List of highways numbered 221
The following highways are numbered 221:
Canada
- Manitoba Provincial Road 221
- Newfoundland and Labrador Route 221
- Nova Scotia Route 221
- Prince Edward Island Route 221
- Quebec Route 221
- Saskatchewan Highway 221
China
- China National Highway 221
Cuba
- Santa Clara–Sagua Road
Costa Rica
- National Route 221
Japan
- Japan National Route 221
United Kingdom
- road
- B221 road
United States
- U.S. Route 221
- Alabama State Route 221
- Arkansas Highway 221
- California State Route 221
- Florida State Road 221
- Georgia State Route 221
- Iowa Highway 221
- K-221
- Kentucky Route 221
- Maine State Route 221
- Minnesota State Highway 221
- Montana Secondary Highway 221
- Nevada State Route 221
- New Mexico State Road 221
- New York State Route 221
- Ohio State Route 221
- Oregon Route 221
- Pennsylvania Route 221
- Tennessee State Route 221
- Texas State Highway 221
- * Texas State Highway Loop 221
- Utah State Route 221
- Washington State Route 221
- Wyoming Highway 221