Personalized copy number and segmental duplication maps using next-generation sequencing
Personalized copy number and segmental duplication maps using next-generation sequencing is a scholarly work by Can Alkan, Jeffrey M. Kidd, Tomas Marques-Bonet, Francesca Antonacci, Jacob O Kitzman, Evan E. Eichler, S. Cenk Sahinalp, Fereydoun Hormozdiari, Maika Malig, Gözde Aksay, and Richard Gibbs, published in 2009 in ''Nature Genetics''. The main subjects of the publication include genome, RNA sequencing, gene, genetics, biological sequence, polyploidy, genomic structural variation, segmental duplication, Copy number analysis, DNA sequencing, copy-number variation, human genome, biology, constraint, gene duplication, gene dosage, and computational biology. The authors present an algorithm (mrFAST) to comprehensively map next-generation sequence reads, which allows for the prediction of absolute copy-number variation of duplicated segments and genes.