguation)
- Southern (Govia Thameslink Railway)
- Southern Alabama Railroad
- Southern California Railway
- Southern Line (disambiguation)
- Southern Mahratta Railway
- Southern Punjab Railway
- Southern Railroad of New Jersey
- Southern Railway (Austria)
- Southern Railway (Turkey)
- Southern Railway (U.S.)
- Southern Railway (UK)
- Southern Railway (Württemberg)
- Southern Railway Depot (disambiguation)
- Southern Railway of British Columbia
- Southern Railway zone
- Southern Railway – Carolina Division
- Southern Railways (Ukraine)
- Southern Xinjiang railway
- Southern railway line, Queensland
- Südbahn (disambiguation)
- Tennessee Southern Railroad
- Vermont Southern Railroad
- Virginia Southern Railroad