Naseer Abdullah worked as a location manager for Gandhi. He made his acting debut in the stage playMischief Mania by Pearl Padamsee. He made his film debut with Dil Aashna Hai and after the film's failure he shifted to advertisements for Digjam and Indian Airlines. He played the antagonist in the television serialKya Hadsaa Kya Haqeeqat. He played Shobana's workaholic husband in the film Mitr, My Friend, which follows an Indian-American family and their life and struggles in San Francisco. A criticnoted that "Nasir Abdullah makes his presence felt" while another wrote that he "now and then does not seem very convinced with what he is doing". He went on to play supporting roles in many films including Main Hoon Na, Page 3, Kuchh Meetha Ho Jaye, Om Shanti Om and Gandhi to Hitler.