Neuroinformatics
Neuroinformatics is the emergent field that combines informatics and neuroscience. Neuroinformatics is related with neuroscience data and information processing by artificial neural networks. There are three main directions where neuroinformatics has to be applied:
- the development of computational models of the nervous system and neural processes;
- the development of tools for analyzing and modeling neuroscience data; and
- the development of tools and databases for management and sharing of neuroscience data at all levels of analysis.
Neuroinformatics in neuropsychology and neurobiology
Models of neural computation
Models of neural computation are attempts to elucidate, in an abstract and mathematical fashion, the core principles that underlie information processing in biological nervous systems, or functional components thereof. Due to the complexity of nervous system behavior, the associated experimental error bounds are ill-defined, but the relative merit of the different models of a particular subsystem can be compared according to how closely they reproduce real-world behaviors or respond to specific input signals. In the closely related field of computational neuroethology, the practice is to include the environment in the model in such a way that the loop is closed. In the cases where competing models are unavailable, or where only gross responses have been measured or quantified, a clearly formulated model can guide the scientist in designing experiments to probe biochemical mechanisms or network connectivity.Neurocomputing technologies
Artificial neural networks
Artificial neural networks, usually simply called neural networks, are computing systems vaguely inspired by the biological neural networks that constitute animal brains. An ANN is based on a collection of connected units or nodes called artificial neurons, which loosely model the neurons in a biological brain. Each connection, like the synapses in a biological brain, can transmit a signal to other neurons. An artificial neuron that receives a signal then processes it and can signal neurons connected to it. The "signal" at a connection is a real number, and the output of each neuron is computed by some non-linear function of the sum of its inputs. The connections are called edges. Neurons and edges typically have a weight that adjusts as learning proceeds. The weight increases or decreases the strength of the signal at a connection. Neurons may have a threshold such that a signal is sent only if the aggregate signal crosses that threshold. Typically, neurons are aggregated into layers. Different layers may perform different transformations on their inputs. Signals travel from the first layer, to the last layer, possibly after traversing the layers multiple times.Brain emulation and mind uploading
Brain emulation is the concept of creating a functioning computational model and emulation of a brain or part of a brain. In December 2006, the Blue Brain project completed a simulation of a rat's neocortical column. The neocortical column is considered the smallest functional unit of the neocortex. The neocortex is the part of the brain thought to be responsible for higher-order functions like conscious thought, and contains 10,000 neurons in the rat brain. In November 2007, the project reported the end of its first phase, delivering a data-driven process for creating, validating, and researching the neocortical column. An artificial neural network described as being "as big and as complex as half of a mouse brain" was run on an IBM Blue Gene supercomputer by the University of Nevada's research team in 2007. Each second of simulated time took ten seconds of computer time. The researchers claimed to observe "biologically consistent" nerve impulses that flowed through the virtual cortex. However, the simulation lacked the structures seen in real mice brains, and they intend to improve the accuracy of the neuron and synapse models.Mind uploading is the process of scanning a physical structure of the brain accurately enough to create an emulation of the mental state and copying it to a computer in a digital form. The computer would then run a simulation of the brain's information processing, such that it would respond in essentially the same way as the original brain and experience having a sentient conscious mind. Substantial mainstream research in related areas is being conducted in animal brain mapping and simulation, development of faster supercomputers, virtual reality, brain–computer interfaces, connectomics, and information extraction from dynamically functioning brains. According to supporters, many of the tools and ideas needed to achieve mind uploading already exist or are currently under active development; however, they will admit that others are, as yet, very speculative, but say they are still in the realm of engineering possibility.
Brain–computer interface
Research on brain–computer interface began in the 1970s at the University of California, Los Angeles under a grant from the National Science Foundation, followed by a contract from DARPA. The papers published after this research also mark the first appearance of the expression brain–computer interface in scientific literature. Recently, studies in Human-computer interaction through the application of machine learning with statistical temporal features extracted from the frontal lobe, EEG brainwave data has shown high levels of success in classifying mental states mental emotional states and thalamocortical dysrhythmia.Neuroengineering & Neuroinformatics
Neuroinformatics is the scientific study of information flow and processing in the nervous system. Institute scientists utilize brain imaging techniques, such as magnetic resonance imaging, to reveal the organization of brain networks involved in human thought. Brain simulation is the concept of creating a functioning computer model of a brain or part of a brain. There are three main directions where neuroinformatics has to be applied:- the development of computational models of the nervous system and neural processes,
- the development of tools for analyzing data from devices for neurological diagnostic devices,
- the development of tools and databases for management and sharing of patients brain data in healthcare institutions.
Brain mapping and simulation
Brain simulation is the concept of creating a functioning computational model of a brain or part of a brain. In December 2006, the Blue Brain project completed a simulation of a rat's neocortical column. The neocortical column is considered the smallest functional unit of the neocortex. The neocortex is the part of the brain thought to be responsible for higher-order functions like conscious thought, and contains 10,000 neurons in the rat brain. In November 2007, the project reported the end of its first phase, delivering a data-driven process for creating, validating, and researching the neocortical column. An artificial neural network described as being "as big and as complex as half of a mouse brain" was run on an IBM Blue Gene supercomputer by the University of Nevada's research team in 2007. Each second of simulated time took ten seconds of computer time. The researchers claimed to observe "biologically consistent" nerve impulses that flowed through the virtual cortex. However, the simulation lacked the structures seen in real mice brains, and they intend to improve the accuracy of the neuron and synapse models.Mind uploading
Mind uploading is the process of scanning a physical structure of the brain accurately enough to create an emulation of the mental state and copying it to a computer in a digital form. The computer would then run a simulation of the brain's information processing, such that it would respond in essentially the same way as the original brain and experience having a sentient conscious mind. Substantial mainstream research in related areas is being conducted in animal brain mapping and simulation, development of faster supercomputers, virtual reality, brain–computer interfaces, connectomics, and information extraction from dynamically functioning brains. According to supporters, many of the tools and ideas needed to achieve mind uploading already exist or are currently under active development; however, they will admit that others are, as yet, very speculative, but say they are still in the realm of engineering possibility.Auxiliary sciences of neuroinformatics
Data analysis and knowledge organisation
Neuroinformatics is also devoted to the development of neurobiology knowledge with computational models and analytical tools for sharing, integration, and analysis of experimental data and advancement of theories about the nervous system function. In the INCF context, this field refers to scientific information about primary experimental data, ontology, metadata, analytical tools, and computational models of the nervous system. The primary data includes experiments and experimental conditions concerning the genomic, molecular, structural, cellular, networks, systems and behavioural level, in all species and preparations in both the normal and disordered states. In the recent decade, as vast amounts of diverse data about the brain were gathered by many research groups, the problem was raised of how to integrate the data from thousands of publications in order to enable efficient tools for further research. The biological and neuroscience data are highly interconnected and complex, and by itself, integration represents a great challenge for scientists.History
The United States National Institute of Mental Health, the National Institute of Drug Abuse and the National Science Foundation provided the National Academy of Sciences Institute of Medicine with funds to undertake a careful analysis and study of the need to introduce computational techniques to brain research. The positive recommendations were reported in 1991. This positive report enabled NIMH, now directed by Allan Leshner, to create the "Human Brain Project", with the first grants awarded in 1993. Next, Koslow pursued the globalization of the HPG and neuroinformatics through the European Union and the Office for Economic Co-operation and Development, Paris, France. Two particular opportunities occurred in 1996.- The first was the existence of the US/European Commission Biotechnology Task force co-chaired by Mary Clutter from NSF. Within the mandate of this committee, of which Koslow was a member the United States European Commission Committee on Neuroinformatics was established and co-chaired by Koslow from the United States. This committee resulted in the European Commission initiating support for neuroinformatics in Framework 5 and it has continued to support activities in neuroinformatics research and training.
- A second opportunity for globalization of neuroinformatics occurred when the participating governments of the Mega Science Forum of the OECD were asked if they had any new scientific initiatives to bring forward for scientific cooperation around the globe. The White House [Office of Science and Technology Policy] requested that agencies in the federal government meet at NIH to decide if cooperation were needed that would be of global benefit. The NIH held a series of meetings in which proposals from different agencies were discussed. The proposal recommendation from the U.S. for the MSF was a combination of the NSF and NIH proposals. Jim Edwards of NSF supported databases and data-sharing in the area of biodiversity.
Community
; Institute of Neuroinformatics, Zurich; Institute for Adaptive and Neural Computation, School of Informatics, University of Edinburgh
;The International Neuroinformatics Coordinating Facility
- National neuroinformatics programs should be continued or initiated in each country should have a national node to both provide research resources nationally and to serve as the contact for national and international coordination.
- An International Neuroinformatics Coordinating Facility should be established. The INCF will coordinate the implementation of a global neuroinformatics network through integration of national neuroinformatics nodes.
- A new international funding scheme should be established.
; Laboratory of Neuroinformatics, Nencki Institute of Experimental Biology
; Neuroimaging & Neuroinformatics, Howard Florey Institute, University of Melbourne
; Montreal Neurological Institute, McGill University
; The THOR Center for Neuroinformatics
; The Neuroinformatics Portal Pilot
; Computational Neuroscience, ITB, Humboldt-University Berlin
; The Neuroinformatics Group in Bielefeld
; Laboratory of Computational Embodied Neuroscience
; Japan national neuroinformatics resource
; Laboratory for Mathematical Neuroscience, RIKEN Brain Science Institute
; Netherlands state program in neuroinformatics
; NUST-SEECS Neuroinformatics Research Lab
; The Blue Brain Project
; Genes to Cognition Project
; The CARMEN project
; EBI Computational Neurobiology, EMBL-EBI
; Neurogenetics GeneNetwork
; The Neuronal Time Series Analysis
; The Cognitive Atlas
; Brain Big Data research group at the Allen Institute for Brain Science